EA201992610A1 - Экспансия -t-клеток, композиции и способы их применения - Google Patents

Экспансия -t-клеток, композиции и способы их применения

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Publication number
EA201992610A1
EA201992610A1 EA201992610A EA201992610A EA201992610A1 EA 201992610 A1 EA201992610 A1 EA 201992610A1 EA 201992610 A EA201992610 A EA 201992610A EA 201992610 A EA201992610 A EA 201992610A EA 201992610 A1 EA201992610 A1 EA 201992610A1
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EA
Eurasian Patent Office
Prior art keywords
compositions
ways
application
cell expansion
expansion
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Application number
EA201992610A
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English (en)
Inventor
Ричард Битсон
Адриан Хэйдэй
Оливер Нусбаумер
Ричард Вулф
Мария Луиза Ианнитто
Натали Маунт
Original Assignee
Кинг'З Колледж Лондон
Гаммадельта Терапьютикс Лимитед
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Publication of EA201992610A1 publication Critical patent/EA201992610A1/ru

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/2318—Interleukin-18 (IL-18)
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/2321—Interleukin-21 (IL-21)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2333—Interleukin-33 (IL-33)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к способам экспансии -Т-клеток из источника негемопоэтической ткани. Настоящее изобретение также относится к композициям подвергнутых экспансии -Т-клеток и способам применения подвергнутых экспансии -Т-клеток (например, как часть адоптивной Т-клеточной терапии).
EA201992610A 2017-05-03 2018-05-03 Экспансия -t-клеток, композиции и способы их применения EA201992610A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1707048.3A GB201707048D0 (en) 2017-05-03 2017-05-03 Expansion of gamma delta cells, compositions, and methods of use thereof
PCT/EP2018/061413 WO2018202808A2 (en) 2017-05-03 2018-05-03 Expansion of gamma delta t cells, compositions, and methods of use thereof

Publications (1)

Publication Number Publication Date
EA201992610A1 true EA201992610A1 (ru) 2020-04-23

Family

ID=59010925

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992610A EA201992610A1 (ru) 2017-05-03 2018-05-03 Экспансия -t-клеток, композиции и способы их применения

Country Status (13)

Country Link
US (2) US11655453B2 (ru)
EP (1) EP3619298A2 (ru)
JP (2) JP2020518289A (ru)
KR (1) KR20200024770A (ru)
CN (1) CN110914410A (ru)
AU (1) AU2018262698A1 (ru)
BR (1) BR112019023076A2 (ru)
CA (1) CA3062386A1 (ru)
EA (1) EA201992610A1 (ru)
GB (1) GB201707048D0 (ru)
MX (1) MX2019013001A (ru)
PH (1) PH12019502485A1 (ru)
WO (1) WO2018202808A2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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CA2587136A1 (en) 2004-11-24 2006-06-22 Fred Hutchinson Cancer Research Center Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
GB201804701D0 (en) 2018-03-23 2018-05-09 Gammadelta Therapeutics Ltd Lymphocytes expressing heterologous targeting constructs
GB201818243D0 (en) 2018-11-08 2018-12-26 Gammadelta Therapeutics Ltd Methods for isolating and expanding cells
KR20210111746A (ko) 2018-11-08 2021-09-13 감마델타 테라퓨틱스 리미티드 세포를 단리 및 증식하는 방법
CN109517793B (zh) * 2018-11-30 2022-05-10 广州长峰生物技术有限公司 一种NK细胞和γδT细胞共培养的建立方法
GB201909144D0 (en) * 2019-06-25 2019-08-07 Autolus Ltd Culture medium
WO2021084063A1 (en) 2019-10-31 2021-05-06 Morphosys Ag Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells
MX2022006547A (es) * 2019-12-03 2022-08-19 Adicet Bio Inc Métodos para la expansión de poblaciones de células t gamma delta con agentes multivalentes y composiciones de estas.
BR112022018770A2 (pt) 2020-03-20 2022-11-22 Gammadelta Therapeutics Ltd Composição alogênica compreendendo células t vd1+, dose, e, método de tratamento de uma malignidade mieloide
GB202006989D0 (en) 2020-05-12 2020-06-24 Gammadelta Therapeutics Ltd Methods for isolating gamma delta t cells
CN113234675A (zh) * 2021-03-31 2021-08-10 广西医科大学 一种γδT细胞以及采用体外制备γδT细胞的方法
GB202105113D0 (en) 2021-04-09 2021-05-26 Gammadelta Therapeutics Ltd Novel method
WO2022221439A1 (en) * 2021-04-14 2022-10-20 The Trustees Of The University Of Pennsylvania Methods to determine treatment efficacy with gamma-delta t cells
WO2023133394A1 (en) * 2022-01-05 2023-07-13 Inhibrx, Inc. Gamma delta t-cell-binding polypeptides and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2643387T3 (es) * 2011-05-19 2017-11-22 Instituto De Medicina Molecular Estirpe celular de linfocitos que comprende células gama-delta, composición y método de producción de la misma
ES2539845B1 (es) 2013-08-05 2016-04-13 Universidad De Alicante Procedimiento y síntesis de monolitos de carbón activo a partir de cascarilla de cacao
US20170107490A1 (en) 2014-06-11 2017-04-20 Polybiocept Ab Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
US11135245B2 (en) * 2014-11-17 2021-10-05 Adicet Bio, Inc. Engineered γδ T-cells
CN114099793A (zh) 2015-04-10 2022-03-01 哈佛学院院长等 免疫细胞捕获装置及其制备和使用方法
KR20180026726A (ko) * 2015-06-09 2018-03-13 림팩 - 림포사이트 액티베이션 테크놀로지스, 에스.에이. Ｔｃｒ감마 델타 양성 ｔ 세포의 생산 방법
JP7146632B2 (ja) 2015-07-21 2022-10-04 ノバルティス アーゲー 免疫細胞の有効性および増大を改善する方法
AU2016344779B2 (en) 2015-10-30 2023-01-05 Cancer Research Technology Limited Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells

Also Published As

Publication number Publication date
JP2020518289A (ja) 2020-06-25
GB201707048D0 (en) 2017-06-14
US11655453B2 (en) 2023-05-23
CN110914410A (zh) 2020-03-24
EP3619298A2 (en) 2020-03-11
WO2018202808A3 (en) 2019-01-03
US20210087528A1 (en) 2021-03-25
WO2018202808A2 (en) 2018-11-08
KR20200024770A (ko) 2020-03-09
MX2019013001A (es) 2021-01-20
AU2018262698A1 (en) 2019-12-12
PH12019502485A1 (en) 2021-01-04
WO2018202808A9 (en) 2019-03-07
CA3062386A1 (en) 2018-11-08
BR112019023076A2 (pt) 2020-06-09
JP2023058687A (ja) 2023-04-25
US20230242878A1 (en) 2023-08-03

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