MX2015000962A - COMPLEJO CRISTALINO DE 1-CIANO-2-(4-CICLOPROPIL-BENCIL)-4-(ß-D-GLU COPIRANOS-1-IL)-BENCENO, METODOS PARA SU PREPARACION Y SU USO PARA PREPARAR MEDICAMENTOS. - Google Patents

COMPLEJO CRISTALINO DE 1-CIANO-2-(4-CICLOPROPIL-BENCIL)-4-(ß-D-GLU COPIRANOS-1-IL)-BENCENO, METODOS PARA SU PREPARACION Y SU USO PARA PREPARAR MEDICAMENTOS.

Info

Publication number
MX2015000962A
MX2015000962A MX2015000962A MX2015000962A MX2015000962A MX 2015000962 A MX2015000962 A MX 2015000962A MX 2015000962 A MX2015000962 A MX 2015000962A MX 2015000962 A MX2015000962 A MX 2015000962A MX 2015000962 A MX2015000962 A MX 2015000962A
Authority
MX
Mexico
Prior art keywords
glucopyranos
cyclopropyl
cyano
benzyl
benzene
Prior art date
Application number
MX2015000962A
Other languages
English (en)
Other versions
MX357906B (es
Inventor
Frank Himmelsbach
Matthias Eckhardt
Tanja Butz
Hans-Juergen Martin
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of MX2015000962A publication Critical patent/MX2015000962A/es
Publication of MX357906B publication Critical patent/MX357906B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a un complejo cristalino de 1-ciano-2-(4-ciclopropil-bencil)-4-(ß-D-glucopiranos-1-il)-bencen o y un aminoácido natural, a métodos para su preparación, así como a sus usos para preparar medicamentos.
MX2015000962A 2012-07-26 2013-07-25 COMPLEJO CRISTALINO DE 1-CIANO-2-(4-CICLOPROPIL-BENCIL)-4-(ß-D-GLU COPIRANOS-1-IL)-BENCENO, MÉTODOS PARA SU PREPARACIÓN Y SU USO PARA PREPARAR MEDICAMENTOS. MX357906B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12177944 2012-07-26
PCT/EP2013/065736 WO2014016381A1 (en) 2012-07-26 2013-07-25 CRYSTALLINE COMPLEX OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß- D-GLUCOPYRANOS-1-YL)-BENZENE, METHODS FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS

Publications (2)

Publication Number Publication Date
MX2015000962A true MX2015000962A (es) 2015-04-16
MX357906B MX357906B (es) 2018-07-30

Family

ID=48874313

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015000962A MX357906B (es) 2012-07-26 2013-07-25 COMPLEJO CRISTALINO DE 1-CIANO-2-(4-CICLOPROPIL-BENCIL)-4-(ß-D-GLU COPIRANOS-1-IL)-BENCENO, MÉTODOS PARA SU PREPARACIÓN Y SU USO PARA PREPARAR MEDICAMENTOS.

Country Status (23)

Country Link
US (1) US9145434B2 (es)
EP (3) EP3351539B1 (es)
JP (2) JP6538556B2 (es)
CN (2) CN104470908A (es)
AR (1) AR091908A1 (es)
AU (1) AU2013294947B2 (es)
BR (1) BR112015001327B1 (es)
CA (1) CA2878698C (es)
DK (2) DK2877460T3 (es)
EA (2) EA201600506A1 (es)
ES (2) ES2694675T3 (es)
FI (1) FI3351539T3 (es)
HR (2) HRP20230081T1 (es)
HU (1) HUE061450T2 (es)
LT (1) LT3351539T (es)
MX (1) MX357906B (es)
PL (2) PL2877460T3 (es)
PT (2) PT3351539T (es)
RS (1) RS63881B1 (es)
SG (1) SG11201500574QA (es)
SI (2) SI2877460T1 (es)
TW (1) TW201418275A (es)
WO (1) WO2014016381A1 (es)

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US9145434B2 (en) 2012-07-26 2015-09-29 Boehringer Ingelheim International Gmbh Crystalline complex of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ss-d-glucopyranos-1-yl)-benzene, methods for its preparation and the use thereof for preparing medicaments
PL2981269T3 (pl) 2013-04-04 2024-02-05 Boehringer Ingelheim Vetmedica Gmbh Leczenie zaburzeń metabolicznych u zwierząt koniowatych
HUE053906T2 (hu) 2013-12-17 2021-07-28 Boehringer Ingelheim Vetmedica Gmbh SGLT2-inhibitorok macskafélék közé tartozó állatok anyagcsere-rendellenességeinek kezelésére
US10603300B2 (en) * 2014-01-23 2020-03-31 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in canine animals
PT3125882T (pt) 2014-04-01 2020-08-17 Boehringer Ingelheim Vetmedica Gmbh Tratamento de distúrbios metabólicos em animais equinos
CN103965020B (zh) * 2014-05-06 2015-09-09 启东东岳药业有限公司 制备5-碘-2-溴苄醇的方法
KR102539788B1 (ko) 2014-09-25 2023-06-07 베링거잉겔하임베트메디카게엠베하 말과 동물의 대사 장애를 예방하기 위한 sglt2 억제제와 도파민 작용제의 병용 치료
HUE052588T2 (hu) * 2014-09-30 2021-05-28 Jiangsu Hengrui Medicine Co Az L-prolin/nátrium-glukóz kotranszporter 2 gátló kristály komplexének kristálya
CZ2015110A3 (cs) * 2015-02-18 2016-08-31 Zentiva, K.S. Pevné formy empagliflozinu
CN107995862B8 (zh) 2015-08-27 2021-12-03 勃林格殷格翰维特梅迪卡有限公司 包含sglt-2抑制剂之液态药物组合物
WO2017203457A1 (en) * 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Solid state forms of empagliflozin
WO2017206827A1 (zh) 2016-05-28 2017-12-07 山东轩竹医药科技有限公司 钠-葡萄糖协同转运蛋白2抑制剂的晶型
CA3085671A1 (en) 2017-12-19 2019-06-27 Boehringer Ingelheim Vetmedica Gmbh Synthesis of the 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(beta-d-glucopyranos-1 -yl)-benzene, l-proline and water
EP4064854A1 (en) 2019-11-28 2022-10-05 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors in the drying-off of non-human mammals
EP4106744A1 (en) 2020-02-17 2022-12-28 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in felines
EP4376830A1 (en) 2021-07-28 2024-06-05 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals
WO2023006718A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in non-human mammals excluding felines, in particular canines
WO2023006745A1 (en) 2021-07-28 2023-02-02 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
WO2023227492A1 (en) 2022-05-25 2023-11-30 Boehringer Ingelheim Vetmedica Gmbh Aqueous pharmaceutical compositions comprising sglt-2 inhibitors

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258141T3 (es) * 2001-04-11 2006-08-16 Bristol-Myers Squibb Company Complejos de aminoacidos de glucosidos c-arilo para el tratamiento de la diabetes y procedimiento.
US7927613B2 (en) * 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7375213B2 (en) * 2003-01-03 2008-05-20 Bristol-Myers Squibb Company Methods of producing C-aryl glucoside SGLT2 inhibitors
CA2557801C (en) * 2004-03-16 2013-06-25 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
EP1926720B1 (en) * 2005-09-08 2010-12-15 Boehringer Ingelheim International GmbH CRYSTALLINE FORMS OF 1-CHLORO-4-(ß-D-GLUCOPYRANOS-1-YL)-2-(4-ETHYNYL-BENZYL)-BENZENE, METHODS FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS
AR059489A1 (es) 2006-02-15 2008-04-09 Boehringer Ingelheim Vetmed Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
TWI370818B (en) * 2006-04-05 2012-08-21 Astellas Pharma Inc Cocrystal of c-glycoside derivative and l-proline
PE20080697A1 (es) * 2006-05-03 2008-08-05 Boehringer Ingelheim Int Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
TW200817424A (en) 2006-08-04 2008-04-16 Daiichi Sankyo Co Ltd Benzylphenyl glucopyranoside derivatives
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WO2008144346A2 (en) * 2007-05-18 2008-11-27 Bristol-Myers Squibb Company Crystal structures of sglt2 inhibitors and processes for their preparation
CN103319445B (zh) * 2007-12-27 2016-01-20 阿斯利康公司 Sglt2抑制剂的晶体结构及其制备方法
NZ591818A (en) * 2008-08-22 2013-01-25 Theracos Inc Processes for the preparation of sglt2 inhibitors
JP4825322B1 (ja) 2008-08-28 2011-11-30 ファイザー・インク ジオキサ−ビシクロ［３．２．１］オクタン−２，３，４−トリオール誘導体
US20100167988A1 (en) 2008-10-22 2010-07-01 Auspex Pharmaceuticals, Inc. Ethoxyphenylmethyl inhibitors of sglt2
WO2011153712A1 (en) * 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
US9145434B2 (en) 2012-07-26 2015-09-29 Boehringer Ingelheim International Gmbh Crystalline complex of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ss-d-glucopyranos-1-yl)-benzene, methods for its preparation and the use thereof for preparing medicaments
PL2981269T3 (pl) 2013-04-04 2024-02-05 Boehringer Ingelheim Vetmedica Gmbh Leczenie zaburzeń metabolicznych u zwierząt koniowatych

Also Published As

Publication number Publication date
FI3351539T3 (fi) 2023-02-19
ES2937665T3 (es) 2023-03-30
EP3351539A1 (en) 2018-07-25
PL3351539T3 (pl) 2023-03-06
BR112015001327B1 (pt) 2022-08-16
CA2878698C (en) 2021-03-23
WO2014016381A1 (en) 2014-01-30
EA025438B1 (ru) 2016-12-30
JP2015522644A (ja) 2015-08-06
AU2013294947A1 (en) 2015-01-22
MX357906B (es) 2018-07-30
AU2013294947B2 (en) 2017-03-30
CN104470908A (zh) 2015-03-25
CN108774200A (zh) 2018-11-09
BR112015001327A2 (pt) 2017-07-04
ES2694675T3 (es) 2018-12-26
EP3351539B1 (en) 2022-11-09
PL2877460T3 (pl) 2019-04-30
SI2877460T1 (sl) 2018-12-31
TW201418275A (zh) 2014-05-16
JP6538556B2 (ja) 2019-07-03
DK3351539T3 (da) 2023-01-30
US9145434B2 (en) 2015-09-29
SG11201500574QA (en) 2015-02-27
US20140031540A1 (en) 2014-01-30
EA201600506A1 (ru) 2017-03-31
DK2877460T3 (en) 2019-01-07
CA2878698A1 (en) 2014-01-30
PT3351539T (pt) 2023-01-17
HRP20230081T1 (hr) 2023-03-17
SI3351539T1 (sl) 2023-03-31
EP2877460B1 (en) 2018-09-12
AR091908A1 (es) 2015-03-11
EP4166548A1 (en) 2023-04-19
RS63881B1 (sr) 2023-02-28
EA201500038A1 (ru) 2015-07-30
LT3351539T (lt) 2023-02-10
HRP20181972T1 (hr) 2019-01-25
JP2018135384A (ja) 2018-08-30
HUE061450T2 (hu) 2023-07-28
EP2877460A1 (en) 2015-06-03
PT2877460T (pt) 2018-12-19

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