BRPI0820535B8 - composições farmacêuticas contendo insulina e um peptídeo insulinotrópico - Google Patents
composições farmacêuticas contendo insulina e um peptídeo insulinotrópicoInfo
- Publication number
- BRPI0820535B8 BRPI0820535B8 BRPI0820535A BRPI0820535A BRPI0820535B8 BR PI0820535 B8 BRPI0820535 B8 BR PI0820535B8 BR PI0820535 A BRPI0820535 A BR PI0820535A BR PI0820535 A BRPI0820535 A BR PI0820535A BR PI0820535 B8 BRPI0820535 B8 BR PI0820535B8
- Authority
- BR
- Brazil
- Prior art keywords
- compositions containing
- pharmaceutical compositions
- containing insulin
- insulinotropic peptide
- peptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
composições farmacêuticas contendo insulina e um peptídeo insulinotrópico. a presente invenção refere-se a uma composição farmacêutica para a administração parenteral compreendendo um peptídeo de insulina basal e um peptídeo de glp-1 insulinotrópico compreendendo pelo menos 6 átomos de zinco por 6 moléculas de insulina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07120880.5 | 2007-11-16 | ||
EP07120880 | 2007-11-16 | ||
PCT/EP2008/065601 WO2009063072A2 (en) | 2007-11-16 | 2008-11-14 | Pharmaceutical compositions containing insulin and an insulinotropic peptide |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0820535A2 BRPI0820535A2 (pt) | 2016-06-21 |
BRPI0820535A8 BRPI0820535A8 (pt) | 2016-10-18 |
BRPI0820535B1 BRPI0820535B1 (pt) | 2020-09-29 |
BRPI0820535B8 true BRPI0820535B8 (pt) | 2021-05-25 |
Family
ID=40639234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0820535A BRPI0820535B8 (pt) | 2007-11-16 | 2008-11-14 | composições farmacêuticas contendo insulina e um peptídeo insulinotrópico |
Country Status (15)
Country | Link |
---|---|
US (1) | US8937042B2 (pt) |
EP (2) | EP2209800B1 (pt) |
JP (2) | JP5241849B2 (pt) |
CN (3) | CN107412742B (pt) |
BR (1) | BRPI0820535B8 (pt) |
CA (1) | CA2705821A1 (pt) |
DK (1) | DK2597103T3 (pt) |
ES (2) | ES2612736T3 (pt) |
HU (2) | HUE030383T2 (pt) |
MX (1) | MX2010005245A (pt) |
NO (1) | NO2017015I2 (pt) |
PL (2) | PL2597103T3 (pt) |
PT (1) | PT2597103T (pt) |
WO (1) | WO2009063072A2 (pt) |
ZA (1) | ZA201003019B (pt) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
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US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
EP1660531A2 (en) * | 2003-08-05 | 2006-05-31 | Novo Nordisk A/S | Novel insulin derivatives |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PL1969004T3 (pl) * | 2005-12-28 | 2012-01-31 | Novo Nordisk As | Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji |
ATE557037T1 (de) | 2006-02-27 | 2012-05-15 | Novo Nordisk As | Insulin derivate |
EA015687B1 (ru) | 2006-05-04 | 2011-10-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Полиморфы |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
ES2744384T3 (es) | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
PE20090938A1 (es) | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo |
CN102037008B (zh) | 2008-03-18 | 2016-08-31 | 诺沃-诺迪斯克有限公司 | 蛋白酶稳定化的、酰化胰岛素类似物 |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
MX2011002558A (es) | 2008-09-10 | 2011-04-26 | Boehringer Ingelheim Int | Terapia de combinacion para el tratamiento de diabetes y estados relacionados. |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
LT2349324T (lt) | 2008-10-17 | 2017-12-27 | Sanofi-Aventis Deutschland Gmbh | Insulino ir glp-1 agonisto derinys |
JP4959005B2 (ja) | 2008-10-30 | 2012-06-20 | ノボ・ノルデイスク・エー/エス | 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療 |
CA2745037C (en) | 2008-12-23 | 2020-06-23 | Boehringer Ingelheim International Gmbh | Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
CN102307577A (zh) | 2009-02-13 | 2012-01-04 | 贝林格尔.英格海姆国际有限公司 | 包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途 |
TWI468171B (zh) | 2009-11-13 | 2015-01-11 | Sanofi Aventis Deutschland | 含glp-1激動劑及甲硫胺酸之醫藥組成物 |
ES2855146T3 (es) | 2009-11-13 | 2021-09-23 | Sanofi Aventis Deutschland | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
CN107115530A (zh) | 2009-11-27 | 2017-09-01 | 勃林格殷格翰国际有限公司 | 基因型糖尿病患者利用dpp‑iv抑制剂例如利拉利汀的治疗 |
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AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
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KR20220025926A (ko) * | 2010-06-24 | 2022-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
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- 2008-11-14 PL PL13155712T patent/PL2597103T3/pl unknown
- 2008-11-14 CN CN201710279962.9A patent/CN107412742B/zh active Active
- 2008-11-14 ES ES13155712.6T patent/ES2612736T3/es active Active
- 2008-11-14 ES ES08849536T patent/ES2430042T3/es active Active
- 2008-11-14 EP EP08849536.1A patent/EP2209800B1/en active Active
- 2008-11-14 EP EP13155712.6A patent/EP2597103B1/en active Active
- 2008-11-14 CA CA2705821A patent/CA2705821A1/en not_active Abandoned
- 2008-11-14 CN CN200880116227A patent/CN101861333A/zh not_active Withdrawn
- 2008-11-14 PL PL08849536T patent/PL2209800T3/pl unknown
- 2008-11-14 JP JP2010533601A patent/JP5241849B2/ja active Active
- 2008-11-14 PT PT131557126T patent/PT2597103T/pt unknown
- 2008-11-14 BR BRPI0820535A patent/BRPI0820535B8/pt active IP Right Grant
- 2008-11-14 HU HUE13155712A patent/HUE030383T2/en unknown
- 2008-11-14 CN CN201611159339.1A patent/CN107115523A/zh active Pending
- 2008-11-14 DK DK13155712.6T patent/DK2597103T3/en active
- 2008-11-14 US US12/741,923 patent/US8937042B2/en active Active
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BRPI0820535A8 (pt) | 2016-10-18 |
DK2597103T3 (en) | 2017-02-13 |
JP5757530B2 (ja) | 2015-07-29 |
PL2209800T3 (pl) | 2013-12-31 |
CN101861333A (zh) | 2010-10-13 |
EP2209800A2 (en) | 2010-07-28 |
ES2612736T3 (es) | 2017-05-18 |
HUS1700016I1 (hu) | 2017-05-29 |
CA2705821A1 (en) | 2009-05-22 |
CN107115523A (zh) | 2017-09-01 |
PT2597103T (pt) | 2017-02-08 |
BRPI0820535B1 (pt) | 2020-09-29 |
HUE030383T2 (en) | 2017-05-29 |
PL2597103T3 (pl) | 2017-04-28 |
CN107412742B (zh) | 2022-03-15 |
JP5241849B2 (ja) | 2013-07-17 |
JP2011503152A (ja) | 2011-01-27 |
CN107412742A (zh) | 2017-12-01 |
NO2017015I1 (no) | 2017-04-21 |
BRPI0820535A2 (pt) | 2016-06-21 |
NO2017015I2 (no) | 2017-04-21 |
WO2009063072A2 (en) | 2009-05-22 |
MX2010005245A (es) | 2010-06-01 |
EP2209800B1 (en) | 2013-07-24 |
US20110152185A1 (en) | 2011-06-23 |
WO2009063072A3 (en) | 2010-01-07 |
ES2430042T3 (es) | 2013-11-18 |
ZA201003019B (en) | 2011-06-29 |
JP2012229214A (ja) | 2012-11-22 |
US8937042B2 (en) | 2015-01-20 |
EP2597103A1 (en) | 2013-05-29 |
EP2597103B1 (en) | 2016-11-02 |
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