CN102307577A - 包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途 - Google Patents
包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途 Download PDFInfo
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Abstract
Description
实施方式 | DPPIV抑制剂 | 第三种抗糖尿病药 |
E1.1 | 选自G2组 | 选自G3组 |
E1.2 | 选自G2组 | 二甲双胍 |
E1.3 | 选自G2组 | 吡格列酮 |
E1.4 | 选自G2组 | 罗格列酮 |
E1.5 | 选自G2组 | 格列本脲 |
E1.6 | 选自G2组 | 格列美脲 |
E1.7 | 选自G2组 | 格列喹酮 |
E1.8 | 选自G2组 | 那格列奈 |
E1.9 | 选自G2组 | 瑞格列奈 |
E1.10 | 利拉列汀 | 选自G3组 |
E1.11 | 利拉列汀 | 二甲双胍 |
E1.12 | 利拉列汀 | 吡格列酮 |
E1.13 | 利拉列汀 | 罗格列酮 |
E1.14 | 利拉列汀 | 格列本脲 |
E1.15 | 利拉列汀 | 格列美脲 |
E1.16 | 利拉列汀 | 格列喹酮 |
E1.17 | 利拉列汀 | 那格列奈 |
E1.18 | 利拉列汀 | 瑞格列奈 |
E1.19 | 西他列汀 | 选自G3组 |
E1.20 | 西他列汀 | 二甲双胍 |
E1.21 | 西他列汀 | 吡格列酮 |
E1.22 | 西他列汀 | 罗格列酮 |
E1.23 | 西他列汀 | 格列本脲 |
E1.24 | 西他列汀 | 格列美脲 |
E1.25 | 西他列汀 | 格列喹酮 |
E1.26 | 西他列汀 | 那格列奈 |
E1.27 | 西他列汀 | 瑞格列奈 |
E1.28 | 维格列汀 | 选自G3组 |
E1.29 | 维格列汀 | 二甲双胍 |
E1.30 | 维格列汀 | 吡格列酮 |
E1.31 | 维格列汀 | 罗格列酮 |
E1.32 | 维格列汀 | 格列本脲 |
E1.33 | 维格列汀 | 格列美脲 |
E1.34 | 维格列汀 | 格列喹酮 |
E1.35 | 维格列汀 | 那格列奈 |
E1.36 | 维格列汀 | 瑞格列奈 |
E1.37 | 阿格列汀 | 选自G3组 |
E1.38 | 阿格列汀 | 二甲双胍 |
E1.39 | 阿格列汀 | 吡格列酮 |
E1.40 | 阿格列汀 | 罗格列酮 |
E1.41 | 阿格列汀 | 格列本脲 |
E1.42 | 阿格列汀 | 格列美脲 |
E1.43 | 阿格列汀 | 格列喹酮 |
E1.44 | 阿格列汀 | 那格列奈 |
E1.45 | 阿格列汀 | 瑞格列奈 |
E1.46 | 萨格列汀 | 选自G3组 |
E1.47 | 萨格列汀 | 二甲双胍 |
E1.48 | 萨格列汀 | 吡格列酮 |
E1.49 | 萨格列汀 | 罗格列酮 |
E1.50 | 萨格列汀 | 格列本脲 |
E1.51 | 萨格列汀 | 格列美脲 |
E1.52 | 萨格列汀 | 格列喹酮 |
E1.53 | 萨格列汀 | 那格列奈 |
E1.54 | 萨格列汀 | 瑞格列奈 |
E1.55 | 卡格列汀 | 选自G3组 |
E1.56 | 卡格列汀 | 二甲双胍 |
E1.57 | 卡格列汀 | 吡格列酮 |
E1.58 | 卡格列汀 | 罗格列酮 |
E1.59 | 卡格列汀 | 格列本脲 |
E1.60 | 卡格列汀 | 格列美脲 |
E1.61 | 卡格列汀 | 格列喹酮 |
E1.62 | 卡格列汀 | 那格列奈 |
E1.63 | 卡格列汀 | 瑞格列奈 |
E1.64 | 美格列汀 | 选自G3组 |
E1.65 | 美格列汀 | 二甲双胍 |
E1.66 | 美格列汀 | 吡格列酮 |
E1.67 | 美格列汀 | 罗格列酮 |
E1.68 | 美格列汀 | 格列本脲 |
E1.69 | 美格列汀 | 格列美脲 |
E1.70 | 美格列汀 | 格列喹酮 |
E1.71 | 美格列汀 | 那格列奈 |
E1.72 | 美格列汀 | 瑞格列奈 |
E1.73 | 度格列汀 | 选自G3组 |
E1.74 | 度格列汀 | 二甲双胍 |
E1.75 | 度格列汀 | 吡格列酮 |
E1.76 | 度格列汀 | 罗格列酮 |
E1.77 | 度格列汀 | 格列本脲 |
E1.78 | 度格列汀 | 格列美脲 |
E1.79 | 度格列汀 | 格列喹酮 |
E1.80 | 度格列汀 | 那格列奈 |
E1.81 | 度格列汀 | 瑞格列奈 |
实施方式 | SGLT2抑制剂 | 第三种抗糖尿病药 |
E2.1 | 选自G1组 | 选自G3组 |
E2.2 | 选自G1组 | 二甲双胍 |
E2.3 | 选自G1组 | 吡格列酮 |
E2.4 | 选自G1组 | 罗格列酮 |
E2.5 | 选自G1组 | 格列本脲 |
E2.6 | 选自G1组 | 格列美脲 |
E2.7 | 选自G1组 | 格列喹酮 |
E2.8 | 选自G1组 | 那格列奈 |
E2.9 | 选自G1组 | 瑞格列奈 |
E2.10 | 化合物(I.9) | 选自G3组 |
E2.11 | 化合物(I.9) | 二甲双胍 |
E2.12 | 化合物(I.9) | 吡格列酮 |
E2.13 | 化合物(I.9) | 罗格列酮 |
E2.14 | 化合物(I.9) | 格列本脲 |
E2.15 | 化合物(I.9) | 格列美脲 |
E2.16 | 化合物(I.9) | 格列喹酮 |
E2.17 | 化合物(I.9) | 那格列奈 |
E2.18 | 化合物(I.9) | 瑞格列奈 |
E2.19 | 达格列净 | 选自G3组 |
E2.20 | 达格列净 | 二甲双胍 |
E2.21 | 达格列净 | 吡格列酮 |
E2.22 | 达格列净 | 罗格列酮 |
E2.23 | 达格列净 | 格列本脲 |
E2.24 | 达格列净 | 格列美脲 |
E2.25 | 达格列净 | 格列喹酮 |
E2.26 | 达格列净 | 那格列奈 |
E2.27 | 达格列净 | 瑞格列奈 |
E2.28 | 坎格列净 | 选自G3组 |
E2.29 | 坎格列净 | 二甲双胍 |
E2.30 | 坎格列净 | 吡格列酮 |
E2.31 | 坎格列净 | 罗格列酮 |
E2.32 | 坎格列净 | 格列本脲 |
E2.33 | 坎格列净 | 格列美脲 |
E2.34 | 坎格列净 | 格列喹酮 |
E2.35 | 坎格列净 | 那格列奈 |
E2.36 | 坎格列净 | 瑞格列奈 |
E2.37 | 阿格列净 | 选自G3组 |
E2.38 | 阿格列净 | 二甲双胍 |
E2.39 | 阿格列净 | 吡格列酮 |
E2.40 | 阿格列净 | 罗格列酮 |
E2.41 | 阿格列净 | 格列本脲 |
E2.42 | 阿格列净 | 格列美脲 |
E2.43 | 阿格列净 | 格列喹酮 |
E2.44 | 阿格列净 | 那格列奈 |
E2.45 | 阿格列净 | 瑞格列奈 |
E2.46 | 瑞格列净 | 选自G3组 |
E2.47 | 瑞格列净 | 二甲双胍 |
E2.48 | 瑞格列净 | 吡格列酮 |
E2.49 | 瑞格列净 | 罗格列酮 |
E2.50 | 瑞格列净 | 格列本脲 |
E2.51 | 瑞格列净 | 格列美脲 |
E2.52 | 瑞格列净 | 格列喹酮 |
E2.53 | 瑞格列净 | 那格列奈 |
E2.54 | 瑞格列净 | 瑞格列奈 |
E2.55 | 舍格列净 | 选自G3组 |
E2.56 | 舍格列净 | 二甲双胍 |
E2.57 | 舍格列净 | 吡格列酮 |
E2.58 | 舍格列净 | 罗格列酮 |
E2.59 | 舍格列净 | 格列本脲 |
E2.60 | 舍格列净 | 格列美脲 |
E2.61 | 舍格列净 | 格列喹酮 |
E2.62 | 舍格列净 | 那格列奈 |
E2.63 | 舍格列净 | 瑞格列奈 |
A | B | Met | A+Met | B+Met | A+B | A+B+Met | |
对照 | n.s. | n.s. | n.s. | # | * | * | ** |
A | n.s. | n.s. | * | * | ** | *** | |
B | n.s. | # | # | # | * | ||
Met | # | # | * | ** | |||
A+Met | n.s. | n.s. | * | ||||
B+Met | n.s. | * | |||||
A+B | * |
Claims (22)
Priority Applications (1)
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CN201510280410.0A CN104906582A (zh) | 2009-02-13 | 2010-02-11 | 包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途 |
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US15230209P | 2009-02-13 | 2009-02-13 | |
US61/152,302 | 2009-02-13 | ||
PCT/EP2010/051736 WO2010092125A1 (en) | 2009-02-13 | 2010-02-11 | Pharmaceutical composition comprising a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof |
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CN201510280410.0A Pending CN104906582A (zh) | 2009-02-13 | 2010-02-11 | 包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途 |
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Cited By (9)
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CN104203250A (zh) * | 2012-03-20 | 2014-12-10 | 勃林格殷格翰国际有限公司 | 包含依帕列净和减肥药的药物组合物 |
CN104418847A (zh) * | 2013-09-10 | 2015-03-18 | 天津药物研究院 | 4-(6-脱氧-β-D-吡喃葡萄糖基)-2-[5-(4-氟苯基)噻吩-2-甲基]-1-甲基苯的制备工艺 |
CN104739835A (zh) * | 2013-12-30 | 2015-07-01 | 中美华世通生物医药科技(武汉)有限公司 | 一种治疗糖尿病的新型药物组合物 |
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CN104418847A (zh) * | 2013-09-10 | 2015-03-18 | 天津药物研究院 | 4-(6-脱氧-β-D-吡喃葡萄糖基)-2-[5-(4-氟苯基)噻吩-2-甲基]-1-甲基苯的制备工艺 |
CN104739835A (zh) * | 2013-12-30 | 2015-07-01 | 中美华世通生物医药科技(武汉)有限公司 | 一种治疗糖尿病的新型药物组合物 |
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CN112512530A (zh) * | 2018-07-19 | 2021-03-16 | 阿斯利康(瑞典)有限公司 | 使用达格列净和包含达格列净的组合物治疗HFpEF的方法 |
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CN111870694B (zh) * | 2020-07-20 | 2022-01-14 | 重庆大学 | Sglt2抑制剂的用途 |
CN114671839A (zh) * | 2020-12-25 | 2022-06-28 | 天地恒一制药股份有限公司 | 达格列净的固体形式复合物及其制备方法与应用 |
CN114671839B (zh) * | 2020-12-25 | 2024-01-09 | 天地恒一制药股份有限公司 | 达格列净的固体形式复合物及其制备方法与应用 |
WO2024055932A1 (zh) * | 2022-09-13 | 2024-03-21 | 亚宝药业集团股份有限公司 | 氮杂环化合物、其药物组合物和用于预防和/或治疗疾病的用途 |
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