JP2017536337A5 - - Google Patents
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- Publication number
- JP2017536337A5 JP2017536337A5 JP2017518189A JP2017518189A JP2017536337A5 JP 2017536337 A5 JP2017536337 A5 JP 2017536337A5 JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017536337 A5 JP2017536337 A5 JP 2017536337A5
- Authority
- JP
- Japan
- Prior art keywords
- chain insulin
- amino acid
- insulin
- region
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462060167P | 2014-10-06 | 2014-10-06 | |
| US62/060,167 | 2014-10-06 | ||
| PCT/US2015/054263 WO2016057529A2 (en) | 2014-10-06 | 2015-10-06 | Biphasic single-chain insulin analogues |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536337A JP2017536337A (ja) | 2017-12-07 |
| JP2017536337A5 true JP2017536337A5 (enExample) | 2018-11-08 |
| JP6829928B2 JP6829928B2 (ja) | 2021-02-17 |
Family
ID=55653938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518189A Active JP6829928B2 (ja) | 2014-10-06 | 2015-10-06 | 二相性単鎖インスリン類似体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10392429B2 (enExample) |
| EP (1) | EP3204410B1 (enExample) |
| JP (1) | JP6829928B2 (enExample) |
| KR (1) | KR102569743B1 (enExample) |
| CN (1) | CN107108716B (enExample) |
| AU (1) | AU2015328222B9 (enExample) |
| BR (1) | BR112017004544A2 (enExample) |
| CA (1) | CA2961037A1 (enExample) |
| IL (1) | IL251503A0 (enExample) |
| WO (1) | WO2016057529A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2936563A1 (en) | 2014-01-13 | 2015-07-16 | Thermalin Diabetes, Llc | Rapid action insulin formulations and pharmaceutical delivery systems |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| HK1255634A1 (zh) * | 2015-12-23 | 2019-08-23 | Case Western Reserve University | 超稳胰岛素类似物在聚合物熔体中的包囊 |
| AU2017361524B2 (en) * | 2016-11-21 | 2022-06-02 | Case Western Reserve University | Rapid-acting insulin analogues of enhanced stability |
| HUE062719T2 (hu) * | 2018-06-29 | 2023-11-28 | Akston Biosciences Corp | Ultra-hosszú hatású inzulin-FC fúziós fehérjék és az alkalmazási eljárások |
| BR112021005366A2 (pt) * | 2018-09-21 | 2021-06-29 | Case Western Reserve University | análogo de insulina de cadeia simples, uso deste e método para reduzir o açúcar no sangue de um paciente |
| US12077568B2 (en) | 2018-10-01 | 2024-09-03 | University Of Houston System | Engineered active single-polypeptide chain insulin analogs |
| US20220002373A1 (en) * | 2018-11-19 | 2022-01-06 | Case Western Reserve University | Single-chain insulin analogues with poly-alanine c-domain sub-segments |
| CA3139946A1 (en) * | 2019-05-17 | 2020-11-26 | Case Western Reserve University | Variant single-chain insulin analogues |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| US20220280614A1 (en) * | 2019-08-02 | 2022-09-08 | Case Western Reserve University | Premixed Ultra-Stable Single-Chain Insulin Analogue Formulations |
| IL296090A (en) * | 2020-03-02 | 2022-11-01 | Thermalin Inc | Compositions containing rapid-acting insulin analogues |
| EP4255469A4 (en) * | 2020-12-07 | 2025-01-22 | Case Western Reserve University | ACYLATED SINGLE-CHAIN INSULIN ANALOGUES |
| CZ310198B6 (cs) * | 2021-07-07 | 2024-11-13 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Deriváty inzulínu se zvýšenou tepelnou stabilitou |
| WO2023041758A1 (en) | 2021-09-20 | 2023-03-23 | Kyon Biotech Ag | Arginase-insulin fusion protein |
| WO2024218715A1 (en) | 2023-04-19 | 2024-10-24 | Btl Healthcare Technologies A.S. | Culture media based on protein hydrolysate and a process for preparing thereof |
| US12668774B2 (en) | 2023-10-12 | 2026-06-30 | Btl Healthcare Technologies A.S. | Product, system and method of cell cultivation |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| WO1990001038A1 (en) | 1988-07-20 | 1990-02-08 | Nordisk Gentofte A/S | Human insulin analogs and preparations containing them |
| US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| DE3844211A1 (de) | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
| DE3936876A1 (de) | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| DK158390D0 (da) | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
| US5422339A (en) | 1991-03-19 | 1995-06-06 | Joslin Diabetes Center, Inc. | Peptides having insulin autoantibody but not insulin receptor binding capacity |
| TW224471B (enExample) | 1991-11-26 | 1994-06-01 | Lilly Co Eli | |
| US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US20030104981A1 (en) | 1995-11-03 | 2003-06-05 | Jelena Mandic | Human insulin analogues |
| DE19652713C2 (de) | 1996-12-18 | 2001-11-22 | Aventis Pharma Gmbh | Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| HUP0004169A3 (en) | 1997-10-24 | 2001-06-28 | Lilly Co Eli | Insoluble insulin compositions and process for production thereof |
| CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
| KR100449454B1 (ko) | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| WO2003053460A1 (en) | 2001-12-19 | 2003-07-03 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
| AU2002346490A1 (en) | 2001-12-20 | 2003-07-09 | Eli Lilly And Company | Insulin molecule having protracted time action |
| WO2003080666A2 (en) | 2002-03-26 | 2003-10-02 | Council Of Scientific And Industrial Research | An adipocyte insulin and a method of treating diabetes |
| JP4602075B2 (ja) | 2002-05-06 | 2010-12-22 | トーマス・ジェファーソン・ユニバーシティ | 脳の健康に効果のあるインスリン関連ペプチド |
| WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
| WO2004096854A2 (en) | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
| TWI345587B (en) | 2003-06-17 | 2011-07-21 | Sembiosys Genetics Inc | Methods for the production of insulin in plants |
| ES2369895T3 (es) | 2003-12-03 | 2011-12-07 | Novo Nordisk A/S | Insulina monocatenaria. |
| ATE513921T1 (de) * | 2005-08-16 | 2011-07-15 | Novo Nordisk As | Verfahren zur herstellung reifer insulinpolypeptide |
| US8343914B2 (en) | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
| WO2007096332A1 (en) | 2006-02-21 | 2007-08-30 | Novo Nordisk A/S | Single-chain insulin analogues and pharmaceutical formulations thereof |
| US8192857B2 (en) | 2006-03-04 | 2012-06-05 | Enerdel, Inc. | Battery assembly and method of forming the same |
| EP2074140B8 (en) | 2006-10-04 | 2015-10-28 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
| US7790677B2 (en) | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
| RU2524423C2 (ru) | 2008-01-09 | 2014-07-27 | Санофи-Авентис Дойчланд Гмбх | Новые производные инсулина с чрезвычайно замедленным профилем время/действие |
| WO2009129250A2 (en) | 2008-04-14 | 2009-10-22 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
| AU2009240636A1 (en) * | 2008-04-22 | 2009-10-29 | Case Western Reserve University | Isoform-specific insulin analogues |
| WO2009133099A2 (en) * | 2008-04-28 | 2009-11-05 | Novo Nordisk A/S | Insulin precursors for diabetes treatment |
| EP2318432B1 (en) | 2008-07-31 | 2015-09-02 | Case Western Reserve University | Halogen-stabilized insulin |
| US9060927B2 (en) * | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| US20120184488A1 (en) | 2009-09-01 | 2012-07-19 | Case Western Reserve University | Insulin analogues of enhanced receptor-binding specificity |
| US8399407B2 (en) | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
| RU2012123642A (ru) | 2009-12-11 | 2014-01-20 | Кейз Вестерн Ризев Юнивесити | Аналоги инсулина, содержащие хлорированные аминокислоты |
| BR112012020481A2 (pt) | 2010-02-22 | 2017-01-10 | Univ Case Western Reserve | método para tratar um paciente, o método compreendendo administrar uma formulação farmacêutica contendo uma quantidade fisiologicamente efetiva de um análogo de insulina ou um sal fisiologicamente. |
| JP5969469B2 (ja) * | 2010-06-16 | 2016-08-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト |
| MX2015005662A (es) * | 2012-11-05 | 2015-08-20 | Univ Case Western Reserve | Analogos de insulina de una sola cadena de larga accion. |
-
2015
- 2015-10-06 AU AU2015328222A patent/AU2015328222B9/en active Active
- 2015-10-06 KR KR1020177006438A patent/KR102569743B1/ko active Active
- 2015-10-06 US US15/517,300 patent/US10392429B2/en active Active
- 2015-10-06 EP EP15849531.7A patent/EP3204410B1/en active Active
- 2015-10-06 CN CN201580054329.9A patent/CN107108716B/zh active Active
- 2015-10-06 BR BR112017004544-3A patent/BR112017004544A2/en not_active IP Right Cessation
- 2015-10-06 WO PCT/US2015/054263 patent/WO2016057529A2/en not_active Ceased
- 2015-10-06 JP JP2017518189A patent/JP6829928B2/ja active Active
- 2015-10-06 CA CA2961037A patent/CA2961037A1/en active Pending
-
2017
- 2017-04-02 IL IL251503A patent/IL251503A0/en unknown
-
2019
- 2019-08-26 US US16/550,973 patent/US11142560B2/en active Active
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