MX2022013498A - Receptores de antigenos quimericos dirigidos a her2. - Google Patents

Receptores de antigenos quimericos dirigidos a her2.

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Publication number
MX2022013498A
MX2022013498A MX2022013498A MX2022013498A MX2022013498A MX 2022013498 A MX2022013498 A MX 2022013498A MX 2022013498 A MX2022013498 A MX 2022013498A MX 2022013498 A MX2022013498 A MX 2022013498A MX 2022013498 A MX2022013498 A MX 2022013498A
Authority
MX
Mexico
Prior art keywords
chimeric antigen
antigen receptors
targeting her2
receptors targeting
her2
Prior art date
Application number
MX2022013498A
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English (en)
Inventor
Stephen J Forman
Christine E Brown
Saul J Priceman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of MX2022013498A publication Critical patent/MX2022013498A/es

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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Abstract

En la presente invención se describe un receptor de antígeno quimérico (CAR, por sus siglas en inglés), caracterizado porque comprende una secuencia de aminoácidos seleccionada del grupo que consiste en: la SEQ ID NO: 26, una variante de la SEQ ID NO: 26 que tiene de 1-5 modificaciones de aminoácidos, la SEQ ID NO: 27, y una variante de la SEQ ID NO: 27 que tiene de 1-5 modificaciones de aminoácidos. Adicionalmente, se describe una población de células T humanas, una composición que comprende dicha población de células T humanas autólogas o alogénicas transducidas por un vector que comprende un casete de expresión que codifica un receptor de antígeno quimérico, y el uso de las mismas en el tratamiento de un cáncer cerebral que expresa HER2 en un paciente.
MX2022013498A 2015-11-04 2018-05-04 Receptores de antigenos quimericos dirigidos a her2. MX2022013498A (es)

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US201562251052P 2015-11-04 2015-11-04

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MX2022013498A true MX2022013498A (es) 2022-11-16

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US (3) US11197919B2 (es)
EP (2) EP4074731A1 (es)
JP (3) JP6932709B2 (es)
KR (1) KR20180083874A (es)
CN (2) CN116063574A (es)
AU (2) AU2016349722A1 (es)
BR (1) BR112018009129A2 (es)
CA (1) CA3004306A1 (es)
ES (1) ES2909973T3 (es)
IL (2) IL259120B (es)
MX (2) MX2018005674A (es)
RU (1) RU2753695C2 (es)
WO (1) WO2017079694A2 (es)

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KR20210014210A (ko) 2014-05-15 2021-02-08 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도
US11197919B2 (en) * 2015-11-04 2021-12-14 City Of Hope Chimeric antigen receptors targeting HER2
KR20180105709A (ko) 2016-02-05 2018-09-28 시티 오브 호프 중추 신경계의 암의 치료를 위한 조작된 t 세포의 투여
US20200095547A1 (en) * 2016-12-02 2020-03-26 Darya ALIZADEH Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors
CN110121505B (zh) 2016-12-28 2023-08-01 株式会社绿十字细胞治疗 嵌合抗原受体和表达其的自然杀伤细胞
EP4491234A3 (en) 2017-02-08 2025-04-09 Dragonfly Therapeutics, Inc. Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
BR112019017197A2 (pt) 2017-02-20 2020-04-14 Dragonfly Therapeutics, Inc. proteínas que se ligam a her2, nkg2d e cd16
CA3056439A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
AU2018245749A1 (en) 2017-03-27 2019-10-03 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
AU2018370195B2 (en) * 2017-11-14 2022-01-13 Green Cross Lab Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
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CN109608547B (zh) * 2017-12-29 2022-03-15 郑州大学第一附属医院 表达Her2的嵌合抗原受体、慢病毒表达载体及其应用
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