JP2018515088A5 - - Google Patents
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- JP2018515088A5 JP2018515088A5 JP2017557346A JP2017557346A JP2018515088A5 JP 2018515088 A5 JP2018515088 A5 JP 2018515088A5 JP 2017557346 A JP2017557346 A JP 2017557346A JP 2017557346 A JP2017557346 A JP 2017557346A JP 2018515088 A5 JP2018515088 A5 JP 2018515088A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- seq
- amino acid
- insulin
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158079P | 2015-05-07 | 2015-05-07 | |
| US62/158,079 | 2015-05-07 | ||
| PCT/US2016/029807 WO2016178905A1 (en) | 2015-05-07 | 2016-04-28 | Fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515088A JP2018515088A (ja) | 2018-06-14 |
| JP2018515088A5 true JP2018515088A5 (enExample) | 2018-08-23 |
| JP6591562B2 JP6591562B2 (ja) | 2019-10-16 |
Family
ID=55953435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557346A Active JP6591562B2 (ja) | 2015-05-07 | 2016-04-28 | 融合タンパク質 |
Country Status (40)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2784603T3 (es) | 2015-06-02 | 2020-09-29 | Novo Nordisk As | Insulinas con extensiones recombinantes polares |
| EP3355931B1 (en) | 2015-10-01 | 2024-06-26 | Novo Nordisk A/S | Protein conjugates |
| RU2719856C1 (ru) | 2016-07-27 | 2020-04-23 | Хьюлетт-Паккард Дивелопмент Компани, Л.П. | Горизонтальный интерфейс для картриджа с запасом текучей среды, имеющего цифровой датчик уровня текучей среды |
| AU2017371217B2 (en) * | 2016-12-09 | 2020-03-19 | Akston Biosciences Corporation | Insulin-Fc fusions and methods of use |
| TR201703622A1 (tr) * | 2017-03-09 | 2018-09-21 | Univ Yeditepe | Obezi̇te tedavi̇si̇ i̇çi̇n bi̇r ürün |
| JP2020513019A (ja) * | 2017-04-05 | 2020-04-30 | ノヴォ ノルディスク アー／エス | オリゴマー伸長インスリン−Ｆｃコンジュゲート |
| EP3743088B1 (en) * | 2018-01-26 | 2022-10-12 | F. Hoffmann-La Roche AG | Il-22 fc compositions and methods of use |
| EP3810640A1 (en) | 2018-06-25 | 2021-04-28 | University of Washington | De novo design of potent and selective interleukin mimetics |
| CN113038964B (zh) * | 2018-06-29 | 2025-05-27 | 德克拉有限公司 | 超长效胰岛素-fc融合蛋白及使用方法 |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| WO2020074544A1 (en) | 2018-10-10 | 2020-04-16 | Novo Nordisk A/S | Oligomer extended insulin-fc conjugates and their medical use |
| MX2021005593A (es) | 2018-11-20 | 2021-08-11 | Univ Washington | Miméticos de interleucina dividida y sus usos. |
| CN113613629A (zh) * | 2019-03-15 | 2021-11-05 | 伊莱利利公司 | 防腐的制剂 |
| WO2021011827A1 (en) * | 2019-07-16 | 2021-01-21 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| TWI844709B (zh) * | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CN114555792A (zh) | 2019-10-15 | 2022-05-27 | 伊莱利利公司 | 重组改造的、脂肪酶/酯酶缺陷型哺乳动物细胞系 |
| DK4073098T5 (da) * | 2019-12-19 | 2024-07-22 | Akston Biosciences Corp | Ultralangtidsvirkende insulin-Fc-fusionsproteiner og fremgangsmåder til anvendelse |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| EP4121449A2 (en) | 2020-03-16 | 2023-01-25 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor beta (il-2rb) binding polypeptides |
| EP4132964A2 (en) | 2020-04-07 | 2023-02-15 | Neoleukin Therapeutics, Inc. | De novo protein decoys of angiotensin-converting enzyme 2 (ace2) |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| US11213581B2 (en) | 2020-04-10 | 2022-01-04 | Akston Biosciences Corporation | Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| US20230272030A1 (en) * | 2020-07-24 | 2023-08-31 | Jiangsu Gensciences Inc. | Insulin-fc fusion protein and application thereof |
| MX2023005197A (es) * | 2020-11-06 | 2023-05-16 | Amgen Inc | Dominio de union a antigeno con tasa de recorte reducida. |
| AU2021400816B2 (en) * | 2020-12-14 | 2025-07-10 | Eli Lilly And Company | Methods of treating diabetes |
| US11667689B2 (en) | 2021-07-23 | 2023-06-06 | Akston Biosciences Corporation | Insulin-Fc fusion proteins and methods of use to treat cancer |
| WO2023044318A2 (en) | 2021-09-15 | 2023-03-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
| TWI871539B (zh) * | 2021-11-15 | 2025-02-01 | 美商美國禮來大藥廠 | 可保存之調配物 |
| TW202342552A (zh) * | 2022-03-16 | 2023-11-01 | 大陸商北京拓界生物醫藥科技有限公司 | 人胰島素類似物、其融合蛋白及醫藥用途 |
| AR129357A1 (es) | 2022-05-18 | 2024-08-14 | Protomer Tech Inc | Compuestos aromáticos que contienen boro y análogos de insulina relacionados |
| EP4543909A1 (en) | 2022-06-23 | 2025-04-30 | Sanofi | Single chain insulins and fc conjugates thereof |
| WO2024137820A1 (en) * | 2022-12-20 | 2024-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin receptor antagonist |
| CN115894720B (zh) * | 2023-01-16 | 2024-07-09 | 中国科学院上海药物研究所 | 一种长效胰岛素-Fc融合蛋白 |
| EP4706053A1 (en) | 2023-05-03 | 2026-03-11 | Eli Lilly and Company | Methods and systems for managing diabetes |
| WO2025059010A1 (en) | 2023-09-11 | 2025-03-20 | Eli Lilly And Company | Methods and systems for managing diabetes |
| WO2025061146A1 (zh) * | 2023-09-20 | 2025-03-27 | 上海迈晋生物医药科技有限公司 | 一种人胰岛素类似物融合蛋白的药物组合物及其医药用途 |
| WO2025080923A1 (en) | 2023-10-13 | 2025-04-17 | Eli Lilly And Company | Insulin-fc fusion proteins |
| US12454565B2 (en) | 2024-03-21 | 2025-10-28 | Akston Biosciences Corporation | PD-L1 analog fusion proteins for antigen specific immunotherapy and methods of use |
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| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| IL118127A0 (en) | 1995-05-05 | 1996-09-12 | Lilly Co Eli | Single chain insulin with high bioactivity |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| EP1196189A2 (en) | 1999-06-25 | 2002-04-17 | Medtronic MiniMed, Inc. | Multiple agent diabetes therapy |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
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| EA008831B1 (ru) | 2003-06-12 | 2007-08-31 | Эли Лилли Энд Компани | Слитые белки аналогов glp-1 |
| DE60333600D1 (de) | 2003-10-02 | 2010-09-09 | Zeiss Carl Smt Ag | Projektionsobjektiv für die halbleiter-lithographie |
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| WO2006097521A1 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Pegylated single-chain insulin |
| US20090069216A1 (en) | 2006-02-21 | 2009-03-12 | Novo Nordisk A/S | Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof |
| EP1996709A2 (en) | 2006-03-13 | 2008-12-03 | Novo Nordisk A/S | Acylated single chain insulin |
| US20090069215A1 (en) | 2006-03-13 | 2009-03-12 | Novo Nordisk A/S | Acylated Single Chain Insulin |
| EP2404934A1 (en) | 2006-09-22 | 2012-01-11 | Novo Nordisk A/S | Protease resistant insulin analogues |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
| CA2687377C (en) * | 2007-05-30 | 2013-05-14 | Genexine Co., Ltd. | Immunoglobulin fusion proteins |
| US20100196405A1 (en) | 2007-07-10 | 2010-08-05 | Kingman Ng | GLP-1 Fc FUSION PROTEIN FORMULATION |
| ES2618073T3 (es) | 2008-03-14 | 2017-06-20 | Novo Nordisk A/S | Análogos de insulina estabilizados frente a proteasas |
| MX2010009850A (es) * | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
| CN102065885A (zh) | 2008-04-22 | 2011-05-18 | 卡斯西部储备大学 | 同种型特异性的胰岛素类似物 |
| GB0812019D0 (en) | 2008-07-02 | 2008-08-06 | Asterion Ltd | Insulin |
| EP2300501B1 (en) | 2008-07-23 | 2014-08-20 | Hanmi Science Co., Ltd. | A polypeptide complex comprising non-peptidyl polymer having three functional ends |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
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| WO2011159895A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
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| CN110134210A (zh) | 2019-04-16 | 2019-08-16 | 深圳市国鑫恒宇科技有限公司 | 一种服务器一体机的温度控制方法、系统、装置及存储介质 |
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2016
- 2016-04-20 AR ARP160101082A patent/AR105616A1/es unknown
- 2016-04-21 JO JOP/2016/0076A patent/JO3658B1/ar active
- 2016-04-22 TW TW105112730A patent/TWI656132B/zh active
- 2016-04-28 JP JP2017557346A patent/JP6591562B2/ja active Active
- 2016-04-28 AU AU2016257659A patent/AU2016257659B2/en active Active
- 2016-04-28 HR HRP20200503TT patent/HRP20200503T1/hr unknown
- 2016-04-28 US US15/140,519 patent/US9855318B2/en active Active
- 2016-04-28 MA MA42037A patent/MA42037B1/fr unknown
- 2016-04-28 PE PE2017002375A patent/PE20180507A1/es unknown
- 2016-04-28 CR CR20170469A patent/CR20170469A/es unknown
- 2016-04-28 DK DK16721605.0T patent/DK3292141T3/da active
- 2016-04-28 TN TNP/2018/000059A patent/TN2018000059A1/en unknown
- 2016-04-28 SG SG11201708194WA patent/SG11201708194WA/en unknown
- 2016-04-28 ES ES16721605T patent/ES2799099T3/es active Active
- 2016-04-28 MD MDE20180255T patent/MD3292141T2/ro unknown
- 2016-04-28 RS RS20200326A patent/RS60044B1/sr unknown
- 2016-04-28 MY MYPI2017704174A patent/MY183025A/en unknown
- 2016-04-28 UA UAA201710105A patent/UA122146C2/uk unknown
- 2016-04-28 WO PCT/US2016/029807 patent/WO2016178905A1/en not_active Ceased
- 2016-04-28 MX MX2017014284A patent/MX388594B/es unknown
- 2016-04-28 NZ NZ736470A patent/NZ736470A/en unknown
- 2016-04-28 EA EA201792199A patent/EA039770B1/ru unknown
- 2016-04-28 CA CA2981102A patent/CA2981102A1/en active Pending
- 2016-04-28 ME MEP-2020-51A patent/ME03709B/me unknown
- 2016-04-28 SI SI201630651T patent/SI3292141T1/sl unknown
- 2016-04-28 CN CN201680023998.4A patent/CN107531806B/zh active Active
- 2016-04-28 PT PT167216050T patent/PT3292141T/pt unknown
- 2016-04-28 PL PL16721605T patent/PL3292141T3/pl unknown
- 2016-04-28 LT LTEP16721605.0T patent/LT3292141T/lt unknown
- 2016-04-28 KR KR1020177031825A patent/KR102059736B1/ko active Active
- 2016-04-28 EP EP16721605.0A patent/EP3292141B1/en active Active
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2017
- 2017-09-19 ZA ZA2017/06334A patent/ZA201706334B/en unknown
- 2017-10-10 IL IL254965A patent/IL254965B/en active IP Right Grant
- 2017-10-17 SV SV2017005548A patent/SV2017005548A/es unknown
- 2017-10-31 CL CL2017002761A patent/CL2017002761A1/es unknown
- 2017-11-02 DO DO2017000258A patent/DOP2017000258A/es unknown
- 2017-11-02 CO CONC2017/0011301A patent/CO2017011301A2/es unknown
- 2017-11-06 EC ECIEPI201773650A patent/ECSP17073650A/es unknown
- 2017-11-07 PH PH12017502025A patent/PH12017502025A1/en unknown
- 2017-11-22 US US15/820,608 patent/US10709766B2/en active Active
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2020
- 2020-03-16 CY CY20201100239T patent/CY1122929T1/el unknown
- 2020-06-05 US US16/893,498 patent/US11253574B2/en active Active
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2022
- 2022-01-18 US US17/577,932 patent/US12059452B2/en active Active
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2024
- 2024-06-27 US US18/756,062 patent/US20250032588A1/en active Pending