MX366400B - Analogo de insulina novedoso y su uso. - Google Patents

Analogo de insulina novedoso y su uso.

Info

Publication number
MX366400B
MX366400B MX2015010471A MX2015010471A MX366400B MX 366400 B MX366400 B MX 366400B MX 2015010471 A MX2015010471 A MX 2015010471A MX 2015010471 A MX2015010471 A MX 2015010471A MX 366400 B MX366400 B MX 366400B
Authority
MX
Mexico
Prior art keywords
insulin
insulin analog
conjugate
novel insulin
analog
Prior art date
Application number
MX2015010471A
Other languages
English (en)
Other versions
MX2015010471A (es
Inventor
Dae Jin Kim
Se Chang Kwon
Sung Youb Jung
In Young Choi
Myung Hyun Jang
Yong Ho Huh
Seung Su Kim
Hyun Uk Kim
Sung Hee Hong
Sang Youn Hwang
Jin Young Kim
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of MX2015010471A publication Critical patent/MX2015010471A/es
Publication of MX366400B publication Critical patent/MX366400B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

La presente invención se refiere a un análogo de insulina que tiene un título de insulina reducido y una afinidad de unión del receptor de insulina reducida en comparación con la forma natural con el fin de incrementar la semivida de la insulina en sangre, un conjugado que se prepara enlazando el análogo de insulina y un vehículo, una formulación de acción prolongada que incluye el conjugado y un procedimiento para preparar el conjugado.
MX2015010471A 2013-02-26 2014-02-26 Analogo de insulina novedoso y su uso. MX366400B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20130020703 2013-02-26
KR20130082511 2013-07-12
KR20140006937 2014-01-20
PCT/KR2014/001593 WO2014133324A1 (ko) 2013-02-26 2014-02-26 신규한 인슐린 아날로그 및 이의 용도

Publications (2)

Publication Number Publication Date
MX2015010471A MX2015010471A (es) 2016-04-25
MX366400B true MX366400B (es) 2019-07-08

Family

ID=51428522

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015010471A MX366400B (es) 2013-02-26 2014-02-26 Analogo de insulina novedoso y su uso.

Country Status (25)

Country Link
US (2) US20160008483A1 (es)
EP (2) EP2963056B1 (es)
JP (3) JP6552968B2 (es)
KR (2) KR20140106452A (es)
CN (2) CN114989289A (es)
AU (2) AU2014221531B2 (es)
BR (1) BR112015019985A2 (es)
CA (1) CA2901873C (es)
CL (1) CL2015002330A1 (es)
DK (1) DK2963056T3 (es)
ES (2) ES2770776T3 (es)
HK (1) HK1211944A1 (es)
IL (1) IL240717B (es)
MX (1) MX366400B (es)
MY (1) MY186990A (es)
PE (2) PE20151409A1 (es)
PH (1) PH12015501814A1 (es)
PT (1) PT2963056T (es)
RU (1) RU2676729C2 (es)
SA (2) SA515360933B1 (es)
SG (2) SG10201907106VA (es)
TW (3) TWI621626B (es)
UA (1) UA119533C2 (es)
WO (1) WO2014133324A1 (es)
ZA (1) ZA201507104B (es)

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AR090281A1 (es) * 2012-03-08 2014-10-29 Hanmi Science Co Ltd Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo
AU2014221531B2 (en) * 2013-02-26 2018-08-23 Hanmi Pharm. Co., Ltd. Novel insulin analog and use thereof
MA39301A1 (fr) * 2014-01-20 2018-01-31 Hanmi Pharmaceutical Co Ltd Insuline à action prolongée et utilisation associée
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
KR20150140177A (ko) 2014-06-05 2015-12-15 한미약품 주식회사 단백질 및 펩타이드의 면역원성을 감소시키는 방법
CN107810202A (zh) * 2015-02-17 2018-03-16 韩美药品株式会社 长效胰岛素或胰岛素类似物复合物
TW201718022A (zh) 2015-07-24 2017-06-01 韓美藥品股份有限公司 製備生理活性多肽接合物的方法
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
KR20170036643A (ko) * 2015-09-24 2017-04-03 한미약품 주식회사 인슐린의 제조 방법
RU2764197C1 (ru) * 2016-09-23 2022-01-14 Ханми Фарм. Ко., Лтд. Аналоги инсулина с пониженной аффинностью к рецептору инсулина и их применение
US20200078470A1 (en) 2016-12-05 2020-03-12 Hanmi Pharm. Co., Ltd. Conjugate with attenuated immune response
HUE055417T2 (hu) 2016-12-09 2021-11-29 Akston Biosciences Corp Inzulin-Fc fúziók és alkalmazási eljárások
EP3578204A4 (en) * 2017-02-03 2021-01-06 Hanmi Pharm. Co., Ltd. BIOACTIVE SUBSTANCE CONJUGATE WITH ENHANCED DURABILITY AND ITS USE
EP3581208A4 (en) 2017-02-07 2020-12-30 Hanmi Pharm. Co., Ltd. NON-PEPTIDIC BINDING COMPOUND, CONJUGATE INCLUDING ITS BINDING COMPOUND, AND METHODS FOR PREPARING SUCH BINDING COMPOUND AND CONJUGATE
KR101941975B1 (ko) 2017-03-17 2019-01-25 고려대학교 산학협력단 Atpif1을 함유하는 당뇨 치료용 약학조성물
BR112019019823A2 (pt) * 2017-03-23 2020-04-22 Hanmi Pharm Ind Co Ltd conjugado, composição farmacêutica para prevenir ou tratar diabetes e método para tratamento de diabetes
US11357861B2 (en) 2017-09-29 2022-06-14 Hanmi Pharm. Co., Ltd Protein complex comprising non-peptidyl polymer-coupled fatty acid derivative compound as linker and preparation method therefor
WO2019066603A1 (ko) 2017-09-29 2019-04-04 한미약품 주식회사 효력이 향상된 지속성 단백질 결합체
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
WO2020006529A1 (en) 2018-06-29 2020-01-02 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
SG11202106168VA (en) 2018-12-11 2021-07-29 Sanofi Sa Insulin analogs having reduced insulin receptor binding affinity
US20220088148A1 (en) 2018-12-21 2022-03-24 Hanmi Pharm, Co., Ltd. A pharmaceutical composition comprising insulin and trigonal glucagon/glp-1/gip receptor agonist
BR112021011557A2 (pt) 2018-12-21 2021-09-14 Hanmi Pharm. Co., Ltd. Formulação complexa e composição farmacêutica incluindo insulina e glucagon
TW202120536A (zh) * 2019-07-31 2021-06-01 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
US11352407B2 (en) 2019-12-19 2022-06-07 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
IL295826A (en) 2020-03-31 2022-10-01 Hanmi Pharm Ind Co Ltd Novel il-2 analogs that stimulate the immune system
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
AU2021253926B2 (en) 2020-04-10 2022-07-21 Akston Biosciences Corporation Antigen specific immunotherapy for COVID-19 fusion proteins and methods of use
CN117487026A (zh) * 2020-07-24 2024-02-02 江苏晟斯生物制药有限公司 胰岛素-Fc融合蛋白及其应用
US11667689B2 (en) 2021-07-23 2023-06-06 Akston Biosciences Corporation Insulin-Fc fusion proteins and methods of use to treat cancer
CN117881691A (zh) * 2021-08-02 2024-04-12 丝芭博株式会社 多孔质体及其制造方法
CN117769616A (zh) * 2021-08-02 2024-03-26 丝芭博株式会社 合成皮革及其制造方法

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Also Published As

Publication number Publication date
SA515360933B1 (ar) 2018-12-23
IL240717A0 (en) 2015-10-29
CN104995206A (zh) 2015-10-21
AU2018267648B2 (en) 2020-04-16
EP3616727A1 (en) 2020-03-04
SG11201506095TA (en) 2015-09-29
EP2963056A1 (en) 2016-01-06
DK2963056T3 (da) 2020-02-17
ZA201507104B (en) 2019-04-24
JP2016510003A (ja) 2016-04-04
NZ710882A (en) 2021-01-29
CA2901873C (en) 2022-05-03
CN114989289A (zh) 2022-09-02
JP6552968B2 (ja) 2019-07-31
SA518400491B1 (ar) 2022-04-07
TWI755579B (zh) 2022-02-21
NZ751062A (en) 2021-04-30
PE20151409A1 (es) 2015-10-07
UA119533C2 (uk) 2019-07-10
IL240717B (en) 2020-05-31
TW201817741A (zh) 2018-05-16
ES2770776T3 (es) 2020-07-03
JP2019187440A (ja) 2019-10-31
PH12015501814B1 (en) 2015-12-07
KR102413691B1 (ko) 2022-06-28
PH12015501814A1 (en) 2015-12-07
EP3616727B1 (en) 2021-03-31
BR112015019985A2 (pt) 2017-08-29
TW201920243A (zh) 2019-06-01
AU2018267648A1 (en) 2018-12-13
CN104995206B (zh) 2022-04-12
TWI708782B (zh) 2020-11-01
PE20191481A1 (es) 2019-10-18
JP2021193089A (ja) 2021-12-23
WO2014133324A1 (ko) 2014-09-04
EP2963056A4 (en) 2017-06-07
ES2868351T3 (es) 2021-10-21
RU2676729C2 (ru) 2019-01-10
KR20140106452A (ko) 2014-09-03
MY186990A (en) 2021-08-26
AU2014221531B2 (en) 2018-08-23
EP2963056B1 (en) 2019-11-13
PT2963056T (pt) 2020-02-19
RU2015138536A (ru) 2017-04-03
TW201520224A (zh) 2015-06-01
US20160008483A1 (en) 2016-01-14
AU2014221531A1 (en) 2015-08-27
CA2901873A1 (en) 2014-09-04
CL2015002330A1 (es) 2015-12-28
TWI621626B (zh) 2018-04-21
SG10201907106VA (en) 2019-09-27
MX2015010471A (es) 2016-04-25
KR20210109491A (ko) 2021-09-06
US20180256731A1 (en) 2018-09-13
HK1211944A1 (en) 2016-06-03

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