ATE557037T1 - Insulin derivate - Google Patents

Insulin derivate

Info

Publication number
ATE557037T1
ATE557037T1 AT10168840T AT10168840T ATE557037T1 AT E557037 T1 ATE557037 T1 AT E557037T1 AT 10168840 T AT10168840 T AT 10168840T AT 10168840 T AT10168840 T AT 10168840T AT E557037 T1 ATE557037 T1 AT E557037T1
Authority
AT
Austria
Prior art keywords
insulin derivatives
chain
amino group
present
lys residue
Prior art date
Application number
AT10168840T
Other languages
English (en)
Inventor
Charlotte Fynbo
Ib Jonassen
Thomas Berglum Kjeldsen
Peter Madsen
Patrick William Garibay
Janos Tibor Kodra
Thomas Hoeg-Jensen
Tina Moller Tagmose
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE557037T1 publication Critical patent/ATE557037T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT10168840T 2006-02-27 2007-02-27 Insulin derivate ATE557037T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06110441 2006-02-27
EP06118253 2006-08-01

Publications (1)

Publication Number Publication Date
ATE557037T1 true ATE557037T1 (de) 2012-05-15

Family

ID=38001155

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07712327T ATE482977T1 (de) 2006-02-27 2007-02-27 Insulinderivate
AT10168840T ATE557037T1 (de) 2006-02-27 2007-02-27 Insulin derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07712327T ATE482977T1 (de) 2006-02-27 2007-02-27 Insulinderivate

Country Status (7)

Country Link
US (1) US8722620B2 (de)
EP (2) EP1991576B1 (de)
JP (2) JP5202338B2 (de)
AT (2) ATE482977T1 (de)
DE (1) DE602007009496D1 (de)
ES (1) ES2387955T3 (de)
WO (1) WO2007096431A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2531988C (en) * 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives
JP4933455B2 (ja) 2005-02-02 2012-05-16 ノヴォ ノルディスク アー／エス 新規のインスリン誘導体
EP2292653B1 (de) 2005-02-02 2014-05-21 Novo Nordisk A/S Neuartige Insulinderivate
PT1969004E (pt) 2005-12-28 2011-11-25 Novo Nordisk As Composições que compreendem uma insulina acilada e zinco e método para criar tais composições
EP1991576B1 (de) 2006-02-27 2010-09-29 Novo Nordisk A/S Insulinderivate
JP5269766B2 (ja) * 2006-05-09 2013-08-21 ノボ・ノルデイスク・エー／エス インスリン誘導体
EP2386572B1 (de) * 2006-05-09 2015-07-08 Novo Nordisk A/S Insulinderivat
RU2524150C2 (ru) 2006-09-22 2014-07-27 Ново Нордиск А/С Аналоги инсулина, устойчивые к протеазам
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US9034818B2 (en) 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
AU2008288413B2 (en) 2007-08-15 2013-09-26 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
WO2009022006A1 (en) 2007-08-15 2009-02-19 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
US8710000B2 (en) 2007-11-08 2014-04-29 Novo Nordisk A/S Insulin derivative
US9260502B2 (en) 2008-03-14 2016-02-16 Novo Nordisk A/S Protease-stabilized insulin analogues
RU2571857C2 (ru) * 2008-03-18 2015-12-20 Ново Нордиск А/С Стабилизированные по отношению к протеазам ацилированные аналоги инсулина
WO2009121884A1 (en) 2008-04-01 2009-10-08 Novo Nordisk A/S Insulin albumin conjugates
AU2009309623B9 (en) * 2008-10-30 2014-10-02 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
WO2010088294A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Conjugate based systems for controlled drug delivery
AU2010208319A1 (en) 2009-01-28 2011-08-11 Smartcells, Inc. Crystalline insulin-conjugates
JP2012516340A (ja) 2009-01-28 2012-07-19 スマートセルズ・インコーポレイテツド 合成コンジュゲートおよびその使用
CA2754950A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
WO2010107520A1 (en) * 2009-03-20 2010-09-23 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
WO2011051486A2 (en) 2009-11-02 2011-05-05 Novo Nordisk A/S Pharmaceutical solution of non covalently bound albumin and acylated insulin
JP2013541500A (ja) 2010-07-28 2013-11-14 スマートセルズ・インコーポレイテツド 組換えレクチン、結合部位修飾レクチンおよびそれらの用途
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
US8933207B2 (en) 2010-07-28 2015-01-13 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CN103596584B (zh) * 2011-06-15 2016-12-14 诺沃—诺迪斯克有限公司 多取代的胰岛素
MX2014012096A (es) 2012-04-11 2014-11-21 Novo Nordisk As Formulaciones de insulina.
EP2991672A1 (de) 2013-04-30 2016-03-09 Novo Nordisk A/S Neuartiges verabreichungsschema
MX366852B (es) 2013-10-04 2019-07-25 Merck Sharp & Dohme Conjugados de insulina sensibles a glucosa.
KR20160065126A (ko) 2013-10-07 2016-06-08 노보 노르디스크 에이/에스 인슐린 유사체의 신규한 유도체
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
US20180110863A1 (en) * 2015-04-08 2018-04-26 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
WO2017032798A1 (en) 2015-08-25 2017-03-02 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
HRP20221324T1 (hr) 2016-12-16 2022-12-23 Novo Nordisk A/S Farmaceutski pripravci koji sadrže inzulin
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
AU2018317810A1 (en) 2017-08-17 2020-03-19 Novo Nordisk A/S Novel acylated insulin analogues and uses thereof
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
BR112021011050A2 (pt) 2018-12-11 2021-08-31 Sanofi Ligante peptídico
PE20221260A1 (es) 2019-12-11 2022-08-16 Novo Nordisk As Analogos de insulina novedosos y usos de estos
CN113075342B (zh) * 2020-01-04 2024-02-27 东莞市东阳光仿制药研发有限公司 一种分离检测德谷胰岛素侧链有关物质的方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US487000A (en) 1892-11-29 Shirt
US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
AU600885B2 (en) 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
NZ222907A (en) 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
AU641631B2 (en) 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
PT93057B (pt) 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina
DK300090D0 (da) 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
DK82893D0 (da) 1993-07-08 1993-07-08 Novo Nordisk As Peptid
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
WO1995007931A1 (en) * 1993-09-17 1995-03-23 Novo Nordisk A/S Acylated insulin
US5639642A (en) 1994-06-16 1997-06-17 Novo Nordisk A/S Synthetic leader peptide sequences
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
CN1196061A (zh) * 1995-03-17 1998-10-14 诺沃挪第克公司 胰岛素衍生物
US6251856B1 (en) * 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
AU5549998A (en) 1997-01-24 1998-08-18 Novo Nordisk A/S Synthetic leader peptide sequences
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
EP1025125B1 (de) 1997-10-24 2003-06-25 Novo Nordisk A/S Aggregate von menschlichen insulinderivaten
US6451762B1 (en) * 1997-10-24 2002-09-17 Novo Nordisk A/S Aggregates of human insulin derivatives
ATE290877T1 (de) * 1998-01-09 2005-04-15 Novo Nordisk As Stabilisierte insulin-zubereitungen
JP2002518408A (ja) 1998-06-12 2002-06-25 キングス・カレツジ・ロンドン インスリン類似体
AU2002349295A1 (en) * 2001-12-02 2003-06-17 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
WO2003075950A1 (en) * 2002-03-13 2003-09-18 Novo Nordisk A/S Minimising body weight gain in insulin treatment
US20040138099A1 (en) * 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
WO2005005477A2 (en) 2003-07-11 2005-01-20 Novo Nordisk A/S Stabilised insulin compositions
US20060183667A1 (en) * 2003-07-11 2006-08-17 Novo Nordisk A/S Stabilised insulin compositions
CA2531988C (en) * 2003-08-05 2016-06-28 Novo Nordisk A/S Novel insulin derivatives
EP1687428A1 (de) 2003-11-14 2006-08-09 Novo Nordisk A/S Verfahren zur herstellung von acyliertem insulin
WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
JP4933455B2 (ja) 2005-02-02 2012-05-16 ノヴォ ノルディスク アー／エス 新規のインスリン誘導体
PT1969004E (pt) 2005-12-28 2011-11-25 Novo Nordisk As Composições que compreendem uma insulina acilada e zinco e método para criar tais composições
EP1991576B1 (de) 2006-02-27 2010-09-29 Novo Nordisk A/S Insulinderivate
EP2386572B1 (de) 2006-05-09 2015-07-08 Novo Nordisk A/S Insulinderivat
JP5269766B2 (ja) * 2006-05-09 2013-08-21 ノボ・ノルデイスク・エー／エス インスリン誘導体
US9034818B2 (en) * 2007-06-13 2015-05-19 Novo Nordisk A/S Pharmaceutical formulations comprising an insulin derivative
US8710000B2 (en) * 2007-11-08 2014-04-29 Novo Nordisk A/S Insulin derivative
DK2597103T3 (en) 2007-11-16 2017-02-13 Novo Nordisk As Stable pharmaceutical compositions comprising liraglutide and degludec
AU2009309623B9 (en) * 2008-10-30 2014-10-02 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
ES2612468T3 (es) 2010-05-10 2017-05-17 Novo Nordisk A/S Procedimiento para la preparación de complejos de insulina-zinc

Also Published As

Publication number Publication date
DE602007009496D1 (de) 2010-11-11
EP2256129A1 (de) 2010-12-01
US8722620B2 (en) 2014-05-13
US20090137454A1 (en) 2009-05-28
EP2256129B1 (de) 2012-05-09
ATE482977T1 (de) 2010-10-15
JP2012214486A (ja) 2012-11-08
JP5475836B2 (ja) 2014-04-16
WO2007096431A1 (en) 2007-08-30
ES2387955T3 (es) 2012-10-04
EP1991576A1 (de) 2008-11-19
JP5202338B2 (ja) 2013-06-05
EP1991576B1 (de) 2010-09-29
JP2009528325A (ja) 2009-08-06

Similar Documents

Publication Publication Date Title
ATE557037T1 (de) Insulin derivate
DE602006018430D1 (de) Gurtspanner mit verschleissausgleich
BRPI0813139A2 (pt) Peptídeo glp-1 com adição de uma cadeia oligossacarídea
EP1993942A4 (de) Förderband mit befestigten zahnstreifen
DE602007010598D1 (de) Befestigungsklemme mit flexiblem gurt
DE602006007068D1 (de) Led mit leuchtstoff
DK1928766T3 (da) Slidbestandig konnektor til en båndtransportør med modulforbindelsesled
DE602005015280D1 (de) Zahnriemen
DE502006005460D1 (de) Bohrspülung enthaltend hydrophobin
DE112006001251A5 (de) Transparentes lichtemittierendes Bauelement
DE602006010262D1 (de) Kettenspannvorrichtung
DE602007005604D1 (de) Blattspanner mit entgegengesetzten spannen
DE502006005217D1 (de) Kettenspanner mit deckelelement
DE602005022138D1 (de) Treibriemen mit scherfesten Zähnen
FR2910111B3 (fr) Tronconneuse
DE602005006210D1 (de) Zahnriemen
DE502005011280D1 (de) Ketten- oder zahnriementrieb
ATE523451T1 (de) Förderband
DK2069189T3 (da) Endeløst elastomerbælte
DE502006007704D1 (de) Fördereinheit
IT1393508B1 (it) Dicarba-analoghi dell'octreotide
DE112006003284A5 (de) Zahnlaschenkette
DE502006006792D1 (de) Fördereinheit
DE112007001401A5 (de) Kette mit mehreren Kettengliedern
DE502005006953D1 (de) Abnehmbare Sicherheitsgurt-Befestigung