WO2007104736A3 - Acylated single chain insulin - Google Patents

Acylated single chain insulin Download PDF

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Publication number
WO2007104736A3
WO2007104736A3 PCT/EP2007/052288 EP2007052288W WO2007104736A3 WO 2007104736 A3 WO2007104736 A3 WO 2007104736A3 EP 2007052288 W EP2007052288 W EP 2007052288W WO 2007104736 A3 WO2007104736 A3 WO 2007104736A3
Authority
WO
WIPO (PCT)
Prior art keywords
single chain
chain insulin
chain
acylated
acylated single
Prior art date
Application number
PCT/EP2007/052288
Other languages
French (fr)
Other versions
WO2007104736A2 (en
Inventor
Peter Madsen
Thomas Boerglum Kjeldsen
Tina Moeller Tagmose
Original Assignee
Novo Nordisk As
Peter Madsen
Thomas Boerglum Kjeldsen
Tina Moeller Tagmose
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As, Peter Madsen, Thomas Boerglum Kjeldsen, Tina Moeller Tagmose filed Critical Novo Nordisk As
Publication of WO2007104736A2 publication Critical patent/WO2007104736A2/en
Publication of WO2007104736A3 publication Critical patent/WO2007104736A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention is related to acylated, single-chain insulin comprising the B- and the A-chain of human insulin or an analogue thereof connected by a connecting peptide, wherein the natural amino acid residue in position B1 or a lysine residue being substituted for the natural amino acid residue in one of the positions B1, B2, B3 or B4 in the human insulin B-chain has been chemically modified by acylation.
PCT/EP2007/052288 2006-03-13 2007-03-12 Acylated single chain insulin WO2007104736A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06111019 2006-03-13
EP06111019.3 2006-03-13

Publications (2)

Publication Number Publication Date
WO2007104736A2 WO2007104736A2 (en) 2007-09-20
WO2007104736A3 true WO2007104736A3 (en) 2007-12-13

Family

ID=38072154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/052288 WO2007104736A2 (en) 2006-03-13 2007-03-12 Acylated single chain insulin

Country Status (1)

Country Link
WO (1) WO2007104736A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5591243B2 (en) 2008-09-12 2014-09-17 ノボ・ノルデイスク・エー／エス Method for acylating peptides or proteins
JP6735561B2 (en) 2012-12-03 2020-08-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． O-glycosylated carboxy-terminal portion (CTP) peptide-based insulin and insulin analogs
AU2014329567B2 (en) 2013-10-04 2019-07-25 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
JP6484337B2 (en) 2014-11-21 2019-03-13 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Insulin receptor partial agonist
US10745457B2 (en) 2015-09-02 2020-08-18 Merck Sharp & Dohme Corp. Process for obtaining insulin with correctly formed disulfide bonds
US11058775B2 (en) 2016-04-26 2021-07-13 Merck Sharp & Dohme Corp. Insulin dimer-incretin conjugates
EP3463429A4 (en) 2016-05-24 2020-07-22 Merck Sharp & Dohme Corp. Insulin receptor partial agonists and glp-1 analogues
US10689430B2 (en) 2016-05-25 2020-06-23 Merck Sharp & Dohme Corp. Insulin receptor partial agonists
EP3272877A1 (en) 2016-07-18 2018-01-24 ETH Zurich B-cell-mimetic cells
SG11201811763SA (en) 2016-07-18 2019-02-27 Eth Zuerich B-cell-mimetic cells
US11041009B2 (en) 2017-03-23 2021-06-22 Merck Sharp & Dohme Corp. Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes
CN113423691A (en) 2018-12-11 2021-09-21 赛诺菲 Peptide binding agents
KR20220031044A (en) 2019-07-31 2022-03-11 일라이 릴리 앤드 캄파니 Relaxin analogues and methods of using them
WO2021185304A1 (en) * 2020-03-18 2021-09-23 东莞市东阳光生物药研发有限公司 Method for preparing long aliphatic chain diacid derivative and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012347A2 (en) * 2003-08-05 2005-02-10 Novo Nordisk A/S Novel insulin derivatives
WO2005047508A1 (en) * 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
WO2005054291A1 (en) * 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012347A2 (en) * 2003-08-05 2005-02-10 Novo Nordisk A/S Novel insulin derivatives
WO2005047508A1 (en) * 2003-11-14 2005-05-26 Novo Nordisk A/S Processes for making acylated insulin
WO2005054291A1 (en) * 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHATNAGAR ET AL: "Molecular variants and derivatives of insulin for improved glycemic control in diabetes", PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 91, no. 3, July 2006 (2006-07-01), pages 199 - 228, XP005351067, ISSN: 0079-6107 *
MARKUSSEN J ET AL: "SOLUBLE, PROLONGED-ACTING INSULIN DERIVATIVES. I. DEGREE OF PROTRACTION AND CRYSTALLIZABILITY OF INSULINS SUBSTITUTED IN THE TERMINI OF THE B-CHAIN", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 1, no. 3, 1 June 1987 (1987-06-01), pages 205 - 213, XP000000187, ISSN: 0269-2139 *
MARKUSSEN J ET AL: "SOLUBLE, PROLONGED-ACTING INSULIN DERIVATIVES. II. DEGREE OF PROTRACTION AND CRYSTALLIZABILITY OF INSULINS SUBSTITUTED IN POSITIONS A17, B8, B13, B27 AND B30", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 1, no. 3, 1987, pages 215 - 223, XP001018792, ISSN: 0269-2139 *
MARKUSSEN J ET AL: "SOLUBLE, PROLONGED-ACTING INSULIN DERIVATIVES. III. DEGREE OF PROTRACTION, CRYSTALLIZABILITY AND CHEMICAL STABILITY OF INSULINS SUBSTITUTED IN POSITIONS A21, B13, B23, B27 AND B30", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 2, no. 2, 1 July 1988 (1988-07-01), pages 157 - 166, XP000006171, ISSN: 0269-2139 *

Also Published As

Publication number Publication date
WO2007104736A2 (en) 2007-09-20

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