CN107108716B - 双相性单链胰岛素类似物 - Google Patents

双相性单链胰岛素类似物

Info

Publication number
CN107108716B
CN107108716B CN201580054329.9A CN201580054329A CN107108716B CN 107108716 B CN107108716 B CN 107108716B CN 201580054329 A CN201580054329 A CN 201580054329A CN 107108716 B CN107108716 B CN 107108716B
Authority
CN
China
Prior art keywords
insulin
chain
sci
seq
glu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580054329.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN107108716A (zh
Inventor
M.维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of CN107108716A publication Critical patent/CN107108716A/zh
Application granted granted Critical
Publication of CN107108716B publication Critical patent/CN107108716B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201580054329.9A 2014-10-06 2015-10-06 双相性单链胰岛素类似物 Active CN107108716B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
US62/060167 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (2)

Publication Number Publication Date
CN107108716A CN107108716A (zh) 2017-08-29
CN107108716B true CN107108716B (zh) 2026-06-19

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580054329.9A Active CN107108716B (zh) 2014-10-06 2015-10-06 双相性单链胰岛素类似物

Country Status (10)

Country Link
US (2) US10392429B2 (enExample)
EP (1) EP3204410B1 (enExample)
JP (1) JP6829928B2 (enExample)
KR (1) KR102569743B1 (enExample)
CN (1) CN107108716B (enExample)
AU (1) AU2015328222B9 (enExample)
BR (1) BR112017004544A2 (enExample)
CA (1) CA2961037A1 (enExample)
IL (1) IL251503A0 (enExample)
WO (1) WO2016057529A2 (enExample)

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HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
AU2017361524B2 (en) * 2016-11-21 2022-06-02 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
HUE062719T2 (hu) * 2018-06-29 2023-11-28 Akston Biosciences Corp Ultra-hosszú hatású inzulin-FC fúziós fehérjék és az alkalmazási eljárások
BR112021005366A2 (pt) * 2018-09-21 2021-06-29 Case Western Reserve University análogo de insulina de cadeia simples, uso deste e método para reduzir o açúcar no sangue de um paciente
US12077568B2 (en) 2018-10-01 2024-09-03 University Of Houston System Engineered active single-polypeptide chain insulin analogs
US20220002373A1 (en) * 2018-11-19 2022-01-06 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
CA3139946A1 (en) * 2019-05-17 2020-11-26 Case Western Reserve University Variant single-chain insulin analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
US20220280614A1 (en) * 2019-08-02 2022-09-08 Case Western Reserve University Premixed Ultra-Stable Single-Chain Insulin Analogue Formulations
IL296090A (en) * 2020-03-02 2022-11-01 Thermalin Inc Compositions containing rapid-acting insulin analogues
EP4255469A4 (en) * 2020-12-07 2025-01-22 Case Western Reserve University ACYLATED SINGLE-CHAIN INSULIN ANALOGUES
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
WO2023041758A1 (en) 2021-09-20 2023-03-23 Kyon Biotech Ag Arginase-insulin fusion protein
WO2024218715A1 (en) 2023-04-19 2024-10-24 Btl Healthcare Technologies A.S. Culture media based on protein hydrolysate and a process for preparing thereof
US12668774B2 (en) 2023-10-12 2026-06-30 Btl Healthcare Technologies A.S. Product, system and method of cell cultivation

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WO2014071405A2 (en) * 2012-11-05 2014-05-08 Case Western Reserve University Long-acting single-chain insulin analogues

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WO2014071405A2 (en) * 2012-11-05 2014-05-08 Case Western Reserve University Long-acting single-chain insulin analogues

Also Published As

Publication number Publication date
EP3204410A4 (en) 2018-03-07
KR20170064533A (ko) 2017-06-09
WO2016057529A2 (en) 2016-04-14
BR112017004544A2 (en) 2018-01-23
WO2016057529A3 (en) 2016-11-03
EP3204410A2 (en) 2017-08-16
US10392429B2 (en) 2019-08-27
KR102569743B1 (ko) 2023-08-23
AU2015328222B9 (en) 2020-12-24
US20190375814A1 (en) 2019-12-12
JP6829928B2 (ja) 2021-02-17
CA2961037A1 (en) 2016-04-14
JP2017536337A (ja) 2017-12-07
CN107108716A (zh) 2017-08-29
US11142560B2 (en) 2021-10-12
AU2015328222A1 (en) 2017-03-16
US20180265560A1 (en) 2018-09-20
IL251503A0 (en) 2017-05-29
EP3204410B1 (en) 2021-01-20
AU2015328222B2 (en) 2020-08-20

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