IL251503A0 - Single-chain biphasic insulin analogs, preparations containing them and their uses - Google Patents

Single-chain biphasic insulin analogs, preparations containing them and their uses

Info

Publication number
IL251503A0
IL251503A0 IL251503A IL25150317A IL251503A0 IL 251503 A0 IL251503 A0 IL 251503A0 IL 251503 A IL251503 A IL 251503A IL 25150317 A IL25150317 A IL 25150317A IL 251503 A0 IL251503 A0 IL 251503A0
Authority
IL
Israel
Prior art keywords
compositions
same
insulin analogues
chain insulin
biphasic
Prior art date
Application number
IL251503A
Other languages
English (en)
Hebrew (he)
Original Assignee
Univ Case Western Reserve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve
Publication of IL251503A0 publication Critical patent/IL251503A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL251503A 2014-10-06 2017-04-02 Single-chain biphasic insulin analogs, preparations containing them and their uses IL251503A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (1)

Publication Number Publication Date
IL251503A0 true IL251503A0 (en) 2017-05-29

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
IL251503A IL251503A0 (en) 2014-10-06 2017-04-02 Single-chain biphasic insulin analogs, preparations containing them and their uses

Country Status (10)

Country Link
US (2) US10392429B2 (enExample)
EP (1) EP3204410B1 (enExample)
JP (1) JP6829928B2 (enExample)
KR (1) KR102569743B1 (enExample)
CN (1) CN107108716A (enExample)
AU (1) AU2015328222B9 (enExample)
BR (1) BR112017004544A2 (enExample)
CA (1) CA2961037A1 (enExample)
IL (1) IL251503A0 (enExample)
WO (1) WO2016057529A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016016290A2 (pt) 2014-01-13 2017-10-03 Thermalin Diabetes Llc Composições farmacêuticas de insulina de ação rápida, conjunto de infusão, sistema de conjunto de infusão e usos de análogos monoméricos ou diméricos de insulina
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
KR20180097517A (ko) * 2015-12-23 2018-08-31 케이스 웨스턴 리저브 유니버시티 매우 안정된 인슐린 유사체의 중합체 용융물 내 캡슐화
AR110193A1 (es) * 2016-11-21 2019-03-06 Univ Case Western Reserve Análogos de insulina de acción rápida de estabilidad mejorada
EP4186920B1 (en) * 2018-06-29 2024-01-03 Akston Biosciences Corporation Ultra-long acting insulin-fc fusion proteins and methods of use
BR112021005366A2 (pt) * 2018-09-21 2021-06-29 Case Western Reserve University análogo de insulina de cadeia simples, uso deste e método para reduzir o açúcar no sangue de um paciente
US12077568B2 (en) 2018-10-01 2024-09-03 University Of Houston System Engineered active single-polypeptide chain insulin analogs
US20220002373A1 (en) * 2018-11-19 2022-01-06 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
AU2020279968A1 (en) * 2019-05-17 2021-12-16 Case Western Reserve University Variant single-chain insulin analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
WO2021026091A1 (en) * 2019-08-02 2021-02-11 Case Western Reserve University Premixed ultra-stable single-chain insulin analogue formulations
US20230088546A1 (en) * 2020-03-02 2023-03-23 Thermalin Inc. Compositions containing rapid-acting insulin analogues
WO2022125587A1 (en) * 2020-12-07 2022-06-16 Case Western Reserve University Acylated single-chain insulin analogues
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
CN118201954A (zh) 2021-09-20 2024-06-14 克云生物科技股份公司 精氨酸酶-胰岛素融合蛋白

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPH03506023A (ja) 1988-07-20 1991-12-26 ノボ　ノルデイスク　アクツイエセルスカプ ポリペプチド
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DE3936876A1 (de) 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK158390D0 (da) 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
US5422339A (en) 1991-03-19 1995-06-06 Joslin Diabetes Center, Inc. Peptides having insulin autoantibody but not insulin receptor binding capacity
TW224471B (enExample) 1991-11-26 1994-06-01 Lilly Co Eli
US6011007A (en) 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US5547929A (en) 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US20030104981A1 (en) 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
DE19652713C2 (de) 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
CA2306877A1 (en) 1997-10-24 1999-05-06 Eli Lilly And Company Insoluble insulin compositions
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US7449443B2 (en) 2000-03-23 2008-11-11 California Institute Of Technology Method for stabilization of proteins using non-natural amino acids
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
KR100449454B1 (ko) 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
AU2002346491A1 (en) 2001-12-19 2003-07-09 Eli Lilly And Company Crystalline compositions for controlling blood glucose
US20050014679A1 (en) 2001-12-20 2005-01-20 Beals John Michael Insulin molecule having protracted time action
AU2003226619A1 (en) 2002-03-26 2003-10-08 Council Of Scientific And Industrial Research An adipocyte insulin and a method of treating diabetes
US7655619B2 (en) 2002-05-06 2010-02-02 Thomas Jefferson University Insulin-associated peptides with effects on cerebral health
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
CA2518776A1 (en) 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
EP1633876B1 (en) 2003-06-17 2008-08-20 SemBioSys Genetics Inc. Methods for the production of insulin in plants
AU2004295023A1 (en) 2003-12-03 2005-06-16 Novo Nordisk A/S Single-chain insulin
JP5366546B2 (ja) * 2005-08-16 2013-12-11 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
WO2007081824A2 (en) 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
EP1991575A1 (en) 2006-02-21 2008-11-19 Novo Nordisk A/S Single-chain insulin analogues and pharmaceutical formulations thereof
US8192857B2 (en) * 2006-03-04 2012-06-05 Enerdel, Inc. Battery assembly and method of forming the same
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
US7790677B2 (en) 2006-12-13 2010-09-07 Elona Biotechnologies Insulin production methods and pro-insulin constructs
ES2613152T3 (es) 2008-01-09 2017-05-22 Sanofi-Aventis Deutschland Gmbh Nuevos derivados de insulina con perfil tiempo/acción extremadamente retardado
US8993516B2 (en) 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
US20110195896A1 (en) * 2008-04-22 2011-08-11 Case Western Reserve University Isoform-specific insulin analogues
WO2009133099A2 (en) 2008-04-28 2009-11-05 Novo Nordisk A/S Insulin precursors for diabetes treatment
EP2318432B1 (en) 2008-07-31 2015-09-02 Case Western Reserve University Halogen-stabilized insulin
US9060927B2 (en) * 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
WO2011028813A2 (en) 2009-09-01 2011-03-10 Case Western Reserve University Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
AU2010327949A1 (en) 2009-12-11 2012-06-28 Case Western Reserve University Insulin analogues with chlorinated amino acids
CN102770153B (zh) 2010-02-22 2014-05-07 卡斯西部储备大学 呈可溶和结晶形式的长效胰岛素类似物制剂
JP5969469B2 (ja) 2010-06-16 2016-08-17 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン受容体に対して高い活性を示す単鎖インスリンアゴニスト
ES2694418T3 (es) * 2012-11-05 2018-12-20 Case Western Reserve University Análogos de insulina de cadena sencilla de acción prolongada

Also Published As

Publication number Publication date
JP6829928B2 (ja) 2021-02-17
WO2016057529A2 (en) 2016-04-14
EP3204410A2 (en) 2017-08-16
US20180265560A1 (en) 2018-09-20
US10392429B2 (en) 2019-08-27
WO2016057529A3 (en) 2016-11-03
AU2015328222A1 (en) 2017-03-16
CN107108716A (zh) 2017-08-29
EP3204410B1 (en) 2021-01-20
US20190375814A1 (en) 2019-12-12
AU2015328222B9 (en) 2020-12-24
BR112017004544A2 (pt) 2018-01-23
US11142560B2 (en) 2021-10-12
KR20170064533A (ko) 2017-06-09
AU2015328222B2 (en) 2020-08-20
KR102569743B1 (ko) 2023-08-23
EP3204410A4 (en) 2018-03-07
JP2017536337A (ja) 2017-12-07
CA2961037A1 (en) 2016-04-14

Similar Documents

Publication Publication Date Title
IL251503A0 (en) Single-chain biphasic insulin analogs, preparations containing them and their uses
IL276695B (en) Antibodies, pharmaceutical preparations and their uses
IL248350B (en) Fast-acting insulin preparations
PL3233108T3 (pl) Kompozycje insuliny o szybkim działaniu
IL246987A0 (en) Heteroaryl amides, preparations containing it and their uses
IL290114A (en) Pharmaceutical preparations, their preparation and uses
PL3223796T3 (pl) Kompozycje farmaceutyczne, ich wytwarzanie i zastosowania
IL252397A0 (en) Pharmaceutical preparations, their preparation and uses
IL252683A0 (en) Pyridyl-cycloalkyl-substituted carboxylic acids, preparations containing them and their medical uses
IL248256B (en) Cyclohexenyl compounds, compositions comprising them and uses thereof
PT3229843T (pt) Composição farmacêutica, a sua preparação e as suas utilizações
IL253600A0 (en) Insulin analogs and preparations containing them
IL250729A0 (en) A pyrazolothiazole compound and a drug containing it
GB201700560D0 (en) Pharmaceutical composition comprising docetaxel
IL248863A0 (en) Preparations containing il-31 and their use
GB201401706D0 (en) Nanoparticle-insulin and insulin analogue compositions
AU2014903032A0 (en) Drug Delivery Composition and Uses Thereof