JP2012507994A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012507994A5 JP2012507994A5 JP2011535101A JP2011535101A JP2012507994A5 JP 2012507994 A5 JP2012507994 A5 JP 2012507994A5 JP 2011535101 A JP2011535101 A JP 2011535101A JP 2011535101 A JP2011535101 A JP 2011535101A JP 2012507994 A5 JP2012507994 A5 JP 2012507994A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- hla
- fusion polypeptide
- antigen
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 230000004927 fusion Effects 0.000 claims 12
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims 6
- 108010024164 HLA-G Antigens Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100027314 Beta-2-microglobulin Human genes 0.000 claims 1
- 101000986079 Homo sapiens HLA class I histocompatibility antigen, alpha chain G Proteins 0.000 claims 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168675A EP2184070A1 (en) | 2008-11-07 | 2008-11-07 | HLA-G proteins and pharmaceutical uses thereof |
| EP08168675.0 | 2008-11-07 | ||
| US11280408P | 2008-11-10 | 2008-11-10 | |
| US61/112,804 | 2008-11-10 | ||
| PCT/EP2009/064575 WO2010052228A1 (en) | 2008-11-07 | 2009-11-04 | Hla-g proteins and pharmaceutical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012507994A JP2012507994A (ja) | 2012-04-05 |
| JP2012507994A5 true JP2012507994A5 (enExample) | 2012-12-06 |
Family
ID=40673439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535101A Pending JP2012507994A (ja) | 2008-11-07 | 2009-11-04 | Ｈｌａ−ｇタンパク質及びその薬学的使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110268737A1 (enExample) |
| EP (2) | EP2184070A1 (enExample) |
| JP (1) | JP2012507994A (enExample) |
| CA (1) | CA2742517A1 (enExample) |
| DK (1) | DK2352509T3 (enExample) |
| ES (1) | ES2423993T3 (enExample) |
| PT (1) | PT2352509E (enExample) |
| WO (1) | WO2010052228A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012530106A (ja) * | 2009-06-18 | 2012-11-29 | エイチエルエイ−ジー・テクノロジーズ | ＨＬＡ−Ｇα１多量体及びその薬学的使用 |
| EP2445935B1 (en) * | 2009-06-25 | 2015-07-01 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Multimeric polypeptides of hla-g including alpha1-alpha3 monomers and pharmaceutical uses thereof |
| BR112014017111A8 (pt) | 2012-01-12 | 2018-05-15 | Biogen Idec Inc | métodos de redução de imunogenicidade contra o fator viii em indivíduos submetidos à terapia de fator viii |
| RU2015106812A (ru) | 2012-08-02 | 2016-09-27 | Ф.Хоффманн-Ля Рош Аг | Способ получения мономерных и мультимерных молекул и их применение |
| JP2016500255A (ja) | 2012-12-11 | 2016-01-12 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ハイスループットなレセプター：リガンド同定の方法 |
| US20170176435A1 (en) * | 2014-01-21 | 2017-06-22 | Albert Einstein College Of Medicine, Inc. | Cellular platform for rapid and comprehensive t-cell immunomonitoring |
| JP6416480B2 (ja) * | 2014-01-29 | 2018-10-31 | 国立大学法人北海道大学 | 関節リウマチまたはその関連疾患の予防または治療剤 |
| US9765330B1 (en) | 2015-01-09 | 2017-09-19 | Nant Holdings Ip, Llc | Compositions and methods for reduction of allograft recognition and rejection |
| JP7071288B2 (ja) | 2016-05-18 | 2022-05-18 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| US11339201B2 (en) | 2016-05-18 | 2022-05-24 | Albert Einstein College Of Medicine | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
| NZ748929A (en) * | 2016-06-03 | 2025-11-28 | Invectys | Anti hla-g specific antibodies |
| KR20230110373A (ko) * | 2016-06-14 | 2023-07-21 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직,및 장기 |
| CN110520149A (zh) | 2016-12-02 | 2019-11-29 | 比奥维拉迪维治疗股份有限公司 | 诱导对凝血因子的免疫耐受性的方法 |
| MX2019007611A (es) | 2016-12-22 | 2020-07-29 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos t y métodos para su uso. |
| EP3565829A4 (en) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHOD OF USING THEREOF |
| CN118453840A (zh) | 2017-03-15 | 2024-08-09 | 库尔生物制药有限公司 | 用于调节免疫应答的方法 |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| JP2021080171A (ja) * | 2018-03-13 | 2021-05-27 | 国立大学法人北海道大学 | 改変タンパク質、医薬品、炎症性疾患の予防又は治療剤及び改変タンパク質の製造方法 |
| TW202208395A (zh) | 2020-05-12 | 2022-03-01 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717498B1 (fr) | 1994-03-18 | 1996-05-03 | Commissariat Energie Atomique | Transcrits du gène de CMH de classe I HLA-G et leurs applications. |
| CA2321222A1 (fr) | 1998-02-20 | 1999-08-26 | Commissariat A L'energie Atomique | Methode de selection de tumeurs exprimant hla-g, sensibles a un traitement anticancereux et ses applications |
| FR2794977B1 (fr) | 1999-06-18 | 2003-10-31 | Commissariat Energie Atomique | Utilisation de compositions contenant des formes solubles d'hla-g dans le traitement de pathologies inflammatoires de la peau, et leur procede d'obtention |
| FR2810047B1 (fr) | 2000-06-13 | 2004-04-02 | Commissariat Energie Atomique | Nouvelle isoforme d'hla-g et ses applications |
| WO2005063808A1 (en) * | 2003-12-31 | 2005-07-14 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| MXPA06014689A (es) * | 2004-06-18 | 2008-03-11 | Regeneron Pharma | Inhibidores del vegf para el tratamiento de efusion pleural maligna. |
| WO2007011044A1 (ja) | 2005-07-15 | 2007-01-25 | Kyushu University, National University Corporation | ジスルフィド結合型hla-g二量体を含む医薬組成物及びジスルフィド結合型hla-g二量体の製造方法 |
| WO2007091078A2 (en) | 2006-02-10 | 2007-08-16 | Axordia Limited | Polypeptide conjugate comprising hla-g and uses thereof, stem cells transfected with hla-g |
| WO2007133811A2 (en) * | 2006-05-15 | 2007-11-22 | Viral Logic Systems Technology Corp. | Cd47 related compositions and methods for treating immunological diseases and disorders |
-
2008
- 2008-11-07 EP EP08168675A patent/EP2184070A1/en not_active Withdrawn
-
2009
- 2009-11-04 EP EP09747827.5A patent/EP2352509B1/en not_active Not-in-force
- 2009-11-04 US US13/127,788 patent/US20110268737A1/en not_active Abandoned
- 2009-11-04 JP JP2011535101A patent/JP2012507994A/ja active Pending
- 2009-11-04 PT PT97478275T patent/PT2352509E/pt unknown
- 2009-11-04 WO PCT/EP2009/064575 patent/WO2010052228A1/en not_active Ceased
- 2009-11-04 CA CA2742517A patent/CA2742517A1/en not_active Abandoned
- 2009-11-04 DK DK09747827.5T patent/DK2352509T3/da active
- 2009-11-04 ES ES09747827T patent/ES2423993T3/es active Active