JP6829928B2 - 二相性単鎖インスリン類似体 - Google Patents

二相性単鎖インスリン類似体 Download PDF

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Publication number
JP6829928B2
JP6829928B2 JP2017518189A JP2017518189A JP6829928B2 JP 6829928 B2 JP6829928 B2 JP 6829928B2 JP 2017518189 A JP2017518189 A JP 2017518189A JP 2017518189 A JP2017518189 A JP 2017518189A JP 6829928 B2 JP6829928 B2 JP 6829928B2
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insulin
chain insulin
chain
amino acid
region
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Japanese (ja)
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JP2017536337A (ja
JP2017536337A5 (enExample
Inventor
ワイス、マイケル
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Case Western Reserve University
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Case Western Reserve University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2017518189A 2014-10-06 2015-10-06 二相性単鎖インスリン類似体 Active JP6829928B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
US62/060,167 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (3)

Publication Number Publication Date
JP2017536337A JP2017536337A (ja) 2017-12-07
JP2017536337A5 JP2017536337A5 (enExample) 2018-11-08
JP6829928B2 true JP6829928B2 (ja) 2021-02-17

Family

ID=55653938

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017518189A Active JP6829928B2 (ja) 2014-10-06 2015-10-06 二相性単鎖インスリン類似体

Country Status (10)

Country Link
US (2) US10392429B2 (enExample)
EP (1) EP3204410B1 (enExample)
JP (1) JP6829928B2 (enExample)
KR (1) KR102569743B1 (enExample)
CN (1) CN107108716A (enExample)
AU (1) AU2015328222B9 (enExample)
BR (1) BR112017004544A2 (enExample)
CA (1) CA2961037A1 (enExample)
IL (1) IL251503A0 (enExample)
WO (1) WO2016057529A2 (enExample)

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KR102351111B1 (ko) 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3393498A4 (en) * 2015-12-23 2019-08-07 Case Western Reserve University SECULATION OF ULTRASTABILEN INSULIN ANALOGUE WITH POLYMER MELTS
CA3044565A1 (en) * 2016-11-21 2018-05-24 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
CN113038964B (zh) * 2018-06-29 2025-05-27 德克拉有限公司 超长效胰岛素-fc融合蛋白及使用方法
BR112021005366A2 (pt) * 2018-09-21 2021-06-29 Case Western Reserve University análogo de insulina de cadeia simples, uso deste e método para reduzir o açúcar no sangue de um paciente
WO2020072181A1 (en) * 2018-10-01 2020-04-09 University Of Houston System Engineered active single-polypeptide chain insulin analogs
JP2022507627A (ja) * 2018-11-19 2022-01-18 ケース ウェスタン リザーブ ユニバーシティ ポリ－アラニンｃ－ドメインのサブセグメントを有する単鎖インスリンアナログ
WO2020236762A2 (en) * 2019-05-17 2020-11-26 Case Western Reserve University Variant single-chain insulin analogues
TW202434620A (zh) 2019-07-31 2024-09-01 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
US20220280614A1 (en) * 2019-08-02 2022-09-08 Case Western Reserve University Premixed Ultra-Stable Single-Chain Insulin Analogue Formulations
IL296090A (en) 2020-03-02 2022-11-01 Thermalin Inc Compositions containing rapid-acting insulin analogues
WO2022125587A1 (en) * 2020-12-07 2022-06-16 Case Western Reserve University Acylated single-chain insulin analogues
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
CN118201954A (zh) 2021-09-20 2024-06-14 克云生物科技股份公司 精氨酸酶-胰岛素融合蛋白

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US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
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JP5866120B2 (ja) 2009-12-11 2016-02-17 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 塩素化アミノ酸を有するインスリン類似体
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Also Published As

Publication number Publication date
AU2015328222B2 (en) 2020-08-20
KR20170064533A (ko) 2017-06-09
EP3204410A4 (en) 2018-03-07
WO2016057529A2 (en) 2016-04-14
EP3204410A2 (en) 2017-08-16
JP2017536337A (ja) 2017-12-07
US10392429B2 (en) 2019-08-27
EP3204410B1 (en) 2021-01-20
US20180265560A1 (en) 2018-09-20
BR112017004544A2 (pt) 2018-01-23
AU2015328222B9 (en) 2020-12-24
AU2015328222A1 (en) 2017-03-16
WO2016057529A3 (en) 2016-11-03
KR102569743B1 (ko) 2023-08-23
US20190375814A1 (en) 2019-12-12
IL251503A0 (en) 2017-05-29
US11142560B2 (en) 2021-10-12
CN107108716A (zh) 2017-08-29
CA2961037A1 (en) 2016-04-14

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