JP2017538395A5 - - Google Patents

Info

Publication number

JP2017538395A5

JP2017538395A5 JP2017514327A JP2017514327A JP2017538395A5 JP 2017538395 A5 JP2017538395 A5 JP 2017538395A5 JP 2017514327 A JP2017514327 A JP 2017514327A JP 2017514327 A JP2017514327 A JP 2017514327A JP 2017538395 A5 JP2017538395 A5 JP 2017538395A5

Authority

JP

Japan

Prior art keywords

polypeptide

amino acid

complex

sequence

seq

Prior art date

2015-10-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 77
• 229920001184 polypeptide Polymers 0.000 claims description 75
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 75
• 150000001413 amino acids Chemical group 0.000 claims description 59
• 229940024606 amino acid Drugs 0.000 claims description 37
• 238000006467 substitution reaction Methods 0.000 claims description 31
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 claims description 28
• 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 claims description 28
• 102000039446 nucleic acids Human genes 0.000 claims description 26
• 108020004707 nucleic acids Proteins 0.000 claims description 26
• 150000007523 nucleic acids Chemical class 0.000 claims description 26
• 102000008300 Mutant Proteins Human genes 0.000 claims description 21
• 108010021466 Mutant Proteins Proteins 0.000 claims description 21
• 238000000034 method Methods 0.000 claims description 21
• 239000000833 heterodimer Substances 0.000 claims description 18
• 239000000203 mixture Substances 0.000 claims description 17
• 239000013598 vector Substances 0.000 claims description 15
• 239000011800 void material Substances 0.000 claims description 15
• 210000004027 cell Anatomy 0.000 claims description 14
• 102220005382 rs33914470 Human genes 0.000 claims description 10
• 102220143003 rs753997345 Human genes 0.000 claims description 10
• 230000004988 N-glycosylation Effects 0.000 claims description 9
• 208000018914 glucose metabolism disease Diseases 0.000 claims description 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
• 102220025225 rs199476363 Human genes 0.000 claims description 8
• 102220123860 rs61760902 Human genes 0.000 claims description 8
• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 7
• 102220353134 c.68G>A Human genes 0.000 claims description 6
• 239000002131 composite material Substances 0.000 claims description 6
• 229960000310 isoleucine Drugs 0.000 claims description 6
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims description 5
• 102220248744 rs145985140 Human genes 0.000 claims description 5
• 102220058798 rs786202903 Human genes 0.000 claims description 5
• 102220503690 GTP-binding protein REM 1_T94N_mutation Human genes 0.000 claims description 4
• 206010012601 diabetes mellitus Diseases 0.000 claims description 4
• 102220230165 rs1064793071 Human genes 0.000 claims description 4
• 239000013603 viral vector Substances 0.000 claims description 4
• 239000000654 additive Substances 0.000 claims description 3
• 230000000996 additive effect Effects 0.000 claims description 3
• 239000003085 diluting agent Substances 0.000 claims description 3
• 102200075235 rs118204106 Human genes 0.000 claims description 3
• 102200078418 rs1805085 Human genes 0.000 claims description 3
• 102200150805 rs1057519492 Human genes 0.000 claims description 2
• 102200027869 rs62517167 Human genes 0.000 claims description 2
• 102220058924 rs749212640 Human genes 0.000 claims description 2
• GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
• KLDBMPMWBVTYGW-AIDJSRAFSA-N 2-aminoacetic acid (2S)-2-amino-3-hydroxypropanoic acid Chemical group NCC(O)=O.NCC(O)=O.NCC(O)=O.NCC(O)=O.OC[C@H](N)C(O)=O KLDBMPMWBVTYGW-AIDJSRAFSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 230000037396 body weight Effects 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 230000002265 prevention Effects 0.000 description 4
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 239000008280 blood Substances 0.000 description 2
• 210000004369 blood Anatomy 0.000 description 2
• 239000003814 drug Substances 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• 238000007920 subcutaneous administration Methods 0.000 description 2
• 229940124597 therapeutic agent Drugs 0.000 description 2
• 230000004580 weight loss Effects 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000000694 effects Effects 0.000 description 1
• 230000037406 food intake Effects 0.000 description 1
• 235000012631 food intake Nutrition 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 235000018770 reduced food intake Nutrition 0.000 description 1