JP2019501647A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019501647A5 JP2019501647A5 JP2018528669A JP2018528669A JP2019501647A5 JP 2019501647 A5 JP2019501647 A5 JP 2019501647A5 JP 2018528669 A JP2018528669 A JP 2018528669A JP 2018528669 A JP2018528669 A JP 2018528669A JP 2019501647 A5 JP2019501647 A5 JP 2019501647A5
- Authority
- JP
- Japan
- Prior art keywords
- chimeric receptor
- domain
- variant
- amino acid
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108700010039 chimeric receptor Proteins 0.000 claims 56
- 235000001014 amino acid Nutrition 0.000 claims 25
- 229940024606 amino acid Drugs 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 238000012986 modification Methods 0.000 claims 13
- 230000004048 modification Effects 0.000 claims 13
- 230000011664 signaling Effects 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- 102220292761 rs576215366 Human genes 0.000 claims 8
- 108010033276 Peptide Fragments Proteins 0.000 claims 7
- 102000007079 Peptide Fragments Human genes 0.000 claims 7
- 230000000139 costimulatory effect Effects 0.000 claims 7
- 230000001086 cytosolic effect Effects 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 108020001756 ligand binding domains Proteins 0.000 claims 6
- 102220610001 Bestrophin-2_L34A_mutation Human genes 0.000 claims 4
- 230000001747 exhibiting effect Effects 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- 102220610000 Bestrophin-2_R31A_mutation Human genes 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102200082944 rs1135071 Human genes 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 102220471762 Proteasome subunit alpha type-7_K28A_mutation Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102200112956 rs104893657 Human genes 0.000 claims 1
- 102200031779 rs3204853 Human genes 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022187652A JP2023022161A (ja) | 2015-12-03 | 2022-11-24 | 修飾キメラ受容体ならびに関連する組成物および方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562262911P | 2015-12-03 | 2015-12-03 | |
| US62/262,911 | 2015-12-03 | ||
| US201662348130P | 2016-06-09 | 2016-06-09 | |
| US62/348,130 | 2016-06-09 | ||
| PCT/US2016/064861 WO2017096329A1 (en) | 2015-12-03 | 2016-12-02 | Modified chimeric receptors and related compositions and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187652A Division JP2023022161A (ja) | 2015-12-03 | 2022-11-24 | 修飾キメラ受容体ならびに関連する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019501647A JP2019501647A (ja) | 2019-01-24 |
| JP2019501647A5 true JP2019501647A5 (enExample) | 2020-01-16 |
| JP7184645B2 JP7184645B2 (ja) | 2022-12-06 |
Family
ID=57851322
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018528669A Active JP7184645B2 (ja) | 2015-12-03 | 2016-12-02 | 修飾キメラ受容体ならびに関連する組成物および方法 |
| JP2022187652A Pending JP2023022161A (ja) | 2015-12-03 | 2022-11-24 | 修飾キメラ受容体ならびに関連する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187652A Pending JP2023022161A (ja) | 2015-12-03 | 2022-11-24 | 修飾キメラ受容体ならびに関連する組成物および方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12139526B2 (enExample) |
| EP (2) | EP4212547A1 (enExample) |
| JP (2) | JP7184645B2 (enExample) |
| CN (2) | CN108884140B (enExample) |
| AU (1) | AU2016363025B2 (enExample) |
| CA (1) | CA3007262A1 (enExample) |
| ES (1) | ES2940607T3 (enExample) |
| MA (1) | MA43380A (enExample) |
| MX (1) | MX2018006789A (enExample) |
| WO (1) | WO2017096329A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013224027B2 (en) | 2012-02-23 | 2019-01-24 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| KR101605421B1 (ko) | 2014-03-05 | 2016-03-23 | 국립암센터 | B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도 |
| JP6696969B2 (ja) | 2014-04-16 | 2020-05-20 | ユノ・セラピューティクス・ゲーエムベーハーＪｕｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｇｍｂｈ | 細胞の集団を拡大する方法、キット、及び装置 |
| SG11201608862SA (en) | 2014-04-23 | 2016-11-29 | Juno Therapeutics Inc | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| US10428305B2 (en) | 2014-05-15 | 2019-10-01 | National University Of Singapore | Modified natural killer cells that express IL15 and uses thereof |
| ES2987087T3 (es) | 2014-12-03 | 2024-11-13 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| HRP20250129T1 (hr) | 2014-12-15 | 2025-04-11 | The Regents Of The University Of California | Bispecifični or-gate kimerni antigenski receptor koji reagira na cd19 i cd20 |
| US11384350B2 (en) | 2014-12-15 | 2022-07-12 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective T cell mediated killing |
| AU2016235388B2 (en) * | 2015-03-20 | 2022-02-03 | Children's National Medical Center | Generating virus or other antigen-specific T cells from a naive T cell population |
| KR20180108567A (ko) | 2015-10-22 | 2018-10-04 | 주노 테라퓨틱스 게엠베하 | 형질도입을 위한 방법, 키트, 제제 및 장치 |
| MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| AU2017319702B2 (en) | 2016-09-02 | 2024-11-14 | The Regents Of The University Of California | Methods and compositions involving interleukin-6 receptor alpha-binding single chain variable fragments |
| KR102664453B1 (ko) * | 2017-02-21 | 2024-05-10 | 주식회사 유틸렉스 | Hla-dr car-t 조성물 및 그를 제조하고 사용하는 방법 |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| AU2018246235B2 (en) | 2017-03-27 | 2023-12-21 | National University Of Singapore | Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy |
| CA3060443A1 (en) | 2017-04-19 | 2018-10-25 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| WO2018197949A1 (en) | 2017-04-27 | 2018-11-01 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
| CA3070998A1 (en) * | 2017-07-25 | 2019-01-31 | Board Of Regents, The University Of Texas System | Enhanced chimeric antigen receptors and use thereof |
| EP3697426B1 (en) * | 2017-10-16 | 2023-07-26 | Lentigen Technology, Inc. | Compositions and methods for treating cancer with anti-cd22 immunotherapy |
| MX2020004240A (es) | 2017-11-01 | 2020-09-25 | Juno Therapeutics Inc | Proceso para generar composiciones terapeuticas de celulas modificadas. |
| TW201932482A (zh) | 2017-11-01 | 2019-08-16 | 美商奇諾治療有限公司 | 對b細胞成熟抗原具特異性之嵌合抗原受體及編碼聚核苷酸 |
| CN111886012A (zh) | 2017-11-06 | 2020-11-03 | 朱诺治疗学股份有限公司 | 细胞疗法与γ分泌酶抑制剂的组合 |
| US12258381B2 (en) | 2018-02-09 | 2025-03-25 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
| WO2019193476A1 (en) | 2018-04-02 | 2019-10-10 | National University Of Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| EP3806871A4 (en) * | 2018-06-12 | 2022-02-23 | The Regents of the University of California | SINGLE-CHAIN BISPECIFIC CHEMICAL ANTIGEN RECEPTORS FOR THE TREATMENT OF CANCER |
| EP3833742A2 (en) * | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| JP7539161B2 (ja) | 2018-08-10 | 2024-08-23 | ユーティレックス カンパニー リミテッド | Ｈｌａ－ｄｒに結合するキメラ抗原受容体およびｃａｒ－ｔ細胞 |
| US12486514B2 (en) | 2018-08-29 | 2025-12-02 | National University Of Singapore | Method to specifically stimulate survival and expansion of genetically-modified immune cells |
| MX2021005013A (es) | 2018-10-31 | 2021-07-21 | Juno Therapeutics Gmbh | Métodos para la selección y estimulación de células y aparatos para los mismos. |
| SG11202104188VA (en) | 2018-11-01 | 2021-05-28 | Juno Therapeutics Inc | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| MX2021012285A (es) | 2019-04-09 | 2021-12-15 | Nurix Therapeutics Inc | Compuestos de piperidina 3-sustituidos para inhibicion del protooncogen-b de linfoma de linea b de casitas (cbl-b) y uso de un inhibidor de cbl-b en combinacion con una vacuna contra el cancer y/o con un virus oncolitico. |
| AU2020278592B2 (en) | 2019-05-17 | 2024-10-10 | Nurix Therapeutics, Inc. | Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof |
| AU2020303696A1 (en) | 2019-06-26 | 2022-01-06 | Nurix Therapeutics, Inc. | Substituted benzyl-triazole compounds for Cbl-b inhibition, and further uses thereof |
| WO2021016606A1 (en) * | 2019-07-24 | 2021-01-28 | Eureka Therapeutics, Inc. | Chimeric antigen receptor t cells and uses thereof |
| TW202118781A (zh) * | 2019-07-30 | 2021-05-16 | 大學健康網絡 | Ｉｉ類ｍｈｃ分子及其使用方法 |
| WO2021021761A1 (en) | 2019-07-30 | 2021-02-04 | Nurix Therapeutics, Inc. | Urea, amide, and substituted heteroaryl compounds for cbl-b inhibition |
| JP7439279B2 (ja) * | 2020-02-13 | 2024-02-27 | イミュノファーム テクノロジー カンパニー リミテッド | キメラ抗原受容体の最適化 |
Family Cites Families (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| WO1990007380A2 (en) | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| ATE159548T1 (de) | 1990-11-13 | 1997-11-15 | Immunex Corp | Bifunktionelle wählbare fusionsgene |
| DE4228458A1 (de) | 1992-08-27 | 1994-06-01 | Beiersdorf Ag | Multicistronische Expressionseinheiten und deren Verwendung |
| AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| AU4278296A (en) | 1994-10-25 | 1996-05-15 | Immulogic Pharmaceutical Corporation | Compositions and treatment for multiple sclerosis |
| US20020150914A1 (en) | 1995-06-30 | 2002-10-17 | Kobenhavns Universitet | Recombinant antibodies from a phage display library, directed against a peptide-MHC complex |
| DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| US6451995B1 (en) | 1996-03-20 | 2002-09-17 | Sloan-Kettering Institute For Cancer Research | Single chain FV polynucleotide or peptide constructs of anti-ganglioside GD2 antibodies, cells expressing same and related methods |
| CA2343156A1 (en) | 1998-09-04 | 2000-03-16 | Sloan-Kettering Institute For Cancer Research | Fusion receptors specific for prostate-specific membrane antigen and uses thereof |
| US6410319B1 (en) | 1998-10-20 | 2002-06-25 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
| AU4705201A (en) | 1999-10-27 | 2001-06-25 | Cel-Sci Corporation | Peptide constructs for treating autoimmune and related diseases |
| EP1287357A2 (en) | 2000-06-02 | 2003-03-05 | Memorial Sloan-Kettering Cancer Center | Artificial antigen presenting cells and methods of use thereof |
| DK1311542T3 (da) | 2000-08-21 | 2008-11-10 | Apitope Technology Bristol Ltd | Tolerogene peptider |
| ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| GB0202399D0 (en) | 2002-02-01 | 2002-03-20 | Univ Bristol | Peptide |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20040138116A1 (en) | 2002-08-30 | 2004-07-15 | Vincent Geenen | Tolerogenic approach for type 1 diabetes |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US20070264229A1 (en) | 2004-09-13 | 2007-11-15 | Strominger Jack L | Peptides for Treatment of Autoimmune Disease |
| US20080118532A1 (en) | 2006-06-01 | 2008-05-22 | Atassi M Zouhair | Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin b peptides |
| EP2141997B1 (en) | 2007-03-30 | 2012-10-31 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| GB0723712D0 (en) | 2007-12-04 | 2008-01-16 | Apitope Technology Bristol Ltd | Peptides |
| EP2227334B1 (en) | 2007-12-07 | 2011-10-12 | Miltenyi Biotec GmbH | A centrifuge for separating a sample into at least two components |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| EP4032552B1 (en) | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| CA2753158A1 (en) | 2009-02-23 | 2010-08-26 | Glenmark Pharmaceuticals S.A. | Humanized antibodies that bind to cd19 and their uses |
| EP2445530B1 (en) | 2009-06-24 | 2016-09-07 | The Feinstein Institute for Medical Research | Method for treating chronic lymphocytic leukemia |
| PT2496698T (pt) | 2009-11-03 | 2019-04-18 | Hope City | Recetor de fator de crescimento epidermal truncado (egfrt) para seleção de células t transduzidas |
| JP6192537B2 (ja) | 2010-08-06 | 2017-09-06 | ルードヴィヒ−マクシミリアン−ウニヴェルズィテート ミュンヘン | Ｔ細胞の標的抗原の同定 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012083069A2 (en) | 2010-12-15 | 2012-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Measurement and monitoring of cell clonality |
| JP6203705B2 (ja) | 2011-03-23 | 2017-09-27 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞免疫療法のための方法および組成物 |
| PE20141271A1 (es) | 2011-04-01 | 2014-10-08 | Sloan Kettering Inst Cancer | Anticuerpos tipo receptor de celulas t especificos para un peptido wt1 presentado por hla-a2 |
| US20140348861A1 (en) | 2011-05-05 | 2014-11-27 | National Institute Of Immunology | Synthetic peptides and random copolymers for the treatment of autoimmune disorders |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| US10208086B2 (en) | 2011-11-11 | 2019-02-19 | Fred Hutchinson Cancer Research Center | Cyclin A1-targeted T-cell immunotherapy for cancer |
| EP2814846B1 (en) | 2012-02-13 | 2020-01-08 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| JP2015511628A (ja) | 2012-04-02 | 2015-04-20 | ユニバーシティ オブ ブリストル | 寛容化誘導組成物 |
| RU2018130123A (ru) | 2012-05-03 | 2018-11-07 | Фред Хатчинсон Кансэр Рисёч Сентер | Клетка, экспрессирующая t-клеточный рецептор (tcr), для применения в клеточной иммунотерапии |
| CN104583230A (zh) * | 2012-07-13 | 2015-04-29 | 宾夕法尼亚大学董事会 | 通过共同引入双特异性抗体增强car t细胞的活性 |
| PH12019550223A1 (en) | 2012-08-20 | 2024-02-19 | Fred Hutchinson Cancer Center | Method and compositions for cellular immunotherapy |
| JP6441802B2 (ja) | 2012-10-02 | 2018-12-19 | メモリアル スローン ケタリング キャンサー センター | 免疫療法のための組成物および方法 |
| US9405601B2 (en) | 2012-12-20 | 2016-08-02 | Mitsubishi Electric Corporation | In-vehicle apparatus and program |
| US9657105B2 (en) * | 2013-03-15 | 2017-05-23 | City Of Hope | CD123-specific chimeric antigen receptor redirected T cells and methods of their use |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| ES2784638T3 (es) | 2014-03-04 | 2020-09-29 | Merck Patent Gmbh | Purificación de anticuerpos robusta |
| CN106163547A (zh) | 2014-03-15 | 2016-11-23 | 诺华股份有限公司 | 使用嵌合抗原受体治疗癌症 |
| IL290655B2 (en) | 2014-05-29 | 2024-05-01 | Us Health | Anti-human papillomavirus 16 E7 T-cell chelates |
| AU2015305531B2 (en) | 2014-08-19 | 2021-05-20 | Novartis Ag | Anti-CD123 chimeric antigen receptor (CAR) for use in cancer treatment |
| BR112017008693A2 (pt) | 2014-10-31 | 2018-02-27 | The Trustees Of The University Of Pennsylvania | célula t modificada, métodos para gerar uma célula t modificada, para tratar uma doença ou condição, para estimular uma resposta imune mediada por célula t e para terapia de transferência de célula adotiva, uso de uma célula t modificada, e, composição. |
| ES2987087T3 (es) * | 2014-12-03 | 2024-11-13 | Juno Therapeutics Inc | Métodos y composiciones para terapia celular adoptiva |
| DK3271382T3 (da) | 2015-03-16 | 2020-05-04 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek |
| CN104910279B (zh) | 2015-06-05 | 2019-02-22 | 重庆精准生物技术有限公司 | 靶向癌胚抗原的嵌合抗原受体、慢病毒表达载体及其制备方法和应用 |
| EP3156067A1 (en) | 2015-10-16 | 2017-04-19 | Max-Delbrück-Centrum Für Molekulare Medizin | High avidity hpv t-cell receptors |
| MA43378A (fr) | 2015-12-03 | 2018-10-10 | Juno Therapeutics Inc | Compositions et méthodes pour la reduction de la réponse immunitaire contre récepteurs d'antigène chimériques |
| NZ782858A (en) | 2015-12-04 | 2025-08-29 | Novartis Ag | Compositions and methods for immunooncology |
| MA46354A (fr) | 2016-10-03 | 2019-08-07 | Juno Therapeutics Inc | Molécules se liant spécifiquement au vph |
| US11952408B2 (en) | 2017-10-03 | 2024-04-09 | Juno Therapeutics, Inc. | HPV-specific binding molecules |
-
2016
- 2016-12-02 EP EP22213396.9A patent/EP4212547A1/en not_active Withdrawn
- 2016-12-02 CN CN201680080438.2A patent/CN108884140B/zh active Active
- 2016-12-02 US US15/780,623 patent/US12139526B2/en active Active
- 2016-12-02 CA CA3007262A patent/CA3007262A1/en active Pending
- 2016-12-02 AU AU2016363025A patent/AU2016363025B2/en not_active Ceased
- 2016-12-02 WO PCT/US2016/064861 patent/WO2017096329A1/en not_active Ceased
- 2016-12-02 EP EP16829013.8A patent/EP3383892B1/en active Active
- 2016-12-02 JP JP2018528669A patent/JP7184645B2/ja active Active
- 2016-12-02 ES ES16829013T patent/ES2940607T3/es active Active
- 2016-12-02 MX MX2018006789A patent/MX2018006789A/es unknown
- 2016-12-02 MA MA043380A patent/MA43380A/fr unknown
- 2016-12-02 CN CN202211269666.8A patent/CN116041538A/zh active Pending
-
2022
- 2022-11-24 JP JP2022187652A patent/JP2023022161A/ja active Pending