HUP9903536A2 - Bázikus anyaggal stabilizált gyógyászati készítmények - Google Patents

Bázikus anyaggal stabilizált gyógyászati készítmények

Info

Publication number
HUP9903536A2
HUP9903536A2 HU9903536A HUP9903536A HUP9903536A2 HU P9903536 A2 HUP9903536 A2 HU P9903536A2 HU 9903536 A HU9903536 A HU 9903536A HU P9903536 A HUP9903536 A HU P9903536A HU P9903536 A2 HUP9903536 A2 HU P9903536A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical composition
basic agent
composition stabilized
basic substance
substance
Prior art date
Application number
HU9903536A
Other languages
English (en)
Inventor
Hiroyuki Kawashima
Katsumi Mashita
Toyojiro Muramatsu
Hironori Sassa
Yasuo Shinoda
Hideatsu Takeuchi
Yoshio Tanizawa
Original Assignee
Kowa Co. Ltd.
Nissan Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co. Ltd., Nissan Chemical Industries, Ltd. filed Critical Kowa Co. Ltd.
Publication of HUP9903536A2 publication Critical patent/HUP9903536A2/hu
Publication of HUP9903536A3 publication Critical patent/HUP9903536A3/hu
Publication of HU227798B1 publication Critical patent/HU227798B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bázikűs anyaggal stabilizált, hatóanyagként (E)-3,5-dihidrőxi-7-[4'-(4''-flűőr-fenil)-2-'-ciklőprőpil-kinőlin-3'-il]-6-hepténsavat, enneksóját vagy észterét tartalmazó gyógyászati készítmények, amelyek vizesőldatának vagy diszperziójának pH-ja 7 és 8 közé esik, ahől a bázikűsanyag valamely ismert savmegkötő szer vagy pH-szabályőzó anyag,amelynek őlyan mennyiségét alkalmazzák, amely szükséges az említett 7és 8 közötti pH-érték biztősításáhőz. E készítmények tartalmazhatnaktővábbá egy vagy több vivőanyagőt (töltőanyagőt), szétesést elősegítőanyagőt, kötőanyagőt és/vagy csúsztatószert. ŕ
HU9903536A 1995-12-22 1996-12-20 Pharmaceutical composition stabilized with a basic agent HU227798B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35465495 1995-12-22
PCT/JP1996/003722 WO1997023200A1 (en) 1995-12-22 1996-12-20 Pharmaceutical composition stabilized with a basic agent

Publications (3)

Publication Number Publication Date
HUP9903536A2 true HUP9903536A2 (hu) 2000-03-28
HUP9903536A3 HUP9903536A3 (en) 2001-06-28
HU227798B1 HU227798B1 (en) 2012-03-28

Family

ID=18439011

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903536A HU227798B1 (en) 1995-12-22 1996-12-20 Pharmaceutical composition stabilized with a basic agent

Country Status (26)

Country Link
EP (1) EP0814782B1 (hu)
JP (1) JP3276962B2 (hu)
KR (1) KR100348842B1 (hu)
CN (1) CN1137684C (hu)
AT (1) ATE228354T1 (hu)
AU (1) AU725622B2 (hu)
CA (1) CA2213608C (hu)
CZ (1) CZ288545B6 (hu)
DE (2) DE69625046T2 (hu)
DK (1) DK0814782T3 (hu)
ES (1) ES2183023T3 (hu)
FR (1) FR11C0007I2 (hu)
HU (1) HU227798B1 (hu)
IL (1) IL121565A (hu)
MX (1) MX9706389A (hu)
NO (2) NO316724B1 (hu)
NZ (1) NZ324446A (hu)
PL (1) PL186907B1 (hu)
PT (1) PT814782E (hu)
RU (1) RU2142790C1 (hu)
SI (1) SI0814782T1 (hu)
SK (1) SK282991B6 (hu)
TW (1) TW436294B (hu)
UA (1) UA29513C2 (hu)
WO (1) WO1997023200A1 (hu)
ZA (1) ZA9610792B (hu)

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US6730418B2 (en) 1999-12-13 2004-05-04 Kabushiki Kaisha Toyota Chuo Kenkyusho Quinoline derivatives and organic electroluminescent devices
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US6242003B1 (en) 2000-04-13 2001-06-05 Novartis Ag Organic compounds
US6806290B2 (en) 2000-06-09 2004-10-19 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
SI1292293T1 (en) 2000-06-09 2004-06-30 LEK farmacevtska dru�ba d.d. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
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TW200404544A (en) * 2002-06-17 2004-04-01 Kowa Co Controlled release pharmaceutical composition
JP4630065B2 (ja) * 2002-09-20 2011-02-09 興和株式会社 外用剤
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
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ATE535614T1 (de) 2003-12-30 2011-12-15 Kowa Co Screening-verfahren fuer gamma-sekretase- inhibitoren
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
SE0400235D0 (sv) * 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
EP1719525B1 (en) 2004-02-25 2014-12-10 Kowa Company, Ltd. Nuclear transfer promoter for cdc42 protein and method of screening the same
US8309574B2 (en) 2004-02-25 2012-11-13 Kowa Company, Ltd. Nuclear transfer promoter for Rac protein and method of screening the same
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
JP2008526861A (ja) 2005-01-06 2008-07-24 メルク エンド カムパニー インコーポレーテッド 炎症性障害を治療するための薬剤併用療法および医薬組成物
EP1726962A1 (en) * 2005-05-24 2006-11-29 Leiden University Medical Center Apolipoprotein E plasma levels for monitoring and reducing the risk of cardiovascular disease
CN101103983B (zh) * 2006-07-14 2012-09-26 海南盛科生命科学研究院 一种用碱试剂稳定的含匹伐他汀钙的药用组合物及制备工艺
JP2010530419A (ja) 2007-06-20 2010-09-09 メルク・シャープ・エンド・ドーム・コーポレイション ジフェニル置換アルカン
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
KR20130137623A (ko) 2010-10-06 2013-12-17 고쿠리츠다이가쿠호우진 도쿄다이가쿠 림프 부종 예방 치료제
KR20140009291A (ko) 2011-01-20 2014-01-22 머크 샤프 앤드 돔 코포레이션 미네랄로코르티코이드 수용체 길항제
EP2698159A4 (en) 2011-04-12 2014-11-05 Sawai Seiyaku Kk PITAVASTATE-CONTAINING PREPARATION AND METHOD OF MANUFACTURING THEREOF
US9487506B2 (en) 2011-04-13 2016-11-08 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
WO2012153181A1 (en) 2011-05-11 2012-11-15 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical composition comprising pitavastatin or its pharmaceutically acceptable salts
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JP5809467B2 (ja) * 2011-07-12 2015-11-11 エルメッド エーザイ株式会社 ピタバスタチン含有組成物及びその製造方法
JP5844574B2 (ja) * 2011-08-10 2016-01-20 共和薬品工業株式会社 ピタバスタチンを含有する安定化された薬物組成物
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Also Published As

Publication number Publication date
CZ288545B6 (cs) 2001-07-11
HUP9903536A3 (en) 2001-06-28
RU2142790C1 (ru) 1999-12-20
SK282991B6 (sk) 2003-01-09
KR100348842B1 (ko) 2002-12-31
AU725622B2 (en) 2000-10-19
SK116097A3 (en) 1998-03-04
CN1137684C (zh) 2004-02-11
IL121565A (en) 2002-02-10
FR11C0007I1 (hu) 2011-04-22
NO2011006I2 (no) 2012-10-01
CZ268197A3 (cs) 1998-05-13
NO973814D0 (no) 1997-08-19
FR11C0007I2 (fr) 2012-03-16
EP0814782B1 (en) 2002-11-27
DE69625046D1 (de) 2003-01-09
HU227798B1 (en) 2012-03-28
EP0814782A1 (en) 1998-01-07
CA2213608C (en) 2003-07-08
WO1997023200A1 (en) 1997-07-03
SI0814782T1 (en) 2003-04-30
TW436294B (en) 2001-05-28
NZ324446A (en) 1999-08-30
PT814782E (pt) 2003-04-30
MX9706389A (es) 1998-08-30
NO973814L (no) 1997-10-13
DE122011000014I1 (de) 2011-11-03
DE69625046T2 (de) 2003-04-10
UA29513C2 (uk) 2000-11-15
CA2213608A1 (en) 1997-07-03
KR19980702370A (ko) 1998-07-15
NO2011006I1 (no) 2011-06-06
CN1189098A (zh) 1998-07-29
AU1171597A (en) 1997-07-17
ES2183023T3 (es) 2003-03-16
JP3276962B2 (ja) 2002-04-22
NO316724B1 (no) 2004-04-19
JPH11503763A (ja) 1999-03-30
ATE228354T1 (de) 2002-12-15
PL321868A1 (en) 1997-12-22
IL121565A0 (en) 1998-02-08
ZA9610792B (en) 1997-07-09
DK0814782T3 (da) 2002-12-16
PL186907B1 (pl) 2004-03-31

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