JP2015518479A5 - - Google Patents

Info

Publication number

JP2015518479A5

JP2015518479A5 JP2015505024A JP2015505024A JP2015518479A5 JP 2015518479 A5 JP2015518479 A5 JP 2015518479A5 JP 2015505024 A JP2015505024 A JP 2015505024A JP 2015505024 A JP2015505024 A JP 2015505024A JP 2015518479 A5 JP2015518479 A5 JP 2015518479A5

Authority

JP

Japan

Prior art keywords

cell

polypeptide

cells

vector

composition

Prior art date

2013-04-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 210000004027 cell Anatomy 0.000 claims description 79
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 36
• 229920001184 polypeptide Polymers 0.000 claims description 34
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 34
• 238000000034 method Methods 0.000 claims description 19
• 230000027455 binding Effects 0.000 claims description 14
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 10
• 229960004641 rituximab Drugs 0.000 claims description 10
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 8
• 108020001507 fusion proteins Proteins 0.000 claims description 8
• 102000037865 fusion proteins Human genes 0.000 claims description 8
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
• 108091008874 T cell receptors Proteins 0.000 claims description 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
• 150000007523 nucleic acids Chemical group 0.000 claims description 6
• 230000002463 transducing effect Effects 0.000 claims description 5
• 108700019146 Transgenes Proteins 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 102000004169 proteins and genes Human genes 0.000 claims description 4
• 108090000623 proteins and genes Proteins 0.000 claims description 4
• 125000006850 spacer group Chemical group 0.000 claims description 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims description 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
• 150000001413 amino acids Chemical class 0.000 claims description 2
• 239000000427 antigen Substances 0.000 claims description 2
• 108091007433 antigens Proteins 0.000 claims description 2
• 102000036639 antigens Human genes 0.000 claims description 2
• 201000011510 cancer Diseases 0.000 claims description 2
• 230000000295 complement effect Effects 0.000 claims description 2
• 238000001415 gene therapy Methods 0.000 claims description 2
• 238000001727 in vivo Methods 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 230000001404 mediated effect Effects 0.000 claims description 2
• 230000026683 transduction Effects 0.000 claims description 2
• 238000010361 transduction Methods 0.000 claims description 2
• 102100026827 Protein associated with UVRAG as autophagy enhancer Human genes 0.000 claims 1
• 101710102978 Protein associated with UVRAG as autophagy enhancer Proteins 0.000 claims 1
• 230000000779 depleting effect Effects 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1