ATE482977T1 - Insulinderivate - Google Patents

Insulinderivate

Info

Publication number
ATE482977T1
ATE482977T1 AT07712327T AT07712327T ATE482977T1 AT E482977 T1 ATE482977 T1 AT E482977T1 AT 07712327 T AT07712327 T AT 07712327T AT 07712327 T AT07712327 T AT 07712327T AT E482977 T1 ATE482977 T1 AT E482977T1
Authority
AT
Austria
Prior art keywords
insulin derivatives
chain
amino group
present
lys residue
Prior art date
Application number
AT07712327T
Other languages
English (en)
Inventor
Charlotte Fynbo
Ib Jonassen
Thomas Kjeldsen
Peter Madsen
Patrick Garibay
Janos Kodra
Thomas Hoeg-Jensen
Tina Tagmose
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE482977T1 publication Critical patent/ATE482977T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT07712327T 2006-02-27 2007-02-27 Insulinderivate ATE482977T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06110441 2006-02-27
EP06118253 2006-08-01
PCT/EP2007/051835 WO2007096431A1 (en) 2006-02-27 2007-02-27 Insulin derivatives

Publications (1)

Publication Number Publication Date
ATE482977T1 true ATE482977T1 (de) 2010-10-15

Family

ID=38001155

Family Applications (2)

Application Number Title Priority Date Filing Date
AT10168840T ATE557037T1 (de) 2006-02-27 2007-02-27 Insulin derivate
AT07712327T ATE482977T1 (de) 2006-02-27 2007-02-27 Insulinderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT10168840T ATE557037T1 (de) 2006-02-27 2007-02-27 Insulin derivate

Country Status (7)

Country Link
US (1) US8722620B2 (de)
EP (2) EP2256129B1 (de)
JP (2) JP5202338B2 (de)
AT (2) ATE557037T1 (de)
DE (1) DE602007009496D1 (de)
ES (1) ES2387955T3 (de)
WO (1) WO2007096431A1 (de)

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EP2256130B1 (de) 2005-02-02 2013-09-25 Novo Nordisk A/S Neuartige Insulinderivate
JP5410020B2 (ja) 2005-02-02 2014-02-05 ノヴォ ノルディスク アー／エス インスリン誘導体
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
US8796205B2 (en) * 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
EP2015770B1 (de) * 2006-05-09 2012-09-26 Novo Nordisk A/S Insulinderivate
EP2404934A1 (de) 2006-09-22 2012-01-11 Novo Nordisk A/S Proteaseresistente Insulinanaloga
ES2563038T3 (es) 2007-04-30 2016-03-10 Novo Nordisk A/S Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca
WO2008152106A1 (en) 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
KR20100053561A (ko) 2007-08-15 2010-05-20 노보 노르디스크 에이/에스 아실 및 알킬렌 글리콜 부분을 갖는 인슐린 유사체
CN101784563B (zh) 2007-08-15 2015-02-04 诺沃-诺迪斯克有限公司 具有包括含亚烷基二醇的氨基酸的重复单位的酰基部分的胰岛素
WO2009060071A1 (en) * 2007-11-08 2009-05-14 Novo Nordisk A/S Insulin derivative
ES2618073T3 (es) 2008-03-14 2017-06-20 Novo Nordisk A/S Análogos de insulina estabilizados frente a proteasas
MX2010009850A (es) 2008-03-18 2010-09-30 Novo Nordisk As Analogos de insulina acilados y etabilizados contra proteasas.
ES2563553T3 (es) 2008-04-01 2016-03-15 Novo Nordisk A/S Conjugados de insulina-albúmina
CA2738615A1 (en) 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
US9050370B2 (en) 2009-01-28 2015-06-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
WO2010088268A1 (en) 2009-01-28 2010-08-05 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
BRPI1007466A2 (pt) 2009-01-28 2018-06-12 Smartcells Inc conjugado de insulina cristalina, formulação de liberação prolongada, e, sistema de distribuição de bomba
US8940690B2 (en) 2009-01-28 2015-01-27 National Institutes Of Health (Nih) Synthetic conjugates and uses thereof
EP2408470A4 (de) 2009-03-20 2012-08-29 Smartcells Inc Lösliche nichtdepot-insulinkonjugate und ihre verwendung
WO2010107519A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
EP2496213B1 (de) 2009-11-02 2015-08-12 Novo Nordisk A/S Pharmazeutische lösung aus nicht kovalent gebundenem albumin und acyliertem insulin
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
WO2012015692A2 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinantly expressed insulin polypeptides and uses thereof
CA2805902A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
CN103596584B (zh) 2011-06-15 2016-12-14 诺沃—诺迪斯克有限公司 多取代的胰岛素
KR20150002777A (ko) 2012-04-11 2015-01-07 노보 노르디스크 에이/에스 인슐린 제제
WO2014177623A1 (en) 2013-04-30 2014-11-06 Novo Nordisk A/S Novel administration regime
US9884125B2 (en) 2013-10-04 2018-02-06 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3280450A4 (de) * 2015-04-08 2018-12-12 Merck Sharp & Dohme Corp. Auf glucose reagierende insulinkonjugate
CA2996455A1 (en) 2015-08-25 2017-03-02 Novo Nordisk A/S Novel insulin derivatives and the medical uses hereof
MA49116A (fr) 2016-12-16 2020-03-25 Novo Nordisk As Compositions pharmaceutiques contenant de l'insuline
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
PE20211264A1 (es) 2017-08-17 2021-07-15 Novo Nordisk As Analogos de insulina acilados novedosos y usos de estos
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
SG11202106168VA (en) 2018-12-11 2021-07-29 Sanofi Sa Insulin analogs having reduced insulin receptor binding affinity
WO2020247297A1 (en) 2019-06-06 2020-12-10 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
CN114096269B (zh) 2019-07-12 2024-06-11 诺和诺德股份有限公司 高浓度胰岛素制剂
FI4073097T3 (fi) 2019-12-11 2024-08-13 Novo Nordisk As Uusia insuliinianalogeja ja niiden käyttötapoja
CN118772259A (zh) * 2019-12-30 2024-10-15 甘李药业股份有限公司 胰岛素衍生物
CN113075342B (zh) * 2020-01-04 2024-02-27 东莞市东阳光仿制药研发有限公司 一种分离检测德谷胰岛素侧链有关物质的方法

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US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
US5905140A (en) 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
EP0954589A1 (de) 1997-01-24 1999-11-10 Novo Nordisk A/S Sythetische signalpeptid-sequenzen.
US5898067A (en) 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
US6451762B1 (en) * 1997-10-24 2002-09-17 Novo Nordisk A/S Aggregates of human insulin derivatives
ES2202899T3 (es) 1997-10-24 2004-04-01 Novo Nordisk A/S Agregados de derivados de la insulina humana.
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EP1086130A1 (de) * 1998-06-12 2001-03-28 Kings College London Insulin analoge
WO2003048195A2 (en) * 2001-12-02 2003-06-12 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
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US20040138099A1 (en) 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes
US20060217290A1 (en) * 2003-04-29 2006-09-28 Kohn Wayne D Insulin analogs having protracted time action
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US20060183667A1 (en) 2003-07-11 2006-08-17 Novo Nordisk A/S Stabilised insulin compositions
KR101159559B1 (ko) 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
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WO2006008238A1 (en) 2004-07-16 2006-01-26 Novo Nordisk A/S Method for selective acylation
EP2256130B1 (de) 2005-02-02 2013-09-25 Novo Nordisk A/S Neuartige Insulinderivate
US20090074882A1 (en) 2005-12-28 2009-03-19 Novo Nordisk A/S Insulin compositions and method of making a composition
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
EP2015770B1 (de) 2006-05-09 2012-09-26 Novo Nordisk A/S Insulinderivate
US8796205B2 (en) 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
WO2008152106A1 (en) 2007-06-13 2008-12-18 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
WO2009060071A1 (en) 2007-11-08 2009-05-14 Novo Nordisk A/S Insulin derivative
ES2612736T3 (es) 2007-11-16 2017-05-18 Novo Nordisk A/S Composiciones farmacéuticas estables que comprenden liraglutida y degludec
CA2738615A1 (en) 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
EP2569002B1 (de) 2010-05-10 2016-10-26 Novo Nordisk A/S Verfahren zur herstellung von insulin-zink komlexen

Also Published As

Publication number Publication date
EP2256129B1 (de) 2012-05-09
US20090137454A1 (en) 2009-05-28
ATE557037T1 (de) 2012-05-15
EP1991576B1 (de) 2010-09-29
DE602007009496D1 (de) 2010-11-11
JP2009528325A (ja) 2009-08-06
JP2012214486A (ja) 2012-11-08
EP2256129A1 (de) 2010-12-01
ES2387955T3 (es) 2012-10-04
WO2007096431A1 (en) 2007-08-30
US8722620B2 (en) 2014-05-13
EP1991576A1 (de) 2008-11-19
JP5475836B2 (ja) 2014-04-16
JP5202338B2 (ja) 2013-06-05

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Legal Events

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