JP2013519721A5 - - Google Patents
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- Publication number
- JP2013519721A5 JP2013519721A5 JP2012553409A JP2012553409A JP2013519721A5 JP 2013519721 A5 JP2013519721 A5 JP 2013519721A5 JP 2012553409 A JP2012553409 A JP 2012553409A JP 2012553409 A JP2012553409 A JP 2012553409A JP 2013519721 A5 JP2013519721 A5 JP 2013519721A5
- Authority
- JP
- Japan
- Prior art keywords
- mhc class
- molecule
- recombinant
- cysteine residues
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 claims 33
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 claims 33
- 102000043131 MHC class II family Human genes 0.000 claims 19
- 108091054438 MHC class II family Proteins 0.000 claims 19
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000588724 Escherichia coli Species 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 241001646716 Escherichia coli K-12 Species 0.000 claims 1
- 241000724791 Filamentous phage Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30572810P | 2010-02-18 | 2010-02-18 | |
| GBGB1002730.8A GB201002730D0 (en) | 2010-02-18 | 2010-02-18 | Product |
| GB1002730.8 | 2010-02-18 | ||
| US61/305,728 | 2010-02-18 | ||
| US31657610P | 2010-03-23 | 2010-03-23 | |
| US61/316,576 | 2010-03-23 | ||
| PCT/GB2011/050325 WO2011101681A2 (en) | 2010-02-18 | 2011-02-18 | Disulphide bond-stabilized functional soluble mhc class ii heterodimers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519721A JP2013519721A (ja) | 2013-05-30 |
| JP2013519721A5 true JP2013519721A5 (enExample) | 2014-03-27 |
| JP5537675B2 JP5537675B2 (ja) | 2014-07-02 |
Family
ID=42113985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553409A Active JP5537675B2 (ja) | 2010-02-18 | 2011-02-18 | ジスルフィド結合により安定化された機能的可溶性ｍｈｃクラスｉｉヘテロ二量体 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8828379B2 (enExample) |
| EP (1) | EP2536746B1 (enExample) |
| JP (1) | JP5537675B2 (enExample) |
| KR (1) | KR101647176B1 (enExample) |
| CN (1) | CN102947330B (enExample) |
| AU (1) | AU2011217027B2 (enExample) |
| CA (1) | CA2789492C (enExample) |
| CY (1) | CY1117697T1 (enExample) |
| DK (1) | DK2536746T3 (enExample) |
| ES (1) | ES2572388T3 (enExample) |
| GB (1) | GB201002730D0 (enExample) |
| HR (1) | HRP20160475T1 (enExample) |
| HU (1) | HUE027952T2 (enExample) |
| PL (1) | PL2536746T3 (enExample) |
| RS (1) | RS54744B1 (enExample) |
| RU (1) | RU2604813C2 (enExample) |
| SI (1) | SI2536746T1 (enExample) |
| WO (1) | WO2011101681A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| SG11201404991YA (en) | 2012-02-23 | 2014-09-26 | Stage Cell Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| EP3901280B1 (en) | 2012-10-17 | 2025-03-12 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
| LT3167065T (lt) * | 2014-07-09 | 2020-07-27 | Lupin Limited | Dviguba cistroninė bakterinė raiškos sistema |
| WO2017004252A1 (en) | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
| US12577289B2 (en) | 2015-06-30 | 2026-03-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Surrogate co-receptors for t cells and methods of use |
| RU2761555C2 (ru) | 2015-10-22 | 2021-12-09 | Джуно Терапьютикс Гмбх | Способы, наборы, средства и устройства для трансдукции |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| US10294454B2 (en) | 2016-08-24 | 2019-05-21 | General Electric Company | Methods and kits for cell activation |
| US20180127481A1 (en) * | 2016-11-09 | 2018-05-10 | Uti Limited Partnership | RECOMBINANT pMHC CLASS II MOLECULES |
| AU2018260380B2 (en) | 2017-04-27 | 2025-02-13 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| DK3817757T3 (da) | 2018-07-06 | 2026-03-09 | Univ California | Peptid-deficient mhc-klasse-i/chaperon-sammensætninger og fremgangsmåder |
| DE102018122546B3 (de) | 2018-09-14 | 2019-12-05 | Immatics Biotechnologies Gmbh | Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden |
| WO2020064915A1 (en) * | 2018-09-28 | 2020-04-02 | Danmarks Tekniske Universitet | High throughput epitope identification and t cell receptor specificity determination using loadable detection molecules |
| WO2020089343A1 (en) | 2018-10-31 | 2020-05-07 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| EP3719033A1 (en) * | 2019-04-02 | 2020-10-07 | imusyn GmbH & Co. KG | Stabilized mhc i |
| WO2021035049A1 (en) * | 2019-08-21 | 2021-02-25 | Uti Limited Partnership | Improved recombinant pmhc molecules |
| EP4028412A2 (en) * | 2019-09-13 | 2022-07-20 | The Regents of The University of California | Systems and methods for the preparation of peptide-mhc-i complexes with native glycan modifications |
| WO2021113297A1 (en) * | 2019-12-02 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
| WO2021138688A1 (en) | 2020-01-03 | 2021-07-08 | The Regents Of The University Of California | Systems and methods for identification of mhc-i peptide epitopes |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| DE102020109447A1 (de) | 2020-04-03 | 2021-10-07 | Jacobs University Bremen Ggmbh | Synthetisches mhc-klasse-ii-protein |
| US12534510B2 (en) | 2020-04-16 | 2026-01-27 | The Regents Of The University Of California | Peptide-receptive MHC-I complex compositions and methods |
| WO2022009049A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| EP4175664A2 (en) | 2020-07-06 | 2023-05-10 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| TW202321312A (zh) * | 2021-09-08 | 2023-06-01 | 俄羅斯聯邦商拜奧卡德聯合股份公司 | 包含基於ｍｈｃ或ｍｈｃ樣蛋白的異源二聚體的二價雙特異性嵌合抗體 |
| CN118813436A (zh) * | 2023-07-24 | 2024-10-22 | 佳吾益(北京)科技有限公司 | 展示单mhc等位基因功能蛋白的工程化细胞 |
| CN119220425A (zh) * | 2023-07-28 | 2024-12-31 | 佳吾益(北京)科技有限公司 | 发现mhc新抗原肽表位的工程化细胞 |
| WO2025137580A1 (en) * | 2023-12-22 | 2025-06-26 | Antiger Therapeutics, Inc. | Class ii hla with inter-chain disulfide bond |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990010457A1 (en) | 1989-03-14 | 1990-09-20 | New York University | Method of treating hiv infections using immunotoxins |
| DK0935607T3 (da) | 1996-08-16 | 2004-12-06 | Harvard College | Oplöselige monovalente og multivalente MHC klasse II-fusionsproteiner samt anvendelser deraf |
| AU741130B2 (en) * | 1997-09-16 | 2001-11-22 | Oregon Health Sciences University | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
| NZ507886A (en) * | 1998-05-19 | 2003-05-30 | Avidex Ltd | Multivalent T cell receptor complexes |
| RU2303264C2 (ru) * | 2001-02-19 | 2007-07-20 | Мерк Патент Гмбх | Способ идентификации эпитопов т-клеток и его применение для получения молекул со сниженной иммуногенностью |
| GB2392158B (en) * | 2002-08-21 | 2005-02-16 | Proimmune Ltd | Chimeric MHC protein and oligomer thereof |
| WO2005044982A2 (en) * | 2003-09-05 | 2005-05-19 | Oregon Health & Science University | Monomeric recombinant mhc molecules useful for manipulation of antigen-specific t cells |
| CA2638892A1 (en) * | 2005-03-18 | 2006-09-28 | Oregon Health & Science University | Recombinant mhc molecules useful for manipulation of antigen-specific t cells |
| WO2008017517A1 (en) * | 2006-08-11 | 2008-02-14 | Life Sciences Research Partners Vzw | Immunogenic peptides and their use in immune disorders |
| CN101548240B (zh) * | 2006-12-01 | 2014-09-17 | 卡尔蔡司Smt有限责任公司 | 具有用于减小像差的可替换、可操纵的校正布置的光学系统 |
| EP2193199B1 (en) | 2007-08-20 | 2013-11-06 | Nextera AS | Pvii phage display |
-
2010
- 2010-02-18 GB GBGB1002730.8A patent/GB201002730D0/en not_active Ceased
-
2011
- 2011-02-18 DK DK11730044.2T patent/DK2536746T3/en active
- 2011-02-18 RU RU2012138302/10A patent/RU2604813C2/ru active
- 2011-02-18 KR KR1020127024287A patent/KR101647176B1/ko active Active
- 2011-02-18 HU HUE11730044A patent/HUE027952T2/en unknown
- 2011-02-18 PL PL11730044T patent/PL2536746T3/pl unknown
- 2011-02-18 CA CA2789492A patent/CA2789492C/en active Active
- 2011-02-18 EP EP11730044.2A patent/EP2536746B1/en active Active
- 2011-02-18 US US13/579,887 patent/US8828379B2/en active Active
- 2011-02-18 WO PCT/GB2011/050325 patent/WO2011101681A2/en not_active Ceased
- 2011-02-18 JP JP2012553409A patent/JP5537675B2/ja active Active
- 2011-02-18 HR HRP20160475TT patent/HRP20160475T1/hr unknown
- 2011-02-18 AU AU2011217027A patent/AU2011217027B2/en active Active
- 2011-02-18 ES ES11730044T patent/ES2572388T3/es active Active
- 2011-02-18 CN CN201180011237.4A patent/CN102947330B/zh active Active
- 2011-02-18 SI SI201130815A patent/SI2536746T1/sl unknown
- 2011-02-18 RS RS20160323A patent/RS54744B1/sr unknown
-
2014
- 2014-07-14 US US14/331,014 patent/US9056920B2/en active Active
-
2016
- 2016-05-11 CY CY20161100397T patent/CY1117697T1/el unknown