SV2017005420A - Composiciones y métodos de uso para tratar trastornos metabólicos - Google Patents

Composiciones y métodos de uso para tratar trastornos metabólicos

Info

Publication number
SV2017005420A
SV2017005420A SV2017005420A SV2017005420A SV2017005420A SV 2017005420 A SV2017005420 A SV 2017005420A SV 2017005420 A SV2017005420 A SV 2017005420A SV 2017005420 A SV2017005420 A SV 2017005420A SV 2017005420 A SV2017005420 A SV 2017005420A
Authority
SV
El Salvador
Prior art keywords
compositions
methods
metabolic disorders
treat metabolic
disorder
Prior art date
Application number
SV2017005420A
Other languages
English (en)
Inventor
Wenyan Shen
Darrin Lindhout
Raj Haldankar
Hugo Matern
Original Assignee
Ngm Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ngm Biopharmaceuticals Inc filed Critical Ngm Biopharmaceuticals Inc
Publication of SV2017005420A publication Critical patent/SV2017005420A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCIÓN DESCRIBE A UN COMPLEJO QUE COMPRENDE UN POLIPÉPTIDO GDF15. SE PROPORCIONAN MÉTODO PARA EL TRATAMIENTO DE INDIVIDUOS CON UN TRASTORNO DE METABOLISMO, TAL COMO TRASTORNO DEL METABOLISMO DE GLUCOSA Y/O UN TRASTORNO DE PESO CORPORAL, Y COMPOSICIONES ASOCIADAS CON ESTOS
SV2017005420A 2014-10-31 2017-04-07 Composiciones y métodos de uso para tratar trastornos metabólicos SV2017005420A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462073737P 2014-10-31 2014-10-31
US201562244604P 2015-10-21 2015-10-21

Publications (1)

Publication Number Publication Date
SV2017005420A true SV2017005420A (es) 2017-10-17

Family

ID=55851475

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2017005420A SV2017005420A (es) 2014-10-31 2017-04-07 Composiciones y métodos de uso para tratar trastornos metabólicos

Country Status (31)

Country Link
US (4) US9920118B2 (es)
EP (2) EP3701969A1 (es)
JP (1) JP6722175B2 (es)
KR (1) KR102672706B1 (es)
CN (2) CN115043945A (es)
AP (1) AP2017009828A0 (es)
AU (1) AU2015339130C1 (es)
CA (1) CA2961587A1 (es)
CL (1) CL2017000864A1 (es)
CO (1) CO2017003487A2 (es)
DK (1) DK3212226T3 (es)
DO (1) DOP2017000097A (es)
EA (1) EA036985B1 (es)
EC (1) ECSP17021754A (es)
ES (1) ES2799503T3 (es)
GT (1) GT201700072A (es)
IL (1) IL251066B (es)
MD (1) MD20170035A2 (es)
MX (1) MX357994B (es)
MY (1) MY186702A (es)
NI (1) NI201700042A (es)
PE (1) PE20171058A1 (es)
PH (1) PH12017500680A1 (es)
PL (1) PL3212226T3 (es)
PT (1) PT3212226T (es)
SG (1) SG11201702580PA (es)
SV (1) SV2017005420A (es)
TN (1) TN2017000113A1 (es)
TW (1) TWI703161B (es)
UA (1) UA121973C2 (es)
WO (1) WO2016069921A1 (es)

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