MX2015010471A - Analogo de insulina novedoso y su uso. - Google Patents
Analogo de insulina novedoso y su uso.Info
- Publication number
- MX2015010471A MX2015010471A MX2015010471A MX2015010471A MX2015010471A MX 2015010471 A MX2015010471 A MX 2015010471A MX 2015010471 A MX2015010471 A MX 2015010471A MX 2015010471 A MX2015010471 A MX 2015010471A MX 2015010471 A MX2015010471 A MX 2015010471A
- Authority
- MX
- Mexico
- Prior art keywords
- insulin
- insulin analog
- conjugate
- novel insulin
- analog
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 7
- 239000004026 insulin derivative Substances 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 102000003746 Insulin Receptor Human genes 0.000 abstract 1
- 108010001127 Insulin Receptor Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000013265 extended release Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a un análogo de insulina que tiene un título de insulina reducido y una afinidad de unión del receptor de insulina reducida en comparación con la forma natural con el fin de incrementar la semivida de la insulina en sangre, un conjugado que se prepara enlazando el análogo de insulina y un vehículo, una formulación de acción prolongada que incluye el conjugado y un procedimiento para preparar el conjugado.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130020703 | 2013-02-26 | ||
| KR20130082511 | 2013-07-12 | ||
| KR20140006937 | 2014-01-20 | ||
| PCT/KR2014/001593 WO2014133324A1 (ko) | 2013-02-26 | 2014-02-26 | 신규한 인슐린 아날로그 및 이의 용도 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015010471A true MX2015010471A (es) | 2016-04-25 |
| MX366400B MX366400B (es) | 2019-07-08 |
Family
ID=51428522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015010471A MX366400B (es) | 2013-02-26 | 2014-02-26 | Analogo de insulina novedoso y su uso. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20160008483A1 (es) |
| EP (2) | EP2963056B1 (es) |
| JP (3) | JP6552968B2 (es) |
| KR (2) | KR20140106452A (es) |
| CN (2) | CN114989289A (es) |
| AU (2) | AU2014221531B2 (es) |
| BR (1) | BR112015019985A2 (es) |
| CA (1) | CA2901873C (es) |
| CL (1) | CL2015002330A1 (es) |
| DK (1) | DK2963056T3 (es) |
| ES (2) | ES2770776T3 (es) |
| HK (1) | HK1211944A1 (es) |
| IL (1) | IL240717B (es) |
| MX (1) | MX366400B (es) |
| MY (1) | MY186990A (es) |
| PE (2) | PE20151409A1 (es) |
| PH (1) | PH12015501814A1 (es) |
| PT (1) | PT2963056T (es) |
| RU (1) | RU2676729C2 (es) |
| SA (2) | SA515360933B1 (es) |
| SG (2) | SG11201506095TA (es) |
| TW (3) | TWI621626B (es) |
| UA (1) | UA119533C2 (es) |
| WO (1) | WO2014133324A1 (es) |
| ZA (1) | ZA201507104B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) * | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| UA119533C2 (uk) * | 2013-02-26 | 2019-07-10 | Ханмі Фарм. Ко., Лтд. | Аналог інсуліну та його застосування |
| BR112016016578A2 (pt) * | 2014-01-20 | 2017-10-03 | Hanmi Pharm Ind Co Ltd | Insulina de ação prolongada e uso daanálogo de insulina, polinucleotídeo, vetor de expressão, transformante, insulina de ação prolongada bem como seu método de preparação e formulação da mesma, conjugado, e uso do mesmo mesma |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
| KR20150140177A (ko) | 2014-06-05 | 2015-12-15 | 한미약품 주식회사 | 단백질 및 펩타이드의 면역원성을 감소시키는 방법 |
| WO2016133372A2 (ko) * | 2015-02-17 | 2016-08-25 | 한미약품 주식회사 | 지속형 인슐린 또는 이의 아날로그 결합체 |
| EP3325496B1 (en) | 2015-07-24 | 2024-02-07 | Hanmi Pharm. Co., Ltd. | Method of preparing physiologically active polypeptide conjugate |
| UY36870A (es) * | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| CN108473548A (zh) * | 2015-09-24 | 2018-08-31 | 韩美药品股份有限公司 | 胰岛素生产方法 |
| TWI774694B (zh) * | 2016-09-23 | 2022-08-21 | 南韓商韓美藥品股份有限公司 | 具有降低對胰島素受體之親和力之胰島素類似物及其用途 |
| WO2018105988A1 (ko) | 2016-12-05 | 2018-06-14 | 한미약품 주식회사 | 면역반응이 약화된 결합체 |
| WO2018107117A1 (en) | 2016-12-09 | 2018-06-14 | Akston Biosciences Corporation | Insulin-fc fusions and methods of use |
| MX2019009149A (es) * | 2017-02-03 | 2019-10-14 | Hanmi Pharm Ind Co Ltd | Conjugado de material bioactivo que tiene sustentabilidad mejorada y uso del mismo. |
| CN110545852B (zh) | 2017-02-07 | 2023-05-26 | 韩美药品株式会社 | 非肽聚合物接头化合物、包含该接头化合物的缀合物及制备该接头化合物和缀合物的方法 |
| KR101941975B1 (ko) | 2017-03-17 | 2019-01-25 | 고려대학교 산학협력단 | Atpif1을 함유하는 당뇨 치료용 약학조성물 |
| BR112019019823A2 (pt) * | 2017-03-23 | 2020-04-22 | Hanmi Pharm Ind Co Ltd | conjugado, composição farmacêutica para prevenir ou tratar diabetes e método para tratamento de diabetes |
| JP7377195B2 (ja) | 2017-09-29 | 2023-11-09 | ハンミ ファーマシューティカル カンパニー リミテッド | リンカーとして非ペプチド性重合体結合脂肪酸誘導体化合物を含むタンパク質結合体及びその製造方法 |
| US20200283492A1 (en) * | 2017-09-29 | 2020-09-10 | Hanmi Pharm Co., Ltd. | Long acting protein complex having an enhanced efficiency |
| SI3892628T1 (sl) | 2018-06-29 | 2023-01-31 | Akston Biosciences Corporation | Ultra dolgo delujoči inzulin-fc-fuzijski proteini in postopki za uporabo |
| US11267862B2 (en) | 2018-06-29 | 2022-03-08 | Akston Biosciences Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| EP3893934A1 (en) | 2018-12-11 | 2021-10-20 | Sanofi | Insulin conjugates |
| CN113453703A (zh) | 2018-12-21 | 2021-09-28 | 韩美药品株式会社 | 包括胰岛素和对胰高血糖素和glp-1和gip受体均具有活性的三重激动剂的药物组合物 |
| CN113365651A (zh) | 2018-12-21 | 2021-09-07 | 韩美药品株式会社 | 包含胰岛素和胰高血糖素的药物组合物 |
| CA3145491A1 (en) * | 2019-07-31 | 2021-02-04 | Stacey Lynn Lee | Relaxin analogs and methods of using the same |
| WO2021126584A1 (en) * | 2019-12-19 | 2021-06-24 | Akston Biosciences Corporation | Ultra-long acting insulin-fc fusion proteins and methods of use |
| US11186623B2 (en) | 2019-12-24 | 2021-11-30 | Akston Bioscience Corporation | Ultra-long acting insulin-Fc fusion proteins and methods of use |
| MX2022011893A (es) | 2020-03-31 | 2022-10-18 | Hanmi Pharm Ind Co Ltd | Nuevos analogos de il-2 inmunoestimuladores. |
| US11192930B2 (en) | 2020-04-10 | 2021-12-07 | Askton Bioscences Corporation | Ultra-long acting insulin-Fc fusion protein and methods of use |
| HUE062716T2 (hu) | 2020-04-10 | 2023-11-28 | Akston Biosciences Corp | Antigénspecifikus immunterápia COVID-19 fúziós fehérjékhez és az alkalmazási eljárások |
| CA3189527A1 (en) * | 2020-07-24 | 2022-01-27 | Jiangsu Gensciences Inc. | Insulin-fc fusion protein and application thereof |
| WO2023004406A2 (en) | 2021-07-23 | 2023-01-26 | Akston Biosciences Corporation | Insulin-fc fusion proteins and methods of use to treat cancer |
| EP4382532A1 (en) * | 2021-08-02 | 2024-06-12 | Spiber Inc. | Porous body and method for producing same |
| CN117769616A (zh) * | 2021-08-02 | 2024-03-26 | 丝芭博株式会社 | 合成皮革及其制造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| DE19735711C2 (de) * | 1997-08-18 | 2001-04-26 | Aventis Pharma Gmbh | Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
| WO2009010428A1 (en) * | 2007-07-16 | 2009-01-22 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
| WO2010080606A1 (en) * | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Insulin analogs |
| WO2011028813A2 (en) * | 2009-09-01 | 2011-03-10 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| AR081066A1 (es) * | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| KR101324828B1 (ko) * | 2010-06-08 | 2013-11-01 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체 |
| WO2012015692A2 (en) * | 2010-07-28 | 2012-02-02 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
| UA119533C2 (uk) * | 2013-02-26 | 2019-07-10 | Ханмі Фарм. Ко., Лтд. | Аналог інсуліну та його застосування |
-
2014
- 2014-02-26 UA UAA201507940A patent/UA119533C2/uk unknown
- 2014-02-26 DK DK14757629.2T patent/DK2963056T3/da active
- 2014-02-26 CA CA2901873A patent/CA2901873C/en active Active
- 2014-02-26 MY MYPI2015001870A patent/MY186990A/en unknown
- 2014-02-26 ES ES14757629T patent/ES2770776T3/es active Active
- 2014-02-26 SG SG11201506095TA patent/SG11201506095TA/en unknown
- 2014-02-26 EP EP14757629.2A patent/EP2963056B1/en active Active
- 2014-02-26 TW TW103106674A patent/TWI621626B/zh active
- 2014-02-26 CN CN202210291419.1A patent/CN114989289A/zh active Pending
- 2014-02-26 MX MX2015010471A patent/MX366400B/es active IP Right Grant
- 2014-02-26 TW TW106143717A patent/TWI708782B/zh active
- 2014-02-26 ES ES19197388T patent/ES2868351T3/es active Active
- 2014-02-26 KR KR1020140022909A patent/KR20140106452A/ko not_active IP Right Cessation
- 2014-02-26 PE PE2015001747A patent/PE20151409A1/es active IP Right Grant
- 2014-02-26 US US14/769,495 patent/US20160008483A1/en not_active Abandoned
- 2014-02-26 BR BR112015019985A patent/BR112015019985A2/pt active Search and Examination
- 2014-02-26 TW TW108100374A patent/TWI755579B/zh active
- 2014-02-26 PT PT147576292T patent/PT2963056T/pt unknown
- 2014-02-26 RU RU2015138536A patent/RU2676729C2/ru active
- 2014-02-26 JP JP2015559199A patent/JP6552968B2/ja active Active
- 2014-02-26 PE PE2019001804A patent/PE20191481A1/es unknown
- 2014-02-26 AU AU2014221531A patent/AU2014221531B2/en active Active
- 2014-02-26 SG SG10201907106VA patent/SG10201907106VA/en unknown
- 2014-02-26 CN CN201480006998.4A patent/CN104995206B/zh active Active
- 2014-02-26 EP EP19197388.2A patent/EP3616727B1/en active Active
- 2014-02-26 WO PCT/KR2014/001593 patent/WO2014133324A1/ko active Application Filing
-
2015
- 2015-08-18 PH PH12015501814A patent/PH12015501814A1/en unknown
- 2015-08-19 CL CL2015002330A patent/CL2015002330A1/es unknown
- 2015-08-20 IL IL240717A patent/IL240717B/en active IP Right Grant
- 2015-08-23 SA SA515360933A patent/SA515360933B1/ar unknown
- 2015-08-23 SA SA518400491A patent/SA518400491B1/ar unknown
- 2015-09-25 ZA ZA2015/07104A patent/ZA201507104B/en unknown
- 2015-12-18 HK HK15112526.1A patent/HK1211944A1/xx unknown
-
2018
- 2018-05-18 US US15/983,923 patent/US20180256731A1/en not_active Abandoned
- 2018-11-22 AU AU2018267648A patent/AU2018267648B2/en active Active
-
2019
- 2019-07-03 JP JP2019124525A patent/JP2019187440A/ja active Pending
-
2021
- 2021-08-19 JP JP2021133932A patent/JP2021193089A/ja active Pending
- 2021-08-19 KR KR1020210109688A patent/KR102413691B1/ko active IP Right Grant
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015501814A1 (en) | Novel insulin analog and use thereof | |
| HUS2300002I1 (hu) | Emberi antitest optimálása, amelyek limfocita aktivációs Gén-3-at (LAG-3) kötnek és azok felhasználása | |
| PH12016501414A1 (en) | Long-acting insulin and use thereof | |
| MX2015000962A (es) | COMPLEJO CRISTALINO DE 1-CIANO-2-(4-CICLOPROPIL-BENCIL)-4-(ß-D-GLU COPIRANOS-1-IL)-BENCENO, METODOS PARA SU PREPARACION Y SU USO PARA PREPARAR MEDICAMENTOS. | |
| PH12016500781A1 (en) | Novel anti-claudin antibodies and methods of use | |
| MX363512B (es) | Proceso de glicoconjugacion. | |
| PH12016501109A1 (en) | Novel anti-dpep3 antibodies and methods of use | |
| EP2891485A4 (en) | METHOD FOR THE PRODUCTION OF MICRO BEADS FOR EMBOLI AND METHOD FOR THE PRODUCTION OF MICRO BEADS FOR BINDING OF ACTIVE SUPPORTING SUPPLEMENTS THEREOF | |
| WO2014197849A3 (en) | Anti-c10orf54 antibodies and uses thereof | |
| NZ629697A (en) | Human anti-cd27 antibodies, methods and uses | |
| EP2824107A4 (en) | ANSA-METALLOCENE COMPOUND AND PROCESS FOR PREPARING SUPPORTED CATALYST USING THE SAME | |
| MX2013008390A (es) | Preparacion de estructuras de metal-triazolato. | |
| MX341578B (es) | Tratamiento de la osteoartritis y del dolor. | |
| ZA201404625B (en) | Polycyclic derivatives, preparation method and medical uses thereof | |
| MX347882B (es) | Procedimiento mejorado para preparar (3e, 7e)-homofarnesol. | |
| MX2015002482A (es) | Composicion inmunogenica. | |
| AR094904A1 (es) | Análogos de insulina y su uso | |
| ZA201409023B (en) | Immunogenic compounds comprising hiv gp41 peptide coupled to crm197 carrier protein | |
| WO2012047267A3 (en) | Polyvalent immunogen | |
| MY189459A (en) | Anti-cancer agents and preparation thereof | |
| TR201904585T4 (tr) | Göz yorgunluğu ve rahatsızlığını bertaraf etmek ve hafifletmek için göz ferahlatıcı madde. | |
| MX2012012489A (es) | Preparacion de polipeptidos y sales de los mismos. | |
| UA98596C2 (ru) | Способ определения иммунного ответа у новорожденных после операции артериального переключения с использованием аутологичной пуповинной крови |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |