SG10201809427SA - Insulin receptor partial agonists - Google Patents

Insulin receptor partial agonists

Info

Publication number
SG10201809427SA
SG10201809427SA SG10201809427SA SG10201809427SA SG10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA
Authority
SG
Singapore
Prior art keywords
partial agonists
insulin receptor
receptor partial
insulin
dimers
Prior art date
Application number
SG10201809427SA
Inventor
Songnian Lin
Lin Yan
Pei Huo
Dmitri Pissarnitski
Danqing Feng
Ravi Nargund
Yuping Zhu
Ahmet Kekec
Christina Madsen-Duggan
Zhi-Cai Shi
Zhicai Wu
Yingjun Mu
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of SG10201809427SA publication Critical patent/SG10201809427SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

INSULIN RECEPTOR PARTIAL AGONISTS OF THE DISCLOSURE Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed. 5 [No Fig Available] 10 [Fig 1]
SG10201809427SA 2014-11-21 2015-11-19 Insulin receptor partial agonists SG10201809427SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462082857P 2014-11-21 2014-11-21
US201562242503P 2015-10-16 2015-10-16

Publications (1)

Publication Number Publication Date
SG10201809427SA true SG10201809427SA (en) 2018-11-29

Family

ID=54838417

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201809427SA SG10201809427SA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists
SG10201809428UA SG10201809428UA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists
SG10201809457YA SG10201809457YA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists
SG11201704064TA SG11201704064TA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists

Family Applications After (3)

Application Number Title Priority Date Filing Date
SG10201809428UA SG10201809428UA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists
SG10201809457YA SG10201809457YA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists
SG11201704064TA SG11201704064TA (en) 2014-11-21 2015-11-19 Insulin receptor partial agonists

Country Status (27)

Country Link
US (4) US20170355743A1 (en)
EP (4) EP3666792A3 (en)
JP (5) JP6484337B2 (en)
KR (2) KR102101136B1 (en)
CN (2) CN112494656B (en)
AR (1) AR102712A1 (en)
AU (3) AU2015349890B2 (en)
BR (3) BR122024000898A2 (en)
CA (2) CA3014641C (en)
CL (3) CL2017001288A1 (en)
CO (1) CO2017004976A2 (en)
CR (1) CR20170208A (en)
DO (1) DOP2017000124A (en)
EA (1) EA036714B1 (en)
ES (1) ES2946247T3 (en)
GT (1) GT201700104A (en)
IL (1) IL252257A0 (en)
MX (3) MX2017006651A (en)
NI (1) NI201700060A (en)
PE (1) PE20170957A1 (en)
PH (1) PH12017500935A1 (en)
SG (4) SG10201809427SA (en)
SV (1) SV2017005445A (en)
TN (1) TN2017000178A1 (en)
TW (1) TW201625673A (en)
WO (1) WO2016081670A2 (en)
ZA (1) ZA201703238B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3177612T3 (en) 2014-08-04 2022-05-16 Nuevolution As POSSIBLE FUSIONED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE DERIVATIVES USE FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGICAL AND AUTO-IMMUNE DISEASES
PH12017500935A1 (en) * 2014-11-21 2017-11-27 Merck Sharp & Dohme Insulin receptor partial agonists
AR105616A1 (en) 2015-05-07 2017-10-25 Lilly Co Eli FUSION PROTEINS
EP3463429A4 (en) * 2016-05-24 2020-07-22 Merck Sharp & Dohme Corp. Insulin receptor partial agonists and glp-1 analogues
EP3463413A4 (en) * 2016-05-25 2020-03-04 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
WO2018077851A1 (en) * 2016-10-24 2018-05-03 Novo Nordisk A/S Bioassay for insulin formulations
EP3668892A1 (en) 2017-08-17 2020-06-24 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
MX2021001284A (en) 2018-08-02 2021-07-15 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy.
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN112898172B (en) * 2019-12-04 2022-05-31 中国科学院大连化学物理研究所 Synthesis method of amphiphilic functional group compound capable of being enzymolyzed by carboxypeptidase
MX2022007265A (en) 2019-12-20 2022-09-09 Nuevolution As Compounds active towards nuclear receptors.
MX2022012260A (en) 2020-03-31 2022-11-30 Nuevolution As Compounds active towards nuclear receptors.
MX2022012259A (en) 2020-03-31 2022-12-08 Nuevolution As Compounds active towards nuclear receptors.
WO2022051665A1 (en) * 2020-09-03 2022-03-10 Dyne Therapeutics, Inc. Methods of preparing protein-oligonucleotide complexes
WO2022055877A2 (en) * 2020-09-09 2022-03-17 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11648318B2 (en) 2021-07-09 2023-05-16 Dyne Therapeutics, Inc. Anti-transferrin receptor (TFR) antibody and uses thereof
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11931421B2 (en) 2022-04-15 2024-03-19 Dyne Therapeutics, Inc. Muscle targeting complexes and formulations for treating myotonic dystrophy

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3907763A (en) 1972-03-01 1975-09-23 Bayer Ag Insulin derivatives crosslinked by a dicarboxylic acid moiety
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
US5304473A (en) 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
WO1995016708A1 (en) 1993-12-17 1995-06-22 Novo Nordisk A/S Proinsulin-like compounds
EP0741188A3 (en) 1995-05-05 1999-07-14 Eli Lilly And Company Single chain insulin with high bioactivity
AU4672699A (en) * 1998-06-08 1999-12-30 Theravance, Inc. Novel sodium channel drugs and uses
DE19908041A1 (en) * 1999-02-24 2000-08-31 Hoecker Hartwig Covalently bridged insulin dimers
KR100449454B1 (en) 2000-10-02 2004-09-21 이현철 Vector for Curing Diabetes Mellitus Containing Gene of Single-chain Insulin Analog
US6852694B2 (en) 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
US7105314B2 (en) 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
DK2226316T3 (en) 2002-05-30 2016-04-11 Scripps Research Inst Copper catalyzed ligation of azides and acetylenes
KR100507796B1 (en) 2003-04-03 2005-08-17 한미약품 주식회사 Peg-biologically active polypeptide homodimer conjugate having enhanced half life in blood and process for the preparation thereof
JP5697831B2 (en) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス Single chain insulin
EP1807105A2 (en) 2004-10-27 2007-07-18 Novo Nordisk A/S Insulin receptor binding peptides with non-insulin gene activation profiles and uses thereof
WO2006050262A2 (en) 2004-11-01 2006-05-11 The Regents Of The University Of California Compositions and methods for modification of biomolecules
US20100216690A1 (en) 2005-03-18 2010-08-26 Novo Nordisk A/S Pegylated Single-Chain Insulin
US20090069216A1 (en) 2006-02-21 2009-03-12 Novo Nordisk A/S Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
WO2007104734A1 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
WO2007104736A2 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
JP2009530242A (en) 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー／エス Acylated single chain insulin
JP2009530243A (en) 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー／エス Acylated single chain insulin
JP5256199B2 (en) 2006-08-07 2013-08-07 テヴァ バイオファーマシューティカルズ ユーエスエー，インコーポレーティッド Albumin-insulin fusion protein
WO2008145721A2 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S N-terminal modification of polypeptides for protection against degradation by aminopeptidases
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
NZ588857A (en) 2008-04-22 2012-07-27 Univ Case Western Reserve Isoform-specific insulin analogue for control blood sugar levels
TWI394580B (en) 2008-04-28 2013-05-01 Halozyme Inc Super fast-acting insulin compositions
LT2349324T (en) * 2008-10-17 2017-12-27 Sanofi-Aventis Deutschland Gmbh Combination of an insulin and a glp-1 agonist
CN102245624B (en) 2008-12-19 2016-08-10 印第安纳大学研究及科技有限公司 Insulin prodrug based on amide
CN102256992B (en) 2008-12-19 2015-04-22 印第安纳大学研究及科技有限公司 Insulin analogs
WO2011059895A1 (en) 2009-11-11 2011-05-19 Quest Diagnostics Investments Incorporated Hexa mutations
US8940860B2 (en) * 2010-06-16 2015-01-27 Indiana University Research And Technology Corporation Single-chain insulin agonists exhibiting high activity at the insulin receptor
US8255297B2 (en) 2010-07-20 2012-08-28 Facebook, Inc. Creation, redemption, and accounting in a virtual currency system
US20140315797A1 (en) 2010-10-15 2014-10-23 Peter Madsen Novel N-Terminally Modified Insulin Derivatives
KR20150021011A (en) * 2011-10-27 2015-02-27 케이스 웨스턴 리저브 유니버시티 Ultra-concentrated rapid-acting insulin analogue formulations
AU2013323669B2 (en) 2012-09-26 2018-03-01 Indiana University Research And Technology Corporation Insulin analog dimers
JP2016517404A (en) 2013-03-15 2016-06-16 ユニベルシテ ドゥ ジュネーブ Insulin production induction method and use thereof
EP3052134B1 (en) * 2013-10-04 2021-05-05 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
WO2015073575A2 (en) * 2013-11-12 2015-05-21 Centre For Probe Development And Commercialization Residualizing linkers and uses thereof
MA43289B1 (en) 2014-01-20 2019-12-31 Hanmi Pharm Ind Co Ltd Long-acting insulin and associated use
PH12017500935A1 (en) * 2014-11-21 2017-11-27 Merck Sharp & Dohme Insulin receptor partial agonists

Also Published As

Publication number Publication date
MX2020014120A (en) 2021-03-25
CN112494656B (en) 2024-01-30
CN108064173B (en) 2021-05-18
SV2017005445A (en) 2018-04-04
JP2018501203A (en) 2018-01-18
KR20170084300A (en) 2017-07-19
DOP2017000124A (en) 2017-08-15
MX2017006651A (en) 2017-08-21
US20170355743A1 (en) 2017-12-14
EP3660040A3 (en) 2020-07-29
AU2018211208B2 (en) 2020-09-10
EP3660041A1 (en) 2020-06-03
TN2017000178A1 (en) 2018-10-19
JP2019014734A (en) 2019-01-31
CA3014641A1 (en) 2016-05-26
CL2017001288A1 (en) 2017-12-15
EP3660040A2 (en) 2020-06-03
JP6703068B2 (en) 2020-06-03
CA3014641C (en) 2020-08-18
SG10201809428UA (en) 2018-11-29
JP6931033B2 (en) 2021-09-01
CN112494656A (en) 2021-03-16
ES2946247T3 (en) 2023-07-14
CR20170208A (en) 2017-07-17
BR112017010481A2 (en) 2018-04-03
EP3666792A3 (en) 2020-07-29
PE20170957A1 (en) 2017-07-13
CA2966765C (en) 2020-04-14
AR102712A1 (en) 2017-03-22
US10800827B2 (en) 2020-10-13
EA036714B1 (en) 2020-12-10
BR122024000898A2 (en) 2024-02-27
SG10201809457YA (en) 2018-11-29
KR102101136B1 (en) 2020-04-14
NI201700060A (en) 2017-07-18
EP3666792A2 (en) 2020-06-17
AU2018211207A1 (en) 2018-08-16
US10017556B2 (en) 2018-07-10
US20180291078A1 (en) 2018-10-11
EP3660041B1 (en) 2023-04-19
SG11201704064TA (en) 2017-06-29
PH12017500935A1 (en) 2017-11-27
TW201625673A (en) 2016-07-16
IL252257A0 (en) 2017-07-31
EA201791117A1 (en) 2017-11-30
AU2018211208A1 (en) 2018-08-16
CN108064173A (en) 2018-05-22
JP6943825B2 (en) 2021-10-06
US10183981B2 (en) 2019-01-22
JP6484337B2 (en) 2019-03-13
AU2015349890B2 (en) 2018-08-30
AU2015349890A1 (en) 2017-06-01
MX2020014121A (en) 2021-03-25
US20190092833A1 (en) 2019-03-28
EP3221343A2 (en) 2017-09-27
US20170107268A1 (en) 2017-04-20
CL2019001144A1 (en) 2019-07-19
JP2019014735A (en) 2019-01-31
WO2016081670A3 (en) 2016-08-04
CL2019001143A1 (en) 2019-07-19
WO2016081670A2 (en) 2016-05-26
ZA201703238B (en) 2018-05-30
CA2966765A1 (en) 2016-05-26
EP3221343B1 (en) 2020-09-16
AU2018211207B2 (en) 2020-04-09
KR102049647B1 (en) 2019-11-29
BR122024000903A2 (en) 2024-02-27
KR20190069622A (en) 2019-06-19
GT201700104A (en) 2018-11-27
BR112017010481A8 (en) 2023-04-11
JP2019011357A (en) 2019-01-24
CO2017004976A2 (en) 2017-10-10
JP2020097572A (en) 2020-06-25

Similar Documents

Publication Publication Date Title
SG10201809427SA (en) Insulin receptor partial agonists
PH12020550781A1 (en) Anti-jagged1 antibodies and methods of use
PH12018500711A1 (en) Anti-pd1 antibodies and methods of use
PH12017500877A1 (en) ANTI-CD79b ANTIBODIES AND METHODS OF USE
MX2017005920A (en) Anti-tim3 antibodies and methods of use.
MY193723A (en) Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1
MX2017003022A (en) Anti-cll-1 antibodies and immunoconjugates.
MX2020004073A (en) Seed train processes and uses thereof.
MX2016015162A (en) Anti-gpc3 antibodies and immunoconjugates.
MX2020012893A (en) Protein formulations.
MX2016016233A (en) Anti-lgr5 antibodies and uses thereof.
MX2019011297A (en) Insulin analog complex with reduced affinity for insulin receptor and use thereof.
MX2016015280A (en) Anti-brdu antibodies and methods of use.
MY167350A (en) Fat-and-oil composition and chocolate
NZ719451A (en) Glucagon analog for treatment of severe hypoglycemia
MA40642A (en) Novel peptide derivatives and uses thereof
EA201991576A1 (en) PARTIAL INSULIN RECEPTOR AGONISTS
NZ744340A (en) Anti-jagged1 antibodies and methods of use
UA99992U (en) 2,34-tetrahydropyridin-6-thiolate