JP2017514515A5 - - Google Patents

Download PDF

Info

Publication number
JP2017514515A5
JP2017514515A5 JP2017504288A JP2017504288A JP2017514515A5 JP 2017514515 A5 JP2017514515 A5 JP 2017514515A5 JP 2017504288 A JP2017504288 A JP 2017504288A JP 2017504288 A JP2017504288 A JP 2017504288A JP 2017514515 A5 JP2017514515 A5 JP 2017514515A5
Authority
JP
Japan
Prior art keywords
blood
brain barrier
barrier shuttle
antibody
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017504288A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017514515A (ja
JP6744856B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2015/052524 external-priority patent/WO2015155694A1/en
Publication of JP2017514515A publication Critical patent/JP2017514515A/ja
Publication of JP2017514515A5 publication Critical patent/JP2017514515A5/ja
Application granted granted Critical
Publication of JP6744856B2 publication Critical patent/JP6744856B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017504288A 2014-04-08 2015-04-08 α−シヌクレインを認識する抗体を含む血液脳関門シャトル Active JP6744856B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461977042P 2014-04-08 2014-04-08
US201461977039P 2014-04-08 2014-04-08
US61/977,039 2014-04-08
US61/977,042 2014-04-08
US201462023373P 2014-07-11 2014-07-11
US62/023,373 2014-07-11
PCT/IB2015/052524 WO2015155694A1 (en) 2014-04-08 2015-04-08 Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020130589A Division JP2020195382A (ja) 2014-04-08 2020-07-31 α−シヌクレインを認識する抗体を含む血液脳関門シャトル

Publications (3)

Publication Number Publication Date
JP2017514515A JP2017514515A (ja) 2017-06-08
JP2017514515A5 true JP2017514515A5 (enExample) 2018-05-10
JP6744856B2 JP6744856B2 (ja) 2020-08-19

Family

ID=53052905

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017504288A Active JP6744856B2 (ja) 2014-04-08 2015-04-08 α−シヌクレインを認識する抗体を含む血液脳関門シャトル
JP2020130589A Pending JP2020195382A (ja) 2014-04-08 2020-07-31 α−シヌクレインを認識する抗体を含む血液脳関門シャトル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020130589A Pending JP2020195382A (ja) 2014-04-08 2020-07-31 α−シヌクレインを認識する抗体を含む血液脳関門シャトル

Country Status (5)

Country Link
US (2) US10562973B2 (enExample)
EP (1) EP3129051A1 (enExample)
JP (2) JP6744856B2 (enExample)
CA (1) CA2944402A1 (enExample)
WO (1) WO2015155694A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3378535T (lt) 2011-10-28 2023-02-27 Prothena Biosciences Limited Humanizuoti antikūnai, atpažįstantys alfa-sinukleiną
WO2013112945A1 (en) 2012-01-27 2013-08-01 Neotope Biosciences Limited Humanized antibodies that recognize alpha-synuclein
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
US10513555B2 (en) 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
CA3028035A1 (en) 2016-07-14 2018-01-18 Bioarctic Ab Brain delivery protein
KR102573778B1 (ko) 2017-02-17 2023-08-31 브리스톨-마이어스 스큅 컴퍼니 알파-시뉴클레인에 대한 항체 및 그의 용도
BR112020011875A2 (pt) * 2017-12-14 2020-11-24 Abl Bio Inc. anticorpo biespecífico ao a-syn/igf1r e uso do mesmo
GB201720975D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
US11753455B2 (en) * 2018-06-21 2023-09-12 Novo Nordisk A/S Compounds for treatment of obesity
AU2019320803A1 (en) * 2018-08-16 2021-03-11 Denali Therapeutics Inc. Engineered bispecific proteins
TWI734279B (zh) * 2018-12-14 2021-07-21 美商美國禮來大藥廠 抗α-突觸核蛋白抗體及其用途
US11155609B2 (en) 2019-04-05 2021-10-26 TauC3 Biologies Limited Anti-TAUC3 antibodies and uses thereof
CA3135181A1 (en) * 2019-04-05 2020-10-08 B-Portal Biologics, Inc. Fusion constructs and uses thereof
WO2020223310A2 (en) * 2019-04-29 2020-11-05 Thomas Jefferson University Methods for treating neurodegenerative disorders
CA3186614A1 (en) 2020-07-23 2022-01-27 Michael SKOV Anti-abeta antibodies
IL301262A (en) * 2020-09-18 2023-05-01 Othair Prothena Ltd Multiepitope vaccine for the treatment of alzheimer's disease
WO2025054419A1 (en) * 2023-09-08 2025-03-13 California Institute Of Technology Compositions for transport of therapeutic cargos using antibody binders targeting ca-iv

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575961A (en) 1977-09-07 1980-10-01 Sekisui Chemical Co Ltd Foamable compositions and their use in preparing foams
DE3133101A1 (de) 1981-08-21 1983-03-10 Hoechst Ag, 6000 Frankfurt Verfahren zur entfernung von katalysatorresten aus polyolefinen
CH652145A5 (de) 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4634666A (en) 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0832981A1 (en) 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5858657A (en) 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
DE69230142T2 (de) 1991-05-15 2000-03-09 Cambridge Antibody Technology Ltd. Verfahren zur herstellung von spezifischen bindungspaargliedern
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
KR0163798B1 (ko) 1991-07-03 1999-01-15 나가따 마사오 열가성 폴리우레탄 탄성체, 그의 제조 방법, 그의 제조 장치 및 그로부터 제조한 탄성 섬유
US5209485A (en) 1991-09-23 1993-05-11 Lisco, Inc. Restricted flight golf ball
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5208362A (en) 1992-02-27 1993-05-04 Ethyl Corporation Process for stabilizing organophosphorus compounds
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
DE69330523T4 (de) 1992-08-21 2012-08-23 Vrije Universiteit Brussel Immunoglobuline ohne leichte ketten
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5914349A (en) 1994-01-10 1999-06-22 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
DE19539493A1 (de) 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US6114148C1 (en) 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
US5888809A (en) 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
CN100405399C (zh) 1999-02-05 2008-07-23 三星电子株式会社 图像纹理恢复方法及其装置
ES2312348T3 (es) 1999-06-16 2009-03-01 Boston Biomedical Research Institute Control inmunologico de niveles de beta-amiloide in vivo.
WO2002034824A2 (en) 2000-10-23 2002-05-02 Dow Global Technologies Inc. Propylene polymer foams
TWI255272B (en) 2000-12-06 2006-05-21 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US6583190B2 (en) 2000-12-27 2003-06-24 Sealed Air Corporation (U.S.) Expandable composition, blowing agent, and process for extruded thermoplastic foams
KR100456392B1 (ko) 2001-02-01 2004-11-10 미쓰이 가가쿠 가부시키가이샤 올레핀계 엘라스토머 가교발포체용 엘라스토머 조성물 및그의 용도
WO2004006955A1 (en) 2001-07-12 2004-01-22 Jefferson Foote Super humanized antibodies
US7657380B2 (en) 2003-12-04 2010-02-02 Xencor, Inc. Methods of generating variant antibodies with increased host string content
EP1531864A4 (en) 2002-05-13 2006-08-23 Alexion Pharma Inc HUMANIZED ANTIBODIES TO THE VENEZOLAN HORSEMEN ENZEPHALITIS VIRUS
TW200509968A (en) 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US9034337B2 (en) 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
US8506959B2 (en) 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US20080014194A1 (en) 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
ES2293096T3 (es) 2002-11-29 2008-03-16 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Nuevos genes de la fosfotransferasa de neomicina y procedimiento para la seleccion de celulas recombinantes de produccion elevada.
US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
DE10338531A1 (de) 2003-08-19 2005-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Reklonierung von Produktionszellen
WO2005047860A2 (en) 2003-11-08 2005-05-26 Elan Pharmaceuticals, Inc. Antibodies to alpha-synuclein
JP2006089637A (ja) 2004-09-24 2006-04-06 Kaneka Corp ポリプロピレン系樹脂発泡シートの製造方法
DK1820022T3 (da) 2004-11-10 2009-09-14 Boehringer Ingelheim Pharma Anvendelse af flow-cytometrisk analyse for at optimere cellebanks-strategier af CHO-celler
US7179873B2 (en) 2005-01-26 2007-02-20 Fina Technology, Inc. Branched ionomers
US20080300204A1 (en) 2005-07-19 2008-12-04 University Of Rochester Alpha-Synuclein Antibodies and Methods Related Thereto
AU2006326301B2 (en) 2005-12-12 2011-04-21 F. Hoffmann-La Roche Ag Antibodies against amyloid beta 4 with glycosylated in the variable region
US8148085B2 (en) 2006-05-15 2012-04-03 Sea Lane Biotechnologies, Llc Donor specific antibody libraries
RU2498999C2 (ru) 2006-07-14 2013-11-20 Ац Иммуне Са Гуманизированное антитело к амилоиду бета
US20080124760A1 (en) 2006-07-26 2008-05-29 Barbara Enenkel Regulatory Nucleic Acid Elements
EP2118300B1 (en) 2007-02-23 2015-05-27 Prothena Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
EP2064242A1 (en) 2007-02-23 2009-06-03 Schering Corporation Engineered anti-il-23p19 antibodies
DK2126093T3 (da) 2007-03-02 2013-01-07 Boehringer Ingelheim Pharma Forbedring af proteinfremstilling
UA96473C2 (ru) 2007-03-22 2011-11-10 Имклоун Ллк Жидкая стойкая композиция, которая содержит антитело imc-а12
TWI464178B (zh) 2007-03-22 2014-12-11 Genentech Inc 細胞凋亡抗-ige抗體
EP2031064A1 (de) 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
EP2237803B1 (en) 2007-12-28 2015-07-01 Prothena Biosciences Limited Treatment and prophylaxis of amyloidosis
EP2260112A4 (en) 2008-04-05 2013-10-09 Single Cell Technology Inc SCREENING PROCESS FOR INDIVIDUAL CELLS FOR THE MANUFACTURE OF BIOLOGICAL ACTIVE SUBSTANCES
TR201901497T4 (tr) 2008-04-29 2019-02-21 Bioarctic Ab Alfa-sinüklein ile ilişkili bozukluklar için terapötik ve teşhis yöntemlerinde kullanıma yönelik antikorlar ve aşılar.
US20120276019A1 (en) 2008-07-25 2012-11-01 Diamedica Inc. Tissue kallikrein for the treatment of parkinson's disease
DE102008048129A1 (de) 2008-09-20 2010-04-22 Lfk-Lenkflugkörpersysteme Gmbh Flugkörper mit zumindest einem Bremsfallschirm sowie Befestigungsvorrichtung zur Befestigung eines Bremsfallschirms an einem Flugkörper
RU2011116112A (ru) 2008-09-26 2012-11-10 Роше Гликарт Аг (Ch) Биспецифические анти-egfr/анти-igf-1r антитела
RU2011117213A (ru) 2008-09-30 2012-11-10 Эббот Лэборетриз (Us) Улучшенные библиотеки антител
EP3699296A1 (en) 2008-11-07 2020-08-26 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
NZ593964A (en) 2008-12-19 2012-12-21 Univ Zuerich Human anti-alpha-synuclein autoantibodies
EP2414391B1 (en) 2009-04-02 2018-11-28 Roche Glycart AG Multispecific antibodies comprising full length antibodies and single chain fab fragments
US20110053803A1 (en) 2009-08-26 2011-03-03 Xin Ge Methods for creating antibody libraries
EP2519537A4 (en) 2009-12-29 2013-07-10 Reddys Lab Ltd Dr CLEANING PROTEINS
LT2646470T (lt) 2010-11-30 2017-06-12 F. Hoffmann-La Roche Ag Mažo giminingumo antitransferino receptorių antikūnai ir jų panaudojimas pernešti gydomąjį vienos grandinės antikūną (scfv) per hematoencefalinį barjerą
US8741298B2 (en) 2011-02-07 2014-06-03 Neotope Biosciences Limited APOE immunotherapy
US20120220730A1 (en) 2011-02-24 2012-08-30 Fina Technology, Inc. High Melt Strength Polypropylene and Methods of Making Same
WO2012160536A1 (en) 2011-05-26 2012-11-29 Dr Reddy's Laboratories Limited Antibody purification
US8715449B2 (en) 2011-06-17 2014-05-06 Berry Plastics Corporation Process for forming an insulated container having artwork
WO2012177997A1 (en) 2011-06-22 2012-12-27 The General Hospital Corporation Treatment of proteinopathies
US9045615B2 (en) 2011-08-24 2015-06-02 Fina Technology, Inc. Metal carboxylate additives for thermoplastics
US20130063945A1 (en) 2011-09-12 2013-03-14 Chaun-Choung Technology Corp. Bulb-type led lamp having replaceable light source module
LT3378535T (lt) 2011-10-28 2023-02-27 Prothena Biosciences Limited Humanizuoti antikūnai, atpažįstantys alfa-sinukleiną
AU2012332767C1 (en) 2011-10-31 2017-02-02 Genentech, Inc. Antibody formulations
US8829114B2 (en) 2011-11-29 2014-09-09 Fina Technology, Inc. Preparation of metallic comonomers for polystyrene
WO2013112945A1 (en) 2012-01-27 2013-08-01 Neotope Biosciences Limited Humanized antibodies that recognize alpha-synuclein
HRP20191153T1 (hr) 2012-08-29 2019-10-04 F. Hoffmann - La Roche Ag Prijenosnik za krvno-moždanu barijeru
US8925815B2 (en) 2012-09-05 2015-01-06 Symbol Technologies, Inc. Checkout system for and method of preventing a customer-operated accessory reader facing a bagging area from imaging targets on products passed through a clerk-operated workstation to the bagging area
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
US10513555B2 (en) 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods

Similar Documents

Publication Publication Date Title
JP2017514515A5 (enExample)
US20240076370A1 (en) Antibodies targeting g-protein coupled receptor and methods of use
US20240124584A1 (en) Igm fc and j-chain mutations that affect igm serum half-life
US10982008B2 (en) Domain-exchanged antibody
RU2742691C2 (ru) Cd3-связывающий домен
US20230048260A1 (en) Therapeutic anti-cd40 ligand antibodies
SI2802606T1 (en) Improves the transfer of healing molecules through the hematoencephalic barrier
JP2013515508A5 (enExample)
CN109715663A (zh) 结合生长抑素受体2的异源二聚抗体
JP2010532764A5 (enExample)
JP2011036254A5 (enExample)
CN108463245A (zh) 具有修饰的j链的结合分子
TW202317615A (zh) 具有交叉結合區定向之雙重可變區類抗體結合蛋白
JP2018510617A5 (enExample)
RU2013125459A (ru) АНТИТЕЛА ПРОТИВ БЕЛКА РЕЦЕПТОРА c-Met
JP2017537082A5 (enExample)
JP2021512159A5 (enExample)
JP2016529213A5 (enExample)
KR20180020142A (ko) Iii형 분비계 표적화 분자
BR112021012337A2 (pt) Proteínas de ligação multiespecíficas baseadas em pseudofab
US20250188166A1 (en) Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof
JPWO2021052349A5 (enExample)
TW202519261A (zh) 用於治療癌症之結合γ-δ T細胞受體之抗體
HK40015379B (zh) 治疗性抗cd40配体抗体
JPWO2019238093A5 (enExample)