PE20181299A1 - Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismos - Google Patents
Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismosInfo
- Publication number
- PE20181299A1 PE20181299A1 PE2018000633A PE2018000633A PE20181299A1 PE 20181299 A1 PE20181299 A1 PE 20181299A1 PE 2018000633 A PE2018000633 A PE 2018000633A PE 2018000633 A PE2018000633 A PE 2018000633A PE 20181299 A1 PE20181299 A1 PE 20181299A1
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- Prior art keywords
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- alanine
- serine
- acid
- glutamine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Referido a un peptido que comprende la siguiente secuencia aminoacidica: R1-X1-X2-GTFTSD-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-R2, en donde: R1 es histidina, desaminohistidilo, dimetilhistidilo (N-dimetilhistidilo), entre otros; X1 es Aib (acido aminoisobutirico), d-alanina, glicina, Sar (N-metilglicina), serina o d-serina; X2 es acido glutamico o glutamina; X3 es leucina o tirosina; X4 es serina o alanina; X5 es lisina o arginina; X6 es glutamina o tirosina; X7 es leucina o metionina; X8 es acido aspartico o acido glutamico; X9 es acido glutamico, serina, acido alfa-metilglutamico o esta suprimido; X10 es glutamina, acido glutamico, lisina, arginina, serina o esta suprimido; X11 es alanina, arginina, valina o esta suprimido; X12 es alanina, arginina, serina, valina o esta suprimido; X13 es lisina, glutamina, arginina, acido alfa-metilglutamico o esta suprimido; X14 es acido aspartico, acido glutamico, leucina o esta suprimido; X15 es fenilalanina o esta suprimido; X16 es isoleucina, valina o esta suprimido; X17 es alanina, cisteina, acido glutamico, lisina, glutamina, acido alfa-metilglutamico o esta suprimido; X18 es triptofano o esta suprimido; X19 es alanina, isoleucina, leucina, serina, valina o esta suprimido; X20 es alanina, lisina, metionina, glutamina, arginina o esta suprimido; X21 es asparagina o esta suprimido; X22 es alanina, glicina, treonina o esta suprimido; X23 es cisteina, lisina o esta suprimido; X24 es un peptido que tiene de 2 a 10 aminoacidos consistentes en combinaciones d alanina, glicina y serina, o esta suprimido; y R2 es KRNRNNIA (SEQ ID NO: 32), GPSSGAPPPS (SEQ ID NO.33), entre otros. Este peptido es un derivado de oxintomodulina capaz de activar el receptor de Peptido similar al glucagon tipo 1 (CLP-1) y el receptor de glucagon; mejor que la oxintomodulina nativa, ya que reduce la ingesta de alimento, suprime el vaciado gastrico y facilita la lipolisis sin efectos secundarios reducidos, y muestra tambien excelentes efectos activadores de receptor; por lo tanto, puede usarse en el tratamiento de la obesidad con seguridad y eficacia. Tambien se refiere a una composicion para la prevencion o el tratamiento de la obesidad que comprende el peptido como un ingrediente activo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR20110056472 | 2011-06-10 |
Publications (1)
Publication Number | Publication Date |
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PE20181299A1 true PE20181299A1 (es) | 2018-08-09 |
Family
ID=47296599
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002789A PE20140765A1 (es) | 2011-06-10 | 2012-06-07 | Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismos |
PE2023001927A PE20240686A1 (es) | 2011-06-10 | 2012-06-07 | Peptidos derivados de oxintomodulina con actividad sobre el receptor de glucagon y el receptor de peptido similar a glucagon de tipo 1 (glp-1) |
PE2018000633A PE20181299A1 (es) | 2011-06-10 | 2012-06-07 | Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismos |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002789A PE20140765A1 (es) | 2011-06-10 | 2012-06-07 | Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismos |
PE2023001927A PE20240686A1 (es) | 2011-06-10 | 2012-06-07 | Peptidos derivados de oxintomodulina con actividad sobre el receptor de glucagon y el receptor de peptido similar a glucagon de tipo 1 (glp-1) |
Country Status (30)
Country | Link |
---|---|
US (4) | US9527898B2 (es) |
EP (3) | EP3434687B1 (es) |
JP (5) | JP6014127B2 (es) |
KR (2) | KR101502299B1 (es) |
CN (1) | CN103732618B (es) |
AR (1) | AR086866A1 (es) |
AU (4) | AU2012267398B2 (es) |
BR (2) | BR112013031794B1 (es) |
CA (2) | CA3064214C (es) |
CL (1) | CL2013003547A1 (es) |
CY (1) | CY1120781T1 (es) |
DK (3) | DK3878859T3 (es) |
ES (3) | ES2875748T3 (es) |
HR (1) | HRP20181591T1 (es) |
HU (1) | HUE040307T2 (es) |
IL (3) | IL245557B (es) |
LT (1) | LT2718318T (es) |
MX (2) | MX350708B (es) |
MY (1) | MY169309A (es) |
PE (3) | PE20140765A1 (es) |
PL (1) | PL2718318T3 (es) |
PT (1) | PT2718318T (es) |
RS (1) | RS57711B1 (es) |
RU (2) | RU2612906C2 (es) |
SG (2) | SG10201604564XA (es) |
SI (1) | SI2718318T1 (es) |
TW (2) | TWI674271B (es) |
UA (2) | UA114710C2 (es) |
WO (1) | WO2012169798A2 (es) |
ZA (1) | ZA201309054B (es) |
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