MX357994B - Composiciones y metodos de uso para tratar trastornos metabolicos. - Google Patents

Composiciones y metodos de uso para tratar trastornos metabolicos.

Info

Publication number
MX357994B
MX357994B MX2017005237A MX2017005237A MX357994B MX 357994 B MX357994 B MX 357994B MX 2017005237 A MX2017005237 A MX 2017005237A MX 2017005237 A MX2017005237 A MX 2017005237A MX 357994 B MX357994 B MX 357994B
Authority
MX
Mexico
Prior art keywords
methods
compositions
metabolic disorders
treating metabolic
disorder
Prior art date
Application number
MX2017005237A
Other languages
English (en)
Other versions
MX2017005237A (es
Inventor
Shen Wenyan
Lindhout Darrin
Haldankar Raj
Matern Hugo
Original Assignee
Ngm Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ngm Biopharmaceuticals Inc filed Critical Ngm Biopharmaceuticals Inc
Publication of MX2017005237A publication Critical patent/MX2017005237A/es
Publication of MX357994B publication Critical patent/MX357994B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

La presente invención se refiere a un complejo que comprende un polipéptido GDF15. Se proporcionan método para el tratamiento de individuos con un trastorno de metabolismo, tal como trastorno del metabolismo de glucosa y/o un trastorno de peso corporal, y composiciones asociadas con estos.
MX2017005237A 2014-10-31 2015-10-29 Composiciones y metodos de uso para tratar trastornos metabolicos. MX357994B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462073737P 2014-10-31 2014-10-31
US201562244604P 2015-10-21 2015-10-21
PCT/US2015/058111 WO2016069921A1 (en) 2014-10-31 2015-10-29 Compositions and methods of use for treating metabolic disorders

Publications (2)

Publication Number Publication Date
MX2017005237A MX2017005237A (es) 2017-06-30
MX357994B true MX357994B (es) 2018-08-01

Family

ID=55851475

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017005237A MX357994B (es) 2014-10-31 2015-10-29 Composiciones y metodos de uso para tratar trastornos metabolicos.

Country Status (32)

Country Link
US (4) US9920118B2 (es)
EP (2) EP3701969A1 (es)
JP (1) JP6722175B2 (es)
KR (1) KR20170074852A (es)
CN (2) CN106687128B (es)
AP (1) AP2017009828A0 (es)
AU (1) AU2015339130C1 (es)
CA (1) CA2961587A1 (es)
CL (1) CL2017000864A1 (es)
CO (1) CO2017003487A2 (es)
DK (1) DK3212226T3 (es)
DO (1) DOP2017000097A (es)
EA (1) EA036985B1 (es)
EC (1) ECSP17021754A (es)
ES (1) ES2799503T3 (es)
GT (1) GT201700072A (es)
IL (1) IL251066B (es)
MD (1) MD20170035A2 (es)
MX (1) MX357994B (es)
MY (1) MY186702A (es)
NI (1) NI201700042A (es)
NZ (1) NZ730054A (es)
PE (1) PE20171058A1 (es)
PH (1) PH12017500680A1 (es)
PL (1) PL3212226T3 (es)
PT (1) PT3212226T (es)
SG (1) SG11201702580PA (es)
SV (1) SV2017005420A (es)
TN (1) TN2017000113A1 (es)
TW (1) TWI703161B (es)
UA (1) UA121973C2 (es)
WO (1) WO2016069921A1 (es)

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