JP2017535292A5 - - Google Patents

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JP2017535292A5
JP2017535292A5 JP2017545528A JP2017545528A JP2017535292A5 JP 2017535292 A5 JP2017535292 A5 JP 2017535292A5 JP 2017545528 A JP2017545528 A JP 2017545528A JP 2017545528 A JP2017545528 A JP 2017545528A JP 2017535292 A5 JP2017535292 A5 JP 2017535292A5
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tumor
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JP2017545528A 2014-11-17 2015-11-17 改変γδT細胞 Active JP7146397B2 (ja)

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US201462080500P 2014-11-17 2014-11-17
US62/080,500 2014-11-17
PCT/US2015/061189 WO2016081518A2 (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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JP2017535292A5 true JP2017535292A5 (enExample) 2019-01-10
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EP (2) EP3220926B1 (enExample)
JP (2) JP7146397B2 (enExample)
KR (1) KR102660362B1 (enExample)
CN (2) CN117143814A (enExample)
AU (2) AU2015350103A1 (enExample)
CA (1) CA2966634C (enExample)
DK (1) DK3220926T3 (enExample)
ES (1) ES3023783T3 (enExample)
IL (2) IL252131B2 (enExample)
MX (1) MX2017006408A (enExample)
RU (1) RU2756247C2 (enExample)
WO (1) WO2016081518A2 (enExample)
ZA (1) ZA201703505B (enExample)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1814580T (pt) 2004-11-24 2016-11-11 Hutchinson Fred Cancer Res Métodos de utilização de il-21 para imunoterapia adotiva e identificação de antigénios tumorais
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
EP3220926B1 (en) 2014-11-17 2024-12-25 Adicet Therapeutics, Inc. Engineered gamma delta t-cells
JP6743051B2 (ja) 2015-01-27 2020-08-19 ラヴァ・セラピューティクス・ベー・フェー Cd1dを標的とする単一ドメイン抗体
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
PL3307875T3 (pl) 2015-06-09 2022-08-01 Lymphact - Lymphocyte Activation Technologies, S.A. Sposoby wytwarzania limfocytów t tcr gamma delta+
EP4295914A3 (en) 2015-09-03 2024-04-10 The UAB Research Foundation Genetically-engineered drug resistant t cells and methods of using the same
MX2018013864A (es) * 2016-05-12 2019-06-10 Adicet Bio Inc Métodos para la expansión selectiva de poblaciones de células t gama y composicicones de estas.
US10426796B2 (en) * 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US12350349B2 (en) 2016-08-03 2025-07-08 Washington University Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors
KR102032354B1 (ko) 2016-11-11 2019-10-16 가톨릭대학교 산학협력단 신규한 배양보조세포 및 이를 이용한 감마 델타 t 세포의 증식 방법
AU2017363311A1 (en) 2016-11-22 2019-06-13 TCR2 Therapeutics Inc. Compositions and methods for TCR reprogramming using fusion proteins
US20210187022A1 (en) * 2016-12-21 2021-06-24 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
SG11201907319QA (en) * 2017-02-08 2019-09-27 Agency Science Tech & Res Gamma delta t cells and a method of augmenting the tumoricidal activity of the same
CN110621321B (zh) 2017-03-15 2024-06-21 浩康生物系统公司 用于造血干细胞移植的组合物和方法
GB201707048D0 (en) * 2017-05-03 2017-06-14 King S College London Expansion of gamma delta cells, compositions, and methods of use thereof
US12384830B2 (en) * 2017-06-02 2025-08-12 Regents Of The University Of Minnesota Compositions and methods for improving immunotherapy
WO2018236986A1 (en) * 2017-06-20 2018-12-27 The Trustees Of Columbia University In The City Of New York Engineered t-cell receptors and methods of their use
AU2018290856B2 (en) 2017-06-28 2025-06-26 Regeneron Pharmaceuticals, Inc. Anti-human papillomavirus (HPV) antigen-binding proteins and methods of use thereof
WO2019053272A1 (en) * 2017-09-15 2019-03-21 King's College London COMPOSITIONS AND METHODS FOR IMPROVING T GAMMA DELTA LYMPHOCYTES IN INTESTINE
TWI687227B (zh) * 2017-10-03 2020-03-11 生倍科技股份有限公司 用於t細胞免疫療法之組合及其用途
CN109777778B (zh) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 一种基因改造的γδT细胞
CA3082818A1 (en) 2017-11-15 2019-05-23 Adicet Bio Inc. Methods for selective expansion of .delta.3 .gamma..delta. t-cell populations and compositions thereof
DE102017127984B4 (de) * 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
CN108129566B (zh) * 2017-12-31 2021-05-11 中国科学院武汉病毒研究所 靶向间皮素的c-型单域抗体及其制备方法与应用
US12215154B2 (en) 2018-01-19 2025-02-04 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting γδ T cells with chimeric antigen receptors
WO2019178463A1 (en) * 2018-03-16 2019-09-19 H. Lee Moffitt Cancer Center And Research Institute Inc. Chimeric antigen receptors with mutated cd28 phosphorylation sites
GB201804701D0 (en) 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
WO2019216338A1 (ja) * 2018-05-08 2019-11-14 国立大学法人大阪大学 ホモ接合型細胞の作製方法
CN110577932A (zh) * 2018-06-07 2019-12-17 亘喜生物科技(上海)有限公司 一种脐带血来源的嵌合抗原受体t细胞
BR112021000914A2 (pt) * 2018-07-18 2021-04-13 Amgen Inc. Receptores quiméricos para steap1 e seus métodos de uso
US11987631B2 (en) 2018-08-01 2024-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-BTN3A antibodies and their use in treating cancer or infectious disorders
CN108949685B (zh) * 2018-08-02 2022-03-29 吉林大学第一医院 一种体外诱导扩增高杀伤活性γδT细胞的方法
US20210177903A1 (en) * 2018-08-07 2021-06-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Car t-cells for the treatment of bone metastatic cancer
WO2020033464A1 (en) 2018-08-07 2020-02-13 H. Lee Moffitt Cancer Center And Research Institute Inc. Car t-cells for the treatment of bone metastatic cancer
CN112105724A (zh) * 2018-08-09 2020-12-18 深圳华大生命科学研究院 无内源hla基因背景的抗原递呈细胞系的构建方法、抗原递呈细胞系及其用途
TW202016293A (zh) * 2018-08-10 2020-05-01 國立大學法人京都大學 Cd3陽性細胞的製造方法
CN113307872B (zh) * 2018-08-11 2022-12-06 广东天科雅生物医药科技有限公司 一种工程化核酸、t细胞及其应用和产生方法
CN109161533B (zh) * 2018-08-28 2020-07-24 深圳市菲鹏生物制药股份有限公司 无血清培养组合物及其应用
EP3853255A1 (en) 2018-09-19 2021-07-28 Lava Therapeutics B.V. Novel bispecific antibodies for use in the treatment of hematological malignancies
BR112021006182A2 (pt) * 2018-10-01 2021-06-29 Adicet Bio, Inc. composições e métodos relativos a células t¿d,d engenheiradas e não engenheiradas para tratamento de tumores hematológicos
EP3860716A2 (en) 2018-10-01 2021-08-11 Adicet Bio Inc. Compositions and methods regarding engineered and non-engineered gamma-delta -t cells for treatment of solid tumors
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
KR20210093908A (ko) 2018-10-23 2021-07-28 리제너론 파아마슈티컬스, 인크. Ny-eso-1 t 세포 수용체 및 이의 사용 방법
GB201818243D0 (en) 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
EP3890757A1 (en) * 2018-12-03 2021-10-13 Adicet Bio Inc. Methods for selective in vivo expansion of gamma delta t-cell populations and compositions thereof
CN111544585B (zh) * 2019-02-11 2024-12-27 北京卡替医疗技术有限公司 一种可助推免疫细胞在体内扩增的佐剂
WO2020166729A1 (ja) * 2019-02-14 2020-08-20 学校法人獨協学園獨協医科大学 T細胞ワクチン
EP3927735A4 (en) * 2019-02-18 2023-09-06 Memorial Sloan Kettering Cancer Center COMBINATIONS OF MULTIPLE CHIMERIC ANTIGEN RECEPTORS FOR IMMUNOTHERAPY
CN113710257A (zh) * 2019-02-24 2021-11-26 盖米达细胞有限公司 γδT细胞归巢和保留的方法,可选地使用自然杀伤细胞,以用于生成用于治疗的细胞组合物
EP3935151A1 (en) * 2019-03-08 2022-01-12 Klinikum der Universität München Ccr8 expressing lymphocytes for targeted tumor therapy
CN109758590B (zh) * 2019-03-28 2022-02-11 广东工业大学 一种用于筛选人前列腺癌肿瘤抗原表位肽的方法
KR20220030208A (ko) * 2019-03-30 2022-03-10 바이오엔테크 유에스 인크. T 세포 조성물의 제조를 위한 조성물 및 방법, 및 그의 용도
WO2020214957A1 (en) 2019-04-19 2020-10-22 Tcrcure Biopharma Corp. Anti-pd-1 antibodies and uses thereof
WO2020219843A1 (en) 2019-04-26 2020-10-29 The University Of North Carolina At Chapel Hill Chimeric antigen receptor constructs and their use in car-t cells
BR112021022089A2 (pt) * 2019-05-08 2022-02-08 Janssen Biotech Inc Materiais e métodos para modulação da imunidade mediada por células t
WO2021011882A1 (en) * 2019-07-17 2021-01-21 Case Western Reserve University Long lived t cells for treating hiv infection
WO2021016652A1 (en) * 2019-07-29 2021-02-04 The University Of Melbourne METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS
MX2022002075A (es) * 2019-08-16 2022-03-17 Gammadelta Therapeutics Ltd Usos terapeuticos de anticuerpos anti-variable delta 1 de tcr.
EP4045635A4 (en) * 2019-10-17 2023-10-25 The University of Hong Kong METHODS FOR PREPARING EXOSOMES DERIVED FROM T-V LYMPHOCYTES FOR THE TREATMENT OF CANCERS ASSOCIATED WITH EPSTEIN-BARR VIRUS
FI4051710T3 (fi) 2019-10-31 2026-01-12 Incyte Corp Kasvainta estävä yhdistelmähoito, joka käsittää cd19-vasta-ainetta ja gamma-delta-t-soluja
JP2023504185A (ja) * 2019-12-03 2023-02-01 アディセット バイオ, インコーポレイテッド γδT細胞集団を多価薬剤で増殖させるための方法及びその組成物
WO2021150804A1 (en) 2020-01-24 2021-07-29 Regeneron Pharmaceuticals, Inc. Preferentially expressed antigen in melanoma (prame) t cell receptors and methods of use thereof
BR112022017419A2 (pt) * 2020-03-03 2022-10-18 Janssen Biotech Inc Células t gama-delta e usos das mesmas
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
WO2021259237A1 (en) * 2020-06-22 2021-12-30 Nanjing Legend Biotech Co., Ltd. GENETIC ENGINEERING OF γδ T CELLS FOR IMMUNOTHERAPY
US20230272110A1 (en) 2020-07-08 2023-08-31 LAVA Therapeutics N.V. Antibodies that bind psma and gamma-delta t cell receptors
CN116333998A (zh) * 2020-07-14 2023-06-27 广州泛恩生物科技有限公司 基于layn阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用
CN117295505A (zh) * 2021-02-08 2023-12-26 加利福尼亚大学董事会 嗜乳脂蛋白亚家族3成员a1(btn3a1,cd277)的调节
GB202105113D0 (en) * 2021-04-09 2021-05-26 Gammadelta Therapeutics Ltd Novel method
CA3235971A1 (en) * 2021-10-20 2023-04-27 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
WO2023092119A2 (en) 2021-11-22 2023-05-25 Ludwig Institute For Cancer Research Ltd Methods for predicting responsiveness to a cancer therapy
US20250025504A1 (en) * 2021-12-05 2025-01-23 Adicet Therapeutics, Inc. Treatment of b cell malignancies
KR20230105166A (ko) 2022-01-03 2023-07-11 주식회사 이뮤노맥스 감마-델타 t 세포의 증식 배양 방법
CN114149978B (zh) * 2022-02-09 2022-04-26 深圳博雅感知药业有限公司 制备car-t细胞的方法
CA3250985A1 (en) 2022-02-16 2023-08-24 Priothera Sas CAR CELL TREATMENT METHODS IN COMBINATION WITH S1P RECEIVER MODULATORS
GB202204926D0 (en) 2022-04-04 2022-05-18 Gammadelta Therapeutics Ltd Method for expanding gammadelta T cells
US20260014199A1 (en) * 2022-06-17 2026-01-15 Gadeta B.V. Modified immune cells
CN115624618A (zh) * 2022-09-16 2023-01-20 深圳善乐生物科技有限公司 一种HPV多肽抗原负载γδT细胞在HPV阳性宫颈癌免疫治疗中的应用
EP4611771A1 (en) 2022-10-31 2025-09-10 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with a combination of adoptive cell therapy and a targeted immunocytokine
CN120882754A (zh) 2023-04-07 2025-10-31 瑞泽恩制药公司 用淋巴毒素β受体激动剂治疗癌症的方法
CN121335919A (zh) 2023-05-25 2026-01-13 瑞泽恩制药公司 结合呈递的hpv16、mart1、cmv、ebv或流感肽的t细胞受体
US12221483B1 (en) * 2024-01-30 2025-02-11 China Medical University Hospital Fusion protein and nucleic acid encoding sequence thereof, and uses of the same
WO2025165915A1 (en) * 2024-01-31 2025-08-07 Adicet Therapeutics, Inc. Compositions and methods for enhancing engineered t cell therapies
WO2025229538A1 (en) * 2024-05-01 2025-11-06 Janssen Biotech, Inc. Materials, methods, and systems for cellular expansion of gamma delta t-cells
WO2026013159A1 (en) * 2024-07-10 2026-01-15 Cytospire Therapeutics Limited Antibodies binding to constant domains of gamma delta t-cell receptors
WO2026013158A1 (en) * 2024-07-10 2026-01-15 Cytospire Therapeutics Limited Antibodies binding to constant domains of gamma delta t-cell receptors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185250A (en) * 1986-07-03 1993-02-09 T Cell Sciences, Inc. Human γ, δT cell antigen receptor polypeptides and nucleic acids
US5260223A (en) 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
EP0633943A4 (en) 1992-04-03 1997-05-02 Alexander T Young GENTHERAPY USING TARGETED VIRAL VECTORS.
CA2110946A1 (en) * 1992-12-09 1994-06-10 Elazar Rabbani Induction of immunocompatibility by nucleic acid
WO2000078348A1 (en) 1999-06-17 2000-12-28 University Of Vermont And State Agricultural College Autologous adoptive immunotherapy with primed antigen-specific t cells or b cells
WO2001022816A1 (en) 1999-09-30 2001-04-05 National Jewish Medical And Research Center MODULATION OF ηδ T CELLS TO REGULATE AIRWAY HYPERRESPONSIVENESS
US6737398B1 (en) 1999-09-30 2004-05-18 National Jewish Medical And Research Center Modulation of γδ T cells to regulate airway hyperresponsiveness
CA2474486C (en) 2002-01-23 2013-05-14 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
CN1306027C (zh) 2002-12-12 2007-03-21 中国医学科学院基础医学研究所 一种体外扩增γδT淋巴细胞的方法
US20060205089A1 (en) 2003-04-14 2006-09-14 Montana State University Mapping discontinuous antibody or aptamer epitopes for protein structure determination and other applications
US7985739B2 (en) 2003-06-04 2011-07-26 The Board Of Trustees Of The Leland Stanford Junior University Enhanced sleeping beauty transposon system and methods for using the same
US7728114B2 (en) * 2004-06-03 2010-06-01 Novimmune S.A. Anti-CD3 antibodies and methods of use thereof
US7340913B2 (en) 2004-08-05 2008-03-11 Manitowoc Foodservice Companies, Inc. Ice machine and ice-making assembly including a water distributor
US20080026986A1 (en) * 2006-06-05 2008-01-31 Rong-Fu Wang Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling
HUE052220T2 (hu) * 2006-09-08 2021-04-28 Abbvie Bahamas Ltd Interleukin-13 kötõfehérjék
JP2012501178A (ja) 2008-08-26 2012-01-19 マクロジェニクス,インコーポレーテッド T細胞受容体抗体およびその使用方法
CN106086047B (zh) 2010-01-22 2021-07-06 陶氏益农公司 靶向基因组改造
WO2012012667A2 (en) 2010-07-21 2012-01-26 Sangamo Biosciences, Inc. Methods and compositions for modification of a hla locus
EA201391449A1 (ru) 2011-04-01 2014-03-31 Мемориал Слоан-Кеттеринг Кэнсер Сентер Антитела против пептидов цитозоля
US9499788B2 (en) 2011-05-19 2016-11-22 Instituto De Medicina Molecular Cell line of lymphocytes comprising gamma-delta T cells, composition and production method thereof
US10391126B2 (en) * 2011-11-18 2019-08-27 Board Of Regents, The University Of Texas System CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA
CA2856895C (en) 2011-11-28 2021-10-26 Merck Patent Gmbh Anti-pd-l1 antibodies and uses thereof
CN103130894B (zh) * 2011-11-30 2017-04-12 中国医学科学院基础医学研究所 抗人γδTCR单克隆抗体的重组单链抗体G5‑4ScFv及其编码基因与应用
EP2684600A1 (en) 2012-07-10 2014-01-15 Laboratoires Meiners Sarl Core-shell capsules and methods for encapsulation of reactive ingredients by diffusional exchange through spherical capsule membranes
WO2014072446A1 (en) 2012-11-08 2014-05-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for inducing il-2-free proliferation of gamma delta t cells
CN102994448A (zh) 2012-12-13 2013-03-27 上海柯莱逊生物技术有限公司 一种体外扩增γδT细胞的方法
CA2902954A1 (en) 2013-03-01 2014-09-04 Regents Of The University Of Minnesota Talen-based gene correction
CA2926859A1 (en) 2013-10-25 2015-04-30 Board Of Regents, The University Of Texas System Polyclonal gamma delta t cells for immunotherapy
US10501540B2 (en) * 2014-04-10 2019-12-10 Lava Therapeutics B.V. Immunoglobulins binding human Vγ9 Vδ2 T cell receptors
EP3220926B1 (en) 2014-11-17 2024-12-25 Adicet Therapeutics, Inc. Engineered gamma delta t-cells
EP3307875B1 (en) * 2015-06-09 2021-12-15 Lymphact - Lymphocyte Activation Technologies, S.A. Methods for the production of tcr gamma delta+ t cells
MA42895A (fr) 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
EP3743081A4 (en) 2018-01-23 2021-12-01 New York University SPECIFIC ANTIBODIES OF THE DELTA 1 CHAIN OF THE T-LYMPHOCYTE RECEPTOR

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