JP2017536337A5 - - Google Patents
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- Publication number
- JP2017536337A5 JP2017536337A5 JP2017518189A JP2017518189A JP2017536337A5 JP 2017536337 A5 JP2017536337 A5 JP 2017536337A5 JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017536337 A5 JP2017536337 A5 JP 2017536337A5
- Authority
- JP
- Japan
- Prior art keywords
- chain insulin
- amino acid
- insulin
- region
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060167P | 2014-10-06 | 2014-10-06 | |
| US62/060,167 | 2014-10-06 | ||
| PCT/US2015/054263 WO2016057529A2 (en) | 2014-10-06 | 2015-10-06 | Biphasic single-chain insulin analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536337A JP2017536337A (ja) | 2017-12-07 |
| JP2017536337A5 true JP2017536337A5 (enExample) | 2018-11-08 |
| JP6829928B2 JP6829928B2 (ja) | 2021-02-17 |
Family
ID=55653938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518189A Active JP6829928B2 (ja) | 2014-10-06 | 2015-10-06 | 二相性単鎖インスリン類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10392429B2 (enExample) |
| EP (1) | EP3204410B1 (enExample) |
| JP (1) | JP6829928B2 (enExample) |
| KR (1) | KR102569743B1 (enExample) |
| CN (1) | CN107108716A (enExample) |
| AU (1) | AU2015328222B9 (enExample) |
| BR (1) | BR112017004544A2 (enExample) |
| CA (1) | CA2961037A1 (enExample) |
| IL (1) | IL251503A0 (enExample) |
| WO (1) | WO2016057529A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102351111B1 (ko) | 2014-01-13 | 2022-01-14 | 써멀린 다이어비티즈, 엘엘씨 | 초속효성 인슐린 제형 및 약제학적 전달 시스템 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| EP3393498A4 (en) * | 2015-12-23 | 2019-08-07 | Case Western Reserve University | SECULATION OF ULTRASTABILEN INSULIN ANALOGUE WITH POLYMER MELTS |
| CA3294636A1 (en) * | 2016-11-21 | 2026-02-10 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| KR20210029210A (ko) * | 2018-06-29 | 2021-03-15 | 악스톤 바이오사이언시스 코퍼레이션 | 초장기 작용 인슐린-fc 융합 단백질 및 사용 방법 |
| US20210371489A1 (en) * | 2018-09-21 | 2021-12-02 | Case Western Reserve University | Site 2 single-chain insulin analogues |
| US12077568B2 (en) | 2018-10-01 | 2024-09-03 | University Of Houston System | Engineered active single-polypeptide chain insulin analogs |
| CN113330025A (zh) * | 2018-11-19 | 2021-08-31 | 卡斯西部储备大学 | 具有聚丙氨酸c结构域子区段的单链胰岛素类似物 |
| CA3139946A1 (en) * | 2019-05-17 | 2020-11-26 | Case Western Reserve University | Variant single-chain insulin analogues |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CA3149925A1 (en) * | 2019-08-02 | 2021-02-11 | Case Western Reserve University | Premixed ultra-stable single-chain insulin analogue formulations |
| IL296090A (en) * | 2020-03-02 | 2022-11-01 | Thermalin Inc | Compositions containing rapid-acting insulin analogues |
| EP4255469A4 (en) * | 2020-12-07 | 2025-01-22 | Case Western Reserve University | ACYLATED SINGLE-CHAIN INSULIN ANALOGUES |
| CZ310198B6 (cs) * | 2021-07-07 | 2024-11-13 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Deriváty inzulínu se zvýšenou tepelnou stabilitou |
| CN118201954A (zh) | 2021-09-20 | 2024-06-14 | 克云生物科技股份公司 | 精氨酸酶-胰岛素融合蛋白 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| JPH03506023A (ja) | 1988-07-20 | 1991-12-26 | ノボ ノルデイスク アクツイエセルスカプ | ポリペプチド |
| US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| DE3844211A1 (de) | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| DE3936876A1 (de) | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK158390D0 (da) | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
| US5422339A (en) | 1991-03-19 | 1995-06-06 | Joslin Diabetes Center, Inc. | Peptides having insulin autoantibody but not insulin receptor binding capacity |
| NZ245170A (en) | 1991-11-26 | 1994-07-26 | Lilly Co Eli | Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US20030104981A1 (en) | 1995-11-03 | 2003-06-05 | Jelena Mandic | Human insulin analogues |
| DE19652713C2 (de) | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| JP2001521006A (ja) | 1997-10-24 | 2001-11-06 | イーライ・リリー・アンド・カンパニー | 不溶性インシュリン組成物 |
| US6531448B1 (en) | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| AU2002346491A1 (en) | 2001-12-19 | 2003-07-09 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
| CZ2004710A3 (cs) | 2001-12-20 | 2005-02-16 | Eli Lilly And Company | Inzulínová sloučenina s protrahovaným účinkem |
| WO2003080666A2 (en) | 2002-03-26 | 2003-10-02 | Council Of Scientific And Industrial Research | An adipocyte insulin and a method of treating diabetes |
| WO2003093299A2 (en) | 2002-05-06 | 2003-11-13 | Thomas Jefferson University | Insulin-associated peptides with effects on cerebral health |
| WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
| EP1620465A2 (en) | 2003-04-29 | 2006-02-01 | Eli Lilly And Company | Insulin analogs having protracted time action |
| PL1633876T3 (pl) | 2003-06-17 | 2009-01-30 | Sembiosys Genetics Inc | Sposoby wytwarzania insuliny w roślinach |
| EP1692168B1 (en) * | 2003-12-03 | 2011-07-20 | Novo Nordisk A/S | Single-chain insulin |
| CN102660614A (zh) | 2005-08-16 | 2012-09-12 | 诺沃-诺迪斯克有限公司 | 制备成熟胰岛素多肽的方法 |
| WO2007081824A2 (en) | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
| US20090069216A1 (en) | 2006-02-21 | 2009-03-12 | Novo Nordisk A/S | Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof |
| US8192857B2 (en) * | 2006-03-04 | 2012-06-05 | Enerdel, Inc. | Battery assembly and method of forming the same |
| WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US7790677B2 (en) | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
| MY152979A (en) | 2008-01-09 | 2014-12-15 | Sanofi Aventis Deutschland | Novel insulin derivatives having an extremely delayed time-action profile |
| US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| EP2296692A4 (en) * | 2008-04-22 | 2012-06-06 | Univ Case Western Reserve | ISOFORM-SPECIFIC INSULIN ANALOG |
| WO2009133099A2 (en) | 2008-04-28 | 2009-11-05 | Novo Nordisk A/S | Insulin precursors for diabetes treatment |
| MX2011001181A (es) | 2008-07-31 | 2011-04-05 | Univ Case Western Reserve | Insulina estabilizada con halogeno. |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| WO2011028813A2 (en) | 2009-09-01 | 2011-03-10 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| US8399407B2 (en) | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| AU2010327949A1 (en) | 2009-12-11 | 2012-06-28 | Case Western Reserve University | Insulin analogues with chlorinated amino acids |
| PH12012501557A1 (en) | 2010-02-22 | 2012-10-22 | Univ Case Western Reserve | Long-acting insulin analogue preparations in soluble and crystalline form |
| JP5969469B2 (ja) | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| AU2013337250B2 (en) | 2012-11-05 | 2017-06-22 | Case Western Reserve University | Long-acting single-chain insulin analogues |
-
2015
- 2015-10-06 BR BR112017004544A patent/BR112017004544A2/pt not_active IP Right Cessation
- 2015-10-06 JP JP2017518189A patent/JP6829928B2/ja active Active
- 2015-10-06 AU AU2015328222A patent/AU2015328222B9/en active Active
- 2015-10-06 CN CN201580054329.9A patent/CN107108716A/zh active Pending
- 2015-10-06 CA CA2961037A patent/CA2961037A1/en active Pending
- 2015-10-06 EP EP15849531.7A patent/EP3204410B1/en active Active
- 2015-10-06 US US15/517,300 patent/US10392429B2/en active Active
- 2015-10-06 WO PCT/US2015/054263 patent/WO2016057529A2/en not_active Ceased
- 2015-10-06 KR KR1020177006438A patent/KR102569743B1/ko active Active
-
2017
- 2017-04-02 IL IL251503A patent/IL251503A0/en unknown
-
2019
- 2019-08-26 US US16/550,973 patent/US11142560B2/en active Active
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