WO2007104736A3 - Acylated single chain insulin - Google Patents
Acylated single chain insulin Download PDFInfo
- Publication number
- WO2007104736A3 WO2007104736A3 PCT/EP2007/052288 EP2007052288W WO2007104736A3 WO 2007104736 A3 WO2007104736 A3 WO 2007104736A3 EP 2007052288 W EP2007052288 W EP 2007052288W WO 2007104736 A3 WO2007104736 A3 WO 2007104736A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- single chain
- chain insulin
- chain
- acylated
- acylated single
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention is related to acylated, single-chain insulin comprising the B- and the A-chain of human insulin or an analogue thereof connected by a connecting peptide, wherein the natural amino acid residue in position B1 or a lysine residue being substituted for the natural amino acid residue in one of the positions B1, B2, B3 or B4 in the human insulin B-chain has been chemically modified by acylation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06111019 | 2006-03-13 | ||
EP06111019.3 | 2006-03-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007104736A2 WO2007104736A2 (en) | 2007-09-20 |
WO2007104736A3 true WO2007104736A3 (en) | 2007-12-13 |
Family
ID=38072154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2007/052288 WO2007104736A2 (en) | 2006-03-13 | 2007-03-12 | Acylated single chain insulin |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007104736A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5591243B2 (en) | 2008-09-12 | 2014-09-17 | ノボ・ノルデイスク・エー/エス | Method for acylating peptides or proteins |
JP6735561B2 (en) | 2012-12-03 | 2020-08-05 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | O-glycosylated carboxy-terminal portion (CTP) peptide-based insulin and insulin analogs |
AU2014329567B2 (en) | 2013-10-04 | 2019-07-25 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
JP6484337B2 (en) | 2014-11-21 | 2019-03-13 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Insulin receptor partial agonist |
US10745457B2 (en) | 2015-09-02 | 2020-08-18 | Merck Sharp & Dohme Corp. | Process for obtaining insulin with correctly formed disulfide bonds |
US11058775B2 (en) | 2016-04-26 | 2021-07-13 | Merck Sharp & Dohme Corp. | Insulin dimer-incretin conjugates |
EP3463429A4 (en) | 2016-05-24 | 2020-07-22 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists and glp-1 analogues |
US10689430B2 (en) | 2016-05-25 | 2020-06-23 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
EP3272877A1 (en) | 2016-07-18 | 2018-01-24 | ETH Zurich | B-cell-mimetic cells |
SG11201811763SA (en) | 2016-07-18 | 2019-02-27 | Eth Zuerich | B-cell-mimetic cells |
US11041009B2 (en) | 2017-03-23 | 2021-06-22 | Merck Sharp & Dohme Corp. | Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes |
CN113423691A (en) | 2018-12-11 | 2021-09-21 | 赛诺菲 | Peptide binding agents |
KR20220031044A (en) | 2019-07-31 | 2022-03-11 | 일라이 릴리 앤드 캄파니 | Relaxin analogues and methods of using them |
WO2021185304A1 (en) * | 2020-03-18 | 2021-09-23 | 东莞市东阳光生物药研发有限公司 | Method for preparing long aliphatic chain diacid derivative and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005012347A2 (en) * | 2003-08-05 | 2005-02-10 | Novo Nordisk A/S | Novel insulin derivatives |
WO2005047508A1 (en) * | 2003-11-14 | 2005-05-26 | Novo Nordisk A/S | Processes for making acylated insulin |
WO2005054291A1 (en) * | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
-
2007
- 2007-03-12 WO PCT/EP2007/052288 patent/WO2007104736A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005012347A2 (en) * | 2003-08-05 | 2005-02-10 | Novo Nordisk A/S | Novel insulin derivatives |
WO2005047508A1 (en) * | 2003-11-14 | 2005-05-26 | Novo Nordisk A/S | Processes for making acylated insulin |
WO2005054291A1 (en) * | 2003-12-03 | 2005-06-16 | Novo Nordisk A/S | Single-chain insulin |
Non-Patent Citations (4)
Title |
---|
BHATNAGAR ET AL: "Molecular variants and derivatives of insulin for improved glycemic control in diabetes", PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY, PERGAMON PRESS, OXFORD, GB, vol. 91, no. 3, July 2006 (2006-07-01), pages 199 - 228, XP005351067, ISSN: 0079-6107 * |
MARKUSSEN J ET AL: "SOLUBLE, PROLONGED-ACTING INSULIN DERIVATIVES. I. DEGREE OF PROTRACTION AND CRYSTALLIZABILITY OF INSULINS SUBSTITUTED IN THE TERMINI OF THE B-CHAIN", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 1, no. 3, 1 June 1987 (1987-06-01), pages 205 - 213, XP000000187, ISSN: 0269-2139 * |
MARKUSSEN J ET AL: "SOLUBLE, PROLONGED-ACTING INSULIN DERIVATIVES. II. DEGREE OF PROTRACTION AND CRYSTALLIZABILITY OF INSULINS SUBSTITUTED IN POSITIONS A17, B8, B13, B27 AND B30", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 1, no. 3, 1987, pages 215 - 223, XP001018792, ISSN: 0269-2139 * |
MARKUSSEN J ET AL: "SOLUBLE, PROLONGED-ACTING INSULIN DERIVATIVES. III. DEGREE OF PROTRACTION, CRYSTALLIZABILITY AND CHEMICAL STABILITY OF INSULINS SUBSTITUTED IN POSITIONS A21, B13, B23, B27 AND B30", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 2, no. 2, 1 July 1988 (1988-07-01), pages 157 - 166, XP000006171, ISSN: 0269-2139 * |
Also Published As
Publication number | Publication date |
---|---|
WO2007104736A2 (en) | 2007-09-20 |
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