JP2019507589A5 - - Google Patents
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- JP2019507589A5 JP2019507589A5 JP2018538769A JP2018538769A JP2019507589A5 JP 2019507589 A5 JP2019507589 A5 JP 2019507589A5 JP 2018538769 A JP2018538769 A JP 2018538769A JP 2018538769 A JP2018538769 A JP 2018538769A JP 2019507589 A5 JP2019507589 A5 JP 2019507589A5
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- Japan
- Prior art keywords
- protein
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- domain
- seq
- fusion protein
- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021189835A JP2022058337A (ja) | 2016-01-20 | 2021-11-24 | 自己免疫疾患の治療のために制御性ｔ細胞を選択的に活性化する分子 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/002,144 US20170204154A1 (en) | 2016-01-20 | 2016-01-20 | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| US15/002,144 | 2016-01-20 | ||
| PCT/US2017/014090 WO2017127514A1 (en) | 2016-01-20 | 2017-01-19 | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189835A Division JP2022058337A (ja) | 2016-01-20 | 2021-11-24 | 自己免疫疾患の治療のために制御性ｔ細胞を選択的に活性化する分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507589A JP2019507589A (ja) | 2019-03-22 |
| JP2019507589A5 true JP2019507589A5 (enExample) | 2020-01-30 |
| JP6983787B2 JP6983787B2 (ja) | 2021-12-17 |
Family
ID=59314394
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538769A Expired - Fee Related JP6983787B2 (ja) | 2016-01-20 | 2017-01-19 | 自己免疫疾患の治療のために制御性ｔ細胞を選択的に活性化する分子 |
| JP2021189835A Pending JP2022058337A (ja) | 2016-01-20 | 2021-11-24 | 自己免疫疾患の治療のために制御性ｔ細胞を選択的に活性化する分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189835A Pending JP2022058337A (ja) | 2016-01-20 | 2021-11-24 | 自己免疫疾患の治療のために制御性ｔ細胞を選択的に活性化する分子 |
Country Status (16)
| Country | Link |
|---|---|
| US (7) | US20170204154A1 (enExample) |
| EP (1) | EP3405482A4 (enExample) |
| JP (2) | JP6983787B2 (enExample) |
| KR (1) | KR20180100237A (enExample) |
| CN (1) | CN108602871A (enExample) |
| AU (2) | AU2017210187B2 (enExample) |
| BR (1) | BR112018014671A2 (enExample) |
| CA (1) | CA3010621A1 (enExample) |
| CL (1) | CL2018001951A1 (enExample) |
| CO (1) | CO2018008558A2 (enExample) |
| EA (1) | EA201891656A1 (enExample) |
| EC (1) | ECSP18062614A (enExample) |
| MX (1) | MX2018008840A (enExample) |
| SG (1) | SG11201805784PA (enExample) |
| WO (1) | WO2017127514A1 (enExample) |
| ZA (1) | ZA201804458B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| MX378790B (es) * | 2014-07-21 | 2025-03-10 | Delinia Inc | Moleculas que activan selectivamente celulas t reguladoras para el tratamiento de enfermedades autoinmunes. |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| WO2018089420A1 (en) * | 2016-11-08 | 2018-05-17 | Delinia, Inc. | Il-2 variants for the treatment of autoimmune diseases |
| EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
| US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
| AU2018273914A1 (en) | 2017-05-24 | 2019-11-14 | Pandion Operations, Inc. | Targeted immunotolerance |
| JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| WO2019173832A2 (en) * | 2018-03-09 | 2019-09-12 | AskGene Pharma, Inc. | Novel cytokine prodrugs |
| US11814434B2 (en) | 2018-03-13 | 2023-11-14 | Tusk Therapeutics Ltd. | Anti-CD25 for tumour specific cell depletion |
| BR112020018709A2 (pt) | 2018-03-28 | 2021-01-05 | Bristol-Myers Squibb Company | Proteínas de fusão do receptor alfa de interleucina-2/interleucina-2 e métodos de uso |
| WO2020023702A1 (en) | 2018-07-25 | 2020-01-30 | AskGene Pharma, Inc. | Novel il-21 prodrugs and methods of use thereof |
| BR122021012517A2 (pt) | 2018-08-06 | 2021-08-10 | Medikine, Inc. | Ligante il-2rgamac, composto compreendendo referido ligante, composição farmacêutica e uso do referido ligante |
| US20220002370A1 (en) * | 2018-09-27 | 2022-01-06 | Xilio Development, Inc. | Masked cytokine polypeptides |
| WO2020092554A1 (en) * | 2018-10-31 | 2020-05-07 | Delinia, Inc. | Multivalent regulatory t cell modulators |
| TW202110885A (zh) | 2019-05-20 | 2021-03-16 | 美商潘迪恩治療公司 | 靶向ＭＡｄＣＡＭ之免疫耐受性 |
| WO2020252264A1 (en) | 2019-06-12 | 2020-12-17 | AskGene Pharma, Inc. | Novel il-15 prodrugs and methods of use thereof |
| PH12022550165A1 (en) | 2019-07-26 | 2023-05-08 | Visterra Inc | Interleukin-2 agents and uses thereof |
| MX2022001971A (es) * | 2019-08-15 | 2022-05-11 | Cytimm Therapeutics Inc | Polipeptidos de interleucina 2 (il-2) modificados, conjugados y usos de los mismos. |
| CA3157354A1 (en) * | 2019-09-16 | 2021-03-25 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Recombinant human neuregulin derivatives and use thereof |
| AU2020380296A1 (en) | 2019-11-05 | 2022-06-16 | Medikine Inc. | IL-2RβγC binding compounds |
| EP4055036A4 (en) | 2019-11-05 | 2024-02-28 | Medikine, Inc. | DUAL IL-2R AND IL-7R BINDING CONNECTIONS |
| TW202136317A (zh) | 2019-12-20 | 2021-10-01 | 美商再生元醫藥公司 | 新穎之ｉｌ２促效劑及其使用方法（二） |
| US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| JP2023514128A (ja) | 2020-02-03 | 2023-04-05 | メディカイン、インコーポレイテッド | ＩＬ－７Ｒαγｃ結合化合物 |
| AU2021217959A1 (en) | 2020-02-03 | 2022-08-18 | Medikine, Inc. | IL-7Rα binding compounds |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| JP2023526282A (ja) | 2020-05-13 | 2023-06-21 | ボナム セラピューティクス，インク． | タンパク質複合体の組成物及びその使用方法 |
| TW202406932A (zh) * | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| IL302114A (en) | 2020-10-29 | 2023-06-01 | Bristol Myers Squibb Co | Fusion proteins for the treatment of disease |
| TW202235431A (zh) | 2020-11-25 | 2022-09-16 | 美商艾希利歐發展股份有限公司 | 腫瘤特異性可裂解連接子 |
| MX2023006599A (es) | 2020-12-04 | 2023-06-19 | Visterra Inc | Metodos de uso de agentes de interleucina-2. |
| TW202317623A (zh) | 2021-06-14 | 2023-05-01 | 美商再生元醫藥公司 | 基於il2之治療劑及其使用方法 |
| CN113789346A (zh) * | 2021-08-25 | 2021-12-14 | 北京伟德杰生物科技有限公司 | 长效化重组人白细胞介素2融合蛋白及其制备方法和应用 |
| KR20240148001A (ko) * | 2022-02-11 | 2024-10-10 | 비스테라, 인크. | 자가면역 질환의 치료를 위한 인터류킨-2 뮤테인 |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| CN115322260B (zh) * | 2022-06-13 | 2026-02-10 | 杭州高田生物医药有限公司 | 能够在肠道内富集且增殖调节性t细胞的融合蛋白及应用 |
| WO2024054868A1 (en) * | 2022-09-07 | 2024-03-14 | Xencor, Inc. | An il-2 fc fusion protein for use in methods for the treatment of plaque psoriasis and atopic dermatitis |
| CN121002050A (zh) * | 2023-02-21 | 2025-11-21 | 艾诺康医药公司 | 编码经修饰的白细胞介素2（il2）多肽的多核苷酸以及其制备和使用方法 |
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| MX378790B (es) * | 2014-07-21 | 2025-03-10 | Delinia Inc | Moleculas que activan selectivamente celulas t reguladoras para el tratamiento de enfermedades autoinmunes. |
| SG11201700629TA (en) | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| US20170216403A1 (en) | 2014-08-12 | 2017-08-03 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
| JP6941561B2 (ja) | 2014-10-09 | 2021-09-29 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 免疫障害を処置するための複数の可変ｉｌ−２用量レジメン |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CN109071623B (zh) | 2016-05-04 | 2022-05-27 | 美国安进公司 | 用于扩增t调节性细胞的白细胞介素-2突变蛋白 |
| WO2018089420A1 (en) | 2016-11-08 | 2018-05-17 | Delinia, Inc. | Il-2 variants for the treatment of autoimmune diseases |
-
2016
- 2016-01-20 US US15/002,144 patent/US20170204154A1/en not_active Abandoned
-
2017
- 2017-01-19 EA EA201891656A patent/EA201891656A1/ru unknown
- 2017-01-19 BR BR112018014671A patent/BR112018014671A2/pt not_active Application Discontinuation
- 2017-01-19 CN CN201780007419.1A patent/CN108602871A/zh active Pending
- 2017-01-19 MX MX2018008840A patent/MX2018008840A/es unknown
- 2017-01-19 KR KR1020187023925A patent/KR20180100237A/ko not_active Ceased
- 2017-01-19 SG SG11201805784PA patent/SG11201805784PA/en unknown
- 2017-01-19 AU AU2017210187A patent/AU2017210187B2/en not_active Ceased
- 2017-01-19 JP JP2018538769A patent/JP6983787B2/ja not_active Expired - Fee Related
- 2017-01-19 EP EP17741904.1A patent/EP3405482A4/en not_active Withdrawn
- 2017-01-19 WO PCT/US2017/014090 patent/WO2017127514A1/en not_active Ceased
- 2017-01-19 CA CA3010621A patent/CA3010621A1/en active Pending
- 2017-09-06 US US15/696,811 patent/US10294287B2/en active Active
-
2018
- 2018-07-03 ZA ZA2018/04458A patent/ZA201804458B/en unknown
- 2018-07-19 CL CL2018001951A patent/CL2018001951A1/es unknown
- 2018-08-15 CO CONC2018/0008558A patent/CO2018008558A2/es unknown
- 2018-08-20 EC ECSENADI201862614A patent/ECSP18062614A/es unknown
-
2019
- 2019-02-05 US US16/267,583 patent/US10875901B2/en not_active Expired - Fee Related
- 2019-03-13 US US16/352,003 patent/US10774126B2/en not_active Expired - Fee Related
- 2019-03-13 US US16/352,249 patent/US10766938B2/en not_active Expired - Fee Related
- 2019-12-30 US US16/729,698 patent/US11535657B2/en active Active
-
2020
- 2020-11-06 US US17/091,190 patent/US20210070828A1/en not_active Abandoned
-
2021
- 2021-10-26 AU AU2021257949A patent/AU2021257949A1/en not_active Abandoned
- 2021-11-24 JP JP2021189835A patent/JP2022058337A/ja active Pending
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