HRP20201419T1 - Pripravci i postupci za imunoterapiju - Google Patents
Pripravci i postupci za imunoterapiju Download PDFInfo
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- HRP20201419T1 HRP20201419T1 HRP20201419TT HRP20201419T HRP20201419T1 HR P20201419 T1 HRP20201419 T1 HR P20201419T1 HR P20201419T T HRP20201419T T HR P20201419TT HR P20201419 T HRP20201419 T HR P20201419T HR P20201419 T1 HRP20201419 T1 HR P20201419T1
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Claims (24)
1. Izolirana imuno odzivna stanica koja sadrži:
1) receptor za prepoznavanje antigena koji je kimerni receptor za antigen (CAR) ili receptor T stanice (TCR) i koja se veže na prvi antigen, pri čemu je vezanje receptora za prvi antigen sposobno aktivirati imuno odzivnu stanicu, i
2) topivi jednolančani varijabilni fragment (scFv) koji se veže na polipeptid koji ima imunosupresivno ili imunostimulacijsko djelovanje.
2. Imuno odzivna stanica prema patentnom zahtjevu 1, naznačena time što antigen sadrži tumorski ili patogeni antigen.
3. Imuno odzivna stanica prema patentnom zahtjevu 1, naznačena time što se topivi scFv izlučuje pomoću stanice.
4. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-3, naznačena time što:
(a) navedeni receptor za prepoznavanje antigena je egzogen;
(b) navedeni receptor za prepoznavanje antigena je endogen; ili
(c) navedeni receptor za prepoznavanje antigena je rekombinantno eksprimiran.
5. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-4, naznačena time što se receptor za prepoznavanje antigena eksprimira iz vektora i/ili pri čemu se scFv eksprimira iz vektora.
6. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-5, naznačena time što je stanica tipa odabranog iz skupine koja sadrži T stanicu, prirođene stanice ubojice (NK), citotoksični T limfocit (CTL), regulatornu T stanicu, te pluripotentnu matičnu stanicu od koje se mogu diferencirati limfoidne stanice.
7. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-6, naznačena time što je navedeni antigen tumorski antigen odabran iz skupine koja sadrži CD19, MUC16, MUCl, CAlX, CEA, CDS, CD7, CD10, CD20, CD22, CD30, CD33, CD34, CD38, CD41, CD44, CD49f, CD56, CD74, CD133, CD138, stanični antigen zaražen citomegalovirusom (CMV), EGP-2, EGP-40, EpCAM, erb-B2,3,4, FBP, fetalni acetilkolin receptor, folatni receptor-a, GD2, GD3, HER-2, hTERT, IL-13R-a2, K-laki lanac, KDR, LeY, molekulu adhezije L1 stanica, MAGE-A1, mezotelin, NKG2D ligande, NY-ES0-1, onkofetalni antigen (h5T4), PSCA, PSMA, ROR1, TAG-72, VEGF-R2, i WT-1.
8. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-7, naznačena time što navedeni polipeptid ima imunosupresivno djelovanje i odabran je iz skupine koja sadrži CD47 polipeptid i njegove ligande, PD-1 polipeptid i njegove ligande, CTLA-4 polipeptid i njegove ligande, i njihove kombinacije.
9. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-7, naznačena time što navedeni polipeptid ima imunostimulacijsko djelovanje i odabran je iz skupine koja sadrži a CD28 polipeptid i njegove ligande, OX-40 polipeptid i njegove ligande, 4-1BB polipeptid i njegove ligande, i njihove kombinacije.
10. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-9, naznačena time što je navedeni antigen CD19 ili MUC16.
11. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-10, naznačena time što je unutarstanična signalizacijska domena navedenog receptora za prepoznavanje antigena unutarstanična signalizacijska domena CD3ξ-lanca CD97, CD11a-CD18, CD2, ICOS, CD27, CD154, CDS, OX40, 4-1BB, CD28 ili njihove kombinacije.
12. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-11, naznačena time što receptor za prepoznavanje antigena sadrži kimerni antigenski receptor.
13. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-12, naznačena time što je antigen CD19.
14. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što je receptor za prepoznavanje antigena 1928z.
15. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-12, naznačena time što je antigen MUC16.
16. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-12 i 15, naznačena time što je receptor za prepoznavanje antigena 4H1128z.
17. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-16, naznačena time što topivi scFv pojačava imunološki odgovor imunoodgovorne stanice.
18. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-17, naznačena time što je imuno odzivna stanica T stanica.
19. Imuno odzivna stanica prema bilo kojem od patentnih zahtjeva 1-18 naznačena time što je za uporabu za smanjenje tumorskog opterećenja i/ili veličine tumora, ili povećanje preživljavanja, kod subjekta koji ima neoplaziju.
20. Imuno odzivna stanica za uporabu prema patentnom zahtjevu 19, naznačena time što je neoplazija odabrana iz skupine koju čine rak krvi, leukemija B stanica, multipli mijelom, akutna limfoblastna leukemija (ALL), kronična limfocitna leukemija, ne-Hodgkinov limfom i rak jajnika.
21. Imuno odzivna stanica za uporabu prema patentnom zahtjevu 19 ili 20, naznačena time što je stanica autologna prema subjektu.
22. Postupak za proizvodnju imuno odzivne stanice prema bilo kojem od patentnih zahtjeva 1-18, naznačen time što postupak sadrži: uvođenje u antigen-specifičnu stanicu nukleinske kiseline koja sadrži sekvencu koja kodira jednolančani varijabilni fragment (scFv) koji veže polipeptid koji ima imunosupresivno djelovanje ili imunostimulacijsko djelovanje.
23. Vektor koji sadrži (a) sekvencu nukleinske kiseline koja kodira receptor za prepoznavanje antigena koji je kimerni antigenski receptor (CAR) ili T stanični receptor (TCR) i koji se veže na prvi antigen i (b) sekvencu nukleinske kiseline koja kodira topivi jednolančani varijabilni fragment (scFv) koji se veže na polipeptid koji ima imunosupresivno djelovanje ili imunostimulacijsko djelovanje.
24. Farmaceutski pripravak naznačen time što sadrži učinkovitu količinu imuno odzivne stanice prema bilo kojem od patentnih zahtjeva 1-18 u farmaceutski prihvatljivoj pomoćnoj tvari.
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