MA49339A - Conjugués insuline-fc à extension oligomère - Google Patents
Conjugués insuline-fc à extension oligomèreInfo
- Publication number
- MA49339A MA49339A MA049339A MA49339A MA49339A MA 49339 A MA49339 A MA 49339A MA 049339 A MA049339 A MA 049339A MA 49339 A MA49339 A MA 49339A MA 49339 A MA49339 A MA 49339A
- Authority
- MA
- Morocco
- Prior art keywords
- conjugates
- oligomer extended
- extended insulin
- relates
- oligomer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne le domaine des conjugués protéiques. Plus particulièrement, l'invention concerne des insulines à extension oligomère, avec des polypeptides monomères fc liés de manière covalente, destinées à être utilisées dans le traitement d'un trouble ou d'un état métabolique, et des procédés de production de tels conjugués d'insuline-fc à extension oligomère. L'invention concerne également de nouveaux fragments fc, des produits intermédiaires et l'utilisation de tels produits intermédiaires dans des processus de synthèse des conjugués d'insuline-fc à extension oligomère selon l'invention. L'invention concerne enfin des compositions pharmaceutiques comprenant les conjugués d'insuline-fc à extension oligomère selon l'invention, et l'utilisation de telles compositions pour le traitement ou la prévention d'états pathologiques associés à des troubles ou à des états métaboliques.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17164950 | 2017-04-05 | ||
EP17208780 | 2017-12-20 | ||
EP18151228 | 2018-01-11 | ||
CN201810276163 | 2018-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA49339A true MA49339A (fr) | 2020-02-12 |
Family
ID=61868527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA049339A MA49339A (fr) | 2017-04-05 | 2018-04-04 | Conjugués insuline-fc à extension oligomère |
Country Status (6)
Country | Link |
---|---|
US (1) | US11471537B2 (fr) |
EP (1) | EP3606560A2 (fr) |
JP (1) | JP2020513019A (fr) |
CN (1) | CN110505885A (fr) |
MA (1) | MA49339A (fr) |
WO (1) | WO2018185131A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6983075B2 (ja) | 2015-06-02 | 2021-12-17 | ノヴォ ノルディスク アー/エス | 極性の組換え延長部を有するインスリン |
MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
EP3606560A2 (fr) | 2017-04-05 | 2020-02-12 | Novo Nordisk A/S | Conjugués insuline-fc à extension oligomère |
EP3696269A4 (fr) * | 2017-10-13 | 2021-09-01 | Bonac Corporation | Molécule d'acide nucléique simple brin et son procédé de production |
EP3863680A1 (fr) * | 2018-10-10 | 2021-08-18 | Novo Nordisk A/S | Conjugués insuline-fc à extension oligomère et leur utilisation médicale |
WO2020125546A1 (fr) * | 2018-12-17 | 2020-06-25 | 荣昌生物制药(烟台)有限公司 | Connecteur destiné à être utilisé dans un conjugué médicament anticorps et applications de connecteur |
CN111217915B (zh) * | 2019-01-08 | 2021-05-14 | 东莞太力生物工程有限公司 | GLP-1类似物Fc融合多肽及其应用 |
WO2023064711A2 (fr) * | 2021-10-14 | 2023-04-20 | Akston Biosciences Corporation | Protéines de fusion insuline-fc à action ultra-longue et méthodes d'utilisation |
AR127619A1 (es) | 2021-11-15 | 2024-02-14 | Lilly Co Eli | FORMULACIONES CONSERVADAS DE FUSIONES DE INSULINA-Fc |
WO2023247640A1 (fr) * | 2022-06-23 | 2023-12-28 | Sanofi | Insulines à chaîne unique et leurs conjugués fc |
CN115850385B (zh) * | 2022-07-04 | 2023-08-11 | 北京惠之衡生物科技有限公司 | 一种促表达肽及其应用 |
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AR099569A1 (es) * | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
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BR112018002033A2 (pt) * | 2015-08-14 | 2018-11-06 | Rc Biotechnologies, Inc. | ligantes covalentes em conjugados de anticorpo-fármaco e métodos para fabricação e uso dos mes-mos |
MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
EP3606560A2 (fr) | 2017-04-05 | 2020-02-12 | Novo Nordisk A/S | Conjugués insuline-fc à extension oligomère |
-
2018
- 2018-04-04 EP EP18715032.1A patent/EP3606560A2/fr not_active Withdrawn
- 2018-04-04 WO PCT/EP2018/058550 patent/WO2018185131A2/fr unknown
- 2018-04-04 US US16/500,897 patent/US11471537B2/en active Active
- 2018-04-04 MA MA049339A patent/MA49339A/fr unknown
- 2018-04-04 JP JP2019554912A patent/JP2020513019A/ja not_active Withdrawn
- 2018-04-04 CN CN201880023755.XA patent/CN110505885A/zh not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP3606560A2 (fr) | 2020-02-12 |
WO2018185131A3 (fr) | 2018-11-15 |
JP2020513019A (ja) | 2020-04-30 |
US20200261595A1 (en) | 2020-08-20 |
WO2018185131A2 (fr) | 2018-10-11 |
CN110505885A (zh) | 2019-11-26 |
US11471537B2 (en) | 2022-10-18 |
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