JP2017501728A5 - - Google Patents
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- Publication number
- JP2017501728A5 JP2017501728A5 JP2016543004A JP2016543004A JP2017501728A5 JP 2017501728 A5 JP2017501728 A5 JP 2017501728A5 JP 2016543004 A JP2016543004 A JP 2016543004A JP 2016543004 A JP2016543004 A JP 2016543004A JP 2017501728 A5 JP2017501728 A5 JP 2017501728A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- amino acid
- binding fragment
- terminal amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920425P | 2013-12-23 | 2013-12-23 | |
| US61/920,425 | 2013-12-23 | ||
| PCT/CA2014/051263 WO2015095972A1 (en) | 2013-12-23 | 2014-12-23 | Antibodies comprising c-terminal light chain polypeptide extensions and conjugates and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017501728A JP2017501728A (ja) | 2017-01-19 |
| JP2017501728A5 true JP2017501728A5 (enExample) | 2018-02-01 |
| JP6585600B2 JP6585600B2 (ja) | 2019-10-02 |
Family
ID=53477259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016543004A Active JP6585600B2 (ja) | 2013-12-23 | 2014-12-23 | Ｃ末端軽鎖ポリペプチド伸長を含有する抗体、ならびにその複合体及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11208497B2 (enExample) |
| EP (1) | EP3087185A4 (enExample) |
| JP (1) | JP6585600B2 (enExample) |
| KR (1) | KR20160122127A (enExample) |
| CN (1) | CN106459981A (enExample) |
| AU (1) | AU2014373593B2 (enExample) |
| BR (1) | BR112016014913A8 (enExample) |
| CA (1) | CA2934818C (enExample) |
| IL (1) | IL246371A0 (enExample) |
| MX (1) | MX2016008355A (enExample) |
| RU (1) | RU2016129724A (enExample) |
| SG (1) | SG11201605093VA (enExample) |
| WO (1) | WO2015095972A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6983511B2 (ja) | 2014-04-25 | 2021-12-17 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 脳中の転移乳癌および他の癌を処置するための方法および組成物 |
| CA3038504A1 (en) * | 2016-10-14 | 2018-04-19 | Dana-Farber Cancer Institute, Inc. | Modular tetrameric bispecific antibody platform |
| US11834506B2 (en) | 2017-02-08 | 2023-12-05 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind NKG2D, CD16, and a tumor-associated antigen for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| ES2955074T3 (es) | 2017-02-20 | 2023-11-28 | Dragonfly Therapeutics Inc | Proteínas que se unen a HER2, NKG2D Y CD16 |
| US11607457B2 (en) | 2017-07-13 | 2023-03-21 | City Of Hope | Anti-cancer phosphorothioate-coupled peptide conjugates and methods of using the same |
| JP7295838B2 (ja) | 2017-07-13 | 2023-06-21 | シティ・オブ・ホープ | ホスホロチオエートコンジュゲートペプチド及びその使用方法 |
| SG11202001930QA (en) * | 2017-09-07 | 2020-04-29 | Dragonfly Therapeutics Inc | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| MX2020008333A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales. |
| ES2986967T3 (es) | 2018-02-08 | 2024-11-13 | Dragonfly Therapeutics Inc | Combinaciones de dominios variables de anticuerpos dirigidas al receptor NKG2D |
| BR112020016939A2 (pt) | 2018-02-20 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Proteínas de ligação multiespecíficas que se ligam a cd33, nkg2d, e cd16 e métodos de uso |
| WO2019213331A1 (en) * | 2018-05-01 | 2019-11-07 | Ambrx, Inc. | A method for optimizing antibody expression |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| SG11202100883SA (en) | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics Inc | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| DK3886914T3 (da) | 2018-11-30 | 2023-07-03 | Bristol Myers Squibb Co | Antistof omfattende en glutaminholdig letkæde-c-terminal forlængelse, konjugater deraf og fremgangsmåder samt anvendelser |
| AU2021268340A1 (en) | 2020-05-06 | 2022-12-08 | Dragonfly Therapeutics, Inc. | Proteins binding NKG2D, CD16 and CLEC12A |
| US12377144B2 (en) | 2021-03-03 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen |
| CN115947830B (zh) * | 2022-12-27 | 2023-09-12 | 优洛生物(上海)有限公司 | 一种经改造的抗体、其制备方法及其用途 |
| EP4548936A1 (en) | 2023-10-30 | 2025-05-07 | BioNTech SE | Antibody-drug conjugates having a tailor-made drug-to-antibody ratio |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2170589C2 (ru) | 1992-10-28 | 2001-07-20 | Генентек Инк. | Композиция для ингибирования ангиогенеза, моноклональное антитело, полипептид, способ ингибирования роста опухоли (варианты) |
| AU5610194A (en) * | 1992-11-16 | 1994-06-08 | Centocor Inc. | Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds |
| US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| US20050159343A1 (en) | 1999-03-26 | 2005-07-21 | Board Of Regents, University Of Texas System | Inhibitors of glycosaminoglycans |
| MXPA03002918A (es) | 2000-10-02 | 2004-04-20 | Arizeke Pharmaceuticals Inc | Composiciones y metodos para el transporte de agentes biologicamente activos a traves de barreras celulares. |
| WO2005000902A1 (en) * | 2003-06-30 | 2005-01-06 | Mu-Hyeon Choe | The dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same |
| WO2007103288A2 (en) * | 2006-03-02 | 2007-09-13 | Seattle Genetics, Inc. | Engineered antibody drug conjugates |
| AU2007257692B2 (en) * | 2006-06-12 | 2013-11-14 | Aptevo Research And Development Llc | Single-chain multivalent binding proteins with effector function |
| PE20140625A1 (es) * | 2007-07-16 | 2014-05-29 | Genentech Inc | ANTICUERPOS ANTI-CD79b E INMUNOCONJUGADOS HUMANIZADOS |
| EP2626371A1 (en) | 2007-07-31 | 2013-08-14 | MedImmune, LLC | Multispecific epitope binding proteins and uses thereof |
| EP2185188B1 (en) * | 2007-08-22 | 2014-08-06 | Medarex, L.L.C. | Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions |
| BRPI0819693A2 (pt) * | 2007-11-30 | 2020-08-18 | Glaxo Group Limited | Construção de ligação de antígeno, método para tratar um paciente que sofre de câncer ou uma doença inflamatória, sequência de polinucleotídeo, polinucleotídeo, célula hospedeira transformada ou transfectada recombinante, método para produziruma construção de ligação de antígeno, e, composição farmacêutica |
| EA201500156A3 (ru) | 2008-01-03 | 2017-09-29 | Дзе Скриппс Рисерч Инститьют | Доставка антител посредством модульного домена распознавания |
| US8454960B2 (en) * | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
| JP2012504970A (ja) * | 2008-10-10 | 2012-03-01 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | Ｔｃｒ複合体免疫治療 |
| US8734796B2 (en) | 2009-03-20 | 2014-05-27 | Amgen Inc. | Carrier immunoglobulins |
| CA2930801C (en) * | 2010-11-05 | 2019-05-28 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| PT2707031T (pt) * | 2011-05-08 | 2019-09-05 | Legochem Biosciences Inc | Conjugados de proteína e agente ativo e processo para a sua preparação |
| CN103857699B (zh) | 2011-05-24 | 2016-08-31 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
| CN110229235A (zh) * | 2011-06-22 | 2019-09-13 | 霍夫曼-拉罗奇有限公司 | 利用包含mhc i类的复合物通过循环中的病毒特异性细胞毒性t细胞清除靶细胞 |
| US9580509B2 (en) * | 2011-11-07 | 2017-02-28 | Medimmune, Llc | Multispecific and multivalent binding proteins and uses thereof |
| WO2013096829A2 (en) | 2011-12-22 | 2013-06-27 | Arizona Biomedical Research Commission | Activation of cellular assault processes in the treatment of glioblastoma multiforme |
| CN104144945A (zh) * | 2012-03-02 | 2014-11-12 | 埃博灵克斯股份有限公司 | 结合铜绿假单胞菌pcrv的单可变结构域抗体 |
| EA201591176A1 (ru) | 2012-12-18 | 2016-02-29 | Новартис Аг | Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном |
-
2014
- 2014-12-23 CA CA2934818A patent/CA2934818C/en active Active
- 2014-12-23 KR KR1020167019769A patent/KR20160122127A/ko not_active Withdrawn
- 2014-12-23 BR BR112016014913A patent/BR112016014913A8/pt not_active Application Discontinuation
- 2014-12-23 RU RU2016129724A patent/RU2016129724A/ru unknown
- 2014-12-23 CN CN201480075958.5A patent/CN106459981A/zh active Pending
- 2014-12-23 SG SG11201605093VA patent/SG11201605093VA/en unknown
- 2014-12-23 JP JP2016543004A patent/JP6585600B2/ja active Active
- 2014-12-23 AU AU2014373593A patent/AU2014373593B2/en active Active
- 2014-12-23 EP EP14874786.8A patent/EP3087185A4/en not_active Withdrawn
- 2014-12-23 US US15/107,884 patent/US11208497B2/en active Active
- 2014-12-23 WO PCT/CA2014/051263 patent/WO2015095972A1/en not_active Ceased
- 2014-12-23 MX MX2016008355A patent/MX2016008355A/es unknown
-
2016
- 2016-06-21 IL IL246371A patent/IL246371A0/en unknown
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