MX354705B - Analogos de glucagon novedosos. - Google Patents
Analogos de glucagon novedosos.Info
- Publication number
- MX354705B MX354705B MX2014003312A MX2014003312A MX354705B MX 354705 B MX354705 B MX 354705B MX 2014003312 A MX2014003312 A MX 2014003312A MX 2014003312 A MX2014003312 A MX 2014003312A MX 354705 B MX354705 B MX 354705B
- Authority
- MX
- Mexico
- Prior art keywords
- glucagon peptides
- glucagon analogues
- novel glucagon
- novel
- hyperglycemia
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
Abstract
La presente invención se refiere a péptidos de glucagón, caracterizados porque comprende: SEQ ID NO. 1, en donde X24 es Lys y en donde por lo menos una de las siguientes sustituciones están presentes : X2 es His, C15 es Glu o X16 es Ala, Ile, Phe, Arg, Thr, Val, Leu Glu, Trp o Tyr, y hasta seis sustituciones de aminoácidos adicionales están presente en el péptido del glucagón y un sustituyente que comprende tres o más porciones cargadas negativamente, en donde una de las porciones cargadas negativamente está distal de una porción lipofílica y en donde el sustituyente ésta unido en el nitrógeno de la cadena lateral de Lys en la posición 24, o una sal, éster, amida o ácido farmacéuticamente aceptable del mismo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11182476 | 2011-09-23 | ||
US201161539148P | 2011-09-26 | 2011-09-26 | |
PCT/EP2012/068649 WO2013041678A1 (en) | 2011-09-23 | 2012-09-21 | Novel glucagon analogues |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014003312A MX2014003312A (es) | 2014-04-25 |
MX354705B true MX354705B (es) | 2018-03-16 |
Family
ID=47911932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014003312A MX354705B (es) | 2011-09-23 | 2012-09-21 | Analogos de glucagon novedosos. |
Country Status (17)
Country | Link |
---|---|
US (4) | US8541368B2 (es) |
EP (1) | EP2758426B1 (es) |
JP (2) | JP6352806B2 (es) |
KR (1) | KR20140070612A (es) |
CN (1) | CN104093735B (es) |
AR (1) | AR088161A1 (es) |
AU (1) | AU2012311484B2 (es) |
BR (1) | BR112014006684A2 (es) |
CA (1) | CA2849673A1 (es) |
IL (1) | IL231199A0 (es) |
IN (1) | IN2014CN02448A (es) |
MX (1) | MX354705B (es) |
MY (1) | MY167234A (es) |
RU (2) | RU2017101333A (es) |
TW (1) | TWI596110B (es) |
WO (1) | WO2013041678A1 (es) |
ZA (1) | ZA201401603B (es) |
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JP6352806B2 (ja) | 2011-09-23 | 2018-07-04 | ノヴォ ノルディスク アー/エス | 新規のグルカゴン類似体 |
MX356641B (es) | 2012-05-03 | 2018-06-07 | Zealand Pharma As | Compuestos agonistas dobles de gip-glp-1 y procedimientos. |
NZ704043A (en) * | 2012-07-23 | 2017-07-28 | Zealand Pharma As | Glucagon analogues |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
AU2013366691A1 (en) | 2012-12-21 | 2015-07-09 | Sanofi | Exendin-4 derivatives |
HUE045573T2 (hu) * | 2013-04-18 | 2020-01-28 | Novo Nordisk As | Stabil, hosszú hatóidejû GLP-1/glükagon receptor ko-agonisták, gyógyászati alkalmazásra |
RU2683039C2 (ru) | 2013-04-18 | 2019-03-26 | Ново Нордиск А/С | Стабильные совместные агонисты рецептора глюкагоноподобного пептида-1/глюкагона пролонгированного действия для медицинского применения |
KR20160021183A (ko) | 2013-06-20 | 2016-02-24 | 노보 노르디스크 에이/에스 | Glp-1 유도체 및 그것의 용도 |
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US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
EP3065767B1 (en) | 2013-11-06 | 2020-12-30 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
MX369770B (es) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Compuestos agonistas triples de glucagón-glp-1-gip. |
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CN106999602B (zh) | 2014-11-27 | 2022-02-01 | 诺和诺德股份有限公司 | Glp-1衍生物及其用途 |
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- 2012-09-21 BR BR112014006684A patent/BR112014006684A2/pt not_active Application Discontinuation
- 2012-09-21 CA CA2849673A patent/CA2849673A1/en not_active Withdrawn
- 2012-09-21 MY MYPI2014000627A patent/MY167234A/en unknown
- 2012-09-21 CN CN201280057736.1A patent/CN104093735B/zh not_active Expired - Fee Related
- 2012-09-21 TW TW101134663A patent/TWI596110B/zh not_active IP Right Cessation
- 2012-09-21 EP EP12759773.0A patent/EP2758426B1/en active Active
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- 2012-09-21 WO PCT/EP2012/068649 patent/WO2013041678A1/en active Application Filing
- 2012-09-21 MX MX2014003312A patent/MX354705B/es active IP Right Grant
- 2012-09-21 RU RU2017101333A patent/RU2017101333A/ru unknown
- 2012-09-21 KR KR1020147010449A patent/KR20140070612A/ko not_active Application Discontinuation
- 2012-09-21 AU AU2012311484A patent/AU2012311484B2/en not_active Ceased
- 2012-09-21 US US13/624,387 patent/US8541368B2/en active Active
- 2012-09-21 RU RU2014114434A patent/RU2610175C2/ru not_active IP Right Cessation
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CA2849673A1 (en) | 2013-03-28 |
BR112014006684A2 (pt) | 2017-03-28 |
AU2012311484B2 (en) | 2017-04-13 |
RU2610175C2 (ru) | 2017-02-08 |
AR088161A1 (es) | 2014-05-14 |
AU2012311484A1 (en) | 2014-03-06 |
RU2017101333A (ru) | 2018-12-19 |
JP2018021081A (ja) | 2018-02-08 |
RU2014114434A (ru) | 2015-10-27 |
EP2758426B1 (en) | 2019-08-07 |
CN104093735B (zh) | 2018-07-06 |
JP2014527975A (ja) | 2014-10-23 |
JP6352806B2 (ja) | 2018-07-04 |
ZA201401603B (en) | 2015-02-25 |
US9486505B2 (en) | 2016-11-08 |
EP2758426A1 (en) | 2014-07-30 |
TWI596110B (zh) | 2017-08-21 |
US20160347812A1 (en) | 2016-12-01 |
IL231199A0 (en) | 2014-04-30 |
WO2013041678A1 (en) | 2013-03-28 |
US20150182594A1 (en) | 2015-07-02 |
MX2014003312A (es) | 2014-04-25 |
US9486506B2 (en) | 2016-11-08 |
US20130288958A1 (en) | 2013-10-31 |
MY167234A (en) | 2018-08-14 |
IN2014CN02448A (es) | 2015-06-19 |
KR20140070612A (ko) | 2014-06-10 |
US20130079278A1 (en) | 2013-03-28 |
CN104093735A (zh) | 2014-10-08 |
TW201329102A (zh) | 2013-07-16 |
US8541368B2 (en) | 2013-09-24 |
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