JP2019516665A5 - - Google Patents

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Publication number
JP2019516665A5
JP2019516665A5 JP2018546587A JP2018546587A JP2019516665A5 JP 2019516665 A5 JP2019516665 A5 JP 2019516665A5 JP 2018546587 A JP2018546587 A JP 2018546587A JP 2018546587 A JP2018546587 A JP 2018546587A JP 2019516665 A5 JP2019516665 A5 JP 2019516665A5
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JP
Japan
Prior art keywords
polypeptide
terminal
mhc
multimeric
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018546587A
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English (en)
Japanese (ja)
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JP2019516665A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/020276 external-priority patent/WO2017151818A2/en
Publication of JP2019516665A publication Critical patent/JP2019516665A/ja
Publication of JP2019516665A5 publication Critical patent/JP2019516665A5/ja
Pending legal-status Critical Current

Links

JP2018546587A 2016-03-02 2017-03-01 T細胞調節多量体ポリペプチド及びその使用方法 Pending JP2019516665A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662302654P 2016-03-02 2016-03-02
US62/302,654 2016-03-02
PCT/US2017/020276 WO2017151818A2 (en) 2016-03-02 2017-03-01 T-cell modulatory multimeric polypeptides and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2019516665A JP2019516665A (ja) 2019-06-20
JP2019516665A5 true JP2019516665A5 (enExample) 2020-04-09

Family

ID=59743228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018546587A Pending JP2019516665A (ja) 2016-03-02 2017-03-01 T細胞調節多量体ポリペプチド及びその使用方法

Country Status (9)

Country Link
US (2) US20190062400A1 (enExample)
EP (1) EP3423108A4 (enExample)
JP (1) JP2019516665A (enExample)
KR (1) KR20180132663A (enExample)
CN (1) CN109311945A (enExample)
AU (1) AU2017226269B2 (enExample)
CA (1) CA3014458A1 (enExample)
IL (1) IL261401A (enExample)
WO (1) WO2017151818A2 (enExample)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
US10048271B2 (en) 2012-12-11 2018-08-14 Albert Einstein College Of Medicine, Inc. Methods for high throughput receptor:ligand identification
RS61943B1 (sr) 2015-04-17 2021-07-30 Alpine Immune Sciences Inc Imunomodulatorni proteini sa prilagodljivim afinitetima
JP6936221B2 (ja) 2015-11-02 2021-09-15 ファイブ プライム セラピューティクス, インコーポレイテッド Cd80細胞外ドメインポリペプチドと、がん治療でのそれらの使用
IL310729A (en) 2016-04-15 2024-04-01 Alpine Immune Sciences Inc Immunomodulatory proteins that are variants of CD80 and their uses
US11505591B2 (en) * 2016-05-18 2022-11-22 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
AU2017266905B2 (en) 2016-05-18 2022-12-15 Albert Einstein College Of Medicine, Inc. Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof
EP3491013A1 (en) 2016-07-28 2019-06-05 Alpine Immune Sciences, Inc. Cd155 variant immunomodulatory proteins and uses thereof
KR102760578B1 (ko) 2016-12-22 2025-02-03 큐 바이오파마, 인크. T-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
IL269000B2 (en) 2017-03-15 2024-06-01 Cue Biopharma Inc Methods for modulating an immune response
EP3596114A2 (en) 2017-03-16 2020-01-22 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
AU2018258661A1 (en) 2017-04-28 2019-10-17 Five Prime Therapeutics, Inc. Methods of treatment with CD80 extracellular domain polypeptides
TW201920249A (zh) * 2017-09-07 2019-06-01 美商信號生物製藥公司 具有結合位點之t細胞調節多聚體多肽及其使用方法
EP3678677A4 (en) * 2017-09-07 2021-06-16 Cue Biopharma, Inc. Antigen-presenting polypeptides and methods of use thereof
CN111886241A (zh) 2018-01-09 2020-11-03 库尔生物制药有限公司 多聚体t细胞调节多肽及其使用方法
WO2020132368A1 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof
TW202045544A (zh) 2019-02-22 2020-12-16 美商戊瑞治療有限公司 用於治療PD-L1陰性腫瘤之CD80胞外結構域Fc融合蛋白
WO2020181272A1 (en) * 2019-03-06 2020-09-10 Cue Biopharma, Inc. Antigen-presenting polypeptides with chemical conjugation sites and methods of use thereof
AU2020282736B2 (en) * 2019-05-29 2025-10-30 Cue Biopharma, Inc. Multimeric T-cell modulatory polypeptides and methods of use thereof
WO2021055594A1 (en) * 2019-09-20 2021-03-25 Cue Biopharma, Inc. T-cell modulatory polypeptides and methods of use thereof
MX2022004873A (es) 2019-10-23 2022-05-13 Cue Biopharma Inc Polipeptidos de tgf-?.
WO2021178975A1 (en) * 2020-03-06 2021-09-10 Albert Einstein College Of Medicine A method to generate chimeric antigen receptor (car) t-cells (car-t cells) from pathogen-specific cytotoxic lymphocytes to enable the subsequent in vivo modulation of their functional activity
JP2023517044A (ja) * 2020-03-09 2023-04-21 ファイザー・インク 融合タンパク質およびその使用
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
EP4157350A4 (en) * 2020-05-26 2025-07-23 Cue Biopharma Inc ANTIGEN-PRESENTING POLYPEPTIDE COMPLEXES AND METHODS OF USE THEREOF
WO2021242935A1 (en) * 2020-05-26 2021-12-02 Cue Biopharma, Inc. Antigen presenting polypeptide complexes and methods of use thereof
KR20230052881A (ko) * 2020-07-14 2023-04-20 큐 바이오파마, 인크. 접합 부위를 갖는 t-세포 조절 폴리펩티드 및 이의 사용 방법
EP4211149A4 (en) 2020-09-09 2024-10-09 Cue Biopharma, Inc. MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF
CA3216273A1 (en) * 2021-04-21 2022-10-27 Ronald D. SEIDEL III Antigen presenting polypeptide complexes bearing tgf-beta and methods of use thereof
US20240270815A1 (en) * 2021-05-26 2024-08-15 Cue Biopharma, Inc. Antigen Presenting Polypeptide Complexes and Methods of Use Thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100797876B1 (ko) * 1998-04-07 2008-01-24 코릭사 코포레이션 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도
PT2726101T (pt) * 2011-06-30 2018-11-21 Genzyme Corp Inibidores da ativação de células t
CN102898504B (zh) * 2012-10-23 2014-08-06 中国农业大学 抗氧化活性合成肽及其用途
PT3480213T (pt) * 2014-06-18 2020-02-04 Albert Einstein College Medicine Polipéptidos syntac e utilizações dos mesmos

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