AR086866A1 - Derivados de oxintomodulina y composicion farmaceutica que los comprende para el tratamiento de la obesidad - Google Patents
Derivados de oxintomodulina y composicion farmaceutica que los comprende para el tratamiento de la obesidadInfo
- Publication number
- AR086866A1 AR086866A1 ARP120102030A ARP120102030A AR086866A1 AR 086866 A1 AR086866 A1 AR 086866A1 AR P120102030 A ARP120102030 A AR P120102030A AR P120102030 A ARP120102030 A AR P120102030A AR 086866 A1 AR086866 A1 AR 086866A1
- Authority
- AR
- Argentina
- Prior art keywords
- suppressed
- alanine
- serine
- glutamic acid
- seq
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Péptido que presenta diferentes actividades sobre un receptor de péptido-1 tipo glucagón y un receptor de glucagón que la oxintomodulina nativa; también una composición para la prevención o el tratamiento de la obesidad que comprende el péptido como ingrediente activo. A diferencia de la oxintomodulina nativa, el péptido de la presente solicitud reduce la ingesta de alimentos, suprime el vaciado gástrico y facilita la lipólisis con efectos secundarios reducidos; además presenta excelentes efectos de activación del receptor. Por lo tanto, se puede usar de manera generalizada en un tratamiento seguro y eficaz de la obesidad.Reivindicación 1: Un péptido caracterizado porque comprende una secuencia de aminoácidos de acuerdo con la fórmula (1): R1-X1-X2-GTFTSD-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-R2 (1) donde R1 es histidina, desamino-histidilo, dimetil-histidilo (N-dimetil-histidilo), b-hidroxiimidazopropionilo, 4-imidazoacetilo, b-carboxi imidazopropionilo o tirosina; X1 es Aib (ácido aminoisobutírico), d-alanina, glicina, Sar (N-metilglicina), serina o d-serina; X2 es ácido glutámico o glutamina; X3 es leucina o tirosina; X4 es serina o alanina; X5 es lisina o arginina; X6 es glutamina o tirosina; X7 es leucina o metionina; X8 es ácido aspártico o ácido glutámico; X9 es ácido glutámico, serina o a-metil-ácido glutámico, o bien ha sido suprimido; X10 es glutamina, ácido glutámico, lisina, arginina o serina, o bien ha sido suprimido; X11 es alanina, arginina o valina, o bien ha sido suprimido; X12 es alanina, arginina, serina o valina, o bien ha sido suprimido; X13 es lisina, glutamina, arginina o a-metil-ácido glutámico, o bien ha sido suprimido; X14 es ácido aspártico, ácido glutámico o leucina, o bien ha sido suprimido; X15 es fenilalanina o ha sido suprimido; X16 es isoleucina o valina, o bien ha sido suprimido; X17 es alanina, cisteína, ácido glutámico, lisina, glutamina o a-metil-ácido glutámico, o bien ha sido suprimido; X18 es triptofano o ha sido suprimido; X19 es alanina, isoleucina, leucina, serina o valina, o bien ha sido suprimido; X20 es alanina, lisina, metionina, glutamina o arginina, o bien ha sido suprimido; X21 es asparragina o ha sido suprimido; X22 es alanina, glicina o treonina, o bien ha sido suprimido; X23 es cisteína o lisina, o bien ha sido suprimido; X24 es un péptido que comprende entre 2 y 10 aminoácidos, que en particular consiste en combinaciones de alanina, glicina y serina, o bien ha sido suprimido; y R2 es KRNRNNIA (SEQ ID Nº 32), GPSSGAPPPS (SEQ ID Nº 33), GPSSGAPPPSK (SEQ ID Nº 34), HSQGTFTSDYSKYLD (SEQ ID Nº 35), HSQGTFTSDYSRYLDK (SEQ ID Nº 36) o HGEGTFTSDLSKQMEEEAVK (SEQ ID Nº 37), o bien ha sido suprimido (es decir, se lo excluye si la secuencia de aminoácidos de fórmula (1) es idéntica a SEQ ID Nº 1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20110056472 | 2011-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086866A1 true AR086866A1 (es) | 2014-01-29 |
Family
ID=47296599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120102030A AR086866A1 (es) | 2011-06-10 | 2012-06-07 | Derivados de oxintomodulina y composicion farmaceutica que los comprende para el tratamiento de la obesidad |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9527898B2 (es) |
| EP (3) | EP3878859B1 (es) |
| JP (5) | JP6014127B2 (es) |
| KR (2) | KR101502299B1 (es) |
| CN (1) | CN103732618B (es) |
| AR (1) | AR086866A1 (es) |
| AU (4) | AU2012267398B2 (es) |
| BR (2) | BR122020011001B1 (es) |
| CA (2) | CA3064214C (es) |
| CL (1) | CL2013003547A1 (es) |
| CY (1) | CY1120781T1 (es) |
| DK (3) | DK3434687T3 (es) |
| ES (3) | ES2692187T3 (es) |
| HR (1) | HRP20181591T1 (es) |
| HU (1) | HUE040307T2 (es) |
| IL (3) | IL245557B (es) |
| LT (1) | LT2718318T (es) |
| MX (2) | MX350708B (es) |
| MY (1) | MY169309A (es) |
| PE (3) | PE20240686A1 (es) |
| PL (1) | PL2718318T3 (es) |
| PT (1) | PT2718318T (es) |
| RS (1) | RS57711B1 (es) |
| RU (2) | RU2739209C2 (es) |
| SG (2) | SG10201604564XA (es) |
| SI (1) | SI2718318T1 (es) |
| TW (2) | TWI674271B (es) |
| UA (2) | UA114710C2 (es) |
| WO (1) | WO2012169798A2 (es) |
| ZA (1) | ZA201309054B (es) |
Families Citing this family (53)
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|---|---|---|---|---|
| KR101382593B1 (ko) * | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
| ES2692187T3 (es) | 2011-06-10 | 2018-11-30 | Hanmi Science Co., Ltd. | Nuevos derivados de oxintomodulina y composición farmacéutica para el tratamiento de obesidad que lo comprende |
| EP2721062B1 (en) * | 2011-06-17 | 2018-11-14 | Hanmi Science Co., Ltd. | A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof |
| JP6352806B2 (ja) | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー／エス | 新規のグルカゴン類似体 |
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| KR101968344B1 (ko) | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
| AR092873A1 (es) | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| KR101993393B1 (ko) * | 2012-11-06 | 2019-10-01 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물 |
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