JP2016511752A5 - - Google Patents
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- JP2016511752A5 JP2016511752A5 JP2015555389A JP2015555389A JP2016511752A5 JP 2016511752 A5 JP2016511752 A5 JP 2016511752A5 JP 2015555389 A JP2015555389 A JP 2015555389A JP 2015555389 A JP2015555389 A JP 2015555389A JP 2016511752 A5 JP2016511752 A5 JP 2016511752A5
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- JP
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- Prior art keywords
- polypeptide
- albumin
- pharmaceutical composition
- amino acid
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 118
- 229920001184 polypeptide Polymers 0.000 claims description 117
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 117
- 102000009027 Albumins Human genes 0.000 claims description 52
- 108010088751 Albumins Proteins 0.000 claims description 52
- 239000012634 fragment Substances 0.000 claims description 22
- 102000008300 Mutant Proteins Human genes 0.000 claims description 16
- 108010021466 Mutant Proteins Proteins 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 230000004048 modification Effects 0.000 claims description 12
- 238000012986 modification Methods 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 8
- 238000004659 sterilization and disinfection Methods 0.000 claims description 8
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 6
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 6
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 6
- 108010071390 Serum Albumin Proteins 0.000 claims description 6
- 102000007562 Serum Albumin Human genes 0.000 claims description 6
- 229940098773 bovine serum albumin Drugs 0.000 claims description 6
- 230000000704 physical effect Effects 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 5
- 230000004988 N-glycosylation Effects 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 4
- 208000018914 glucose metabolism disease Diseases 0.000 claims description 4
- 230000013595 glycosylation Effects 0.000 claims description 4
- 238000006206 glycosylation reaction Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000002953 phosphate buffered saline Substances 0.000 claims description 4
- 230000000069 prophylactic effect Effects 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 239000013598 vector Substances 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 3
- 238000007920 subcutaneous administration Methods 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 206010012601 diabetes mellitus Diseases 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 230000037406 food intake Effects 0.000 claims description 2
- 235000012631 food intake Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 230000005847 immunogenicity Effects 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000013603 viral vector Substances 0.000 claims description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361758456P | 2013-01-30 | 2013-01-30 | |
| US61/758,456 | 2013-01-30 | ||
| US201361882542P | 2013-09-25 | 2013-09-25 | |
| US61/882,542 | 2013-09-25 | ||
| PCT/US2014/013232 WO2014120619A2 (en) | 2013-01-30 | 2014-01-27 | Compositions and methods of use in treating metabolic disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016511752A JP2016511752A (ja) | 2016-04-21 |
| JP2016511752A5 true JP2016511752A5 (enExample) | 2016-10-27 |
| JP6272907B2 JP6272907B2 (ja) | 2018-01-31 |
Family
ID=51263106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555389A Expired - Fee Related JP6272907B2 (ja) | 2013-01-30 | 2014-01-27 | 代謝障害の処置における組成物及び使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9828415B2 (enExample) |
| EP (1) | EP2950807B1 (enExample) |
| JP (1) | JP6272907B2 (enExample) |
| KR (1) | KR101993714B1 (enExample) |
| AU (1) | AU2014212640B2 (enExample) |
| BR (1) | BR112015018104A2 (enExample) |
| CA (1) | CA2899170C (enExample) |
| RU (1) | RU2704285C2 (enExample) |
| WO (1) | WO2014120619A2 (enExample) |
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| AU2012229103A1 (en) | 2011-03-15 | 2013-10-31 | Massachusetts Institute Of Technology | Multiplexed detection with isotope-coded reporters |
| BR112014018575A2 (pt) | 2012-01-26 | 2017-07-04 | Amgen Inc | polipetídeos de fator de diferenciação de crescimento 15 (gdf-15) |
| JP6254146B2 (ja) | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 代謝障害を治療するための組成物および方法 |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| KR101993714B1 (ko) | 2013-01-30 | 2019-06-28 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사 장애를 치료하는데 이용하기 위한 조성물과 방법 |
| ES2828985T3 (es) | 2013-06-07 | 2021-05-28 | Massachusetts Inst Technology | Detección basada en la afinidad de biomarcadores sintéticos codificados por ligando |
| EP3027642B1 (en) * | 2013-07-31 | 2020-08-19 | Amgen Inc. | Growth differentiation factor 15 (gdf-15) constructs |
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| PL3212226T3 (pl) * | 2014-10-31 | 2020-11-02 | Ngm Biopharmaceuticals, Inc. | Kompozycje i sposoby stosowania w leczeniu zaburzeń metabolicznych |
| CN107108754A (zh) * | 2014-12-22 | 2017-08-29 | 诺和诺德股份有限公司 | α‑1‑抗胰蛋白酶(A1AT)融合蛋白及其用途 |
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| TWI724392B (zh) | 2018-04-06 | 2021-04-11 | 美商美國禮來大藥廠 | 生長分化因子15促效劑化合物及其使用方法 |
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| US12257308B2 (en) | 2018-04-30 | 2025-03-25 | Duke University | Stimuli-responsive PEG-like polymer-based drug delivery platform |
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| CN119751697A (zh) | 2018-10-22 | 2025-04-04 | 詹森药业有限公司 | 胰高血糖素样肽1（glp1）-生长分化因子15（gdf15）融合蛋白及其用途 |
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| AU2020219142B2 (en) * | 2019-02-05 | 2025-11-06 | Syracuse University | Peptide ligands of the GDNF family receptor a-like (GFRAL) receptor |
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| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
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| CN114729020A (zh) * | 2019-11-26 | 2022-07-08 | 株式会社柳韩洋行 | 长效gdf15融合蛋白及包含其的药物组合物 |
| US20230093708A1 (en) * | 2020-03-04 | 2023-03-23 | Duke University | Protein nanoparticle design and application |
| CN115244076B (zh) * | 2020-10-27 | 2023-08-04 | 北京质肽生物医药科技有限公司 | Gdf15融合蛋白及其用途 |
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2014
- 2014-01-27 KR KR1020157023041A patent/KR101993714B1/ko not_active Expired - Fee Related
- 2014-01-27 JP JP2015555389A patent/JP6272907B2/ja not_active Expired - Fee Related
- 2014-01-27 EP EP14746188.3A patent/EP2950807B1/en not_active Not-in-force
- 2014-01-27 RU RU2015136440A patent/RU2704285C2/ru active
- 2014-01-27 WO PCT/US2014/013232 patent/WO2014120619A2/en not_active Ceased
- 2014-01-27 AU AU2014212640A patent/AU2014212640B2/en not_active Ceased
- 2014-01-27 CA CA2899170A patent/CA2899170C/en active Active
- 2014-01-27 BR BR112015018104A patent/BR112015018104A2/pt not_active IP Right Cessation
- 2014-01-27 US US14/763,262 patent/US9828415B2/en not_active Expired - Fee Related
-
2017
- 2017-10-20 US US15/789,679 patent/US10323075B2/en active Active
-
2019
- 2019-04-29 US US16/397,578 patent/US20200087366A1/en not_active Abandoned
-
2021
- 2021-05-26 US US17/330,984 patent/US20210388047A1/en not_active Abandoned
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