JP2017533706A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017533706A5 JP2017533706A5 JP2017523266A JP2017523266A JP2017533706A5 JP 2017533706 A5 JP2017533706 A5 JP 2017533706A5 JP 2017523266 A JP2017523266 A JP 2017523266A JP 2017523266 A JP2017523266 A JP 2017523266A JP 2017533706 A5 JP2017533706 A5 JP 2017533706A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- modified
- tcr
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 255
- 238000000034 method Methods 0.000 claims description 143
- 239000000427 antigen Substances 0.000 claims description 117
- 102000036639 antigens Human genes 0.000 claims description 117
- 108091007433 antigens Proteins 0.000 claims description 117
- 210000004027 cell Anatomy 0.000 claims description 94
- 108091008874 T cell receptors Proteins 0.000 claims description 83
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 83
- 102000039446 nucleic acids Human genes 0.000 claims description 71
- 108020004707 nucleic acids Proteins 0.000 claims description 71
- 150000007523 nucleic acids Chemical class 0.000 claims description 71
- 230000000139 costimulatory effect Effects 0.000 claims description 34
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 30
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims description 30
- 239000012634 fragment Substances 0.000 claims description 29
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims description 28
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 201000010099 disease Diseases 0.000 claims description 25
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims description 18
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims description 18
- 208000023275 Autoimmune disease Diseases 0.000 claims description 17
- 230000028993 immune response Effects 0.000 claims description 16
- 102000018697 Membrane Proteins Human genes 0.000 claims description 15
- 108010052285 Membrane Proteins Proteins 0.000 claims description 15
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 230000003834 intracellular effect Effects 0.000 claims description 15
- 208000030507 AIDS Diseases 0.000 claims description 14
- 208000000659 Autoimmune lymphoproliferative syndrome Diseases 0.000 claims description 14
- 208000001640 Fibromyalgia Diseases 0.000 claims description 14
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 14
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims description 14
- 208000003456 Juvenile Arthritis Diseases 0.000 claims description 14
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 14
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 14
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 14
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 claims description 14
- 208000011580 syndromic disease Diseases 0.000 claims description 14
- 201000011510 cancer Diseases 0.000 claims description 13
- 201000001981 dermatomyositis Diseases 0.000 claims description 13
- 230000011664 signaling Effects 0.000 claims description 13
- 208000007465 Giant cell arteritis Diseases 0.000 claims description 12
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims description 12
- 238000012258 culturing Methods 0.000 claims description 12
- 206010043207 temporal arteritis Diseases 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 9
- 102100027207 CD27 antigen Human genes 0.000 claims description 8
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 8
- 208000034189 Sclerosis Diseases 0.000 claims description 8
- 238000004520 electroporation Methods 0.000 claims description 8
- 208000008190 Agammaglobulinemia Diseases 0.000 claims description 7
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims description 7
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims description 7
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims description 7
- 208000023328 Basedow disease Diseases 0.000 claims description 7
- 208000009137 Behcet syndrome Diseases 0.000 claims description 7
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims description 7
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims description 7
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 7
- 206010006187 Breast cancer Diseases 0.000 claims description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims description 7
- 102100035793 CD83 antigen Human genes 0.000 claims description 7
- 201000002829 CREST Syndrome Diseases 0.000 claims description 7
- 208000031229 Cardiomyopathies Diseases 0.000 claims description 7
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 7
- 208000015943 Coeliac disease Diseases 0.000 claims description 7
- 206010009944 Colon cancer Diseases 0.000 claims description 7
- 208000011231 Crohn disease Diseases 0.000 claims description 7
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 7
- 208000015023 Graves' disease Diseases 0.000 claims description 7
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims description 7
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 7
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims description 7
- 206010020983 Hypogammaglobulinaemia Diseases 0.000 claims description 7
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 7
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims description 7
- 206010021263 IgA nephropathy Diseases 0.000 claims description 7
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims description 7
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
- 206010025323 Lymphomas Diseases 0.000 claims description 7
- 208000027530 Meniere disease Diseases 0.000 claims description 7
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims description 7
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims description 7
- 206010033128 Ovarian cancer Diseases 0.000 claims description 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 7
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 7
- 208000031845 Pernicious anaemia Diseases 0.000 claims description 7
- 206010065159 Polychondritis Diseases 0.000 claims description 7
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims description 7
- 206010060862 Prostate cancer Diseases 0.000 claims description 7
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 7
- 201000004681 Psoriasis Diseases 0.000 claims description 7
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 7
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 7
- 208000012322 Raynaud phenomenon Diseases 0.000 claims description 7
- 208000033464 Reiter syndrome Diseases 0.000 claims description 7
- 206010038389 Renal cancer Diseases 0.000 claims description 7
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 7
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 7
- 206010072148 Stiff-Person syndrome Diseases 0.000 claims description 7
- 208000001106 Takayasu Arteritis Diseases 0.000 claims description 7
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 7
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 7
- 206010047642 Vitiligo Diseases 0.000 claims description 7
- 208000004631 alopecia areata Diseases 0.000 claims description 7
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims description 7
- 208000036923 autoimmune primary adrenal insufficiency Diseases 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 7
- 201000010881 cervical cancer Diseases 0.000 claims description 7
- 208000019069 chronic childhood arthritis Diseases 0.000 claims description 7
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims description 7
- 208000029742 colonic neoplasm Diseases 0.000 claims description 7
- 210000003027 ear inner Anatomy 0.000 claims description 7
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 7
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 7
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims description 7
- 201000010982 kidney cancer Diseases 0.000 claims description 7
- 208000032839 leukemia Diseases 0.000 claims description 7
- 201000007270 liver cancer Diseases 0.000 claims description 7
- 208000014018 liver neoplasm Diseases 0.000 claims description 7
- 201000005202 lung cancer Diseases 0.000 claims description 7
- 208000020816 lung neoplasm Diseases 0.000 claims description 7
- 206010025135 lupus erythematosus Diseases 0.000 claims description 7
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 7
- 201000006417 multiple sclerosis Diseases 0.000 claims description 7
- 206010028417 myasthenia gravis Diseases 0.000 claims description 7
- 201000002528 pancreatic cancer Diseases 0.000 claims description 7
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 7
- 230000003071 parasitic effect Effects 0.000 claims description 7
- 201000006292 polyarteritis nodosa Diseases 0.000 claims description 7
- 208000005987 polymyositis Diseases 0.000 claims description 7
- 208000002574 reactive arthritis Diseases 0.000 claims description 7
- 201000003068 rheumatic fever Diseases 0.000 claims description 7
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 7
- 201000000306 sarcoidosis Diseases 0.000 claims description 7
- 201000000849 skin cancer Diseases 0.000 claims description 7
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 7
- 208000020408 systemic-onset juvenile idiopathic arthritis Diseases 0.000 claims description 7
- 230000003612 virological effect Effects 0.000 claims description 7
- 108010082808 4-1BB Ligand Proteins 0.000 claims description 6
- 102000002627 4-1BB Ligand Human genes 0.000 claims description 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 6
- 201000003066 Diffuse Scleroderma Diseases 0.000 claims description 6
- 108010002352 Interleukin-1 Proteins 0.000 claims description 6
- 108010002350 Interleukin-2 Proteins 0.000 claims description 6
- 108010002386 Interleukin-3 Proteins 0.000 claims description 6
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims description 6
- 206010039710 Scleroderma Diseases 0.000 claims description 6
- 102000015215 Stem Cell Factor Human genes 0.000 claims description 6
- 108010039445 Stem Cell Factor Proteins 0.000 claims description 6
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 210000004700 fetal blood Anatomy 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 6
- 230000037390 scarring Effects 0.000 claims description 6
- 238000010257 thawing Methods 0.000 claims description 6
- 210000004881 tumor cell Anatomy 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 238000010361 transduction Methods 0.000 claims description 5
- 230000026683 transduction Effects 0.000 claims description 5
- 238000001890 transfection Methods 0.000 claims description 5
- 206010034277 Pemphigoid Diseases 0.000 claims description 3
- 206010046851 Uveitis Diseases 0.000 claims description 3
- 201000003278 cryoglobulinemia Diseases 0.000 claims description 3
- 208000019707 Cryoglobulinemic vasculitis Diseases 0.000 claims description 2
- 206010003230 arteritis Diseases 0.000 claims description 2
- 201000002481 Myositis Diseases 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 238000011259 co-electroporation Methods 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 230000027455 binding Effects 0.000 description 33
- 150000003384 small molecules Chemical class 0.000 description 16
- 108700010039 chimeric receptor Proteins 0.000 description 15
- 210000001519 tissue Anatomy 0.000 description 11
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 10
- 230000009089 cytolysis Effects 0.000 description 10
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 description 8
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 7
- 208000026872 Addison Disease Diseases 0.000 description 6
- 201000004624 Dermatitis Diseases 0.000 description 6
- 208000012528 Juvenile dermatomyositis Diseases 0.000 description 6
- 201000010415 childhood type dermatomyositis Diseases 0.000 description 6
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 6
- 230000036039 immunity Effects 0.000 description 6
- 230000021633 leukocyte mediated immunity Effects 0.000 description 6
- 108020003175 receptors Proteins 0.000 description 6
- 102000005962 receptors Human genes 0.000 description 6
- 230000004936 stimulating effect Effects 0.000 description 6
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 6
- -1 CD86 Proteins 0.000 description 5
- 208000011038 Cold agglutinin disease Diseases 0.000 description 5
- 206010009868 Cold type haemolytic anaemia Diseases 0.000 description 5
- 101001043809 Homo sapiens Interleukin-7 receptor subunit alpha Proteins 0.000 description 5
- 102100021593 Interleukin-7 receptor subunit alpha Human genes 0.000 description 5
- 230000005784 autoimmunity Effects 0.000 description 5
- 238000009172 cell transfer therapy Methods 0.000 description 5
- 230000001939 inductive effect Effects 0.000 description 5
- 108010032795 CD8 receptor Proteins 0.000 description 4
- 108010091326 Cryoglobulins Proteins 0.000 description 4
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 description 4
- 201000009906 Meningitis Diseases 0.000 description 4
- 241000721454 Pemphigus Species 0.000 description 4
- 241000219095 Vitis Species 0.000 description 4
- 235000009754 Vitis X bourquina Nutrition 0.000 description 4
- 235000012333 Vitis X labruscana Nutrition 0.000 description 4
- 235000014787 Vitis vinifera Nutrition 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 230000004913 activation Effects 0.000 description 4
- 230000001627 detrimental effect Effects 0.000 description 4
- 108010041397 CD4 Antigens Proteins 0.000 description 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 102100026882 Alpha-synuclein Human genes 0.000 description 2
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 description 2
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 2
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 description 2
- 210000000612 antigen-presenting cell Anatomy 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000004068 intracellular signaling Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 description 1
- 108010074708 B7-H1 Antigen Proteins 0.000 description 1
- 102100038078 CD276 antigen Human genes 0.000 description 1
- 101710185679 CD276 antigen Proteins 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 102100025221 CD70 antigen Human genes 0.000 description 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 1
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 description 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 description 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
- 102100022339 Integrin alpha-L Human genes 0.000 description 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 description 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 108020001756 ligand binding domains Proteins 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021084334A JP2021121208A (ja) | 2014-10-31 | 2021-05-19 | 改変t細胞に関する方法および組成物 |
| JP2023088510A JP7757343B2 (ja) | 2014-10-31 | 2023-05-30 | 改変t細胞に関する方法および組成物 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462073144P | 2014-10-31 | 2014-10-31 | |
| US201462073540P | 2014-10-31 | 2014-10-31 | |
| US201462073681P | 2014-10-31 | 2014-10-31 | |
| US201462073343P | 2014-10-31 | 2014-10-31 | |
| US201462073467P | 2014-10-31 | 2014-10-31 | |
| US62/073,681 | 2014-10-31 | ||
| US62/073,144 | 2014-10-31 | ||
| US62/073,540 | 2014-10-31 | ||
| US62/073,343 | 2014-10-31 | ||
| US62/073,467 | 2014-10-31 | ||
| PCT/US2015/058339 WO2016070061A1 (en) | 2014-10-31 | 2015-10-30 | Methods and compositions for modified t cells |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021084334A Division JP2021121208A (ja) | 2014-10-31 | 2021-05-19 | 改変t細胞に関する方法および組成物 |
| JP2023088510A Division JP7757343B2 (ja) | 2014-10-31 | 2023-05-30 | 改変t細胞に関する方法および組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2017533706A JP2017533706A (ja) | 2017-11-16 |
| JP2017533706A5 true JP2017533706A5 (enExample) | 2018-12-06 |
| JPWO2016070061A5 JPWO2016070061A5 (enExample) | 2023-06-08 |
| JP7372728B2 JP7372728B2 (ja) | 2023-11-01 |
Family
ID=55858404
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523266A Active JP7372728B2 (ja) | 2014-10-31 | 2015-10-30 | 改変t細胞に関する方法および組成物 |
| JP2021084334A Withdrawn JP2021121208A (ja) | 2014-10-31 | 2021-05-19 | 改変t細胞に関する方法および組成物 |
| JP2023088510A Active JP7757343B2 (ja) | 2014-10-31 | 2023-05-30 | 改変t細胞に関する方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021084334A Withdrawn JP2021121208A (ja) | 2014-10-31 | 2021-05-19 | 改変t細胞に関する方法および組成物 |
| JP2023088510A Active JP7757343B2 (ja) | 2014-10-31 | 2023-05-30 | 改変t細胞に関する方法および組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20170258835A1 (enExample) |
| EP (2) | EP4653013A2 (enExample) |
| JP (3) | JP7372728B2 (enExample) |
| KR (1) | KR20170074243A (enExample) |
| CN (1) | CN107106670A (enExample) |
| AU (1) | AU2015338984A1 (enExample) |
| CA (1) | CA2964958A1 (enExample) |
| HK (1) | HK1243333A1 (enExample) |
| WO (1) | WO2016070061A1 (enExample) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| US11059880B2 (en) | 2015-06-30 | 2021-07-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with MHC chimeric receptors and methods of use in immunotherapy |
| EP3340995A4 (en) * | 2015-08-28 | 2019-04-03 | The Trustees Of The University Of Pennsylvania | METHOD AND COMPOSITIONS FOR CELLS FOR EXPRESSING A CHIMERIC INTRA-CELLULAR SIGNAL MOLECULE |
| US11649435B2 (en) | 2015-08-28 | 2023-05-16 | The Trustees Of The University Of Pennsylvania | Methods and compositions for cells expressing a chimeric intracellular signaling molecule |
| CN109310744A (zh) | 2015-09-23 | 2019-02-05 | 赛通免疫有限责任公司 | 用于免疫治疗的flt3定向car细胞 |
| US12241053B2 (en) | 2015-10-09 | 2025-03-04 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| WO2017075465A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3 |
| WO2017075451A1 (en) | 2015-10-28 | 2017-05-04 | The Broad Institute Inc. | Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1 |
| WO2017087708A1 (en) | 2015-11-19 | 2017-05-26 | The Brigham And Women's Hospital, Inc. | Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity |
| AU2016366226B2 (en) * | 2015-12-09 | 2023-06-01 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of using same |
| CN109477073B (zh) * | 2016-03-31 | 2024-04-12 | 来恩生物医药私人有限公司 | 表达外源病毒特异性t细胞受体(tcr)的非活化t细胞 |
| AU2017251116A1 (en) * | 2016-04-15 | 2018-12-06 | Zymeworks Inc. | Multi-specific antigen-binding constructs targeting immunotherapeutics |
| CN107522786A (zh) * | 2016-06-20 | 2017-12-29 | 深圳市体内生物医药科技有限公司 | 一种分子、表达其的细胞及其制备方法和用途 |
| CN107586342A (zh) * | 2016-07-08 | 2018-01-16 | 生命序有限公司 | 重组免疫检查点受体及其应用 |
| CN107586341A (zh) * | 2016-07-08 | 2018-01-16 | 生命序有限公司 | 重组免疫检查点受体及免疫检查点抑制分子的共表达及应用 |
| AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| AU2017319151B2 (en) | 2016-08-30 | 2024-01-11 | Memorial Sloan Kettering Cancer Center | Immune cell compositions and methods of use for treating viral and other infections |
| US20190262399A1 (en) | 2016-09-07 | 2019-08-29 | The Broad Institute, Inc. | Compositions and methods for evaluating and modulating immune responses |
| CA3036745A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| WO2018067991A1 (en) | 2016-10-07 | 2018-04-12 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| WO2018089386A1 (en) | 2016-11-11 | 2018-05-17 | The Broad Institute, Inc. | Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN108264562B (zh) * | 2016-12-30 | 2021-08-10 | 惠和生物技术(上海)有限公司 | 一种结合cd3和t细胞正共刺激分子的双功能分子及其应用 |
| EP3575319A4 (en) * | 2016-12-30 | 2021-03-10 | Shanghai Sinobio Biotech Co., Ltd. | BIFUNCTIONAL MOLECULE AND USE OF IT |
| US12473343B2 (en) | 2017-01-10 | 2025-11-18 | The General Hospital Corporation | Targeted t cells with cytotoxicity toward immunosuppressive cells |
| WO2018183908A1 (en) | 2017-03-31 | 2018-10-04 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating ovarian tumors |
| EP3606518A4 (en) | 2017-04-01 | 2021-04-07 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR DETECTION AND MODULATION OF IMMUNOTHERAPY RESISTANCE GENE SIGNATURE IN CANCER |
| EP3610266A4 (en) | 2017-04-12 | 2021-04-21 | Massachusetts Eye and Ear Infirmary | TUMOR SIGNATURE FOR METASTASIS, COMPOSITIONS OF MATERIAL AND THEIR METHODS OF USE |
| AU2018251206A1 (en) * | 2017-04-14 | 2019-10-31 | The General Hospital Corporation | Chimeric antigen receptor T cells targeting the tumor microenvironment |
| JP2020517281A (ja) * | 2017-04-26 | 2020-06-18 | メモリアル スローン ケタリング キャンサー センター | すぐに使える凍結保存細胞 |
| EP3622092A4 (en) | 2017-05-11 | 2021-06-23 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF |
| KR102379189B1 (ko) | 2017-06-13 | 2022-03-25 | 엘지디스플레이 주식회사 | 연성 표시 패널을 포함하는 롤러블 디스플레이 장치 |
| EP3638218A4 (en) | 2017-06-14 | 2021-06-09 | The Broad Institute, Inc. | COMPOSITIONS AND METHOD OF TARGETING COMPLEMENTING COMPONENT 3 FOR INHIBITION OF TUMOR GROWTH |
| WO2019014581A1 (en) | 2017-07-14 | 2019-01-17 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF A CYTOTOXIC LYMPHOCYTE |
| EP3681531A1 (en) * | 2017-09-15 | 2020-07-22 | Kite Pharma, Inc. | Methods and systems for performing a patient-specific immunotherapy procedure with chain-of-custody and chain-of-identity biological sample tracking |
| CA3075778A1 (en) * | 2017-09-18 | 2019-03-21 | Trustees Of Boston University | Methods for treating netosis and neutrophil activation |
| KR102839644B1 (ko) | 2017-09-22 | 2025-07-31 | 우시 바이올로직스 아일랜드 리미티드 | 신규한 이중특이적 폴리펩티드 복합체 |
| US12043870B2 (en) | 2017-10-02 | 2024-07-23 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
| WO2019084055A1 (en) | 2017-10-23 | 2019-05-02 | Massachusetts Institute Of Technology | CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS |
| EP3710039A4 (en) | 2017-11-13 | 2021-08-04 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH |
| WO2019094955A1 (en) | 2017-11-13 | 2019-05-16 | The Broad Institute, Inc. | Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas |
| CN109970864A (zh) * | 2017-12-28 | 2019-07-05 | 上海细胞治疗研究院 | 一种双向激活共刺激分子受体及其用途 |
| US11994512B2 (en) | 2018-01-04 | 2024-05-28 | Massachusetts Institute Of Technology | Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity |
| WO2019141774A1 (en) | 2018-01-19 | 2019-07-25 | Miltenyi Biotec Gmbh | Regulatory t cell expressing a chimeric antigen receptor |
| KR20200130324A (ko) * | 2018-02-23 | 2020-11-18 | 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 | Cd83-결합 키메라 항원 수용체 |
| WO2019168923A1 (en) | 2018-03-01 | 2019-09-06 | University Of Kansas | Techniques for generating cell-based therapeutics using recombinant t cell receptor genes |
| CN112955184A (zh) * | 2018-03-15 | 2021-06-11 | 基本解决方案公司 | 可编程免疫细胞受体复合物系统 |
| US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
| WO2019222642A1 (en) * | 2018-05-18 | 2019-11-21 | Senti Biosciences, Inc. | Engineered immune cells and methods of use |
| WO2019232542A2 (en) | 2018-06-01 | 2019-12-05 | Massachusetts Institute Of Technology | Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients |
| US12036240B2 (en) | 2018-06-14 | 2024-07-16 | The Broad Institute, Inc. | Compositions and methods targeting complement component 3 for inhibiting tumor growth |
| EP3829312A4 (en) * | 2018-08-04 | 2022-07-06 | Abcyte Therapeutics Inc. | MULTIFUNCTIONAL AND MULTI-TARGETING CAR SYSTEM AND METHODS OF USE |
| CN112805369A (zh) * | 2018-08-08 | 2021-05-14 | 南特生物公司 | 重组cd1限制性t细胞及方法 |
| WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
| WO2020081730A2 (en) | 2018-10-16 | 2020-04-23 | Massachusetts Institute Of Technology | Methods and compositions for modulating microenvironment |
| US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
| CN111378622B (zh) * | 2018-12-29 | 2022-12-02 | 华东师范大学 | 核酸编码的car-t细胞及其制备方法和应用 |
| CN109722437B (zh) * | 2018-12-29 | 2020-01-07 | 广州百暨基因科技有限公司 | 一种通用型car-t细胞及其制备方法和用途 |
| US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
| WO2020156405A1 (en) * | 2019-01-28 | 2020-08-06 | Wuxi Biologics (Shanghai) Co. Ltd. | Novel bispecific cd3/cd20 polypeptide complexes |
| WO2020186101A1 (en) | 2019-03-12 | 2020-09-17 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
| EP3942023A1 (en) | 2019-03-18 | 2022-01-26 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
| US20220378827A1 (en) * | 2019-04-12 | 2022-12-01 | Emory University | Compositions and methods for promoting hematopoietic cell cytotoxicity |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| US20220226464A1 (en) | 2019-05-28 | 2022-07-21 | Massachusetts Institute Of Technology | Methods and compositions for modulating immune responses |
| US20220282333A1 (en) | 2019-08-13 | 2022-09-08 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
| US12421557B2 (en) | 2019-08-16 | 2025-09-23 | The Broad Institute, Inc. | Methods for predicting outcomes and treating colorectal cancer using a cell atlas |
| US12018081B1 (en) * | 2019-08-28 | 2024-06-25 | The Regents Of The University Of Colorado, A Body Corporate | Photoconjugation reactions for modification of specific proteins on live cells |
| US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| JP7682859B2 (ja) | 2019-09-11 | 2025-05-26 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 前立腺幹細胞抗原(psca)キメラ抗原受容体(car)を含む組成物および方法 |
| CN112500492B (zh) * | 2019-09-13 | 2023-08-04 | 中国科学院分子细胞科学卓越创新中心 | 一种嵌合抗原受体及其用途 |
| US12297426B2 (en) | 2019-10-01 | 2025-05-13 | The Broad Institute, Inc. | DNA damage response signature guided rational design of CRISPR-based systems and therapies |
| US12394502B2 (en) | 2019-10-02 | 2025-08-19 | The General Hospital Corporation | Method for predicting HLA-binding peptides using protein structural features |
| US12195725B2 (en) | 2019-10-03 | 2025-01-14 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity |
| US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
| US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
| US11844800B2 (en) | 2019-10-30 | 2023-12-19 | Massachusetts Institute Of Technology | Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia |
| US12165747B2 (en) | 2020-01-23 | 2024-12-10 | The Broad Institute, Inc. | Molecular spatial mapping of metastatic tumor microenvironment |
| CN115397517A (zh) | 2020-04-17 | 2022-11-25 | 希望之城 | 用于治疗flt3阳性恶性肿瘤的靶向flt3的嵌合抗原受体修饰细胞 |
| CN111574616B (zh) * | 2020-06-17 | 2021-02-02 | 深圳豪石生物科技有限公司 | 分离的t细胞受体和应用 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| CN116635519A (zh) * | 2020-11-26 | 2023-08-22 | 上海医药集团生物治疗技术有限公司 | 一种经修饰的免疫细胞及其应用 |
| US20240112754A1 (en) * | 2021-03-12 | 2024-04-04 | Adaptive Biotechnologies Corporation | Crohn's Disease-Associated T Cell Receptor-Related Methods |
| KR20230157371A (ko) | 2021-03-17 | 2023-11-16 | 다이이찌 산쿄 가부시키가이샤 | 항아세틸콜린 수용체 자기 항체에 대한 키메라 수용체를 코드하는 유전자 |
| CN115505572B (zh) * | 2021-06-22 | 2025-11-14 | 康立泰生物医药(青岛)有限公司 | 一种增强型抗肿瘤nk细胞及其制备方法和应用 |
| CN116083369B (zh) * | 2022-09-01 | 2025-05-09 | 华中科技大学同济医学院附属同济医院 | 双特异性抗体修饰囊泡、双特异性抗体、核酸、重组载体、基因工程细胞、方法和应用 |
| EP4598949A1 (en) | 2022-10-07 | 2025-08-13 | The General Hospital Corporation | Methods and compositions for high-throughput discovery of peptide-mhc targeting binding proteins |
| WO2024124044A1 (en) | 2022-12-07 | 2024-06-13 | The Brigham And Women’S Hospital, Inc. | Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025064482A2 (en) * | 2023-09-19 | 2025-03-27 | Ginkgo Bioworks, Inc. | Chimeric immune cell receptors |
| CN117106035B (zh) * | 2023-10-25 | 2024-04-23 | 烟台药物研究所 | 一种肿瘤靶向多肽、多肽偶联药物及制备与应用 |
| WO2025097055A2 (en) | 2023-11-02 | 2025-05-08 | The Broad Institute, Inc. | Compositions and methods of use of t cells in immunotherapy |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA120409A (en) | 1909-05-13 | 1909-09-07 | Hiram Lucas Piper | Signal lamp |
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4694778A (en) | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| EP0519596B1 (en) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| US6080840A (en) | 1992-01-17 | 2000-06-27 | Slanetz; Alfred E. | Soluble T cell receptors |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| EP0663817B1 (en) | 1993-08-10 | 1999-08-11 | W.L. Gore & Associates, Inc. | Cell encapsulating device |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| KR20050085971A (ko) | 1995-04-27 | 2005-08-29 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US5626561A (en) | 1995-06-07 | 1997-05-06 | Gore Hybrid Technologies, Inc. | Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
| WO1996039993A1 (en) | 1995-06-07 | 1996-12-19 | Gore Hybrid Technologies, Inc. | An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
| WO1997010807A1 (en) | 1995-09-22 | 1997-03-27 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| WO1998024893A2 (en) | 1996-12-03 | 1998-06-11 | Abgenix, Inc. | TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM |
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| KR100663319B1 (ko) | 1997-04-14 | 2007-01-02 | 마이크로메트 에이지 | 인간 17-1에이항원에 대해 특이성을 갖는 인간항체 및 그용도 |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6678556B1 (en) | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| US7171264B1 (en) | 1999-05-10 | 2007-01-30 | Genetronics, Inc. | Intradermal delivery of active agents by needle-free injection and electroporation |
| CA2401327C (en) | 2000-03-03 | 2014-05-06 | Valentis, Inc. | Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use |
| AU4761601A (en) | 2000-04-11 | 2001-10-23 | Genentech Inc | Multivalent antibodies and uses therefor |
| EP1188825A1 (en) * | 2000-09-18 | 2002-03-20 | Universiteit Leiden | T cell receptor transfer into a candidate effector cell or a precursor thereof |
| DE10109854A1 (de) | 2001-03-01 | 2002-09-12 | Thomas Stanislawski | Polypeptide eines hdm2-Protein spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| JP2006506954A (ja) * | 2002-04-29 | 2006-03-02 | ゲンパト77 ファーマコジェネティクス エージー | Tcr及びtirc7に結合する新規な抗体、並びに治療及び診断におけるその使用 |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20040014645A1 (en) | 2002-05-28 | 2004-01-22 | Advisys, Inc. | Increased delivery of a nucleic acid construct in vivo by the poly-L-glutamate ("PLG") system |
| US7328064B2 (en) | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
| US20050070841A1 (en) | 2002-07-04 | 2005-03-31 | Inovio As | Electroporation device and injection apparatus |
| DE10244457A1 (de) * | 2002-09-24 | 2004-04-01 | Johannes-Gutenberg-Universität Mainz | Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren |
| US7993650B2 (en) | 2003-07-04 | 2011-08-09 | Affibody Ab | Polypeptides having binding affinity for HER2 |
| JP5634008B2 (ja) | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
| EP1611850A1 (fr) * | 2004-06-28 | 2006-01-04 | Cardio Life Research S.A. | Dispositif d'occlusion et de ponction étanche pour structure anatomique. |
| CA2572467A1 (en) * | 2004-07-01 | 2006-01-19 | Virxsys Corporation | Vector packaging cell line |
| US7585960B2 (en) | 2005-05-11 | 2009-09-08 | Theramab Gmbh | Nucleic acids encoding superagonistic anti-CD28 antibodies |
| PL1907424T3 (pl) | 2005-07-01 | 2015-12-31 | Squibb & Sons Llc | Ludzkie monoklonalne przeciwciała wobec liganda zaprogramowanej śmierci 1 (PD-L1) |
| GB0524788D0 (en) | 2005-12-05 | 2006-01-11 | Affibody Ab | Polypeptides |
| EP1957642A2 (en) | 2005-12-07 | 2008-08-20 | Genetronics, Inc. | Variable volume electroporation chamber and methods therefore |
| WO2009019117A1 (en) | 2007-08-03 | 2009-02-12 | Affibody Ab | Igf-1r binding polypeptides and their use |
| EP2072525A1 (en) | 2007-12-21 | 2009-06-24 | Affibody AB | New polypeptides having affinity for HER2 |
| SI2235064T1 (sl) | 2008-01-07 | 2016-04-29 | Amgen Inc. | Metoda za izdelavo heterodimernih molekul - protitelesa fc z uporabo elektrostatičnih usmerjevalnih učinkov |
| MX2011004467A (es) | 2008-10-31 | 2011-07-28 | Biogen Idec Inc | Moleculas de objetivo light y usos de las mismas. |
| JO3096B1 (ar) | 2008-11-07 | 2017-03-15 | Imclone Llc | الأجسام المضادة لمستقبل ii مضاد tgfb |
| GB0911566D0 (en) * | 2009-07-03 | 2009-08-12 | Immunocore Ltd | T cell receptors |
| GB0917090D0 (en) * | 2009-09-29 | 2009-11-11 | Ucl Biomedica Plc | T-cell receptor |
| EP2494038B1 (en) * | 2009-10-27 | 2019-06-26 | Immunicum AB | Method for proliferation of antigen-specific t cells |
| SG10201407519TA (en) * | 2009-11-19 | 2015-01-29 | Univ Singapore | Method For Producing T Cell Receptor-Like Monoclonal Antibodies And Uses Thereof |
| PT2619223T (pt) * | 2010-09-21 | 2019-07-11 | Us Health | Recetores de células t anti-ssx-2 e materiais e métodos de utilização relacionados |
| EP3915588A1 (en) * | 2011-07-29 | 2021-12-01 | The Trustees of the University of Pennsylvania | Switch costimulatory receptors |
| JP5737082B2 (ja) | 2011-08-31 | 2015-06-17 | 富士通株式会社 | ポインタ位置補正方法、ポインタ位置補正プログラムおよびサーバ装置 |
| CN103946952A (zh) | 2011-09-16 | 2014-07-23 | 宾夕法尼亚大学董事会 | 用于治疗癌症的rna改造的t细胞 |
| US9447194B2 (en) * | 2012-02-13 | 2016-09-20 | Seattle Children's Hospital | Bispecific chimeric antigen receptors and encoding polynucleotides thereof |
| ES2786263T3 (es) * | 2012-07-13 | 2020-10-09 | Univ Pennsylvania | Mejora de la actividad de los CAR de linfocitos T mediante la introducción conjunta de un anticuerpo biespecífico |
| MX370148B (es) | 2012-10-02 | 2019-12-03 | Memorial Sloan Kettering Cancer Center | Composiciones y su uso para inmunoterapia. |
| IL298125A (en) | 2013-02-26 | 2023-01-01 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
| AU2014225788B2 (en) * | 2013-03-05 | 2018-03-29 | Baylor College Of Medicine | Engager cells for immunotherapy |
| MA41538A (fr) * | 2014-10-17 | 2017-12-26 | Baylor College Medicine | Cellules immunitaires bipartites et tripartites de signalisation |
-
2015
- 2015-10-30 HK HK18102826.6A patent/HK1243333A1/zh unknown
- 2015-10-30 US US15/518,922 patent/US20170258835A1/en active Pending
- 2015-10-30 EP EP25207728.4A patent/EP4653013A2/en active Pending
- 2015-10-30 KR KR1020177014658A patent/KR20170074243A/ko not_active Withdrawn
- 2015-10-30 WO PCT/US2015/058339 patent/WO2016070061A1/en not_active Ceased
- 2015-10-30 AU AU2015338984A patent/AU2015338984A1/en not_active Abandoned
- 2015-10-30 CA CA2964958A patent/CA2964958A1/en not_active Abandoned
- 2015-10-30 JP JP2017523266A patent/JP7372728B2/ja active Active
- 2015-10-30 CN CN201580071613.7A patent/CN107106670A/zh active Pending
- 2015-10-30 EP EP15855013.7A patent/EP3212225B1/en active Active
-
2021
- 2021-05-19 JP JP2021084334A patent/JP2021121208A/ja not_active Withdrawn
-
2023
- 2023-05-30 JP JP2023088510A patent/JP7757343B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017533706A5 (enExample) | ||
| JP2017535261A5 (enExample) | ||
| Liu et al. | Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T | |
| US11679132B2 (en) | Methods for enhancing efficacy of therapeutic immune cells | |
| JP7273421B2 (ja) | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 | |
| Zhang et al. | Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside | |
| JP2021058196A5 (enExample) | ||
| Rezvani et al. | Engineering natural killer cells for cancer immunotherapy | |
| Vitale et al. | An historical overview: the discovery of how NK cells can kill enemies, recruit defense troops, and more | |
| JP7146397B2 (ja) | 改変γδT細胞 | |
| Bollino et al. | Chimeric antigen receptor–engineered natural killer and natural killer T cells for cancer immunotherapy | |
| JP2017533707A5 (enExample) | ||
| Kriegsmann et al. | NKT cells—New players in CAR cell immunotherapy? | |
| Dianat‐Moghadam et al. | Natural killer cell–based immunotherapy: From transplantation toward targeting cancer stem cells | |
| JP2018504910A5 (enExample) | ||
| IL320642A (en) | Preparations and methods for engineering T cells | |
| CN105848484A (zh) | 用于免疫治疗的多克隆γδ T细胞 | |
| JP2017535292A5 (enExample) | ||
| CN110072533A (zh) | 选择性扩增γδT细胞群的方法及其组合物 | |
| JP2021525518A (ja) | 細胞をゲノム編集及び活性化するための方法 | |
| JP2014533928A5 (enExample) | ||
| JP7591405B2 (ja) | ユニバーサル抗原提示細胞およびその使用 | |
| CA3189677A1 (en) | Chimeric molecules providing targeted costimulation for adoptive cell therapy | |
| WO2022037562A1 (en) | Engineered immunoresponsive cells and uses thereof | |
| JP2025535365A (ja) | Il18と結合した新規cd19結合体を含むcar-t構築物およびその使用方法 |