MXPA05013723A - Metodos para loa produccion de insulina en plantas. - Google Patents
Metodos para loa produccion de insulina en plantas.Info
- Publication number
- MXPA05013723A MXPA05013723A MXPA05013723A MXPA05013723A MXPA05013723A MX PA05013723 A MXPA05013723 A MX PA05013723A MX PA05013723 A MXPA05013723 A MX PA05013723A MX PA05013723 A MXPA05013723 A MX PA05013723A MX PA05013723 A MXPA05013723 A MX PA05013723A
- Authority
- MX
- Mexico
- Prior art keywords
- insulin
- nucleic acid
- plants
- production
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen metodos para la produccion de insulina en plantas. En una modalidad, la presente invencion proporciona un metodo para la expresion de insulina en plantas comprendiendo: (a) proporcionar una construccion de acido nucleico quimerico comprendiendo en la direccion de transcripcion 5' a 3' como componentes operablemente enlazados: (i) una secuencia de acidos nucleicos capaz de controlar la expresion en celulas de semilla vegetales; y (ii) una secuencia de acidos nucleicos codificando un polipeptido de insulina; (b) introducir la construccion de acido nucleico quimerico en una celula vegetal, y (c) desarrollar la celula vegetal en una planta madura capaz de producir la semilla en donde la semilla expresa insulina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47881803P | 2003-06-17 | 2003-06-17 | |
US54953904P | 2004-03-04 | 2004-03-04 | |
PCT/CA2004/000896 WO2004111244A2 (en) | 2003-06-17 | 2004-06-17 | Methods for the production of insulin in plants |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05013723A true MXPA05013723A (es) | 2006-03-13 |
Family
ID=33555509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05013723A MXPA05013723A (es) | 2003-06-17 | 2004-06-17 | Metodos para loa produccion de insulina en plantas. |
Country Status (24)
Country | Link |
---|---|
US (2) | US7547821B2 (es) |
EP (2) | EP1633876B1 (es) |
JP (2) | JP4864701B2 (es) |
KR (1) | KR101216762B1 (es) |
CN (1) | CN1836047B (es) |
AR (1) | AR044803A1 (es) |
AT (1) | ATE405660T1 (es) |
AU (1) | AU2004247762B2 (es) |
BR (1) | BRPI0411479A (es) |
CA (1) | CA2528741A1 (es) |
CY (1) | CY1108477T1 (es) |
DE (1) | DE602004015980D1 (es) |
DK (1) | DK1633876T3 (es) |
EA (1) | EA014887B1 (es) |
ES (1) | ES2313018T3 (es) |
HK (1) | HK1088037A1 (es) |
IL (1) | IL172469A (es) |
MX (1) | MXPA05013723A (es) |
NO (1) | NO20055885L (es) |
NZ (1) | NZ544522A (es) |
PL (1) | PL1633876T3 (es) |
PT (1) | PT1633876E (es) |
TW (1) | TWI345587B (es) |
WO (1) | WO2004111244A2 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393998B2 (en) | 2002-03-08 | 2008-07-01 | Prodigene, Inc. | Commercial production of insulin and insulin-like proteins in plants |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
WO2004044206A1 (en) * | 2002-11-12 | 2004-05-27 | Ckd Bio Corp. | Plasmids expressing human insulin and the preparation method for human insuling thereby |
US20040173547A1 (en) * | 2003-03-06 | 2004-09-09 | Roth Michael Carl | Bolt on attachment to facilitate hanging of pneumatic tool |
AR044803A1 (es) * | 2003-06-17 | 2005-10-05 | Sembiosys Genetics Inc | Metodos para la produccion de insulina |
CA2528845A1 (en) * | 2003-06-20 | 2004-12-29 | Sembiosys Genetics Inc. | Modified oleosins |
TW200526778A (en) * | 2003-11-14 | 2005-08-16 | Sembiosys Genetics Inc | Methods for the production of apolipoproteins in transgenic plants |
CA2574953A1 (en) | 2004-07-26 | 2006-02-09 | Dow Global Technolgies Inc. | Process for improved protein expression by strain engineering |
CA2609367C (en) | 2005-05-23 | 2014-08-19 | Arcadia Biosciences, Inc. | Safflower with elevated gamma-linolenic acid |
EP2261364A3 (en) * | 2005-05-27 | 2011-03-30 | The University of Central Florida, | Chloroplasts engineered to express pharmaceutical proteins |
EP2189532A1 (en) * | 2005-07-01 | 2010-05-26 | Nestec S.A. | Promoters from coffee |
US8343914B2 (en) * | 2006-01-06 | 2013-01-01 | Case Western Reserve University | Fibrillation resistant proteins |
ATE497008T1 (de) | 2006-08-31 | 2011-02-15 | Monsanto Technology Llc | Verfahren zur herstellung transgener pflanzen |
WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2008134461A2 (en) | 2007-04-27 | 2008-11-06 | Dow Global Technologies, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2009115469A1 (en) * | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
US8993516B2 (en) * | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
WO2009132129A2 (en) * | 2008-04-22 | 2009-10-29 | Case Western Reserve University | Isoform-specific insulin analogues |
PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
KR20120129875A (ko) | 2008-07-31 | 2012-11-28 | 케이스 웨스턴 리저브 유니버시티 | 염소화 아미노산을 갖는 인슐린 유사체 |
US9200053B2 (en) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulin analogues containing penta-fluoro-Phenylalanine at position B24 |
CN101736029B (zh) * | 2008-11-21 | 2013-01-02 | 复旦大学 | 一种利用植物油体蛋白表达系统生产人胰岛素样生长因子-i的方法 |
US8399407B2 (en) * | 2009-09-17 | 2013-03-19 | Case Western Reserve University | Non-standard insulin analogues |
MX2012006568A (es) | 2009-12-11 | 2012-12-17 | Univ Case Western Reserve | Analogos de insulina con aminoacidos clorados. |
CN102268451B (zh) * | 2010-06-01 | 2014-03-12 | 安胜军 | 一种含有人胰岛素基因的表达载体及其构建方法与应用 |
WO2011158242A2 (en) | 2010-06-16 | 2011-12-22 | Futuragene Israel Ltd. | Pest -resistant plants containing a combination of a spider toxin and a chitinase |
US20130164288A1 (en) | 2010-09-07 | 2013-06-27 | Protalix Ltd. | Readthrough acetylcholinesterase (ache-r) for treating or preventing parkinson's disease |
US9006176B2 (en) * | 2011-10-18 | 2015-04-14 | AmideBio LLC | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
US9352456B2 (en) | 2011-10-26 | 2016-05-31 | Black & Decker Inc. | Power tool with force sensing electronic clutch |
US9481721B2 (en) | 2012-04-11 | 2016-11-01 | Novo Nordisk A/S | Insulin formulations |
EP2986315A4 (en) | 2013-04-17 | 2017-03-01 | AmideBio LLC | Chemically and thermodynamically stable insulin analogues and improved methods for their production |
KR101625746B1 (ko) | 2013-09-23 | 2016-05-31 | 순천대학교 산학협력단 | 프로미니인슐린 재조합 단백질이 발현된 형질전환 식물 및 이의 제조방법 |
JP6829928B2 (ja) | 2014-10-06 | 2021-02-17 | ケース ウェスタン リザーブ ユニバーシティCase Western Reserve University | 二相性単鎖インスリン類似体 |
CN115154591B (zh) | 2016-12-16 | 2023-04-14 | 诺和诺德股份有限公司 | 含胰岛素的药物组合物 |
KR102642178B1 (ko) * | 2017-08-08 | 2024-02-29 | 중앙대학교 산학협력단 | 돌연변이에 의해, 혈중 반감기 및 공수병 바이러스 중화 효능이 증대된 공수병 바이러스 중화 항체 |
KR20200119237A (ko) * | 2018-02-09 | 2020-10-19 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 인간 인슐린 유사체의 코돈 최적화된 전구체 유전자 및 신호 펩티드 유전자 |
CN114144426A (zh) * | 2019-04-19 | 2022-03-04 | 印地安纳大学理事会 | 餐时或基础胰岛素类似物通过内部二硒桥的稳定化 |
CN115151273A (zh) * | 2019-12-06 | 2022-10-04 | 美商玛丽莫里斯博士联合有限责任公司 | 用于治疗和预防1型糖尿病的方法和组合物 |
CA3174156A1 (en) * | 2020-07-03 | 2022-01-06 | Nachi GUPTA | Modified insulin and glucokinase nucleic acids for treating diabetes |
EP4190905A1 (en) | 2021-12-01 | 2023-06-07 | Core Biogenesis | Method for the purification of recombinant proteins using oil body proteins |
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UA48104C2 (uk) | 1991-10-04 | 2002-08-15 | Новартіс Аг | Фрагмент днк, який містить послідовність,що кодує інсектицидний протеїн, оптимізовану для кукурудзи,фрагмент днк, який забезпечує направлену бажану для серцевини стебла експресію зв'язаного з нею структурного гена в рослині, фрагмент днк, який забезпечує специфічну для пилку експресію зв`язаного з нею структурного гена в рослині, рекомбінантна молекула днк, спосіб одержання оптимізованої для кукурудзи кодуючої послідовності інсектицидного протеїну, спосіб захисту рослин кукурудзи щонайменше від однієї комахи-шкідника |
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CN1295129A (zh) * | 2000-08-25 | 2001-05-16 | 林忠平 | 利用转基因番茄生产人胰岛素的方法 |
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AR044803A1 (es) * | 2003-06-17 | 2005-10-05 | Sembiosys Genetics Inc | Metodos para la produccion de insulina |
-
2004
- 2004-06-17 AR ARP040102114A patent/AR044803A1/es active IP Right Grant
- 2004-06-17 PT PT04737835T patent/PT1633876E/pt unknown
- 2004-06-17 WO PCT/CA2004/000896 patent/WO2004111244A2/en active IP Right Grant
- 2004-06-17 AT AT04737835T patent/ATE405660T1/de active
- 2004-06-17 JP JP2006515598A patent/JP4864701B2/ja not_active Expired - Fee Related
- 2004-06-17 BR BRPI0411479-5A patent/BRPI0411479A/pt not_active IP Right Cessation
- 2004-06-17 US US10/869,040 patent/US7547821B2/en not_active Expired - Fee Related
- 2004-06-17 DE DE602004015980T patent/DE602004015980D1/de active Active
- 2004-06-17 TW TW093117421A patent/TWI345587B/zh not_active IP Right Cessation
- 2004-06-17 PL PL04737835T patent/PL1633876T3/pl unknown
- 2004-06-17 CN CN2004800236023A patent/CN1836047B/zh not_active Expired - Fee Related
- 2004-06-17 DK DK04737835T patent/DK1633876T3/da active
- 2004-06-17 EA EA200600050A patent/EA014887B1/ru not_active IP Right Cessation
- 2004-06-17 EP EP04737835A patent/EP1633876B1/en not_active Not-in-force
- 2004-06-17 MX MXPA05013723A patent/MXPA05013723A/es active IP Right Grant
- 2004-06-17 ES ES04737835T patent/ES2313018T3/es active Active
- 2004-06-17 NZ NZ544522A patent/NZ544522A/en not_active IP Right Cessation
- 2004-06-17 AU AU2004247762A patent/AU2004247762B2/en not_active Ceased
- 2004-06-17 CA CA002528741A patent/CA2528741A1/en not_active Abandoned
- 2004-06-17 EP EP08007159A patent/EP1959017A1/en not_active Withdrawn
-
2005
- 2005-12-08 IL IL172469A patent/IL172469A/en not_active IP Right Cessation
- 2005-12-12 NO NO20055885A patent/NO20055885L/no not_active Application Discontinuation
- 2005-12-16 KR KR1020057024281A patent/KR101216762B1/ko not_active IP Right Cessation
-
2006
- 2006-08-18 HK HK06109198.5A patent/HK1088037A1/xx not_active IP Right Cessation
-
2008
- 2008-11-03 CY CY20081101246T patent/CY1108477T1/el unknown
-
2009
- 2009-05-12 US US12/464,207 patent/US20090282583A1/en not_active Abandoned
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2011
- 2011-06-03 JP JP2011124794A patent/JP2011200251A/ja active Pending
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