MA49339A - Conjugués insuline-fc à extension oligomère - Google Patents

Conjugués insuline-fc à extension oligomère

Info

Publication number
MA49339A
MA49339A MA049339A MA49339A MA49339A MA 49339 A MA49339 A MA 49339A MA 049339 A MA049339 A MA 049339A MA 49339 A MA49339 A MA 49339A MA 49339 A MA49339 A MA 49339A
Authority
MA
Morocco
Prior art keywords
conjugates
oligomer extended
extended insulin
relates
oligomer
Prior art date
Application number
MA049339A
Other languages
English (en)
Inventor
Tina Møller Agmose
Maria Leonardo De
Thomas Børglum Kjeldsen
János Tibor Kodra
Zhaosheng Lin
Lennart Lykke
Peter Madsen
Martin Werner Borchsenius Münzel
Lone Pridal
zhe Wan
Yuanyuan Zhang
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MA49339A publication Critical patent/MA49339A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne le domaine des conjugués protéiques. Plus particulièrement, l'invention concerne des insulines à extension oligomère, avec des polypeptides monomères fc liés de manière covalente, destinées à être utilisées dans le traitement d'un trouble ou d'un état métabolique, et des procédés de production de tels conjugués d'insuline-fc à extension oligomère. L'invention concerne également de nouveaux fragments fc, des produits intermédiaires et l'utilisation de tels produits intermédiaires dans des processus de synthèse des conjugués d'insuline-fc à extension oligomère selon l'invention. L'invention concerne enfin des compositions pharmaceutiques comprenant les conjugués d'insuline-fc à extension oligomère selon l'invention, et l'utilisation de telles compositions pour le traitement ou la prévention d'états pathologiques associés à des troubles ou à des états métaboliques.
MA049339A 2017-04-05 2018-04-04 Conjugués insuline-fc à extension oligomère MA49339A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP17164950 2017-04-05
EP17208780 2017-12-20
EP18151228 2018-01-11
CN201810276163 2018-03-30

Publications (1)

Publication Number Publication Date
MA49339A true MA49339A (fr) 2020-02-12

Family

ID=61868527

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049339A MA49339A (fr) 2017-04-05 2018-04-04 Conjugués insuline-fc à extension oligomère

Country Status (6)

Country Link
US (1) US11471537B2 (fr)
EP (1) EP3606560A2 (fr)
JP (1) JP2020513019A (fr)
CN (1) CN110505885A (fr)
MA (1) MA49339A (fr)
WO (1) WO2018185131A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3303380B1 (fr) 2015-06-02 2020-01-15 Novo Nordisk A/S Insulines à extensions recombinées polaires
MA43348A (fr) 2015-10-01 2018-08-08 Novo Nordisk As Conjugués de protéines
MA49339A (fr) 2017-04-05 2020-02-12 Novo Nordisk As Conjugués insuline-fc à extension oligomère
WO2019074110A1 (fr) * 2017-10-13 2019-04-18 株式会社ボナック Molécule d'acide nucléique simple brin et son procédé de production
CN112839681A (zh) * 2018-10-10 2021-05-25 诺和诺德股份有限公司 寡聚体延伸的胰岛素-Fc缀合物及其医学用途
AU2019405358A1 (en) * 2018-12-17 2021-01-28 Remegen Co., Ltd. A linker for antibody-drug conjugates and its use
CN111217915B (zh) * 2019-01-08 2021-05-14 东莞太力生物工程有限公司 GLP-1类似物Fc融合多肽及其应用
WO2023064711A2 (fr) * 2021-10-14 2023-04-20 Akston Biosciences Corporation Protéines de fusion insuline-fc à action ultra-longue et méthodes d'utilisation
AR127619A1 (es) 2021-11-15 2024-02-14 Lilly Co Eli FORMULACIONES CONSERVADAS DE FUSIONES DE INSULINA-Fc
WO2023247640A1 (fr) * 2022-06-23 2023-12-28 Sanofi Insulines à chaîne unique et leurs conjugués fc
CN115947822B (zh) * 2022-07-04 2023-08-18 北京惠之衡生物科技有限公司 一种长效酰化胰岛素衍生物及其药物组合物和应用

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE286509C (fr)
DE257197C (fr)
US3914252A (en) 1971-03-15 1975-10-21 Continental Oil Co Preparation of N-iodocompounds
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
WO1992009690A2 (fr) 1990-12-03 1992-06-11 Genentech, Inc. Methode d'enrichissement pour des variantes de l'hormone de croissance avec des proprietes de liaison modifiees
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
ES2190388T3 (es) 1995-09-21 2006-04-01 Genentech, Inc. Variantes de la hormona de crecimiento humana.
AU728657B2 (en) 1996-03-18 2001-01-18 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
WO1998022577A1 (fr) 1996-11-15 1998-05-28 Maria Grazia Masucci Proteines de fusion a demi-vie allongee
CN1269805A (zh) 1997-07-14 2000-10-11 博尔德生物技术公司 生长激素和相关蛋白的衍生物
AU782496B2 (en) 1999-07-13 2005-08-04 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
CA2390691C (fr) 1999-12-24 2016-05-10 Genentech, Inc. Methodes et compositions permettant de prolonger les demi-vies d'elimination de composes bioactifs
US20060183197A1 (en) 2001-01-11 2006-08-17 Andersen Kim V Variant growth hormone molecules conjugated with macromolecules compounds
WO2002055532A2 (fr) 2001-01-11 2002-07-18 Maxygen Aps Molecules d'hormone de croissance ameliorees
PE20020908A1 (es) 2001-03-21 2002-10-26 Cell Therapeutics Inc Produccion recombinante de polimeros polianionicos y uso de de los mismos
CA2463639A1 (fr) 2001-11-12 2003-05-22 University Of Wales College Of Medicine Variations de l'hormone de croissance chez les humains et leurs utilisations
GB2389115B (en) 2001-12-14 2005-03-16 Asterion Ltd Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone
EP2364996B1 (fr) 2002-09-27 2016-11-09 Xencor Inc. Variantes FC optimisées et leurs procédés de génération
US20040180054A1 (en) 2003-03-13 2004-09-16 Hanmi Pharm. Co., Ltd. Physiologically active polypeptide conjugate having prolonged in vivo half-life
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
JP4870569B2 (ja) * 2003-11-13 2012-02-08 ハンミ ホールディングス カンパニー リミテッド 免疫グロブリン断片を用いた蛋白質結合体およびその製造方法
KR100594607B1 (ko) 2004-11-03 2006-06-30 재단법인서울대학교산학협력재단 신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
EP1841787A2 (fr) 2005-01-25 2007-10-10 Cell Therapeutics, Inc. Conjugues de proteine biologiquement actives possedant une demi-vie in vivo modifiee
EP1843790A2 (fr) 2005-01-27 2007-10-17 Novo Nordisk A/S Derives d'insuline conjugues avec des polymeres ramifies structurellement bien definis
WO2006087354A2 (fr) 2005-02-16 2006-08-24 Novo Nordisk A/S Derives d'agents insulinotropiques conjugues a des polymeres ramifies structurellement bien definis
KR100754667B1 (ko) 2005-04-08 2007-09-03 한미약품 주식회사 비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물
US8008443B2 (en) 2005-04-26 2011-08-30 Medimmune, Llc Modulation of antibody effector function by hinge domain engineering
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US8492129B2 (en) 2005-12-12 2013-07-23 Innova Biosciences, Ltd. Production of conjugates
EP1971355B1 (fr) 2005-12-20 2020-03-11 Duke University Procedes et compositions pour l'administration d'agents actifs a proprietes pharmacologiques ameliorees
EP1996937A4 (fr) 2006-03-06 2009-04-08 Amunix Inc Materiels génétiques et utilisations correspondantes
US9505823B2 (en) 2006-08-07 2016-11-29 TEV A Biopharmaceuticals USA, Inc. Albumin-insulin fusion proteins
HUE029512T2 (en) 2006-09-22 2017-03-28 Novo Nordisk As Protease Resistant Insulin Analogs
EP2094728B1 (fr) 2006-10-26 2013-04-10 Janssen Biotech, Inc. Procédés d'adaptation d'anticorps monoclonaux à l'être humain
WO2008049711A1 (fr) * 2006-10-27 2008-05-02 Novo Nordisk A/S Insuline à peptide ajouté
US20100303723A1 (en) 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
WO2008092117A2 (fr) 2007-01-25 2008-07-31 Xencor, Inc. Nouvelles insertions, délétions et substitutions d'immunoglobulines
KR20080095141A (ko) 2007-04-23 2008-10-28 포항공과대학교 산학협력단 인간 알부민 링커를 통하여 면역글로불린의 Ｆｃ에 결합된생리학적 활성 폴리펩티드의 융합 폴리펩티드, 및 이의제조방법
CN101687933B (zh) 2007-05-30 2015-11-25 浦项工科大学校产学协力团 免疫球蛋白融合蛋白
JP6071165B2 (ja) 2007-05-31 2017-02-01 ゲンマブ エー／エス 安定なＩｇＧ４抗体
WO2009015345A1 (fr) 2007-07-25 2009-01-29 Amgen Inc. Compositions pharmaceutiques comprenant des protéines de fusion fc
AU2008287340A1 (en) 2007-08-15 2009-02-19 Amunix, Inc. Compositions and methods for modifying properties of biologically active polypeptides
JP5314033B2 (ja) * 2007-10-22 2013-10-16 メルク セローノ ソシエテ アノニム 突然変異ＩｇＧＦｃフラグメントと融合した単一ＩＦＮ−ベータ
CN102625813A (zh) 2008-06-20 2012-08-01 诺华公司 具有降低的聚集的免疫球蛋白
WO2010001196A1 (fr) 2008-07-02 2010-01-07 Koninklijke Philips Electronics N.V. Configuration de ressort en v et ensembles de fixation d'extrémité pour celle-ci destinés à être utilisés dans un appareil de soins d'hygiène corporelle
MY151184A (en) 2008-07-23 2014-04-30 Hanmi Science Co Ltd A polypeptide complex comprising non-peptidyl polymer having three functional ends
CN102348715B (zh) 2009-02-03 2017-12-08 阿穆尼克斯运营公司 延伸重组多肽和包含该延伸重组多肽的组合物
GB0914110D0 (en) 2009-08-12 2009-09-16 Medical Res Council Peptide libraries
US9493578B2 (en) * 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
MX2012003939A (es) 2009-09-30 2012-07-30 Glaxo Group Ltd Fusiones y conjugados de farmaco.
WO2011059684A1 (fr) * 2009-10-29 2011-05-19 Centocor Ortho Biotech Inc. Variantes de glycosylation des anticorps
US8637637B2 (en) 2010-01-12 2014-01-28 Bill Nai-Chau Sun Fc fusion proteins of human growth hormone
AR081066A1 (es) * 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
EP2571510B1 (fr) 2010-05-21 2018-08-08 XL-protein GmbH Polypeptides de bobine aléatoires en proline/alanine biosynthétique
KR101337797B1 (ko) 2010-07-14 2013-12-06 한미사이언스 주식회사 지속형 인간 성장 호르몬 결합체 액상 제제
EP2694528A1 (fr) 2011-04-05 2014-02-12 Martin-Protean, LLC Isolement de peptides contenant de la cystéine
UA117901C2 (uk) 2011-07-06 2018-10-25 Ґенмаб Б.В. Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
WO2013130684A1 (fr) 2012-02-27 2013-09-06 Amunix Operating Inc. Compositions de conjugués xten-folate et des procédés de préparation de celles-ci
WO2013170272A2 (fr) 2012-05-11 2013-11-14 Alexander Krantz Marquage spécifique d'un site et administration ciblée de protéines pour le traitement d'un cancer
JP2016521701A (ja) 2013-06-07 2016-07-25 ノヴォ ノルディスク アー／エス 成熟インスリンポリペプチドを作製するための方法
KR102302634B1 (ko) 2013-09-13 2021-09-14 더 스크립스 리서치 인스티튜트 변형된 치료제 및 이의 조성물
CA2966352A1 (fr) 2013-11-26 2015-06-04 The Brigham And Women's Hospital, Inc. Compositions et procedes pour moduler une reponse immunitaire
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3114143B1 (fr) 2014-03-05 2020-07-08 UCB Biopharma SRL Protéines fc multimères
CN106687482B (zh) 2014-09-17 2022-01-25 诺和诺德股份有限公司 能够结合组织因子途径抑制剂(1-161)上的两个表位的抗体
KR20160101702A (ko) 2015-02-17 2016-08-25 한미약품 주식회사 지속형 인슐린 또는 이의 아날로그 결합체
AR105616A1 (es) * 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3303380B1 (fr) 2015-06-02 2020-01-15 Novo Nordisk A/S Insulines à extensions recombinées polaires
TWI715611B (zh) * 2015-08-14 2021-01-11 美商Ｒｃ生物科技公司 抗體藥物偶聯物的共價鍵連接子及其製備方法與應用
MA43348A (fr) 2015-10-01 2018-08-08 Novo Nordisk As Conjugués de protéines
MA49339A (fr) 2017-04-05 2020-02-12 Novo Nordisk As Conjugués insuline-fc à extension oligomère

Also Published As

Publication number Publication date
WO2018185131A2 (fr) 2018-10-11
WO2018185131A3 (fr) 2018-11-15
EP3606560A2 (fr) 2020-02-12
JP2020513019A (ja) 2020-04-30
CN110505885A (zh) 2019-11-26
US20200261595A1 (en) 2020-08-20
US11471537B2 (en) 2022-10-18

Similar Documents

Publication Publication Date Title
MA49339A (fr) Conjugués insuline-fc à extension oligomère
MX2018005387A (es) Variantes de fgf21.
MX2019012081A (es) Proteina de fusion del factor de crecimiento 21 de fibroblastos humanos (hfgf21), metodo de preparacion de la misma y su uso.
EP4378962A3 (fr) Polypeptide de fusion anticancéreux
AU2018240515A1 (en) Nucleic acids encoding CRISPR-associated proteins and uses thereof
WO2018033254A3 (fr) Arn pour la cancérothérapie
WO2016187220A3 (fr) Anticorps anti-ror1
MX2019011117A (es) Anticuerpo b7-h3, fragmento de union a antigeno de los mismos y uso medico de los mismos.
MX2017014716A (es) Polipeptido de fusion anti-cancer.
WO2017077329A3 (fr) Acides nucléiques, peptides et méthodes
MX2020006999A (es) Farmaceuticos de peptidos mejorados para el tratamiento de nash y otros trastornos.
WO2015128403A3 (fr) Nouveaux dérivés de l'insuline et leurs utilisations médicales
WO2020076969A3 (fr) Variants d'anticorps anti-lap et leurs utilisations
MX2017000378A (es) ANTICUERPOS DE UNION A PROTOFIBRILLAS BETA AMILOIDE (Aß) MEJORADOS.
NZ759601A (en) Aggrecan binding immunoglobulins
WO2018071741A8 (fr) Sulfoxyalkyle organonitro, composés apparentés et compositions pharmaceutiques destinées à être utilisées en médecine
MX2018002223A (es) Derivados de insulina novedosos y usos medicos de los mismos.
MX2023010328A (es) Composiciones de medicamentos a base de peptido de colageno y metodos y dispositivos para su produccion y uso.
WO2018154118A3 (fr) Nouveaux composés aromatiques
MX2019003970A (es) Péptidos de arginasa inmunogénicos.
ZA202201827B (en) Therapeutic fusion proteins
PH12020550050A1 (en) Novel acylated insulin analogues and uses thereof
MX2021001545A (es) Péptidos penetrantes celulares.
MX2018009499A (es) Anticuerpos monoclonales especificos de egfl6 y metodos de su uso.
MX2021010766A (es) Anticuerpos que se unen a la proteína del gen 6 inducible por el factor de necrosis tumoral (tsg-6) y usos de estos.