RU2756247C2 - Генетически модифицированные гамма дельта т-клетки - Google Patents

Генетически модифицированные гамма дельта т-клетки Download PDF

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RU2756247C2
RU2756247C2 RU2017121115A RU2017121115A RU2756247C2 RU 2756247 C2 RU2756247 C2 RU 2756247C2 RU 2017121115 A RU2017121115 A RU 2017121115A RU 2017121115 A RU2017121115 A RU 2017121115A RU 2756247 C2 RU2756247 C2 RU 2756247C2
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cells
cell
antigen
tumor
modified
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RU2017121115A3 (enExample
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Марианне Тереза САНТАГУИДА
Энди Ан-дех ЛИН
Орит ФУРД
Айя Якобовиц
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Эдисет Био, Инк.
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RU2017121115A 2014-11-17 2015-11-17 Генетически модифицированные гамма дельта т-клетки RU2756247C2 (ru)

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Application Number Priority Date Filing Date Title
US201462080500P 2014-11-17 2014-11-17
US62/080,500 2014-11-17
PCT/US2015/061189 WO2016081518A2 (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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RU2017121115A RU2017121115A (ru) 2018-12-19
RU2017121115A3 RU2017121115A3 (enExample) 2019-07-17
RU2756247C2 true RU2756247C2 (ru) 2021-09-28

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EP (2) EP3220926B1 (enExample)
JP (2) JP7146397B2 (enExample)
KR (1) KR102660362B1 (enExample)
CN (2) CN107249605A (enExample)
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Publication number Priority date Publication date Assignee Title
EP1814580B1 (en) 2004-11-24 2016-08-10 Fred Hutchinson Cancer Research Center Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
US10501540B2 (en) 2014-04-10 2019-12-10 Lava Therapeutics B.V. Immunoglobulins binding human Vγ9 Vδ2 T cell receptors
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
RU2756247C2 (ru) 2014-11-17 2021-09-28 Эдисет Био, Инк. Генетически модифицированные гамма дельта т-клетки
MX386714B (es) 2015-01-27 2025-03-11 Lava Therapeutics N V Anticuerpos de dominio simple dirigidos al grupo de diferenciación 1d (cd1d).
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
KR20240063197A (ko) 2015-06-09 2024-05-09 감마델타 테라퓨틱스 엘티디 Tcr 감마 델타 양성 t 세포의 생산 방법
JP7105188B2 (ja) 2015-08-25 2022-07-22 ザ・ユー・エイ・ビー・リサーチ・フアンデーシヨン 幹細胞移植方法
US12005078B2 (en) 2015-09-03 2024-06-11 The Uab Research Foundation Genetically engineered drug resistant T cells and methods of using the same
CN118421557A (zh) 2016-05-12 2024-08-02 阿迪塞特治疗公司 选择性扩增γδT细胞群的方法及其组合物
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) * 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US12350349B2 (en) 2016-08-03 2025-07-08 Washington University Gene editing of CAR-T cells for the treatment of T cell malignancies with chimeric antigen receptors
KR102032354B1 (ko) 2016-11-11 2019-10-16 가톨릭대학교 산학협력단 신규한 배양보조세포 및 이를 이용한 감마 델타 ｔ 세포의 증식 방법
CN110177803A (zh) 2016-11-22 2019-08-27 T细胞受体治疗公司 用于使用融合蛋白进行tcr重新编程的组合物和方法
CA3047999A1 (en) * 2016-12-21 2018-06-28 TCR2 Therapeutics Inc. Engineered t cells for the treatment of cancer
MY200528A (en) * 2017-02-08 2023-12-30 Agency Science Tech & Res Gamma delta t cells and a method of augmenting the tumoricidal activity of the same
CN118662615A (zh) 2017-03-15 2024-09-20 浩康生物系统公司 用于造血干细胞移植的组合物和方法
GB201707048D0 (en) * 2017-05-03 2017-06-14 King S College London Expansion of gamma delta cells, compositions, and methods of use thereof
US12384830B2 (en) * 2017-06-02 2025-08-12 Regents Of The University Of Minnesota Compositions and methods for improving immunotherapy
WO2018236986A1 (en) * 2017-06-20 2018-12-27 The Trustees Of Columbia University In The City Of New York MODIFIED T CELL RECEPTORS AND METHODS OF USING SAME
IL299348B2 (en) 2017-06-28 2025-05-01 Regeneron Pharma Antigen-binding proteins against human papillomavirus and methods of using them
EP4467146A3 (en) * 2017-09-15 2025-05-07 King's College London Compositions and methods for enhancing gamma delta t cells in the gut
TWI687227B (zh) * 2017-10-03 2020-03-11 生倍科技股份有限公司 用於t細胞免疫療法之組合及其用途
CN109777778B (zh) * 2017-11-14 2023-07-18 中国科学院广州生物医药与健康研究院 一种基因改造的γδT细胞
CA3082818A1 (en) * 2017-11-15 2019-05-23 Adicet Bio Inc. Methods for selective expansion of .delta.3 .gamma..delta. t-cell populations and compositions thereof
DE102017127984B4 (de) 2017-11-27 2019-12-05 Immatics US, Inc. Verfahren für die Vermehrung und Aktivierung von γδ-T-Zellen
CN108129566B (zh) * 2017-12-31 2021-05-11 中国科学院武汉病毒研究所 靶向间皮素的c-型单域抗体及其制备方法与应用
US12215154B2 (en) 2018-01-19 2025-02-04 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting γδ T cells with chimeric antigen receptors
US12077598B2 (en) 2018-03-16 2024-09-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Chimeric antigen receptors with mutated CD28 phosphorylation sites
GB201804701D0 (en) 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
WO2019216338A1 (ja) * 2018-05-08 2019-11-14 国立大学法人大阪大学 ホモ接合型細胞の作製方法
CN110577932A (zh) * 2018-06-07 2019-12-17 亘喜生物科技（上海）有限公司 一种脐带血来源的嵌合抗原受体t细胞
MX2021000617A (es) * 2018-07-18 2021-04-13 Amgen Inc Receptores quimericos de steap1 y metodos de uso de los mismos.
PL3830119T3 (pl) * 2018-08-01 2026-05-25 Imcheck Therapeutics Przeciwciała anty-btn3a i ich zastosowanie w leczeniu nowotworów albo zaburzeń zakaźnych
CN108949685B (zh) * 2018-08-02 2022-03-29 吉林大学第一医院 一种体外诱导扩增高杀伤活性γδT细胞的方法
US12569507B2 (en) * 2018-08-07 2026-03-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. CAR T-cells for the treatment of bone metastatic cancer
WO2020033464A1 (en) 2018-08-07 2020-02-13 H. Lee Moffitt Cancer Center And Research Institute Inc. Car t-cells for the treatment of bone metastatic cancer
CN112105724A (zh) * 2018-08-09 2020-12-18 深圳华大生命科学研究院 无内源hla基因背景的抗原递呈细胞系的构建方法、抗原递呈细胞系及其用途
JP7382603B2 (ja) * 2018-08-10 2023-11-17 国立大学法人京都大学 Ｃｄ３陽性細胞の製造方法
CN113307872B (zh) * 2018-08-11 2022-12-06 广东天科雅生物医药科技有限公司 一种工程化核酸、t细胞及其应用和产生方法
CN109161533B (zh) * 2018-08-28 2020-07-24 深圳市菲鹏生物制药股份有限公司 无血清培养组合物及其应用
JP7457007B2 (ja) 2018-09-19 2024-03-27 ラヴァ・セラピューティクス・エヌ・ヴイ 二重作用ＣＤ１ｄ免疫グロブリン
US12698340B2 (en) * 2018-10-01 2026-08-04 Adicet Therapeutics, Inc. Compositions and methods regarding engineered and non-engineered γδ T-cells for treatment of solid tumors
BR112021006182A2 (pt) * 2018-10-01 2021-06-29 Adicet Bio, Inc. composições e métodos relativos a células t¿d,d engenheiradas e não engenheiradas para tratamento de tumores hematológicos
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN113454110B (zh) 2018-10-23 2024-07-02 里珍纳龙药品有限公司 Ny-eso-1 t细胞受体和其使用方法
GB201818243D0 (en) 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
CA3126896A1 (en) 2018-12-03 2020-06-11 Adicet Bio Inc. Methods for selective in vivo expansion of .gamma. .delta. t-cell populations and compositions thereof
CN111544585B (zh) * 2019-02-11 2024-12-27 北京卡替医疗技术有限公司 一种可助推免疫细胞在体内扩增的佐剂
WO2020166729A1 (ja) * 2019-02-14 2020-08-20 学校法人獨協学園獨協医科大学 Ｔ細胞ワクチン
CA3130489A1 (en) * 2019-02-18 2020-08-27 Memorial Sloan-Kettering Cancer Center Combinations of multiple chimeric antigen receptors for immunotherapy
EP3927353A4 (en) * 2019-02-24 2022-11-23 Gamida-Cell Ltd. METHOD OF ECOTAXY AND RETENTION OF GAMMADELTA T LYMPHOCYTES, OPTIONALLY WITH NATURAL KILLER CELLS, ALLOWING THE GENERATION OF CELLULAR COMPOSITIONS FOR USE IN THERAPY
WO2020182681A1 (en) * 2019-03-08 2020-09-17 Klinikum Der Universität München Ccr8 expressing lymphocytes for targeted tumor therapy
CN109758590B (zh) * 2019-03-28 2022-02-11 广东工业大学 一种用于筛选人前列腺癌肿瘤抗原表位肽的方法
US20220282217A1 (en) * 2019-03-30 2022-09-08 Biontech Us Inc. Compositions and methods for preparing t cell compositions and uses thereof
CN113811329B (zh) 2019-04-19 2025-10-14 天科雅生物科技有限公司 抗pd-1抗体和其用途
WO2020219843A1 (en) * 2019-04-26 2020-10-29 The University Of North Carolina At Chapel Hill Chimeric antigen receptor constructs and their use in car-t cells
JP7686571B2 (ja) * 2019-05-08 2025-06-02 ヤンセン バイオテツク，インコーポレーテツド Ｔ細胞媒介性免疫を調節するための材料及び方法
CA3144413A1 (en) * 2019-07-17 2021-01-21 Rafick-Pierre Sekaly Long lived t cells for treating hiv infection
WO2021016652A1 (en) * 2019-07-29 2021-02-04 The University Of Melbourne METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS
JP2022545196A (ja) * 2019-08-16 2022-10-26 ガンマデルタ セラピューティクス リミテッド 抗ｔｃｒデルタ可変１抗体の治療的使用
CN114555785B (zh) * 2019-10-17 2024-12-06 香港大学 制备v-t细胞衍生的外泌体以治疗epstein-barr病毒相关癌症的方法
LT4051710T (lt) 2019-10-31 2026-03-10 Incyte Corporation Priešnavikinė kompleksinė terapija, apimanti anti-cd19 antikūną ir gama delta ląsteles
IL293459A (en) * 2019-12-03 2022-07-01 Adicet Bio Inc Methods for expanding γδ t-cell populations with multivalent agents and compositions thereof
BR112022014461A2 (pt) 2020-01-24 2022-09-13 Regeneron Pharma Antígeno preferencialmente expresso em receptores de células t de melanoma (prame) e métodos de uso dos mesmos
GB202002581D0 (en) * 2020-02-24 2020-04-08 Gammadelta Therapeutics Ltd Novel antibodies
CR20220431A (es) * 2020-03-03 2023-02-21 Janssen Biotech Inc CÉLULAS T yo Y USOS DE ESTAS
WO2021222479A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
WO2021259237A1 (en) * 2020-06-22 2021-12-30 Nanjing Legend Biotech Co., Ltd. GENETIC ENGINEERING OF γδ T CELLS FOR IMMUNOTHERAPY
CN116323667A (zh) 2020-07-08 2023-06-23 拉法医疗股份有限公司 结合PSMA和γ-δT细胞受体的抗体
CN116333995A (zh) * 2020-07-14 2023-06-27 广州泛恩生物科技有限公司 基于cxcr6阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用
CN117295505A (zh) * 2021-02-08 2023-12-26 加利福尼亚大学董事会 嗜乳脂蛋白亚家族3成员a1（btn3a1，cd277）的调节
GB202105113D0 (en) * 2021-04-09 2021-05-26 Gammadelta Therapeutics Ltd Novel method
WO2023069322A1 (en) * 2021-10-20 2023-04-27 University Of Pittsburgh – Of The Commonwealth System Of Higher Education Methods and materials for expanding tumor infiltrating gamma-delta t cells
WO2023092119A2 (en) 2021-11-22 2023-05-25 Ludwig Institute For Cancer Research Ltd Methods for predicting responsiveness to a cancer therapy
AU2022401701A1 (en) * 2021-12-05 2024-06-20 Adicet Therapeutics, Inc. Treatment of b cell malignancies
KR20230105166A (ko) 2022-01-03 2023-07-11 주식회사 이뮤노맥스 감마-델타 t 세포의 증식 배양 방법
CN114149978B (zh) * 2022-02-09 2022-04-26 深圳博雅感知药业有限公司 制备car-t细胞的方法
CA3250985A1 (en) 2022-02-16 2023-08-24 Priothera Sas CAR CELL TREATMENT METHODS IN COMBINATION WITH S1P RECEIVER MODULATORS
GB202204926D0 (en) 2022-04-04 2022-05-18 Gammadelta Therapeutics Ltd Method for expanding gammadelta T cells
US20260014199A1 (en) * 2022-06-17 2026-01-15 Gadeta B.V. Modified immune cells
CN115624618A (zh) * 2022-09-16 2023-01-20 深圳善乐生物科技有限公司 一种HPV多肽抗原负载γδT细胞在HPV阳性宫颈癌免疫治疗中的应用
IL320128A (en) 2022-10-31 2025-06-01 Regeneron Pharma Methods for treating cancer using a combination of adoptive cell therapy and a targeted immunocytokine
EP4688857A1 (en) 2023-04-07 2026-02-11 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with a lymphotoxin beta receptor agonist
EP4720109A1 (en) 2023-05-25 2026-04-08 Regeneron Pharmaceuticals, Inc. T cell receptors that bind presented hpv16-, mart1-, cmv-, ebv-, or influenza- peptides
US12221483B1 (en) * 2024-01-30 2025-02-11 China Medical University Hospital Fusion protein and nucleic acid encoding sequence thereof, and uses of the same
WO2025165915A1 (en) * 2024-01-31 2025-08-07 Adicet Therapeutics, Inc. Compositions and methods for enhancing engineered t cell therapies
WO2025223534A1 (en) * 2024-04-26 2025-10-30 Nanjing Legend Biotech Co., Ltd. Methods for expanding t cells
WO2025229538A1 (en) * 2024-05-01 2025-11-06 Janssen Biotech, Inc. Materials, methods, and systems for cellular expansion of gamma delta t-cells
WO2026013159A1 (en) * 2024-07-10 2026-01-15 Cytospire Therapeutics Limited Antibodies binding to constant domains of gamma delta t-cell receptors
WO2026013158A1 (en) * 2024-07-10 2026-01-15 Cytospire Therapeutics Limited Antibodies binding to constant domains of gamma delta t-cell receptors
WO2026096743A1 (en) 2024-10-30 2026-05-07 Immatics US, Inc. Methods for gamma delta t cells manufacturing
WO2026096605A1 (en) * 2024-10-31 2026-05-07 Pointloma Biosciences, Inc. Methods for activation and expansion of gamma delta t cells
WO2026099401A1 (en) * 2024-11-07 2026-05-15 Cytospire Therapeutics Ltd Novel immunoconjugates
WO2026126652A1 (ja) * 2024-12-13 2026-06-18 学校法人藤田学園 抗ＣＤ３８ ＣＡＲ－γδＴ細胞

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060205089A1 (en) * 2003-04-14 2006-09-14 Montana State University Mapping discontinuous antibody or aptamer epitopes for protein structure determination and other applications
US20080026986A1 (en) * 2006-06-05 2008-01-31 Rong-Fu Wang Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling
WO2013074916A1 (en) * 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185250A (en) * 1986-07-03 1993-02-09 T Cell Sciences, Inc. Human γ, δT cell antigen receptor polypeptides and nucleic acids
US5260223A (en) 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
AU3940293A (en) 1992-04-03 1993-11-08 Alexander T. YOUNG Gene therapy using targeted viral vectors
CA2110946A1 (en) * 1992-12-09 1994-06-10 Elazar Rabbani Induction of immunocompatibility by nucleic acid
JP2003502387A (ja) 1999-06-17 2003-01-21 ザ ユニバーシティ オブ バーモント アンド ステイト アグリカルチュラル カレッジ プライミングされた抗原特異的ｔ細胞またはｂ細胞を用いる自己養子免疫療法
US6737398B1 (en) 1999-09-30 2004-05-18 National Jewish Medical And Research Center Modulation of γδ T cells to regulate airway hyperresponsiveness
WO2001022816A1 (en) 1999-09-30 2001-04-05 National Jewish Medical And Research Center MODULATION OF ηδ T CELLS TO REGULATE AIRWAY HYPERRESPONSIVENESS
ATE347593T1 (de) 2002-01-23 2006-12-15 Univ Utah Res Found Zielgerichtete chromosomale mutagenese mit zinkfingernukleasen
CN1306027C (zh) * 2002-12-12 2007-03-21 中国医学科学院基础医学研究所 一种体外扩增γδT淋巴细胞的方法
US7985739B2 (en) 2003-06-04 2011-07-26 The Board Of Trustees Of The Leland Stanford Junior University Enhanced sleeping beauty transposon system and methods for using the same
SG188175A1 (en) * 2004-06-03 2013-03-28 Novimmune Sa Anti-cd3 antibodies and methods of use thereof
US7340913B2 (en) 2004-08-05 2008-03-11 Manitowoc Foodservice Companies, Inc. Ice machine and ice-making assembly including a water distributor
US8338173B2 (en) * 2005-08-11 2012-12-25 University College Cardiff Consultants Limited Preparation of antigen-presenting human γδ T cells and use in immunotherapy
HUE052220T2 (hu) * 2006-09-08 2021-04-28 Abbvie Bahamas Ltd Interleukin-13 kötõfehérjék
CA2735193A1 (en) 2008-08-26 2010-03-11 Macrogenics, Inc. T-cell receptor antibodies and methods of use thereof
CN105925535A (zh) * 2009-06-05 2016-09-07 细胞动力国际有限公司 重编程t细胞和造血细胞的方法
CA2787494C (en) 2010-01-22 2019-09-17 Dow Agrosciences Llc Targeted genomic alteration
CA2805442C (en) 2010-07-21 2020-05-12 Sangamo Biosciences, Inc. Methods and compositions for modification of an hla locus
ES2785081T3 (es) 2011-04-01 2020-10-05 Memorial Sloan Kettering Cancer Center Anticuerpos biespecíficos similares a receptores de células T específicos para un péptido de WT1 presentado por HLA-A2
EP2710123B1 (en) 2011-05-19 2017-07-12 Instituto de Medicina Molecular Cell line of lymphocytes comprising gamma-delta t cells, composition and production method thereof
BR112014012819B1 (pt) * 2011-11-28 2022-08-16 Merck Patent Gmbh Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição
CN103130894B (zh) * 2011-11-30 2017-04-12 中国医学科学院基础医学研究所 抗人γδTCR单克隆抗体的重组单链抗体G5‑4ScFv及其编码基因与应用
EP2684600A1 (en) 2012-07-10 2014-01-15 Laboratoires Meiners Sarl Core-shell capsules and methods for encapsulation of reactive ingredients by diffusional exchange through spherical capsule membranes
US20150259645A1 (en) 2012-11-08 2015-09-17 INSERM (Institut National de la Santé et de la Recherche Médicale Method for inducing il-2-free proliferation of gamma delta t cells
CN102994448A (zh) 2012-12-13 2013-03-27 上海柯莱逊生物技术有限公司 一种体外扩增γδT细胞的方法
WO2014134412A1 (en) 2013-03-01 2014-09-04 Regents Of The University Of Minnesota Talen-based gene correction
US9907820B2 (en) 2013-10-25 2018-03-06 Board Of Regents, The University Of Texas System Polyclonal gamma delta T cells for immunotherapy
US10501540B2 (en) * 2014-04-10 2019-12-10 Lava Therapeutics B.V. Immunoglobulins binding human Vγ9 Vδ2 T cell receptors
RU2756247C2 (ru) 2014-11-17 2021-09-28 Эдисет Био, Инк. Генетически модифицированные гамма дельта т-клетки
JP6799895B2 (ja) * 2015-06-09 2020-12-16 リンファクト−リンフォサイト アクティベイション テクノロジーズ エス．エー． ＴＣＲγδ＋Ｔ細胞の生産方法
MA42895A (fr) 2015-07-15 2018-05-23 Juno Therapeutics Inc Cellules modifiées pour thérapie cellulaire adoptive
WO2019147735A1 (en) 2018-01-23 2019-08-01 New York University Antibodies specific to delta 1 chain of t cell receptor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060205089A1 (en) * 2003-04-14 2006-09-14 Montana State University Mapping discontinuous antibody or aptamer epitopes for protein structure determination and other applications
US20080026986A1 (en) * 2006-06-05 2008-01-31 Rong-Fu Wang Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling
WO2013074916A1 (en) * 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. KABELITZ et al., The Multifunctionality of Human V[gamma]9V[delta]2 [gamma][delta] T Cells: Clonal Plasticity or Distinct Subsets? Plasticity of Human [gamma][delta] T Cells // SCANDINAVIAN JOURNAL OF IMMUNOLOGY, GB, (20120901), vol. 76, no. 3, pages 213 - 222. *
D. KABELITZ et al., The Multifunctionality of Human V[gamma]9V[delta]2 [gamma][delta] T Cells: Clonal Plasticity or Distinct Subsets? Plasticity of Human [gamma][delta] T Cells // SCANDINAVIAN JOURNAL OF IMMUNOLOGY, GB, (20120901), vol. 76, no. 3, pages 213 - 222. GROH V ET AL, "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB"// PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19990608), vol. 96, no. 12, pages 6879 - 6884. *
GROH V ET AL, "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB"// PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (19990608), vol. 96, no. 12, pages 6879 - 6884. *

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