KR102569743B1 - 이상 단일 사슬 인슐린 유사체 - Google Patents

이상 단일 사슬 인슐린 유사체 Download PDF

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Publication number
KR102569743B1
KR102569743B1 KR1020177006438A KR20177006438A KR102569743B1 KR 102569743 B1 KR102569743 B1 KR 102569743B1 KR 1020177006438 A KR1020177006438 A KR 1020177006438A KR 20177006438 A KR20177006438 A KR 20177006438A KR 102569743 B1 KR102569743 B1 KR 102569743B1
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KR20170064533A (ko
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마이클 웨이쓰
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케이스 웨스턴 리저브 유니버시티
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
KR1020177006438A 2014-10-06 2015-10-06 이상 단일 사슬 인슐린 유사체 Active KR102569743B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060167P 2014-10-06 2014-10-06
US62/060,167 2014-10-06
PCT/US2015/054263 WO2016057529A2 (en) 2014-10-06 2015-10-06 Biphasic single-chain insulin analogues

Publications (2)

Publication Number Publication Date
KR20170064533A KR20170064533A (ko) 2017-06-09
KR102569743B1 true KR102569743B1 (ko) 2023-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177006438A Active KR102569743B1 (ko) 2014-10-06 2015-10-06 이상 단일 사슬 인슐린 유사체

Country Status (10)

Country Link
US (2) US10392429B2 (enExample)
EP (1) EP3204410B1 (enExample)
JP (1) JP6829928B2 (enExample)
KR (1) KR102569743B1 (enExample)
CN (1) CN107108716A (enExample)
AU (1) AU2015328222B9 (enExample)
BR (1) BR112017004544A2 (enExample)
CA (1) CA2961037A1 (enExample)
IL (1) IL251503A0 (enExample)
WO (1) WO2016057529A2 (enExample)

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WO2015106269A2 (en) 2014-01-13 2015-07-16 Thermalin Diabetes, Llc Rapid action insulin formulations and pharmaceutical delivery systems
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
HK1255634A1 (zh) * 2015-12-23 2019-08-23 Case Western Reserve University 超稳胰岛素类似物在聚合物熔体中的包囊
TW201831504A (zh) * 2016-11-21 2018-09-01 美國凱斯西方瑞瑟夫大學 增強穩定性之速效胰島素類似物
DK4186920T5 (da) * 2018-06-29 2024-07-22 Akston Biosciences Corp Ultra-langtidsvirkende insulin-fc-fusionsproteiner og fremgangsmåder til anvendelse
EP3853246A4 (en) * 2018-09-21 2023-01-11 Case Western Reserve University Site 2 single-chain insulin analogues
WO2020072181A1 (en) * 2018-10-01 2020-04-09 University Of Houston System Engineered active single-polypeptide chain insulin analogs
US20220002373A1 (en) * 2018-11-19 2022-01-06 Case Western Reserve University Single-chain insulin analogues with poly-alanine c-domain sub-segments
WO2020236762A2 (en) * 2019-05-17 2020-11-26 Case Western Reserve University Variant single-chain insulin analogues
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
US20220280614A1 (en) * 2019-08-02 2022-09-08 Case Western Reserve University Premixed Ultra-Stable Single-Chain Insulin Analogue Formulations
JP2023532165A (ja) * 2020-03-02 2023-07-27 サーマリン インク． 速効型インスリンアナログを含む組成物
US20240043493A1 (en) * 2020-12-07 2024-02-08 Case Western Reserve University Acylated single-chain insulin analogues
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou
JP2024531773A (ja) 2021-09-20 2024-08-29 キュオン バイオテック アー・ゲー アルギナーゼ－インスリン融合タンパク質

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Also Published As

Publication number Publication date
AU2015328222A1 (en) 2017-03-16
US20180265560A1 (en) 2018-09-20
CN107108716A (zh) 2017-08-29
US11142560B2 (en) 2021-10-12
AU2015328222B9 (en) 2020-12-24
EP3204410A2 (en) 2017-08-16
EP3204410A4 (en) 2018-03-07
KR20170064533A (ko) 2017-06-09
WO2016057529A3 (en) 2016-11-03
JP2017536337A (ja) 2017-12-07
US20190375814A1 (en) 2019-12-12
IL251503A0 (en) 2017-05-29
EP3204410B1 (en) 2021-01-20
BR112017004544A2 (pt) 2018-01-23
JP6829928B2 (ja) 2021-02-17
CA2961037A1 (en) 2016-04-14
US10392429B2 (en) 2019-08-27
AU2015328222B2 (en) 2020-08-20
WO2016057529A2 (en) 2016-04-14

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