JP2019522466A5 - - Google Patents

Info

Publication number

JP2019522466A5

JP2019522466A5 JP2018560657A JP2018560657A JP2019522466A5 JP 2019522466 A5 JP2019522466 A5 JP 2019522466A5 JP 2018560657 A JP2018560657 A JP 2018560657A JP 2018560657 A JP2018560657 A JP 2018560657A JP 2019522466 A5 JP2019522466 A5 JP 2019522466A5

Authority

JP

Japan

Prior art keywords

polypeptide

mhc

multimeric

terminus

epitope

Prior art date

2017-05-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 229920001184 polypeptide Polymers 0.000 claims 89
• 102000004196 processed proteins & peptides Human genes 0.000 claims 89
• 108090000765 processed proteins & peptides Proteins 0.000 claims 89
• 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 19
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 19
• 230000002519 immonomodulatory effect Effects 0.000 claims 15
• 125000003275 alpha amino acid group Chemical group 0.000 claims 12
• 102000008096 B7-H1 Antigen Human genes 0.000 claims 11
• 108010074708 B7-H1 Antigen Proteins 0.000 claims 11
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• 102000004169 proteins and genes Human genes 0.000 claims 7
• 108090000623 proteins and genes Proteins 0.000 claims 7
• 239000013604 expression vector Substances 0.000 claims 6
• 238000003259 recombinant expression Methods 0.000 claims 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 210000004899 c-terminal region Anatomy 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
• 108060003951 Immunoglobulin Proteins 0.000 claims 2
• 102000043131 MHC class II family Human genes 0.000 claims 2
• 108091054438 MHC class II family Proteins 0.000 claims 2
• 102220619489 Protein mago nashi homolog_E72R_mutation Human genes 0.000 claims 2
• 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
• 102220580347 Ubiquitin thioesterase otulin_Y56D_mutation Human genes 0.000 claims 2
• 102000018358 immunoglobulin Human genes 0.000 claims 2
• 102200046996 rs104894932 Human genes 0.000 claims 2
• 102200117957 rs33947020 Human genes 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102220633920 Alpha-1-antitrypsin_T37A_mutation Human genes 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 102220479097 CD59 glycoprotein_D49R_mutation Human genes 0.000 claims 1
• 102220465530 Lymphocyte activation gene 3 protein_R125A_mutation Human genes 0.000 claims 1
• 102000043129 MHC class I family Human genes 0.000 claims 1
• 108091054437 MHC class I family Proteins 0.000 claims 1
• 102220508980 Protein lin-37 homolog_K124A_mutation Human genes 0.000 claims 1
• 102000004338 Transferrin Human genes 0.000 claims 1
• 108090000901 Transferrin Proteins 0.000 claims 1
• 102000015736 beta 2-Microglobulin Human genes 0.000 claims 1
• 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 239000000833 heterodimer Substances 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102200110965 rs199422212 Human genes 0.000 claims 1
• 102220007497 rs33947020 Human genes 0.000 claims 1
• 102220277413 rs377430566 Human genes 0.000 claims 1
• 102220203056 rs753524431 Human genes 0.000 claims 1
• 102220264878 rs756388446 Human genes 0.000 claims 1
• 102220020885 rs80356880 Human genes 0.000 claims 1
• 239000012581 transferrin Substances 0.000 claims 1