TR200001050T2 - Çözünmez insülin bileşimleri - Google Patents
Çözünmez insülin bileşimleriInfo
- Publication number
- TR200001050T2 TR200001050T2 TR2000/01050T TR200001050T TR200001050T2 TR 200001050 T2 TR200001050 T2 TR 200001050T2 TR 2000/01050 T TR2000/01050 T TR 2000/01050T TR 200001050 T TR200001050 T TR 200001050T TR 200001050 T2 TR200001050 T2 TR 200001050T2
- Authority
- TR
- Turkey
- Prior art keywords
- insulin
- nph
- unopened
- blood sugar
- acylated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Bulus açillenmis insülin, açillenmis analog insülin ve açillenmis proinsülinlerin olusturdugu grup içinden seçilen protein ihtiva eden çözünmez bilesimlerle ilgilidir. Bilesim formülleri diabet hastalarinin kan sekeri seviyelerini düzenlemek için kullanilir. Bilesim civa, protamin ve bir fenolik terkip ile kompleks hale gelmis açillenmis proteinden olusur ve elde edilen mikro kristal NPH insülin kristallerine benzer fakat deri altina uygulandiginda daha uzun ve etkin bir kan sekeri düzenleme özelligine sahiptir. Ayrica NPH gibi tekrar süspansiyon haline getirilebilir ve diger çözülebilir insülinlerle de karistirilabilir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6310497P | 1997-10-24 | 1997-10-24 | |
US8893098P | 1998-06-11 | 1998-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200001050T2 true TR200001050T2 (tr) | 2000-08-21 |
Family
ID=26743043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/01050T TR200001050T2 (tr) | 1997-10-24 | 1998-10-22 | Çözünmez insülin bileşimleri |
Country Status (21)
Country | Link |
---|---|
US (3) | US6268335B1 (tr) |
EP (1) | EP1039920A4 (tr) |
JP (2) | JP2001521004A (tr) |
KR (1) | KR20010024556A (tr) |
CN (1) | CN1276731A (tr) |
AR (1) | AR020047A1 (tr) |
AU (2) | AU1111799A (tr) |
BR (1) | BR9813111A (tr) |
CA (2) | CA2306877A1 (tr) |
CO (1) | CO4970769A1 (tr) |
EA (1) | EA200000453A1 (tr) |
HR (1) | HRP20000236A2 (tr) |
HU (1) | HUP0004169A3 (tr) |
ID (1) | ID24890A (tr) |
IL (1) | IL134901A0 (tr) |
NO (1) | NO20002038L (tr) |
PE (1) | PE123799A1 (tr) |
PL (1) | PL340255A1 (tr) |
SV (1) | SV1998000125A (tr) |
TR (1) | TR200001050T2 (tr) |
WO (2) | WO1999021573A1 (tr) |
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DK0705275T3 (da) | 1993-06-21 | 1999-09-20 | Novo Nordisk As | AspB28-insulin-krystaller |
WO1995007931A1 (en) * | 1993-09-17 | 1995-03-23 | Novo Nordisk A/S | Acylated insulin |
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US5597893A (en) | 1994-10-31 | 1997-01-28 | Eli Lilly And Company | Preparation of stable insulin analog crystals |
US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
AU720966B2 (en) | 1995-03-17 | 2000-06-22 | Novo Nordisk A/S | Insulin derivatives |
US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
US5877153A (en) | 1996-06-11 | 1999-03-02 | Commonwealth Biotechnologies Inc. | Heparin-binding peptides |
US5948751A (en) | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
EP0910402B1 (en) | 1996-06-20 | 2007-08-08 | Novo Nordisk A/S | Insulin preparations containing mannitol |
ATE294189T1 (de) | 1997-02-07 | 2005-05-15 | Novo Nordisk As | Kristallisation von proteinen |
ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
-
1998
- 1998-10-22 BR BR9813111-7A patent/BR9813111A/pt not_active IP Right Cessation
- 1998-10-22 ID IDW20000748A patent/ID24890A/id unknown
- 1998-10-22 CA CA002306877A patent/CA2306877A1/en not_active Abandoned
- 1998-10-22 AU AU11117/99A patent/AU1111799A/en not_active Abandoned
- 1998-10-22 EA EA200000453A patent/EA200000453A1/ru unknown
- 1998-10-22 KR KR1020007004395A patent/KR20010024556A/ko not_active Application Discontinuation
- 1998-10-22 HU HU0004169A patent/HUP0004169A3/hu unknown
- 1998-10-22 JP JP2000517731A patent/JP2001521004A/ja not_active Withdrawn
- 1998-10-22 WO PCT/US1998/022313 patent/WO1999021573A1/en not_active Application Discontinuation
- 1998-10-22 CO CO98061475A patent/CO4970769A1/es unknown
- 1998-10-22 IL IL13490198A patent/IL134901A0/xx unknown
- 1998-10-22 PE PE1998000996A patent/PE123799A1/es not_active Application Discontinuation
- 1998-10-22 CA CA002306905A patent/CA2306905A1/en not_active Abandoned
- 1998-10-22 US US09/177,685 patent/US6268335B1/en not_active Expired - Lifetime
- 1998-10-22 AR ARP980105267A patent/AR020047A1/es unknown
- 1998-10-22 AU AU11166/99A patent/AU747926B2/en not_active Ceased
- 1998-10-22 EP EP98953852A patent/EP1039920A4/en not_active Withdrawn
- 1998-10-22 SV SV1998000125A patent/SV1998000125A/es unknown
- 1998-10-22 PL PL98340255A patent/PL340255A1/xx not_active Application Discontinuation
- 1998-10-22 WO PCT/US1998/022434 patent/WO1999021578A1/en not_active Application Discontinuation
- 1998-10-22 CN CN98810334A patent/CN1276731A/zh active Pending
- 1998-10-22 JP JP2000517736A patent/JP2001521006A/ja not_active Withdrawn
- 1998-10-22 TR TR2000/01050T patent/TR200001050T2/tr unknown
-
2000
- 2000-04-18 NO NO20002038A patent/NO20002038L/no not_active Application Discontinuation
- 2000-04-21 HR HR20000236A patent/HRP20000236A2/hr not_active Application Discontinuation
-
2001
- 2001-01-17 US US09/761,903 patent/US6465426B2/en not_active Expired - Fee Related
- 2001-12-06 US US10/010,038 patent/US20020082199A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HUP0004169A3 (en) | 2001-06-28 |
NO20002038D0 (no) | 2000-04-18 |
US20010036916A1 (en) | 2001-11-01 |
HUP0004169A2 (hu) | 2001-05-28 |
EP1039920A1 (en) | 2000-10-04 |
EP1039920A4 (en) | 2003-05-28 |
ID24890A (id) | 2000-08-31 |
CO4970769A1 (es) | 2000-11-07 |
PE123799A1 (es) | 1999-12-13 |
IL134901A0 (en) | 2001-05-20 |
AR020047A1 (es) | 2002-04-10 |
JP2001521004A (ja) | 2001-11-06 |
EA200000453A1 (ru) | 2000-10-30 |
KR20010024556A (ko) | 2001-03-26 |
JP2001521006A (ja) | 2001-11-06 |
SV1998000125A (es) | 1999-05-24 |
AU747926B2 (en) | 2002-05-30 |
HRP20000236A2 (en) | 2001-02-28 |
US6268335B1 (en) | 2001-07-31 |
US6465426B2 (en) | 2002-10-15 |
WO1999021578A1 (en) | 1999-05-06 |
US20020082199A1 (en) | 2002-06-27 |
BR9813111A (pt) | 2000-08-15 |
AU1111799A (en) | 1999-05-17 |
CN1276731A (zh) | 2000-12-13 |
NO20002038L (no) | 2000-06-26 |
WO1999021573A1 (en) | 1999-05-06 |
CA2306905A1 (en) | 1999-05-06 |
AU1116699A (en) | 1999-05-17 |
CA2306877A1 (en) | 1999-05-06 |
PL340255A1 (en) | 2001-01-29 |
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