MA46146A1 - Insuline a action prolongée et utilisation associée - Google Patents

Insuline a action prolongée et utilisation associée

Info

Publication number
MA46146A1
MA46146A1 MA46146A MA46146A MA46146A1 MA 46146 A1 MA46146 A1 MA 46146A1 MA 46146 A MA46146 A MA 46146A MA 46146 A MA46146 A MA 46146A MA 46146 A1 MA46146 A1 MA 46146A1
Authority
MA
Morocco
Prior art keywords
long
insulin
acting insulin
associated use
acting
Prior art date
Application number
MA46146A
Other languages
English (en)
Inventor
Sang Youn Hwang
Sung Youb Jung
Euh Lim Oh
Sung Hee Park
Hyun Uk Kim
Chang Ki Lim
Se Chang Kwon
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of MA46146A1 publication Critical patent/MA46146A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne : un analogue de l'insuline dans lequel la force de liaison au récepteur de l'insuline est réduite afin d'augmenter la demi-vie de l'insuline dans le sang ; une insuline à action prolongée utilisant celui-ci ; un complexe ; et un procédé de préparation de l'insuline à action prolongée.
MA46146A 2014-01-20 2015-01-20 Insuline a action prolongée et utilisation associée MA46146A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140006938 2014-01-20
PCT/KR2015/000576 WO2015108398A1 (fr) 2014-01-20 2015-01-20 Insuline à action prolongée et utilisation associée

Publications (1)

Publication Number Publication Date
MA46146A1 true MA46146A1 (fr) 2020-12-31

Family

ID=53543214

Family Applications (3)

Application Number Title Priority Date Filing Date
MA46146A MA46146A1 (fr) 2014-01-20 2015-01-20 Insuline a action prolongée et utilisation associée
MA39301A MA39301A1 (fr) 2014-01-20 2015-01-20 Insuline à action prolongée et utilisation associée
MA43289A MA43289B1 (fr) 2014-01-20 2015-01-20 Insuline à action prolongée et utilisation associée

Family Applications After (2)

Application Number Title Priority Date Filing Date
MA39301A MA39301A1 (fr) 2014-01-20 2015-01-20 Insuline à action prolongée et utilisation associée
MA43289A MA43289B1 (fr) 2014-01-20 2015-01-20 Insuline à action prolongée et utilisation associée

Country Status (22)

Country Link
US (1) US10253082B2 (fr)
EP (1) EP3098235A4 (fr)
JP (1) JP2017505141A (fr)
KR (1) KR102406654B1 (fr)
CN (2) CN105916877A (fr)
AU (1) AU2015206890B2 (fr)
BR (1) BR112016016578A2 (fr)
CA (1) CA2937168A1 (fr)
CL (1) CL2016001844A1 (fr)
CR (1) CR20160376A (fr)
DO (1) DOP2016000176A (fr)
EA (1) EA201691374A1 (fr)
EC (1) ECSP16068524A (fr)
IL (1) IL246782B (fr)
MA (3) MA46146A1 (fr)
MX (1) MX369656B (fr)
MY (1) MY186251A (fr)
PE (1) PE20161153A1 (fr)
PH (1) PH12016501414B1 (fr)
SG (1) SG11201605680PA (fr)
WO (1) WO2015108398A1 (fr)
ZA (1) ZA201605626B (fr)

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EP3097092B1 (fr) 2014-01-20 2020-08-26 Cleave Biosciences, Inc. Pyrimidines condensées en tant qu'inhibiteurs du complexe p97
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AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
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KR102698929B1 (ko) * 2016-09-23 2024-08-27 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된, 인슐린 아날로그 및 이의 용도
AU2018215840A1 (en) * 2017-02-03 2019-08-01 Hanmi Pharm. Co., Ltd. Long-Acting Conjugate Of A Physiologically Active Material And Use Thereof
AU2018239037B2 (en) * 2017-03-23 2022-05-26 Hanmi Pharm. Co., Ltd. Insulin analog complex with reduced affinity for insulin receptor and use thereof
EP3689914A4 (fr) * 2017-09-29 2021-08-25 Hanmi Pharm. Co., Ltd. Conjugué de protéine persistant à efficacité améliorée
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CA3169564A1 (fr) 2020-03-31 2021-10-07 Hanmi Pharm. Co., Ltd. Nouveaux analogues d'il-2 immunostimulants
CN115894720B (zh) * 2023-01-16 2024-07-09 中国科学院上海药物研究所 一种长效胰岛素-Fc融合蛋白

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Also Published As

Publication number Publication date
EA201691374A1 (ru) 2016-12-30
PE20161153A1 (es) 2016-10-27
MX369656B (es) 2019-11-15
ZA201605626B (en) 2017-11-29
MY186251A (en) 2021-06-30
KR102406654B1 (ko) 2022-06-10
MA39301A1 (fr) 2018-01-31
IL246782B (en) 2020-01-30
DOP2016000176A (es) 2017-02-15
PH12016501414A1 (en) 2016-09-14
MX2016009434A (es) 2017-01-18
MA43289B1 (fr) 2019-12-31
JP2017505141A (ja) 2017-02-16
AU2015206890A1 (en) 2016-08-04
US10253082B2 (en) 2019-04-09
CN116987172A (zh) 2023-11-03
IL246782A0 (en) 2016-08-31
PH12016501414B1 (en) 2016-09-14
BR112016016578A2 (pt) 2017-10-03
CR20160376A (es) 2016-10-07
AU2015206890B2 (en) 2019-05-23
KR20150087130A (ko) 2015-07-29
EP3098235A4 (fr) 2017-10-18
US20170101455A1 (en) 2017-04-13
CA2937168A1 (fr) 2015-07-23
EP3098235A1 (fr) 2016-11-30
CN105916877A (zh) 2016-08-31
WO2015108398A1 (fr) 2015-07-23
CL2016001844A1 (es) 2017-01-06
ECSP16068524A (es) 2018-11-30
SG11201605680PA (en) 2016-09-29

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