PT1633876E - Métodos para a produção de insulina em plantas - Google Patents

Métodos para a produção de insulina em plantas Download PDF

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Publication number
PT1633876E
PT1633876E PT04737835T PT04737835T PT1633876E PT 1633876 E PT1633876 E PT 1633876E PT 04737835 T PT04737835 T PT 04737835T PT 04737835 T PT04737835 T PT 04737835T PT 1633876 E PT1633876 E PT 1633876E
Authority
PT
Portugal
Prior art keywords
insulin
plants
production
methods
Prior art date
Application number
PT04737835T
Other languages
English (en)
Inventor
Gijs Van Rooijen
Maurice M Moloney
Joseph Boothe
Richard Keon
Cory Nykiforuk
Original Assignee
Sembiosys Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sembiosys Genetics Inc filed Critical Sembiosys Genetics Inc
Publication of PT1633876E publication Critical patent/PT1633876E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT04737835T 2003-06-17 2004-06-17 Métodos para a produção de insulina em plantas PT1633876E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47881803P 2003-06-17 2003-06-17
US54953904P 2004-03-04 2004-03-04

Publications (1)

Publication Number Publication Date
PT1633876E true PT1633876E (pt) 2008-11-03

Family

ID=33555509

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04737835T PT1633876E (pt) 2003-06-17 2004-06-17 Métodos para a produção de insulina em plantas

Country Status (24)

Country Link
US (2) US7547821B2 (pt)
EP (2) EP1633876B1 (pt)
JP (2) JP4864701B2 (pt)
KR (1) KR101216762B1 (pt)
CN (1) CN1836047B (pt)
AR (1) AR044803A1 (pt)
AT (1) ATE405660T1 (pt)
AU (1) AU2004247762B2 (pt)
BR (1) BRPI0411479A (pt)
CA (1) CA2528741A1 (pt)
CY (1) CY1108477T1 (pt)
DE (1) DE602004015980D1 (pt)
DK (1) DK1633876T3 (pt)
EA (1) EA014887B1 (pt)
ES (1) ES2313018T3 (pt)
HK (1) HK1088037A1 (pt)
IL (1) IL172469A (pt)
MX (1) MXPA05013723A (pt)
NO (1) NO20055885L (pt)
NZ (1) NZ544522A (pt)
PL (1) PL1633876T3 (pt)
PT (1) PT1633876E (pt)
TW (1) TWI345587B (pt)
WO (1) WO2004111244A2 (pt)

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JP5749155B2 (ja) 2008-03-18 2015-07-15 ノボ・ノルデイスク・エー／エス プロテアーゼ安定化アシル化インスリンアナログ
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
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US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
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WO2013059213A1 (en) * 2011-10-18 2013-04-25 Amidebio, Llc Chemically and thermodynamically stable insulin analogues and improved methods for their production
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WO2014172488A2 (en) 2013-04-17 2014-10-23 AmideBio LLC Chemically and thermodynamically stable insulin analogues and improved methods for their production
KR101625746B1 (ko) 2013-09-23 2016-05-31 순천대학교 산학협력단 프로미니인슐린 재조합 단백질이 발현된 형질전환 식물 및 이의 제조방법
JP6829928B2 (ja) 2014-10-06 2021-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 二相性単鎖インスリン類似体
US20220096607A1 (en) * 2015-04-09 2022-03-31 Kinetiq Therapeutics, Llc Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof
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KR102642178B1 (ko) * 2017-08-08 2024-02-29 중앙대학교 산학협력단 돌연변이에 의해, 혈중 반감기 및 공수병 바이러스 중화 효능이 증대된 공수병 바이러스 중화 항체
CN111094572B (zh) * 2018-02-09 2023-04-04 江苏恒瑞医药股份有限公司 一种密码子优化的人胰岛素类似物前体基因和信号肽基因
WO2020214955A1 (en) * 2019-04-19 2020-10-22 The Trustees Of Indiana University Stabilization of prandial or basal insulin analogues by an internal diselenide bridge
CN115151273A (zh) * 2019-12-06 2022-10-04 美商玛丽莫里斯博士联合有限责任公司 用于治疗和预防1型糖尿病的方法和组合物
JP2023542241A (ja) * 2020-07-03 2023-10-05 クリヤ セラピューティクス， インコーポレイテッド 糖尿病を処置するための修飾型インスリンおよびグルコキナーゼ核酸
EP4190905A1 (en) 2021-12-01 2023-06-07 Core Biogenesis Method for the purification of recombinant proteins using oil body proteins

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Also Published As

Publication number Publication date
ATE405660T1 (de) 2008-09-15
EP1959017A1 (en) 2008-08-20
IL172469A (en) 2011-08-31
EP1633876A2 (en) 2006-03-15
US7547821B2 (en) 2009-06-16
TWI345587B (en) 2011-07-21
CN1836047A (zh) 2006-09-20
CN1836047B (zh) 2010-12-22
ES2313018T3 (es) 2009-03-01
EA200600050A1 (ru) 2006-06-30
IL172469A0 (en) 2006-04-10
HK1088037A1 (en) 2006-10-27
PL1633876T3 (pl) 2009-01-30
JP2007523611A (ja) 2007-08-23
JP2011200251A (ja) 2011-10-13
EP1633876B1 (en) 2008-08-20
JP4864701B2 (ja) 2012-02-01
AU2004247762A1 (en) 2004-12-23
CY1108477T1 (el) 2014-04-09
KR20060052705A (ko) 2006-05-19
AR044803A1 (es) 2005-10-05
CA2528741A1 (en) 2004-12-23
EA014887B1 (ru) 2011-02-28
WO2004111244A3 (en) 2005-02-03
MXPA05013723A (es) 2006-03-13
DK1633876T3 (da) 2008-12-08
US20090282583A1 (en) 2009-11-12
BRPI0411479A (pt) 2006-07-25
NO20055885L (no) 2006-01-17
AU2004247762B2 (en) 2010-05-27
DE602004015980D1 (de) 2008-10-02
NZ544522A (en) 2008-03-28
US20050039235A1 (en) 2005-02-17
TW200510529A (en) 2005-03-16
WO2004111244A2 (en) 2004-12-23
KR101216762B1 (ko) 2013-01-02

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