DE69625046D1 - Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium - Google Patents

Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium

Info

Publication number
DE69625046D1
DE69625046D1 DE69625046T DE69625046T DE69625046D1 DE 69625046 D1 DE69625046 D1 DE 69625046D1 DE 69625046 T DE69625046 T DE 69625046T DE 69625046 T DE69625046 T DE 69625046T DE 69625046 D1 DE69625046 D1 DE 69625046D1
Authority
DE
Germany
Prior art keywords
pharmaceutical composition
basic medium
composition stabilized
composition
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69625046T
Other languages
English (en)
Other versions
DE69625046T2 (de
Inventor
Toyojiro Muramatsu
Katsumi Mashita
Yasuo Shinoda
Hironori Sassa
Hiroyuki Kawashima
Yoshio Tanizawa
Hideatsu Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Nissan Chemical Corp
Original Assignee
Kowa Co Ltd
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd, Nissan Chemical Corp filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of DE69625046D1 publication Critical patent/DE69625046D1/de
Publication of DE69625046T2 publication Critical patent/DE69625046T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69625046T 1995-12-22 1996-12-20 Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium Expired - Lifetime DE69625046T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35465495 1995-12-22
PCT/JP1996/003722 WO1997023200A1 (en) 1995-12-22 1996-12-20 Pharmaceutical composition stabilized with a basic agent

Publications (2)

Publication Number Publication Date
DE69625046D1 true DE69625046D1 (de) 2003-01-09
DE69625046T2 DE69625046T2 (de) 2003-04-10

Family

ID=18439011

Family Applications (2)

Application Number Title Priority Date Filing Date
DE201112000014 Pending DE122011000014I1 (de) 1995-12-22 1996-12-20 Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium.
DE69625046T Expired - Lifetime DE69625046T2 (de) 1995-12-22 1996-12-20 Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE201112000014 Pending DE122011000014I1 (de) 1995-12-22 1996-12-20 Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium.

Country Status (26)

Country Link
EP (1) EP0814782B1 (de)
JP (1) JP3276962B2 (de)
KR (1) KR100348842B1 (de)
CN (1) CN1137684C (de)
AT (1) ATE228354T1 (de)
AU (1) AU725622B2 (de)
CA (1) CA2213608C (de)
CZ (1) CZ288545B6 (de)
DE (2) DE122011000014I1 (de)
DK (1) DK0814782T3 (de)
ES (1) ES2183023T3 (de)
FR (1) FR11C0007I2 (de)
HU (1) HU227798B1 (de)
IL (1) IL121565A (de)
MX (1) MX9706389A (de)
NO (2) NO316724B1 (de)
NZ (1) NZ324446A (de)
PL (1) PL186907B1 (de)
PT (1) PT814782E (de)
RU (1) RU2142790C1 (de)
SI (1) SI0814782T1 (de)
SK (1) SK282991B6 (de)
TW (1) TW436294B (de)
UA (1) UA29513C2 (de)
WO (1) WO1997023200A1 (de)
ZA (1) ZA9610792B (de)

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CO5140079A1 (es) * 1998-10-14 2002-03-22 Novartis Ag Composicion farmaceutica de liberacion sostenida y metodo para liberar un agente farmaceuticamente activo de liberacion sostenida y metodo para liberar un agente far- maceuticamente activo
SI20109A (sl) * 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stabilna farmacevtska formulacija
EP1161236A1 (de) * 1999-03-08 2001-12-12 Merck & Co., Inc. Dihydroxy offen-säure und salze von hmg-co-a reductase inhibitoren
EP1036563A1 (de) * 1999-03-08 2000-09-20 MERCK & CO. INC. Dihydroxy offen Saüre und Salzen von hmg-coa reductase Inhibitoren
US6569461B1 (en) 1999-03-08 2003-05-27 Merck & Co., Inc. Dihydroxy open-acid and salts of HMG-CoA reductase inhibitors
WO2001042218A1 (fr) * 1999-12-13 2001-06-14 Kabushiki Kaisha Toyota Chuo Kenkyusho Derives de quinoleine et dispositifs electroluminescents organiques
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
USRE44578E1 (en) 2000-04-10 2013-11-05 Teva Pharmaceutical Industries, Ltd. Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids
US6242003B1 (en) 2000-04-13 2001-06-05 Novartis Ag Organic compounds
US6806290B2 (en) 2000-06-09 2004-10-19 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
ATE260101T1 (de) 2000-06-09 2004-03-15 Lek Tovarna Farmacevtskih Stabilisierte pharmazeutisch wirksame zubereitung und diese enthaltende arzneizusammensetzung
US20060127474A1 (en) 2001-04-11 2006-06-15 Oskar Kalb Pharmaceutical compositions comprising fluvastatin
TW200404544A (en) * 2002-06-17 2004-04-01 Kowa Co Controlled release pharmaceutical composition
WO2004026297A1 (ja) * 2002-09-20 2004-04-01 Kowa Co., Ltd. 外用剤
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
CN100471835C (zh) 2003-12-23 2009-03-25 默克公司 抗高胆固醇血症化合物
JPWO2005063294A1 (ja) 2003-12-30 2007-12-13 興和株式会社 γ−セクレターゼ複合体形成阻害剤
US8314124B2 (en) 2004-02-06 2012-11-20 Active Biotech Ab Crystalline salts of quinoline compounds and methods for preparing them
SE0400235D0 (sv) 2004-02-06 2004-02-06 Active Biotech Ab New composition containing quinoline compounds
EP1719525B1 (de) 2004-02-25 2014-12-10 Kowa Company, Ltd. Nukleartransferpromotor für cdc42 protein und screening-verfahren dafür
EP1719524B1 (de) 2004-02-25 2014-11-26 Kowa Company, Ltd. Nukleartransfer-promotor für rac protein und screening-verfahren dafür
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2006204038A1 (en) 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
EP1726962A1 (de) * 2005-05-24 2006-11-29 Leiden University Medical Center Apolipoprotein E-plasmaspiegel zur Überwachung und Reduktion des Risikos der kardiovaskulairen Erkrankungen
CN101103983B (zh) * 2006-07-14 2012-09-26 海南盛科生命科学研究院 一种用碱试剂稳定的含匹伐他汀钙的药用组合物及制备工艺
EP2170065A4 (de) 2007-06-20 2011-11-23 Merck Sharp & Dohme Diphenylsubstituierte alkane
US8372877B2 (en) 2010-04-16 2013-02-12 Cumberland Pharmaceuticals Stabilized statin formulations
CN103153299A (zh) 2010-10-06 2013-06-12 国立大学法人东京大学 淋巴水肿预防治疗剂
WO2012097744A1 (en) 2011-01-20 2012-07-26 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
WO2012141160A1 (ja) 2011-04-12 2012-10-18 沢井製薬株式会社 ピタバスタチン含有製剤及びその製造方法
WO2012139495A1 (en) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
WO2012153181A1 (en) 2011-05-11 2012-11-15 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical composition comprising pitavastatin or its pharmaceutically acceptable salts
CN102861018A (zh) * 2011-07-05 2013-01-09 南京长澳医药科技有限公司 一种匹伐他汀钙制剂及其制备工艺
JP5809467B2 (ja) * 2011-07-12 2015-11-11 エルメッド エーザイ株式会社 ピタバスタチン含有組成物及びその製造方法
JP5844574B2 (ja) * 2011-08-10 2016-01-20 共和薬品工業株式会社 ピタバスタチンを含有する安定化された薬物組成物
WO2013055606A1 (en) 2011-10-13 2013-04-18 Merck Sharp & Dohme Corp. Mineralocorticoid receptor antagonists
KR101461841B1 (ko) 2012-08-08 2014-11-13 코와 가부시키가이샤 의약
CN102885797A (zh) * 2012-10-29 2013-01-23 福州海王福药制药有限公司 一种含匹伐他汀钙的组合物及其制备方法和应用
US9750723B2 (en) 2013-10-31 2017-09-05 Ohio University Prevention and treatment of non-alcoholic fatty liver disease
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
JP6648108B2 (ja) 2014-07-18 2020-02-14 オハイオ ユニバーシティー 生物学的シグナル伝達を改変するためのイミダゾール及びチアゾール組成物
CN105343008A (zh) * 2015-12-15 2016-02-24 青岛华之草医药科技有限公司 一种匹伐他汀钙组合物
CN107913257A (zh) * 2016-10-10 2018-04-17 北京阜康仁生物制药科技有限公司 一种包含瑞舒伐他汀钙的药物组合物及其制备方法
JP6937195B2 (ja) * 2017-09-01 2021-09-22 興和株式会社 医薬組成物
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

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CA1327010C (en) * 1986-02-13 1994-02-15 Tadashi Makino Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production
CA1336714C (en) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US5030447A (en) * 1988-03-31 1991-07-09 E. R. Squibb & Sons, Inc. Pharmaceutical compositions having good stability
JP3528186B2 (ja) * 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them

Also Published As

Publication number Publication date
CN1137684C (zh) 2004-02-11
PT814782E (pt) 2003-04-30
HUP9903536A3 (en) 2001-06-28
ZA9610792B (en) 1997-07-09
NZ324446A (en) 1999-08-30
FR11C0007I2 (fr) 2012-03-16
EP0814782B1 (de) 2002-11-27
MX9706389A (es) 1998-08-30
NO973814L (no) 1997-10-13
CZ288545B6 (cs) 2001-07-11
CA2213608C (en) 2003-07-08
HU227798B1 (en) 2012-03-28
HUP9903536A2 (hu) 2000-03-28
WO1997023200A1 (en) 1997-07-03
SK116097A3 (en) 1998-03-04
AU1171597A (en) 1997-07-17
TW436294B (en) 2001-05-28
NO973814D0 (no) 1997-08-19
JP3276962B2 (ja) 2002-04-22
JPH11503763A (ja) 1999-03-30
PL186907B1 (pl) 2004-03-31
AU725622B2 (en) 2000-10-19
FR11C0007I1 (de) 2011-04-22
KR19980702370A (ko) 1998-07-15
SK282991B6 (sk) 2003-01-09
IL121565A (en) 2002-02-10
IL121565A0 (en) 1998-02-08
ES2183023T3 (es) 2003-03-16
CA2213608A1 (en) 1997-07-03
RU2142790C1 (ru) 1999-12-20
KR100348842B1 (ko) 2002-12-31
DK0814782T3 (da) 2002-12-16
DE122011000014I1 (de) 2011-11-03
UA29513C2 (uk) 2000-11-15
CZ268197A3 (cs) 1998-05-13
NO2011006I1 (no) 2011-06-06
EP0814782A1 (de) 1998-01-07
DE69625046T2 (de) 2003-04-10
ATE228354T1 (de) 2002-12-15
CN1189098A (zh) 1998-07-29
NO316724B1 (no) 2004-04-19
SI0814782T1 (en) 2003-04-30
NO2011006I2 (no) 2012-10-01
PL321868A1 (en) 1997-12-22

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R069 Supplementary protection certificate granted

Free format text: PRODUCT NAME: PITAVASTATIN GEGEBENENFALLS IN FORM EINES PHARMAZEUTISCH ANNEHMBAREN SALZES ODER ESTER NL RVG 103768 RVG 103769 RVG 106928 20100810 S DAVON; NAT. REGISTRATION NO/DATE: 75160.00.00 75161.00.00 79602.00.00 20110211 FIRST REGISTRATION:

Spc suppl protection certif: 122011000014

Filing date: 20110408

Expiry date: 20161221

Extension date: 20211220