PL1633876T3 - Sposoby wytwarzania insuliny w roślinach - Google Patents

Sposoby wytwarzania insuliny w roślinach

Info

Publication number
PL1633876T3
PL1633876T3 PL04737835T PL04737835T PL1633876T3 PL 1633876 T3 PL1633876 T3 PL 1633876T3 PL 04737835 T PL04737835 T PL 04737835T PL 04737835 T PL04737835 T PL 04737835T PL 1633876 T3 PL1633876 T3 PL 1633876T3
Authority
PL
Poland
Prior art keywords
insulin
plants
production
methods
Prior art date
Application number
PL04737835T
Other languages
English (en)
Inventor
Maurice M Moloney
Joseph Boothe
Richard Keon
Cory Nykiforuk
Rooijen Gijs Van
Original Assignee
Sembiosys Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sembiosys Genetics Inc filed Critical Sembiosys Genetics Inc
Publication of PL1633876T3 publication Critical patent/PL1633876T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL04737835T 2003-06-17 2004-06-17 Sposoby wytwarzania insuliny w roślinach PL1633876T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47881803P 2003-06-17 2003-06-17
US54953904P 2004-03-04 2004-03-04
PCT/CA2004/000896 WO2004111244A2 (en) 2003-06-17 2004-06-17 Methods for the production of insulin in plants
EP04737835A EP1633876B1 (en) 2003-06-17 2004-06-17 Methods for the production of insulin in plants

Publications (1)

Publication Number Publication Date
PL1633876T3 true PL1633876T3 (pl) 2009-01-30

Family

ID=33555509

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04737835T PL1633876T3 (pl) 2003-06-17 2004-06-17 Sposoby wytwarzania insuliny w roślinach

Country Status (23)

Country Link
US (2) US7547821B2 (pl)
EP (2) EP1959017A1 (pl)
JP (2) JP4864701B2 (pl)
KR (1) KR101216762B1 (pl)
CN (1) CN1836047B (pl)
AR (1) AR044803A1 (pl)
AT (1) ATE405660T1 (pl)
AU (1) AU2004247762B2 (pl)
BR (1) BRPI0411479A (pl)
CA (1) CA2528741A1 (pl)
CY (1) CY1108477T1 (pl)
DE (1) DE602004015980D1 (pl)
DK (1) DK1633876T3 (pl)
EA (1) EA014887B1 (pl)
ES (1) ES2313018T3 (pl)
IL (1) IL172469A (pl)
MX (1) MXPA05013723A (pl)
NO (1) NO20055885L (pl)
NZ (1) NZ544522A (pl)
PL (1) PL1633876T3 (pl)
PT (1) PT1633876E (pl)
TW (1) TWI345587B (pl)
WO (1) WO2004111244A2 (pl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003213815A1 (en) 2002-03-08 2003-09-22 Prodigene, Inc. Production of insulin and insulin-like proteins in plants
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
EP1563075A4 (en) * 2002-11-12 2006-09-06 Ckd Bio Corp HUMANINSULIN EXPRESSIVE PLASMIDE AND METHOD FOR THE PRODUCTION OF HUMANINSULIN THEREWITH
US20040173547A1 (en) * 2003-03-06 2004-09-09 Roth Michael Carl Bolt on attachment to facilitate hanging of pneumatic tool
ATE405660T1 (de) * 2003-06-17 2008-09-15 Sembiosys Genetics Inc Verfahren zur insulinproduktion in pflanzen
WO2004113376A1 (en) * 2003-06-20 2004-12-29 Sembiosys Genetics Inc. Modified oleosins
TW200526778A (en) * 2003-11-14 2005-08-16 Sembiosys Genetics Inc Methods for the production of apolipoproteins in transgenic plants
EP1774017B1 (en) 2004-07-26 2013-05-15 Pfenex Inc. Process for improved protein expression by strain engineering
AR053477A1 (es) 2005-05-23 2007-05-09 Arcadia Biosciences Inc Cartamo con acido gamma - linolenico elevado
AU2006309281B2 (en) * 2005-05-27 2011-11-03 University Of Central Florida Chloroplasts engineered to express pharmaceutical proteins
AP2007004262A0 (en) * 2005-07-01 2007-12-31 Cornell Res Foundation Inc Oleosin genes and promoters from coffee
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
US8395020B2 (en) 2006-08-31 2013-03-12 Monsanto Technology Llc Methods for rapidly transforming monocots
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9394571B2 (en) 2007-04-27 2016-07-19 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
WO2009132129A2 (en) * 2008-04-22 2009-10-29 Case Western Reserve University Isoform-specific insulin analogues
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (ko) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
CN101736029B (zh) * 2008-11-21 2013-01-02 复旦大学 一种利用植物油体蛋白表达系统生产人胰岛素样生长因子-i的方法
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
JP5866120B2 (ja) 2009-12-11 2016-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 塩素化アミノ酸を有するインスリン類似体
CN102268451B (zh) * 2010-06-01 2014-03-12 安胜军 一种含有人胰岛素基因的表达载体及其构建方法与应用
CN103154022A (zh) 2010-06-16 2013-06-12 富途锐基尼以色列有限公司 抗害虫植物
EP2613799A1 (en) 2010-09-07 2013-07-17 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease
US9006176B2 (en) * 2011-10-18 2015-04-14 AmideBio LLC Chemically and thermodynamically stable insulin analogues and improved methods for their production
US9352456B2 (en) 2011-10-26 2016-05-31 Black & Decker Inc. Power tool with force sensing electronic clutch
CA2870313A1 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
US9163073B2 (en) 2013-04-17 2015-10-20 Amidebio, Llc Chemically and thermodynamically stable insulin analogues and improved methods for their production
KR101625746B1 (ko) 2013-09-23 2016-05-31 순천대학교 산학협력단 프로미니인슐린 재조합 단백질이 발현된 형질전환 식물 및 이의 제조방법
CA2961037A1 (en) 2014-10-06 2016-04-14 Case Western Reserve University Biphasic single-chain insulin analogues
US20220096607A1 (en) * 2015-04-09 2022-03-31 Kinetiq Therapeutics, Llc Subcutaneous therapeutic enzyme formulations, uses, and methods for generating thereof
ES2886837T3 (es) 2016-12-16 2021-12-21 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
KR102642178B1 (ko) * 2017-08-08 2024-02-29 중앙대학교 산학협력단 돌연변이에 의해, 혈중 반감기 및 공수병 바이러스 중화 효능이 증대된 공수병 바이러스 중화 항체
US20210032307A1 (en) * 2018-02-09 2021-02-04 Jiangsu Hengrui Medicine Co., Ltd. Codon optimized precursor gene and signal peptide gene of human insulin analogue
EP3956355B1 (en) * 2019-04-19 2025-11-26 The Trustees of Indiana University Stabilization of prandial or basal insulin analogues by an internal diselenide bridge
WO2021113136A1 (en) * 2019-12-06 2021-06-10 Dr. Mary Morris & Associates, Llc Methods and compositions for the treatment and prevention of type 1 diabetes
IL299545A (en) * 2020-07-03 2023-02-01 Kriya Therapeutics Inc Different insulin and glucokinase nucleic acids for the treatment of diabetes
EP4190905A1 (en) 2021-12-01 2023-06-07 Core Biogenesis Method for the purification of recombinant proteins using oil body proteins

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971856A (en) 1975-03-03 1976-07-27 Archer Daniels Midland Company Process for preparing soy protein concentrate
US6174724B1 (en) 1983-01-17 2001-01-16 Monsanto Company Chimeric genes suitable for expression in plant cells
NL8300698A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
US5504200A (en) 1983-04-15 1996-04-02 Mycogen Plant Science, Inc. Plant gene expression
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5008241A (en) 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
US4956282A (en) * 1985-07-29 1990-09-11 Calgene, Inc. Mammalian peptide expression in plant cells
NZ217113A (en) 1985-08-07 1988-06-30 Monsanto Co Production of eucaryotic plants which are glyphosate resistant, vectors (transformation and expression), chimeric gene and plant cells
US5273894A (en) 1986-08-23 1993-12-28 Hoechst Aktiengesellschaft Phosphinothricin-resistance gene, and its use
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
ATE169955T1 (de) 1987-05-20 1998-09-15 Ciba Geigy Ag Verfahren zur herstellug von transgene zea mays- pflanzen, die aus protoplasten oder aus von protopflasten erhaltenen zellen regeneriert wurden
DK336188D0 (da) 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
CA1341467C (en) 1988-07-29 2004-12-07 John C. Rogers Producing commercially valuable polypeptides with genetically transformed endosperm tissue
AU641631B2 (en) 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
DK0392225T3 (da) 1989-03-24 2003-09-22 Syngenta Participations Ag Sygdomsresistente transgene planter
NL8901932A (nl) 1989-07-26 1991-02-18 Mogen Int Produktie van heterologe eiwitten in planten of plantecellen.
US4940935A (en) 1989-08-28 1990-07-10 Ried Ashman Manufacturing Automatic SMD tester
US5959177A (en) * 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5202422A (en) * 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
KR910014790A (ko) 1990-01-10 1991-08-31 한태희 랩탑 컴퓨터의 기능선택방법 및 인터페이스회로
AU7583691A (en) * 1990-03-05 1991-10-10 Upjohn Company, The Protein expression via seed specific regulatory sequences
US5650554A (en) 1991-02-22 1997-07-22 Sembiosys Genetics Inc. Oil-body proteins as carriers of high-value peptides in plants
UA48104C2 (uk) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника
ATE229076T1 (de) 1992-04-02 2002-12-15 Sembiosys Genetics Inc Cis elemente des ölkörperproteins als regulationische signale
EP0677112B1 (en) * 1992-12-28 2003-03-26 Stichting Scheikundig Onderzoek In Nederland (Son) Method for obtaining transgenic plants showing a modified fructan pattern
US5474978A (en) 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5633437A (en) 1994-10-11 1997-05-27 Sandoz Ltd. Gene exhibiting resistance to acetolactate synthase inhibitor herbicides
US6040496A (en) 1995-06-30 2000-03-21 Novartis Finance Corporation Use of translationally altered RNA to confer resistance to maize dwarf mosaic virus and other monocotyledonous plant viruses
US5577474A (en) * 1995-11-29 1996-11-26 General Motors Corporation Torque estimation for engine speed control
CA2246242A1 (en) * 1996-02-08 1997-08-14 Institut Fur Pflanzengenetik Und Kulturpflanzenforschung Cassettes for the expression of storable proteins in plants
US5856452A (en) * 1996-12-16 1999-01-05 Sembiosys Genetics Inc. Oil bodies and associated proteins as affinity matrices
TW505697B (en) 1997-04-25 2002-10-11 Sembiosys Genetics Inc Method for cleavage of fusion proteins
CA2305628C (en) * 1997-09-30 2008-08-26 The Regents Of The University Of California Production of proteins in plant seeds
AR016229A1 (es) * 1998-04-27 2001-06-20 Demegen Inc Genes utiles para incrementar el contenido proteico de plantas, proteinas codificadas por dichos genes, celulas de plantas transfectadas con dichos genesy metodos para incrementar el contenido proteico o no proteico de plantas
US6429357B1 (en) 1999-05-14 2002-08-06 Dekalb Genetics Corp. Rice actin 2 promoter and intron and methods for use thereof
ATE326539T1 (de) 1999-08-27 2006-06-15 Sembiosys Genetics Inc Samenspezifischer promoter aus flachs (linum usitatissimum)
US6521738B2 (en) 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
EP2080803B1 (en) * 2000-03-01 2011-05-25 Auburn University Plastid transformation vectors for expressing proinsulin fused to the cholera toxin B-subunit in plants
CN1295129A (zh) * 2000-08-25 2001-05-16 林忠平 利用转基因番茄生产人胰岛素的方法
BR0116220A (pt) * 2000-12-19 2003-09-23 Sembiosys Genetics Inc Métodos para a produção de proteìnas multiméricas e composições relacionadas
EP1261119A3 (en) 2001-05-22 2003-11-12 Powerdsine Limited Power factor corrector with efficient ripple attenuator
AU2003213815A1 (en) * 2002-03-08 2003-09-22 Prodigene, Inc. Production of insulin and insulin-like proteins in plants
CN1382734A (zh) * 2002-03-15 2002-12-04 林忠平 利用转基因生菜生产人胰岛素的方法
ATE405660T1 (de) * 2003-06-17 2008-09-15 Sembiosys Genetics Inc Verfahren zur insulinproduktion in pflanzen

Also Published As

Publication number Publication date
EP1633876B1 (en) 2008-08-20
IL172469A0 (en) 2006-04-10
JP4864701B2 (ja) 2012-02-01
PT1633876E (pt) 2008-11-03
KR101216762B1 (ko) 2013-01-02
EA200600050A1 (ru) 2006-06-30
DE602004015980D1 (de) 2008-10-02
US20050039235A1 (en) 2005-02-17
AU2004247762A1 (en) 2004-12-23
ATE405660T1 (de) 2008-09-15
TWI345587B (en) 2011-07-21
NO20055885L (no) 2006-01-17
WO2004111244A3 (en) 2005-02-03
WO2004111244A2 (en) 2004-12-23
TW200510529A (en) 2005-03-16
MXPA05013723A (es) 2006-03-13
US20090282583A1 (en) 2009-11-12
AR044803A1 (es) 2005-10-05
JP2007523611A (ja) 2007-08-23
KR20060052705A (ko) 2006-05-19
EA014887B1 (ru) 2011-02-28
CA2528741A1 (en) 2004-12-23
BRPI0411479A (pt) 2006-07-25
EP1959017A1 (en) 2008-08-20
CY1108477T1 (el) 2014-04-09
ES2313018T3 (es) 2009-03-01
JP2011200251A (ja) 2011-10-13
CN1836047B (zh) 2010-12-22
IL172469A (en) 2011-08-31
HK1088037A1 (en) 2006-10-27
NZ544522A (en) 2008-03-28
US7547821B2 (en) 2009-06-16
CN1836047A (zh) 2006-09-20
DK1633876T3 (da) 2008-12-08
EP1633876A2 (en) 2006-03-15
AU2004247762B2 (en) 2010-05-27

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