MX369656B - Insulina de accion prolongada y uso de la misma. - Google Patents

Insulina de accion prolongada y uso de la misma.

Info

Publication number
MX369656B
MX369656B MX2016009434A MX2016009434A MX369656B MX 369656 B MX369656 B MX 369656B MX 2016009434 A MX2016009434 A MX 2016009434A MX 2016009434 A MX2016009434 A MX 2016009434A MX 369656 B MX369656 B MX 369656B
Authority
MX
Mexico
Prior art keywords
long
insulin
acting insulin
acting
blood
Prior art date
Application number
MX2016009434A
Other languages
English (en)
Other versions
MX2016009434A (es
Inventor
Youb Jung Sung
Youn Hwang Sang
Lim Oh Euh
Hee Park Sung
Uk Kim Hyun
Ki Lim Chang
Chang Kwon Se
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of MX2016009434A publication Critical patent/MX2016009434A/es
Publication of MX369656B publication Critical patent/MX369656B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a un análogo de insulina que presenta una afinidad reducida de la unión al receptor de insulina con el propósito de aumentar la vida media en sangre de la insulina, y a una insulina de acción prolongada, a un conjugado, y a un método de preparación de una insulina de acción prolongada que la utilice.
MX2016009434A 2014-01-20 2015-01-20 Insulina de accion prolongada y uso de la misma. MX369656B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140006938 2014-01-20
PCT/KR2015/000576 WO2015108398A1 (ko) 2014-01-20 2015-01-20 지속형 인슐린 및 그 용도

Publications (2)

Publication Number Publication Date
MX2016009434A MX2016009434A (es) 2017-01-18
MX369656B true MX369656B (es) 2019-11-15

Family

ID=53543214

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009434A MX369656B (es) 2014-01-20 2015-01-20 Insulina de accion prolongada y uso de la misma.

Country Status (22)

Country Link
US (1) US10253082B2 (es)
EP (1) EP3098235A4 (es)
JP (1) JP2017505141A (es)
KR (1) KR102406654B1 (es)
CN (2) CN105916877A (es)
AU (1) AU2015206890B2 (es)
BR (1) BR112016016578A2 (es)
CA (1) CA2937168A1 (es)
CL (1) CL2016001844A1 (es)
CR (1) CR20160376A (es)
DO (1) DOP2016000176A (es)
EA (1) EA201691374A1 (es)
EC (1) ECSP16068524A (es)
IL (1) IL246782B (es)
MA (3) MA39301A1 (es)
MX (1) MX369656B (es)
MY (1) MY186251A (es)
PE (1) PE20161153A1 (es)
PH (1) PH12016501414B1 (es)
SG (1) SG11201605680PA (es)
WO (1) WO2015108398A1 (es)
ZA (1) ZA201605626B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ722624A (en) 2014-01-20 2017-09-29 Cleave Biosciences Inc Fused pyrimidines as inhibitors of p97 complex
CA2966765C (en) 2014-11-21 2020-04-14 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
WO2017052305A1 (en) * 2015-09-24 2017-03-30 Hanmi Pharm. Co., Ltd. Method of insulin production
CN110546161B (zh) * 2016-09-23 2024-01-26 韩美药品股份有限公司 对胰岛素受体具有降低的结合力的胰岛素类似物及其用途
MX2019009149A (es) * 2017-02-03 2019-10-14 Hanmi Pharm Ind Co Ltd Conjugado de material bioactivo que tiene sustentabilidad mejorada y uso del mismo.
CA3054899A1 (en) * 2017-03-23 2018-09-27 Hanmi Pharm. Co., Ltd. Insulin analog complex with reduced affinity for insulin receptor and use thereof
EP3689914A4 (en) * 2017-09-29 2021-08-25 Hanmi Pharm. Co., Ltd. PERSISTENT PROTEIN CONJUGATE WITH IMPROVED EFFICIENCY
KR102666154B1 (ko) * 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
KR102646845B1 (ko) * 2018-08-08 2024-03-14 주식회사 대웅제약 클로스트리파인을 이용한 지속형 인슐린 아날로그 복합체의 활성형 제조방법
JP2022511567A (ja) 2018-12-11 2022-01-31 サノフイ インスリンコンジュゲート
TWI844709B (zh) * 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
IL295826A (en) * 2020-03-31 2022-10-01 Hanmi Pharm Ind Co Ltd Novel il-2 analogs that stimulate the immune system
CN115894720B (zh) * 2023-01-16 2024-07-09 中国科学院上海药物研究所 一种长效胰岛素-Fc融合蛋白

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175145A (en) 1988-08-26 1992-12-29 Amylin Pharmaceuticals, Inc. Treatment of diabetes mellitus with amylin agonists
US5422339A (en) * 1991-03-19 1995-06-06 Joslin Diabetes Center, Inc. Peptides having insulin autoantibody but not insulin receptor binding capacity
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
AU728657B2 (en) 1996-03-18 2001-01-18 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
AU762351B2 (en) 1999-01-06 2003-06-26 Genentech Inc. Insulin-like growth factor (IGF) I mutant variants
AR036711A1 (es) 2001-10-05 2004-09-29 Bayer Corp Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
US20050176108A1 (en) * 2003-03-13 2005-08-11 Young-Min Kim Physiologically active polypeptide conjugate having prolonged in vivo half-life
BRPI0409600A (pt) 2003-04-29 2006-04-18 Lilly Co Eli análogo de insulina, composição, método de tratamento de hiperglicemia, e, análogo de pró-insulina
SI1648933T1 (sl) 2003-07-25 2010-01-29 Conjuchem Biotechnologies Inc Dolgo delujoäś inzulinski derivat in metoda zanj
RU2352583C2 (ru) 2003-11-13 2009-04-20 Ханми Фарм. Инд. Ко., Лтд. ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ Fc-ОБЛАСТЬ ИММУНОГЛОБУЛИНА В КАЧЕСТВЕ НОСИТЕЛЯ
JP5366546B2 (ja) 2005-08-16 2013-12-11 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
JP5550338B2 (ja) * 2006-07-31 2014-07-16 ノボ・ノルデイスク・エー／エス ペグ化持続型インスリン
WO2008049711A1 (en) * 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
US7790677B2 (en) 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
JP2008169195A (ja) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
JP2009019027A (ja) 2007-07-16 2009-01-29 Hanmi Pharmaceutical Co Ltd アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体
EP2017288A1 (en) 2007-07-16 2009-01-21 Novo Nordisk A/S Protease stabilized, pegylated insulin analogues
CN101743252A (zh) 2007-07-16 2010-06-16 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、peg化的胰岛素类似物
AU2008288413B2 (en) 2007-08-15 2013-09-26 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
PT2597103T (pt) 2007-11-16 2017-02-08 Novo Nordisk As Composições farmacêuticas contendo insulina e um péptido insulinotrófico
NZ586589A (en) 2008-01-09 2012-04-27 Sanofi Aventis Deutschland Novel insulin analogues having an extremely delayed time-action profile
DE102008025008A1 (de) 2008-05-24 2009-11-26 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP2229407B1 (de) 2008-01-09 2016-11-16 Sanofi-Aventis Deutschland GmbH Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil
DE102008003568A1 (de) 2008-01-09 2009-07-16 Sanofi-Aventis Deutschland Gmbh Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP2254905B1 (en) * 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
KR101755529B1 (ko) * 2008-03-18 2017-07-07 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
DK3228320T3 (da) 2008-10-17 2020-03-09 Sanofi Aventis Deutschland Kombination af et insulin og en glp-1-agonist
US8697632B2 (en) 2008-12-19 2014-04-15 Indiana University Research And Technology Corporation Amide based insulin prodrugs
WO2010080606A1 (en) * 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Insulin analogs
NZ595344A (en) 2009-03-27 2013-09-27 Glaxo Group Ltd Drug fusions and conjugates
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
KR101058209B1 (ko) 2009-12-30 2011-08-22 전자부품연구원 Ｏｆｄｍ 방식의 디지털 방송 시스템의 빠른 동기 방법
AR081066A1 (es) * 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
KR101330868B1 (ko) 2010-06-08 2013-11-18 한미사이언스 주식회사 면역글로불린 단편을 이용한 인슐린 유도체 약물 결합체
KR101324828B1 (ko) 2010-06-08 2013-11-01 한미사이언스 주식회사 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체
US8940860B2 (en) * 2010-06-16 2015-01-27 Indiana University Research And Technology Corporation Single-chain insulin agonists exhibiting high activity at the insulin receptor
KR101382593B1 (ko) 2010-07-21 2014-04-10 한미사이언스 주식회사 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물
US9074015B2 (en) 2010-07-28 2015-07-07 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
BR112013018269A2 (pt) 2011-01-20 2017-06-06 Zealand Pharma As combinação de análogos acilados do glucagon com análogos da insulina
MY180513A (en) 2011-03-02 2020-12-01 Oerlikon Surface Solutions Ag Trubbach Sliding component coated with metal-comprising carbon layer for improving wear and friction behavior by tribological applications under lubricated conditions
CN102675452B (zh) 2011-03-17 2015-09-16 重庆富进生物医药有限公司 具持续降血糖和受体高结合的人胰岛素及类似物的偶联物
RU2578641C2 (ru) 2011-05-03 2016-03-27 Тейджин Арамид Б.В. Пуленепробиваемая панель
UA113626C2 (xx) 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
SG10201606243YA (en) 2011-06-02 2016-09-29 Prolor Biotech Inc Long-acting glp-1/glucagon receptor agonists
EP3878859B1 (en) 2011-06-10 2023-11-01 Hanmi Science Co., Ltd. Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
MX353402B (es) 2011-06-17 2018-01-11 Hanmi Science Co Ltd Un conjugado que comprende oxintomodulina y un fragmento de inmunoglobulina, y uso del mismo.
WO2013089463A1 (en) 2011-12-16 2013-06-20 Lg Innotek Co., Ltd. Method for deposition of silicon carbide and silicon carbide epitaxial wafer
US20150299286A1 (en) 2012-01-20 2015-10-22 Case Western Reserve University Glutamic acid-stabilized insulin analogues
KR101665009B1 (ko) 2012-03-09 2016-10-11 한미사이언스 주식회사 비알콜성 지방간 질환의 예방 또는 치료용 약학적 조성물
KR101968344B1 (ko) 2012-07-25 2019-04-12 한미약품 주식회사 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
AR091902A1 (es) 2012-07-25 2015-03-11 Hanmi Pharm Ind Co Ltd Formulacion liquida de un conjugado de insulina de accion prolongada
AR092862A1 (es) 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
AR094821A1 (es) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
DK2916819T3 (da) 2012-11-06 2019-10-14 Hanmi Pharm Ind Co Ltd Væskeformig formulering af proteinkonjugat omfattende oxyntomodulinet og et immunoglobulin-fragment
EP2963056B1 (en) 2013-02-26 2019-11-13 Hanmi Pharm. Co., Ltd. Insulin analog and use thereof
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
KR101676542B1 (ko) 2014-12-30 2016-11-16 건국대학교 산학협력단 프로인슐린의 면역학적 용도

Also Published As

Publication number Publication date
CR20160376A (es) 2016-10-07
KR102406654B1 (ko) 2022-06-10
EA201691374A1 (ru) 2016-12-30
CL2016001844A1 (es) 2017-01-06
CA2937168A1 (en) 2015-07-23
MA39301A1 (fr) 2018-01-31
PE20161153A1 (es) 2016-10-27
CN116987172A (zh) 2023-11-03
ZA201605626B (en) 2017-11-29
EP3098235A1 (en) 2016-11-30
IL246782B (en) 2020-01-30
IL246782A0 (en) 2016-08-31
PH12016501414A1 (en) 2016-09-14
MY186251A (en) 2021-06-30
US20170101455A1 (en) 2017-04-13
ECSP16068524A (es) 2018-11-30
WO2015108398A1 (ko) 2015-07-23
CN105916877A (zh) 2016-08-31
MA43289B1 (fr) 2019-12-31
BR112016016578A2 (pt) 2017-10-03
PH12016501414B1 (en) 2020-10-30
SG11201605680PA (en) 2016-09-29
KR20150087130A (ko) 2015-07-29
AU2015206890B2 (en) 2019-05-23
MX2016009434A (es) 2017-01-18
JP2017505141A (ja) 2017-02-16
EP3098235A4 (en) 2017-10-18
US10253082B2 (en) 2019-04-09
MA46146A1 (fr) 2020-12-31
DOP2016000176A (es) 2017-02-15
AU2015206890A1 (en) 2016-08-04

Similar Documents

Publication Publication Date Title
PH12016501414A1 (en) Long-acting insulin and use thereof
SA518400491B1 (ar) نظير إنسولين جديد واستخدامه
MX2018015853A (es) Anticuerpos multiespecificos frente a los grupos de diferenciacion 40 y 137 (cd40 y cd137).
EP3141276A4 (en) Safety insulin pen needle
IL246661B (en) Human antibodies to pd–l1
IL247740A0 (en) Antibodies that bind to cd3 epsilon from human and cynomolgus
SG10201809427SA (en) Insulin receptor partial agonists
GB201414499D0 (en) Method and system for delivering funding options to a user
MA40386A (fr) Procédé de préparation de cabozantinib marqué au fluor-18 et d'analogues de celui-ci
MX2016009858A (es) Fusiones anti proteína convertasa subtilisina/kexina tipo 9 (anti-pcsk9)n péptido 1 similar a glucagón (glp-1) y métodos de uso.
EP3119453A4 (en) System for syringe engagement to an injector
EP3171888A4 (en) Chromatography process for purification of inlsulin and insulin analogs
EP3509512A4 (en) CANNULA FOR USE IN INTRA-BONE INJECTIONS
MX2015003034A (es) Jeringa que contiene una composicion, en particular farmaceutica, que comprende inmunoglobulinas, su metodo de fabricacion y uso.
EP3231432A4 (en) Agent for hypodermic injections and production method for syringes containing agent for hypodermic injections
MX2016001691A (es) Moleculas de union al receptor bag3 para uso como un medicamento.
MX2016003035A (es) Preparacion de 3-fluoropropil-nor-beta-cit radioyodado.
NZ719745A (en) Soluble fc gamma receptor for treatment of autoimmune bullous diseases
PL3191106T3 (pl) Kompozycja zawierająca mikroalgę wzbogaconą w krzem do stosowania terapeutycznego
AU2014900562A0 (en) A system and a method for facilitating the administering of a healthcare program to a patient
PH12014000104A1 (en) Therapeutic methods and compositions for treating diabetes
IN2014MU01191A (es)

Legal Events

Date Code Title Description
FG Grant or registration