CR20170469A - Proteínas de fusión - Google Patents
Proteínas de fusiónInfo
- Publication number
- CR20170469A CR20170469A CR20170469A CR20170469A CR20170469A CR 20170469 A CR20170469 A CR 20170469A CR 20170469 A CR20170469 A CR 20170469A CR 20170469 A CR20170469 A CR 20170469A CR 20170469 A CR20170469 A CR 20170469A
- Authority
- CR
- Costa Rica
- Prior art keywords
- fusion proteins
- present
- diabetes
- useful
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158079P | 2015-05-07 | 2015-05-07 | |
| PCT/US2016/029807 WO2016178905A1 (en) | 2015-05-07 | 2016-04-28 | Fusion proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20170469A true CR20170469A (es) | 2017-11-14 |
Family
ID=55953435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170469A CR20170469A (es) | 2015-05-07 | 2016-04-28 | Proteínas de fusión |
Country Status (40)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6983075B2 (ja) | 2015-06-02 | 2021-12-17 | ノヴォ ノルディスク アー／エス | 極性の組換え延長部を有するインスリン |
| MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
| EP3798001A1 (en) | 2016-07-27 | 2021-03-31 | Hewlett-Packard Development Company, L.P. | Horizontal interface for fluid supply cartridge having digital fluid level sensor |
| EP3939605A1 (en) * | 2016-12-09 | 2022-01-19 | Akston Biosciences Corporation | Insulin-fc fusions and methods of use |
| TR201703622A1 (tr) * | 2017-03-09 | 2018-09-21 | Univ Yeditepe | Obezi̇te tedavi̇si̇ i̇çi̇n bi̇r ürün |
| MA49339A (fr) * | 2017-04-05 | 2020-02-12 | Novo Nordisk As | Conjugués insuline-fc à extension oligomère |
| ES2932861T3 (es) * | 2018-01-26 | 2023-01-27 | Hoffmann La Roche | Composiciones de IL-22 Fc y procedimientos de uso |
| JP2021528052A (ja) | 2018-06-25 | 2021-10-21 | ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ | 強力で選択的なインターロイキン模倣体のデノボ設計 |
| US11267862B2 (en) * | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| BR112020026777A2 (pt) | 2018-06-29 | 2021-03-30 | Akston Biosciences Corporation | Proteínas de fusão, composição farmacêutica, método para reduzir o nível de glicose, célula e cdna |
| CN112839681A (zh) | 2018-10-10 | 2021-05-25 | 诺和诺德股份有限公司 | 寡聚体延伸的胰岛素-Fc缀合物及其医学用途 |
| CN120040576A (zh) | 2018-11-20 | 2025-05-27 | 华盛顿大学 | 分拆白介素模拟物和它们的用途 |
| JP7728176B2 (ja) * | 2019-03-15 | 2025-08-22 | イーライ リリー アンド カンパニー | 保存製剤 |
| WO2021011827A1 (en) * | 2019-07-16 | 2021-01-21 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| TW202434620A (zh) * | 2019-07-31 | 2024-09-01 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| WO2021076620A1 (en) | 2019-10-15 | 2021-04-22 | Eli Lilly And Company | Recombinantly engineered, lipase/esterase-deficient mammalian cell lines |
| DK4073098T5 (da) | 2019-12-19 | 2024-07-22 | Akston Biosciences Corp | Ultralangtidsvirkende insulin-Fc-fusionsproteiner og fremgangsmåder til anvendelse |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| US20230340071A1 (en) | 2020-03-16 | 2023-10-26 | Neoleukin Therapeutics, Inc. | Interleukin-2 Receptor Beta (IL-2RB) Binding Polypeptides |
| CA3173628A1 (en) | 2020-04-07 | 2021-10-14 | Thomas Linsky | De novo protein decoys of angiotensin-converting enzyme 2 (ace2) |
| LT3972987T (lt) | 2020-04-10 | 2023-09-25 | Akston Biosciences Corporation | Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| US11198719B2 (en) | 2020-04-29 | 2021-12-14 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| CN113968911B (zh) * | 2020-07-24 | 2023-10-10 | 江苏晟斯生物制药有限公司 | 胰岛素-Fc融合蛋白及其应用 |
| EP4240407A1 (en) * | 2020-11-06 | 2023-09-13 | Amgen Inc. | Antigen binding domain with reduced clipping rate |
| AU2021401635A1 (en) * | 2020-12-14 | 2023-06-22 | Eli Lilly And Company | Methods of treating diabetes |
| US11667689B2 (en) | 2021-07-23 | 2023-06-06 | Akston Biosciences Corporation | Insulin-Fc fusion proteins and methods of use to treat cancer |
| WO2023044318A2 (en) | 2021-09-15 | 2023-03-23 | Neoleukin Therapeutics, Inc. | Interleukin-2 receptor βeta (il-2rβ) binding polypeptides |
| AR127619A1 (es) * | 2021-11-15 | 2024-02-14 | Lilly Co Eli | FORMULACIONES CONSERVADAS DE FUSIONES DE INSULINA-Fc |
| WO2023174370A1 (zh) * | 2022-03-16 | 2023-09-21 | 北京拓界生物医药科技有限公司 | 人胰岛素类似物、其融合蛋白及医药用途 |
| KR20250005573A (ko) | 2022-05-18 | 2025-01-09 | 프로토머 테크놀로지스 인크. | 방향족 붕소-함유 화합물 및 관련 인슐린 유사체 |
| CN119403824A (zh) | 2022-06-23 | 2025-02-07 | 赛诺菲 | 单链胰岛素及其Fc缀合物 |
| WO2024137820A1 (en) * | 2022-12-20 | 2024-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Insulin receptor antagonist |
| CN115894720B (zh) * | 2023-01-16 | 2024-07-09 | 中国科学院上海药物研究所 | 一种长效胰岛素-Fc融合蛋白 |
| WO2024229093A1 (en) | 2023-05-03 | 2024-11-07 | Eli Lilly And Company | Methods and systems for managing diabetes |
| WO2025059010A1 (en) | 2023-09-11 | 2025-03-20 | Eli Lilly And Company | Methods and systems for managing diabetes |
| WO2025061146A1 (zh) * | 2023-09-20 | 2025-03-27 | 上海迈晋生物医药科技有限公司 | 一种人胰岛素类似物融合蛋白的药物组合物及其医药用途 |
| WO2025080923A1 (en) | 2023-10-13 | 2025-04-17 | Eli Lilly And Company | Insulin-fc fusion proteins |
| US12454565B2 (en) | 2024-03-21 | 2025-10-28 | Akston Biosciences Corporation | PD-L1 analog fusion proteins for antigen specific immunotherapy and methods of use |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| HU225496B1 (en) | 1993-04-07 | 2007-01-29 | Scios Inc | Pharmaceutical compositions of prolonged delivery, containing peptides |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| WO1996034882A1 (en) | 1995-05-05 | 1996-11-07 | Eli Lilly And Company | Single chain insulin with high bioactivity |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| CA2369839A1 (en) | 1999-06-25 | 2001-01-04 | Minimed, Inc. | Compositions of insulin and insulin-related peptide for treating diabetes |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| CZ2004710A3 (cs) | 2001-12-20 | 2005-02-16 | Eli Lilly And Company | Inzulínová sloučenina s protrahovaným účinkem |
| MXPA05013565A (es) * | 2003-06-12 | 2006-03-09 | Lilly Co Eli | Proteinas de fusion analogas al glp-1. |
| US7448763B2 (en) | 2003-10-02 | 2008-11-11 | Carl Zeiss Smt Ag | Optical subassembly and projection objective in semiconductor lithography |
| EP1692168B1 (en) | 2003-12-03 | 2011-07-20 | Novo Nordisk A/S | Single-chain insulin |
| WO2006097521A1 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Pegylated single-chain insulin |
| JP2009527526A (ja) | 2006-02-21 | 2009-07-30 | ノボ・ノルデイスク・エー／エス | 単鎖インスリンのアナログとその製薬的製剤 |
| WO2007104737A1 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
| EP1996709A2 (en) | 2006-03-13 | 2008-12-03 | Novo Nordisk A/S | Acylated single chain insulin |
| CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
| ES2554773T3 (es) | 2006-10-04 | 2015-12-23 | Case Western Reserve University | Insulina y análogos de la insulina resistentes a la fibrilación |
| WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
| CA2687377C (en) * | 2007-05-30 | 2013-05-14 | Genexine Co., Ltd. | Immunoglobulin fusion proteins |
| EP2175834B8 (en) | 2007-07-10 | 2012-08-22 | Eli Lilly And Company | Glp-1-fc fusion protein formulation |
| WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| ES2611007T3 (es) * | 2008-03-18 | 2017-05-04 | Novo Nordisk A/S | Análogos de insulina acilada, estabilizados frente a proteasas |
| KR20110021758A (ko) | 2008-04-22 | 2011-03-04 | 케이스 웨스턴 리저브 유니버시티 | 이형체-특이적 인슐린 유사체 |
| GB0812019D0 (en) | 2008-07-02 | 2008-08-06 | Asterion Ltd | Insulin |
| US9636420B2 (en) | 2008-07-23 | 2017-05-02 | Hanmi Science Co., Ltd. | Polypeptide complex comprising non-peptidyl polymer having three functional ends |
| AR081066A1 (es) | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| KR101324828B1 (ko) | 2010-06-08 | 2013-11-01 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체 |
| US8940860B2 (en) | 2010-06-16 | 2015-01-27 | Indiana University Research And Technology Corporation | Single-chain insulin agonists exhibiting high activity at the insulin receptor |
| AU2012214419B2 (en) | 2011-02-09 | 2015-12-24 | Glaxosmithkline Llc | Lyophilized formulations |
| CN102718870B (zh) * | 2011-05-24 | 2014-04-30 | 马鞍山中美德康生物科技有限公司 | 一种胰岛素生物增敏剂及其应用 |
| UA113626C2 (xx) | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
| CN102516393B (zh) * | 2011-11-30 | 2017-03-15 | 北京康明百奥新药研发有限公司 | 胰岛素模拟肽融合蛋白和突变体及其应用 |
| CN103509118B (zh) * | 2012-06-15 | 2016-03-23 | 郭怀祖 | 胰岛素-Fc融合蛋白 |
| EP2869830B1 (en) | 2012-07-09 | 2016-10-12 | Novo Nordisk A/S | Novel use of insulin derivatives |
| AR091902A1 (es) | 2012-07-25 | 2015-03-11 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de un conjugado de insulina de accion prolongada |
| AR092862A1 (es) | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
| JP6387008B2 (ja) | 2012-09-26 | 2018-09-05 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリンアナローグダイマー |
| WO2014071405A2 (en) | 2012-11-05 | 2014-05-08 | Case Western Reserve University | Long-acting single-chain insulin analogues |
| CA2899418C (en) | 2013-02-26 | 2022-05-03 | Hanmi Pharm. Co., Ltd. | Site-specific insulin conjugate |
| AU2014236451B2 (en) * | 2013-03-14 | 2018-08-09 | Regeneron Pharmaceuticals, Inc. | Apelin fusion proteins and uses thereof |
| EP3055325B1 (en) | 2013-10-07 | 2018-01-03 | Novo Nordisk A/S | Novel derivative of an insulin analogue |
| MA46146A1 (fr) | 2014-01-20 | 2020-12-31 | Hanmi Pharm Ind Co Ltd | Insuline a action prolongée et utilisation associée |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及ｇｌｐ-１/昇糖素雙重促效劑之治療糖尿病之組成物 |
| KR20160001391A (ko) | 2014-06-27 | 2016-01-06 | 한미약품 주식회사 | 신규한 지속형 인슐린 아날로그 결합체 및 이의 용도 |
| KR20160007295A (ko) | 2014-07-11 | 2016-01-20 | 한미약품 주식회사 | 인슐린 아날로그 |
| CN107108716A (zh) | 2014-10-06 | 2017-08-29 | 卡斯西部储备大学 | 双相性单链胰岛素类似物 |
| ES2946247T3 (es) | 2014-11-21 | 2023-07-14 | Merck Sharp & Dohme Llc | Agonistas parciales del receptor de insulina |
| EP3260139A4 (en) | 2015-02-17 | 2018-09-05 | Hanmi Pharm. Co., Ltd. | Long-acting insulin or insulin analogue complex |
| CN110134210A (zh) | 2019-04-16 | 2019-08-16 | 深圳市国鑫恒宇科技有限公司 | 一种服务器一体机的温度控制方法、系统、装置及存储介质 |
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2016
- 2016-04-20 AR ARP160101082A patent/AR105616A1/es unknown
- 2016-04-21 JO JOP/2016/0076A patent/JO3658B1/ar active
- 2016-04-22 TW TW105112730A patent/TWI656132B/zh active
- 2016-04-28 HR HRP20200503TT patent/HRP20200503T1/hr unknown
- 2016-04-28 US US15/140,519 patent/US9855318B2/en active Active
- 2016-04-28 DK DK16721605.0T patent/DK3292141T3/da active
- 2016-04-28 CA CA2981102A patent/CA2981102A1/en active Pending
- 2016-04-28 ES ES16721605T patent/ES2799099T3/es active Active
- 2016-04-28 MX MX2017014284A patent/MX388594B/es unknown
- 2016-04-28 EA EA201792199A patent/EA039770B1/ru unknown
- 2016-04-28 ME MEP-2020-51A patent/ME03709B/me unknown
- 2016-04-28 TN TNP/2018/000059A patent/TN2018000059A1/en unknown
- 2016-04-28 SI SI201630651T patent/SI3292141T1/sl unknown
- 2016-04-28 EP EP16721605.0A patent/EP3292141B1/en active Active
- 2016-04-28 PL PL16721605T patent/PL3292141T3/pl unknown
- 2016-04-28 UA UAA201710105A patent/UA122146C2/uk unknown
- 2016-04-28 CR CR20170469A patent/CR20170469A/es unknown
- 2016-04-28 RS RS20200326A patent/RS60044B1/sr unknown
- 2016-04-28 KR KR1020177031825A patent/KR102059736B1/ko active Active
- 2016-04-28 PE PE2017002375A patent/PE20180507A1/es unknown
- 2016-04-28 LT LTEP16721605.0T patent/LT3292141T/lt unknown
- 2016-04-28 MA MA42037A patent/MA42037B1/fr unknown
- 2016-04-28 CN CN201680023998.4A patent/CN107531806B/zh active Active
- 2016-04-28 NZ NZ736470A patent/NZ736470A/en unknown
- 2016-04-28 PT PT167216050T patent/PT3292141T/pt unknown
- 2016-04-28 WO PCT/US2016/029807 patent/WO2016178905A1/en not_active Ceased
- 2016-04-28 MY MYPI2017704174A patent/MY183025A/en unknown
- 2016-04-28 SG SG11201708194WA patent/SG11201708194WA/en unknown
- 2016-04-28 AU AU2016257659A patent/AU2016257659B2/en active Active
- 2016-04-28 MD MDE20180255T patent/MD3292141T2/ro unknown
- 2016-04-28 JP JP2017557346A patent/JP6591562B2/ja active Active
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2017
- 2017-09-19 ZA ZA2017/06334A patent/ZA201706334B/en unknown
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- 2017-11-02 CO CONC2017/0011301A patent/CO2017011301A2/es unknown
- 2017-11-02 DO DO2017000258A patent/DOP2017000258A/es unknown
- 2017-11-06 EC ECIEPI201773650A patent/ECSP17073650A/es unknown
- 2017-11-07 PH PH12017502025A patent/PH12017502025B1/en unknown
- 2017-11-22 US US15/820,608 patent/US10709766B2/en active Active
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2020
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2022
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2024
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