MX2021007556A - Método y sistemas de predicción de epítopos específicos de hla de clase ii y caracterización de células t cd4+. - Google Patents
Método y sistemas de predicción de epítopos específicos de hla de clase ii y caracterización de células t cd4+.Info
- Publication number
- MX2021007556A MX2021007556A MX2021007556A MX2021007556A MX2021007556A MX 2021007556 A MX2021007556 A MX 2021007556A MX 2021007556 A MX2021007556 A MX 2021007556A MX 2021007556 A MX2021007556 A MX 2021007556A MX 2021007556 A MX2021007556 A MX 2021007556A
- Authority
- MX
- Mexico
- Prior art keywords
- characterization
- prediction
- cells
- systems
- hla class
- Prior art date
Links
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/30—Detection of binding sites or motifs
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
Abstract
La presente divulgación proporciona un método para preparar una vacuna contra el cáncer personalizada. La presente divulgación también proporciona un método para entrenar un modelo de predicción de presentación de HLA-péptidos de aprendizaje automático.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862783914P | 2018-12-21 | 2018-12-21 | |
US201962826827P | 2019-03-29 | 2019-03-29 | |
US201962855379P | 2019-05-31 | 2019-05-31 | |
US201962891101P | 2019-08-23 | 2019-08-23 | |
PCT/US2019/068084 WO2020132586A1 (en) | 2018-12-21 | 2019-12-20 | Method and systems for prediction of hla class ii-specific epitopes and characterization of cd4+ t cells |
Publications (1)
Publication Number | Publication Date |
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MX2021007556A true MX2021007556A (es) | 2021-09-10 |
Family
ID=71101917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007556A MX2021007556A (es) | 2018-12-21 | 2019-12-20 | Método y sistemas de predicción de epítopos específicos de hla de clase ii y caracterización de células t cd4+. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11183272B2 (es) |
EP (1) | EP3899954A4 (es) |
JP (2) | JP7236543B2 (es) |
KR (1) | KR20210130705A (es) |
CN (1) | CN113474840A (es) |
AU (1) | AU2019404547A1 (es) |
CA (1) | CA3124457A1 (es) |
IL (1) | IL284195A (es) |
MX (1) | MX2021007556A (es) |
SG (1) | SG11202106678PA (es) |
WO (1) | WO2020132586A1 (es) |
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ES2965475T3 (es) * | 2017-02-12 | 2024-04-15 | Biontech Us Inc | Métodos y composiciones basados en HLA y usos de los mismos |
US11176429B2 (en) * | 2019-05-13 | 2021-11-16 | International Business Machines Corporation | Counter rare training date for artificial intelligence |
CA3142227A1 (en) | 2019-05-31 | 2020-12-03 | Rubryc Therapeutics, Inc. | Meso-scale engineered peptides and methods of selecting |
WO2021247858A1 (en) * | 2020-06-03 | 2021-12-09 | Xenotherapeutics, Inc. | Selection and monitoring methods for xenotransplantation |
EP4168569A1 (en) * | 2020-06-18 | 2023-04-26 | Personalis, Inc. | Machine-learning techniques for predicting surface-presenting peptides |
WO2022043881A1 (en) * | 2020-08-28 | 2022-03-03 | Immunitybio, Inc. | Computerized tool for prediction of proteasomal cleavage |
US11403316B2 (en) | 2020-11-23 | 2022-08-02 | Peptilogics, Inc. | Generating enhanced graphical user interfaces for presentation of anti-infective design spaces for selecting drug candidates |
WO2022119863A1 (en) * | 2020-12-01 | 2022-06-09 | Rubryc Therapeutics, Inc. | Generalized scaffolds for polypeptide display and uses thereof |
CN116583903A (zh) * | 2020-12-09 | 2023-08-11 | 上海瑞宏迪医药有限公司 | 基于机器学习的肽免疫原性预测、鉴别系统及方法 |
KR20230161977A (ko) * | 2021-03-25 | 2023-11-28 | 제넨테크, 인크. | 신경망을 사용한 펩티드 면역원성 예측 |
CN113807468B (zh) * | 2021-10-15 | 2022-05-27 | 南京澄实生物科技有限公司 | 基于多模态深度编码的hla抗原呈递预测方法和系统 |
WO2023164425A1 (en) * | 2022-02-22 | 2023-08-31 | The Children's Hospital Of Philadelphia | Systems and methods for generating chimeric major histocompatibility complex (mhc) molecules with desired peptide-binding specificities |
WO2024015892A1 (en) * | 2022-07-13 | 2024-01-18 | The Broad Institute, Inc. | Hla-ii immunopeptidome methods and systems for antigen discovery |
CN114913939B (zh) * | 2022-07-19 | 2022-11-15 | 北京科技大学 | 高通量平台和机器学习优化的药物组合设计方法及装置 |
CN115331728B (zh) * | 2022-08-12 | 2023-06-30 | 杭州力文所生物科技有限公司 | 一种稳定折叠的富含二硫键的多肽设计方法及其电子设备 |
WO2024036308A1 (en) * | 2022-08-12 | 2024-02-15 | Biontech Us Inc. | Methods and systems for prediction of hla epitopes |
CN115333735B (zh) * | 2022-10-11 | 2023-03-14 | 浙江御安信息技术有限公司 | 一种数据的安全传输方法 |
CN116469457B (zh) * | 2023-06-14 | 2023-10-13 | 普瑞基准科技(北京)有限公司 | Mhc与抗原多肽结合、呈递及免疫原性的预测模型训练方法和装置 |
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BR112014027374B1 (pt) | 2012-05-03 | 2022-05-31 | Fred Hutchinson Cancer Research Center | Método para gerar um receptor de células t (tcr) com afinidade aumentada |
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2019
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- 2019-12-20 JP JP2021536205A patent/JP7236543B2/ja active Active
- 2019-12-20 MX MX2021007556A patent/MX2021007556A/es unknown
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US11183272B2 (en) | 2021-11-23 |
JP7236543B2 (ja) | 2023-03-09 |
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SG11202106678PA (en) | 2021-07-29 |
US20220199198A1 (en) | 2022-06-23 |
JP2023071806A (ja) | 2023-05-23 |
EP3899954A4 (en) | 2022-09-14 |
JP2022518355A (ja) | 2022-03-15 |
WO2020132586A1 (en) | 2020-06-25 |
AU2019404547A1 (en) | 2021-07-22 |
EP3899954A1 (en) | 2021-10-27 |
CA3124457A1 (en) | 2020-06-25 |
US20200279616A1 (en) | 2020-09-03 |
CN113474840A (zh) | 2021-10-01 |
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