JP2019500894A5 - - Google Patents

Info

Publication number

JP2019500894A5

JP2019500894A5 JP2018543279A JP2018543279A JP2019500894A5 JP 2019500894 A5 JP2019500894 A5 JP 2019500894A5 JP 2018543279 A JP2018543279 A JP 2018543279A JP 2018543279 A JP2018543279 A JP 2018543279A JP 2019500894 A5 JP2019500894 A5 JP 2019500894A5

Authority

JP

Japan

Prior art keywords

amino acid

variant

seq

domain

nucleic acid

Prior art date

2016-11-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001413 amino acids Chemical class 0.000 claims 25
• 230000004048 modification Effects 0.000 claims 25
• 238000012986 modification Methods 0.000 claims 25
• 125000003275 alpha amino acid group Chemical group 0.000 claims 18
• 102000039446 nucleic acids Human genes 0.000 claims 17
• 108020004707 nucleic acids Proteins 0.000 claims 17
• 150000007523 nucleic acids Chemical class 0.000 claims 17
• 210000001744 T-lymphocyte Anatomy 0.000 claims 13
• 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 12
• 230000000139 costimulatory effect Effects 0.000 claims 9
• 238000000034 method Methods 0.000 claims 8
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 7
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 7
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 4
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 108090000765 processed proteins & peptides Proteins 0.000 claims 4
• 230000011664 signaling Effects 0.000 claims 4
• 210000003071 memory t lymphocyte Anatomy 0.000 claims 3
• 125000006850 spacer group Chemical group 0.000 claims 3
• 239000013598 vector Substances 0.000 claims 3
• 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
• 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 2
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108010083359 Antigen Receptors Proteins 0.000 claims 1
• 102000006306 Antigen Receptors Human genes 0.000 claims 1
• 208000003174 Brain Neoplasms Diseases 0.000 claims 1
• 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 1
• 102100033467 L-selectin Human genes 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 230000000735 allogeneic effect Effects 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• 230000002463 transducing effect Effects 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1