EA036985B1 - Композиции и способы лечения метаболических расстройств - Google Patents

Композиции и способы лечения метаболических расстройств Download PDF

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Publication number
EA036985B1
EA036985B1 EA201790405A EA201790405A EA036985B1 EA 036985 B1 EA036985 B1 EA 036985B1 EA 201790405 A EA201790405 A EA 201790405A EA 201790405 A EA201790405 A EA 201790405A EA 036985 B1 EA036985 B1 EA 036985B1
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EA
Eurasian Patent Office
Prior art keywords
polypeptide
sequence
amino acid
seq
gdf15
Prior art date
Application number
EA201790405A
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English (en)
Russian (ru)
Other versions
EA201790405A1 (ru
Inventor
Уэньян Шен
Даррин Линдхаут
Радж Халданкар
Хуго Матерн
Original Assignee
НДжМ БИОФАРМАСЬЮТИКАЛЗ, ИНК.
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Publication of EA201790405A1 publication Critical patent/EA201790405A1/ru
Publication of EA036985B1 publication Critical patent/EA036985B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EA201790405A 2014-10-31 2015-10-29 Композиции и способы лечения метаболических расстройств EA036985B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462073737P 2014-10-31 2014-10-31
US201562244604P 2015-10-21 2015-10-21
PCT/US2015/058111 WO2016069921A1 (en) 2014-10-31 2015-10-29 Compositions and methods of use for treating metabolic disorders

Publications (2)

Publication Number Publication Date
EA201790405A1 EA201790405A1 (ru) 2017-09-29
EA036985B1 true EA036985B1 (ru) 2021-01-25

Family

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EA201790405A EA036985B1 (ru) 2014-10-31 2015-10-29 Композиции и способы лечения метаболических расстройств

Country Status (30)

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US (4) US9920118B2 (enExample)
EP (2) EP3212226B1 (enExample)
JP (1) JP6722175B2 (enExample)
KR (1) KR102672706B1 (enExample)
CN (2) CN115043945A (enExample)
AP (1) AP2017009828A0 (enExample)
AU (1) AU2015339130C1 (enExample)
CL (1) CL2017000864A1 (enExample)
CO (1) CO2017003487A2 (enExample)
DK (1) DK3212226T3 (enExample)
DO (1) DOP2017000097A (enExample)
EA (1) EA036985B1 (enExample)
EC (1) ECSP17021754A (enExample)
ES (1) ES2799503T3 (enExample)
GT (1) GT201700072A (enExample)
IL (1) IL251066B (enExample)
MD (1) MD20170035A2 (enExample)
MX (1) MX357994B (enExample)
MY (1) MY186702A (enExample)
NI (1) NI201700042A (enExample)
PE (1) PE20171058A1 (enExample)
PH (1) PH12017500680A1 (enExample)
PL (1) PL3212226T3 (enExample)
PT (1) PT3212226T (enExample)
SG (1) SG11201702580PA (enExample)
SV (1) SV2017005420A (enExample)
TN (1) TN2017000113A1 (enExample)
TW (1) TWI703161B (enExample)
UA (1) UA121973C2 (enExample)
WO (1) WO2016069921A1 (enExample)

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